ITGB3 (integrin subunit beta 3)

基因基本信息

基因基本信息

symbol:
ITGB3
locus group:
protein-coding gene
location:
17q21.32
gene_family:
CD molecules|Integrins
alias symbol:
CD61|GPIIIa
alias name:
platelet glycoprotein IIIa|antigen…
entrez id:
3690
ensembl gene id:
ENSG00000259207
ucsc gene id:
uc002ilj.4
refseq accession:
NM_000212
hgnc_id:
HGNC:6156
approved reserved:
1988-06-09

基因染色体位置

基因染色体位置

17q21.32
基因染色体位置图

基因简述

基因简述

ITGB3基因编码整合素β3亚基，是整合素家族的重要成员。整合素家族是一类跨膜受体蛋白，由α和β亚基组成异二聚体，主要介导细胞与细胞外基质（ECM）的黏附以及细胞间信号传导。ITGB3与αIIb（血小板）或αv（广泛表达）亚基结合，分别形成αIIbβ3（GPIIb/IIIa）和αvβ3受体。αIIbβ3在血小板活化中起关键作用，介导血小板聚集和血栓形成；而αvβ3参与血管生成、骨吸收和肿瘤转移等过程。ITGB3基因突变可导致Glanzmann血小板无力症，患者表现为出血倾向，因为血小板无法正常聚集。ITGB3多态性（如PlA1/A2）与心血管疾病风险相关。ITGB3过表达可能促进肿瘤细胞迁移、侵袭和血管生成，尤其在黑色素瘤、胶质母细胞瘤和乳腺癌中；而降低表达则可能抑制这些过程，但增加出血风险。ITGB3与多种疾病相关，包括动脉粥样硬化、骨质疏松和癌症转移。该基因属于整合素β亚基家族，成员具有共同的结构特征：胞外区含有金属离子依赖的黏附位点，跨膜区和较短的胞内尾部。整合素家族成员普遍参与细胞-ECM相互作用、细胞迁移、增殖和存活等基本生物学过程。

The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. [provided by RefSeq, Jul 2008]

的ITGB3蛋白质产物是整β链测试3整合素是一个α链和一个β链组成的积分细胞表面蛋白。一个给定的链条可能会导致不同的整合多个合作伙伴结合起来。整合素β3与血小板阿尔法防爆链一起找到。整是已知参与细胞粘附以及细胞表面介导的信号。 [由RefSeq的，2008年7月提供]

OMIM数据库中对ITGB3基因的介绍     Wikipedia数据库中对ITGB3基因的介绍

基因序列

基因序列

ITGB3基因的碱基序列：[NCBI]
Loading Gene Browser...

基因突变

基因突变

ITGB3基因的碱基突变：           仅显示部分snp
rs4634       rs4642       rs5917       rs5918       rs5919       rs5920       rs5921       rs15908       rs884696       rs951351       rs984370       rs988684       rs999323       rs1000232       rs1009312       rs1051430       rs1051452      

基因表达

基因表达

ITGB3基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向Tm值
反向引物序列
反向Tm值
评分
CCTTTGTTTGTGTATGCACAG
58
GAAGCTCACCTTGGAAAGG
59
CATTGTCCAGCCTAATGACG
59
GAGGGATAATCCATGGTAGTGG
60
AGTCAGTGAAAGAGCTTAAGGA
59
ATCTGACGACACAGTCATCC
60
CATTGTCCAGCCTAATGACG
59
GAGGGATAATCCATGGTAGTGG
60
AAGATTGGAGACACGGTGAG
60
TATGGTAAAGGACTTCTCCTTCTC
60
GTGTATGCACAGTTGATTGC
58
GAAGCTCACCTTGGAAAGG
59
GCATTGTCCAGCCTAATGAC
59
AGGGATAATCCATGGTAGTGG
59
GCATTGTCCAGCCTAATGAC
59
AGGGATAATCCATGGTAGTGG
59
TGTATGCACAGTTGATTGCA
59
GAAGCTCACCTTGGAAAGG
59
TTGTCCAGCCTAATGACGG
60
AAGAGGGATAATCCATGGTAGTG
60

转录因子

转录因子

转录因子
影响基因
影响类型
参考文献链接（PubMed）
ETS1
ITGB3
Unknown
11556732
FOSL1
ITGB3
Repression
23319049
HOXA10
ITGB3
Unknown
11875117
HOXD3
ITGB3
Unknown
14610084
JUND
ITGB3
Repression
23319049
SP1
ITGB3
Repression
23319049

基因本体信息

ITGB3基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 质膜
  • 细胞质
  • 细胞外
  • 高尔基体
  • 囊泡
  • 细胞骨架
  • 内质网
  • 细胞核
  • 内体
  • 溶酶体
  • 线粒体

ITGB3基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0007229
I3L4X8 (UniProtKB)
IEA
GO:0016021
I3L4X8 (UniProtKB)
IEA
GO:0001618
P05106 (UniProtKB)
IEA
GO:0001934
P05106 (UniProtKB)
TAS
GO:0001938
P05106 (UniProtKB)
IMP
GO:0001968
P05106 (UniProtKB)
IMP
GO:0002020
P05106 (UniProtKB)
IDA
GO:0002576
P05106 (UniProtKB)
TAS
GO:0003756
P05106 (UniProtKB)
IDA
GO:0003756
P05106 (UniProtKB)
IDA
GO:0005161
P05106 (UniProtKB)
TAS
GO:0005515
P05106 (UniProtKB)
IPI
GO:0005515
P05106 (UniProtKB)
IPI
GO:0005515
P05106 (UniProtKB)
IPI
GO:0005515
P05106 (UniProtKB)
IPI
GO:0005515
P05106 (UniProtKB)
IPI
GO:0005515
P05106 (UniProtKB)
IPI
GO:0005515
P05106 (UniProtKB)
IPI
GO:0005515
P05106 (UniProtKB)
IPI
GO:0005515
P05106 (UniProtKB)
IPI
GO:0005515
P05106 (UniProtKB)
IPI
GO:0005515
P05106 (UniProtKB)
IPI
GO:0005515
P05106 (UniProtKB)
IPI
GO:0005515
P05106 (UniProtKB)
IPI
GO:0005515
P05106 (UniProtKB)
IPI
GO:0005515
P05106 (UniProtKB)
IPI
GO:0005515
P05106 (UniProtKB)
IPI
GO:0005515
P05106 (UniProtKB)
IPI
GO:0005515
P05106 (UniProtKB)
IPI
GO:0005515
P05106 (UniProtKB)
IPI
GO:0005515
P05106 (UniProtKB)
IPI
GO:0005515
P05106 (UniProtKB)
IPI
GO:0005515
P05106 (UniProtKB)
IPI
GO:0005515
P05106 (UniProtKB)
IPI
GO:0005515
P05106 (UniProtKB)
IPI
GO:0005515
P05106 (UniProtKB)
IPI
GO:0005515
P05106 (UniProtKB)
IPI
GO:0005634
P05106 (UniProtKB)
IDA
GO:0005886
P05106 (UniProtKB)
IDA
GO:0005886
P05106 (UniProtKB)
TAS
GO:0005886
P05106 (UniProtKB)
TAS
GO:0005886
P05106 (UniProtKB)
TAS
GO:0005886
P05106 (UniProtKB)
TAS
GO:0005886
P05106 (UniProtKB)
TAS
GO:0005886
P05106 (UniProtKB)
TAS
GO:0005886
P05106 (UniProtKB)
TAS
GO:0005886
P05106 (UniProtKB)
TAS
GO:0005886
P05106 (UniProtKB)
TAS
GO:0005886
P05106 (UniProtKB)
TAS
GO:0005886
P05106 (UniProtKB)
TAS
GO:0005886
P05106 (UniProtKB)
TAS
GO:0005886
P05106 (UniProtKB)
TAS
GO:0005886
P05106 (UniProtKB)
TAS
GO:0005886
P05106 (UniProtKB)
TAS
GO:0005886
P05106 (UniProtKB)
TAS
GO:0005886
P05106 (UniProtKB)
TAS
GO:0005886
P05106 (UniProtKB)
TAS
GO:0005886
P05106 (UniProtKB)
TAS
GO:0005886
P05106 (UniProtKB)
TAS
GO:0005886
P05106 (UniProtKB)
TAS
GO:0005886
P05106 (UniProtKB)
TAS
GO:0005886
P05106 (UniProtKB)
TAS
GO:0005886
P05106 (UniProtKB)
TAS
GO:0005886
P05106 (UniProtKB)
TAS
GO:0005886
P05106 (UniProtKB)
TAS
GO:0005886
P05106 (UniProtKB)
TAS
GO:0005886
P05106 (UniProtKB)
TAS
GO:0005886
P05106 (UniProtKB)
TAS
GO:0005886
P05106 (UniProtKB)
TAS
GO:0005886
P05106 (UniProtKB)
TAS
GO:0005886
P05106 (UniProtKB)
TAS
GO:0005886
P05106 (UniProtKB)
TAS
GO:0005886
P05106 (UniProtKB)
TAS
GO:0005886
P05106 (UniProtKB)
TAS
GO:0005886
P05106 (UniProtKB)
TAS
GO:0005886
P05106 (UniProtKB)
TAS
GO:0005886
P05106 (UniProtKB)
TAS
GO:0005886
P05106 (UniProtKB)
TAS
GO:0005886
P05106 (UniProtKB)
TAS
GO:0005886
P05106 (UniProtKB)
TAS
GO:0005886
P05106 (UniProtKB)
TAS
GO:0005886
P05106 (UniProtKB)
TAS
GO:0005886
P05106 (UniProtKB)
TAS
GO:0005886
P05106 (UniProtKB)
TAS
GO:0005886
P05106 (UniProtKB)
TAS
GO:0005886
P05106 (UniProtKB)
TAS
GO:0005886
P05106 (UniProtKB)
TAS
GO:0005886
P05106 (UniProtKB)
TAS
GO:0005886
P05106 (UniProtKB)
TAS
GO:0005887
P05106 (UniProtKB)
TAS
GO:0005925
P05106 (UniProtKB)
IDA
GO:0005925
P05106 (UniProtKB)
IDA
GO:0005925
P05106 (UniProtKB)
IDA
GO:0007044
P05106 (UniProtKB)
IEA
GO:0007155
P05106 (UniProtKB)
TAS
GO:0007155
P05106 (UniProtKB)
TAS
GO:0007160
P05106 (UniProtKB)
IDA
GO:0007160
P05106 (UniProtKB)
IMP
GO:0007160
P05106 (UniProtKB)
IMP
GO:0007229
P05106 (UniProtKB)
TAS
GO:0007229
P05106 (UniProtKB)
IDA
GO:0007596
P05106 (UniProtKB)
TAS
GO:0008305
P05106 (UniProtKB)
IDA
GO:0009986
P05106 (UniProtKB)
IDA
GO:0009986
P05106 (UniProtKB)
IDA
GO:0009986
P05106 (UniProtKB)
IDA
GO:0009986
P05106 (UniProtKB)
IDA
GO:0009986
P05106 (UniProtKB)
IDA
GO:0009986
P05106 (UniProtKB)
IDA
GO:0009986
P05106 (UniProtKB)
IDA
GO:0009986
P05106 (UniProtKB)
IDA
GO:0009986
P05106 (UniProtKB)
IDA
GO:0010595
P05106 (UniProtKB)
IMP
GO:0010745
P05106 (UniProtKB)
IMP
GO:0010888
P05106 (UniProtKB)
IMP
GO:0014909
P05106 (UniProtKB)
IMP
GO:0015026
P05106 (UniProtKB)
TAS
GO:0016049
P05106 (UniProtKB)
IMP
GO:0016477
P05106 (UniProtKB)
IMP
GO:0019899
P05106 (UniProtKB)
IPI
GO:0030168
P05106 (UniProtKB)
IMP
GO:0030198
P05106 (UniProtKB)
TAS
GO:0030949
P05106 (UniProtKB)
TAS
GO:0031092
P05106 (UniProtKB)
TAS
GO:0031258
P05106 (UniProtKB)
IDA
GO:0031527
P05106 (UniProtKB)
IDA
GO:0031528
P05106 (UniProtKB)
IDA
GO:0031589
P05106 (UniProtKB)
IMP
GO:0032147
P05106 (UniProtKB)
IMP
GO:0032369
P05106 (UniProtKB)
IMP
GO:0032587
P05106 (UniProtKB)
IDA
GO:0034113
P05106 (UniProtKB)
IMP
GO:0034446
P05106 (UniProtKB)
IDA
GO:0034683
P05106 (UniProtKB)
IDA
GO:0034683
P05106 (UniProtKB)
IDA
GO:0034683
P05106 (UniProtKB)
IDA
GO:0034683
P05106 (UniProtKB)
IDA
GO:0035295
P05106 (UniProtKB)
TAS
GO:0035867
P05106 (UniProtKB)
IDA
GO:0038027
P05106 (UniProtKB)
IMP
GO:0042060
P05106 (UniProtKB)
IC
GO:0042470
P05106 (UniProtKB)
IDA
GO:0042802
P05106 (UniProtKB)
IPI
GO:0042802
P05106 (UniProtKB)
IPI
GO:0043184
P05106 (UniProtKB)
IPI
GO:0043184
P05106 (UniProtKB)
TAS
GO:0043235
P05106 (UniProtKB)
IDA
GO:0045124
P05106 (UniProtKB)
TAS
GO:0045715
P05106 (UniProtKB)
IMP
GO:0046718
P05106 (UniProtKB)
IMP
GO:0048010
P05106 (UniProtKB)
TAS
GO:0048333
P05106 (UniProtKB)
IEP
GO:0050731
P05106 (UniProtKB)
IMP
GO:0050748
P05106 (UniProtKB)
IMP
GO:0050839
P05106 (UniProtKB)
IPI
GO:0050840
P05106 (UniProtKB)
IDA
GO:0050900
P05106 (UniProtKB)
TAS
GO:0050919
P05106 (UniProtKB)
IMP
GO:0060055
P05106 (UniProtKB)
TAS
GO:0070062
P05106 (UniProtKB)
IDA
GO:0070062
P05106 (UniProtKB)
IDA
GO:0070527
P05106 (UniProtKB)
IMP
GO:0071062
P05106 (UniProtKB)
TAS
GO:0017134
P05106 (UniProtKB)
IDA
GO:0019960
P05106 (UniProtKB)
IDA
GO:0031994
P05106 (UniProtKB)
IDA
GO:0038132
P05106 (UniProtKB)
IDA

基因相关microRNA

基因相关microRNA

可能调控 ITGB3基因的相关microRNA：     

基因相互作用关系

基因相互作用关系

Reactome

MINT

BioGrid

IntAct

mentha

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因通路

基因通路

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Thrombasthenia 0.608217928 46 9 BeFree_CLINVAR_CTD_human_GAD_LHGDN_MGD_ORPHANET_UNIPROT
Myocardial Infarction 0.39304913 44 1 BeFree_CLINVAR_CTD_human_GAD_LHGDN_RGD
Glanzmann Thrombasthenia, Autosomal Dominant 0.32 1 1 CLINVAR_MGD_UNIPROT
Cerebrovascular accident 0.25330848 26 0 BeFree_CTD_human_GAD_LHGDN_RGD
Acute Coronary Syndrome 0.140193776 9 0 BeFree_CTD_human_GAD_LHGDN
Autistic Disorder 0.136816922 8 2 BeFree_CTD_human_GAD_LHGDN
Prostatic Neoplasms 0.136346101 7 0 CTD_human_LHGDN
Thrombocytopenia 0.130182764 5 0 CTD_human_GAD_LHGDN
Neonatal Alloimmune Thrombocytopenia 0.125091382 3 0 CTD_human_GAD_LHGDN
Coronary Thrombosis 0.124810009 11 0 BeFree_CTD_human_GAD

基因相关服务

基因相关服务

联系方式

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