KLK10 (kallikrein related peptidase 10)
- symbol:
- KLK10
- locus group:
- protein-coding gene
- location:
- 19q13.41
- gene_family:
- Kallikreins
- alias symbol:
- NES1
- alias name:
- None
- entrez id:
- 5655
- ensembl gene id:
- ENSG00000129451
- ucsc gene id:
- uc002pva.4
- refseq accession:
- NM_002776
- hgnc_id:
- HGNC:6358
- approved reserved:
- 1997-05-09
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its encoded protein is secreted and may play a role in suppression of tumorigenesis in breast and prostate cancers. Alternate splicing of this gene results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
激肽释放酶是具有多种生理功能的丝氨酸蛋白酶的一个亚组。越来越多的证据表明，许多激肽释放酶在肿瘤发生牵连，部分为新的癌症和其他疾病的生物标志物的潜力。该基因是位于集群染色体19上的十五个激肽释放酶亚家族成员及其编码的蛋白分泌的一个，并且可以在肿瘤发生的抑制在乳腺癌和前列腺癌的作用。在多个转录该基因的结果的选择性剪接变体编码相同的蛋白质。 [由RefSeq的，2008年7月提供]
基因本体信息
KLK10基因（以及对应的蛋白质）的细胞分布位置：
- 质膜
- 细胞质
- 细胞外
- 高尔基体
- 囊泡
- 细胞骨架
- 内质网
- 细胞核
- 内体
- 溶酶体
- 线粒体
KLK10基因的本体（GO）信息：
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Mammary Neoplasms | 0.128987376 | 6 | 0 | BeFree_CTD_human_LHGDN |
| ovarian neoplasm | 0.122995792 | 3 | 0 | BeFree_CTD_human_LHGDN |
| Stomach Neoplasms | 0.12272435 | 1 | 0 | CTD_human_LHGDN |
| Spontaneous abortion | 0.12 | 1 | 0 | CTD_human |
| Malignant neoplasm of breast | 0.004071628 | 15 | 0 | BeFree |
| Malignant neoplasm of ovary | 0.003995683 | 6 | 0 | BeFree_GAD |
| Breast Carcinoma | 0.003528744 | 13 | 0 | BeFree |
| Malignant neoplasm of prostate | 0.003181358 | 4 | 0 | BeFree_GAD |
| Epithelial ovarian cancer | 0.002909916 | 3 | 0 | BeFree_GAD |
| Carcinoma, Papillary | 0.00272435 | 1 | 0 | LHGDN |
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