IL6 (interleukin 6)

基因基本信息

基因基本信息

symbol:
IL6
locus group:
protein-coding gene
location:
7p15.3
gene_family:
Interferons|Interleukins
alias symbol:
IL-6|BSF2|HGF|HSF
alias name:
interferon, beta 2
entrez id:
3569
ensembl gene id:
ENSG00000136244
ucsc gene id:
uc064bxs.1
refseq accession:
NM_000600
hgnc_id:
HGNC:6018
approved reserved:
1986-01-01

基因染色体位置

基因染色体位置

7p15.3
基因染色体位置图

基因简述

基因简述

IL6（白细胞介素6）是一种多功能细胞因子，属于白细胞介素家族，在免疫调节、炎症反应、造血和代谢过程中发挥核心作用。它主要由T细胞、巨噬细胞、内皮细胞和脂肪细胞产生，通过结合IL6受体（IL6R）和gp130信号转导蛋白激活JAK-STAT、MAPK和PI3K通路，影响靶细胞的增殖、分化和功能。IL6在急性炎症中起保护作用，促进肝细胞产生急性期蛋白（如C反应蛋白）和发热反应，同时刺激B细胞分化为浆细胞以增强抗体产生。然而，IL6的持续过表达与多种慢性炎症性疾病和自身免疫疾病相关，如类风湿性关节炎、克罗恩病和 Castleman病，还参与某些癌症（如多发性骨髓瘤）的发展，促进肿瘤细胞增殖和血管生成。IL6基因突变可能导致异常信号传导，例如IL6受体增益性突变与幼年特发性关节炎相关，而功能丧失突变可能增加感染风险。IL6过表达会加剧炎症反应和组织损伤，而降低表达可能削弱免疫防御但减轻炎症性疾病症状。IL6属于白细胞介素家族，该家族成员均为细胞因子，主要调节免疫细胞间的通讯和炎症反应。针对IL6或其受体的单克隆抗体（如托珠单抗）已用于治疗类风湿性关节炎和细胞因子风暴（如COVID-19重症病例），体现了其作为治疗靶点的重要性。

None

无

OMIM数据库中对IL6基因的介绍     Wikipedia数据库中对IL6基因的介绍

基因序列

基因序列

IL6基因的碱基序列：[NCBI]
Loading Gene Browser...

基因突变

基因突变

IL6基因的碱基突变：           仅显示部分snp
rs940367       rs1474347       rs1474348       rs1524107       rs1548216       rs1554606       rs1800795       rs1800796       rs1800797       rs2002792       rs2066992       rs2069824       rs2069826       rs2069827       rs2069828       rs2069829       rs2069830      

基因表达

基因表达

IL6基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向Tm值
反向引物序列
反向Tm值
评分
ACTCACCTCTTCAGAACGA
58
TGTTACATGTCTCCTTTCTCAG
58
ATTCAATGAGGAGACTTGCCT
60
CTGTTCTGGAGGTACTCTAGG
59
ATTCAATGAGGAGACTTGCCT
60
CTGTTCTGGAGGTACTCTAGG
59
ATTCAATGAGGAGACTTGCCT
60
CTGTTCTGGAGGTACTCTAGG
59
ACTCACCTCTTCAGAACGA
58
TGTTACATGTCTCCTTTCTCAG
58
AACTCCTTCTCCACAATACC
57
GTTCTGAAGAGGTGAGTGG
58
ACTCACCTCTTCAGAACGA
58
TGTTACATGTCTCCTTTCTCAG
58
ACTCACCTCTTCAGAACGA
58
TGTTACATGTCTCCTTTCTCAG
58
ATTCAATGAGGAGACTTGCCT
60
CTGTTCTGGAGGTACTCTAGG
59
ACTCACCTCTTCAGAACGA
58
TGTTACATGTCTCCTTTCTCAG
58

转录因子

转录因子

转录因子
影响基因
影响类型
参考文献链接（PubMed）
AHR
IL6
Activation
20511231
AHR
IL6
Unknown
18483242; 23349129
ATF4
IL6
Unknown
16931790
CEBPA
IL6
Unknown
11975924
CEBPB
IL6
Activation
10903137; 8725624
CEBPB
IL6
Unknown
11120852
CREB1
IL6
Activation
8725624
DDIT3
IL6
Activation
12706815
EGR1
IL6
Repression
15517885
EGR2
IL6
Unknown
24007274

基因本体信息

IL6基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 质膜
  • 细胞质
  • 细胞外
  • 高尔基体
  • 囊泡
  • 细胞骨架
  • 内质网
  • 细胞核
  • 内体
  • 溶酶体
  • 线粒体

IL6基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0005125
B4DNV3 (UniProtKB)
IEA
GO:0005138
B4DNV3 (UniProtKB)
IEA
GO:0005576
B4DNV3 (UniProtKB)
IEA
GO:0006955
B4DNV3 (UniProtKB)
IEA
GO:0005125
B5MC14 (UniProtKB)
IEA
GO:0005138
B5MC14 (UniProtKB)
IEA
GO:0005576
B5MC14 (UniProtKB)
IEA
GO:0006955
B5MC14 (UniProtKB)
IEA
GO:0005125
B5MC21 (UniProtKB)
IEA
GO:0005138
B5MC21 (UniProtKB)
IEA
GO:0005576
B5MC21 (UniProtKB)
IEA
GO:0006955
B5MC21 (UniProtKB)
IEA
GO:0005125
B5MCZ3 (UniProtKB)
IEA
GO:0005138
B5MCZ3 (UniProtKB)
IEA
GO:0005576
B5MCZ3 (UniProtKB)
IEA
GO:0006955
B5MCZ3 (UniProtKB)
IEA
GO:0005125
C9J5B0 (UniProtKB)
IEA
GO:0005138
C9J5B0 (UniProtKB)
IEA
GO:0005576
C9J5B0 (UniProtKB)
IEA
GO:0006955
C9J5B0 (UniProtKB)
IEA
GO:0001781
P05231 (UniProtKB)
IDA
GO:0001878
P05231 (UniProtKB)
IEA
GO:0002384
P05231 (UniProtKB)
TAS
GO:0002384
P05231 (UniProtKB)
IDA
GO:0002446
P05231 (UniProtKB)
TAS
GO:0002548
P05231 (UniProtKB)
IC
GO:0002675
P05231 (UniProtKB)
IDA
GO:0002690
P05231 (UniProtKB)
TAS
GO:0005125
P05231 (UniProtKB)
ISS
GO:0005125
P05231 (UniProtKB)
NAS
GO:0005125
P05231 (UniProtKB)
IDA
GO:0005125
P05231 (UniProtKB)
IDA
GO:0005138
P05231 (UniProtKB)
IPI
GO:0005138
P05231 (UniProtKB)
NAS
GO:0005515
P05231 (UniProtKB)
IPI
GO:0005515
P05231 (UniProtKB)
IPI
GO:0005515
P05231 (UniProtKB)
IPI
GO:0005515
P05231 (UniProtKB)
IPI
GO:0005576
P05231 (UniProtKB)
TAS
GO:0005576
P05231 (UniProtKB)
TAS
GO:0005576
P05231 (UniProtKB)
TAS
GO:0005576
P05231 (UniProtKB)
TAS
GO:0005576
P05231 (UniProtKB)
TAS
GO:0005576
P05231 (UniProtKB)
TAS
GO:0005576
P05231 (UniProtKB)
TAS
GO:0005576
P05231 (UniProtKB)
TAS
GO:0005576
P05231 (UniProtKB)
TAS
GO:0005576
P05231 (UniProtKB)
TAS
GO:0005576
P05231 (UniProtKB)
TAS
GO:0005576
P05231 (UniProtKB)
TAS
GO:0005576
P05231 (UniProtKB)
TAS
GO:0005576
P05231 (UniProtKB)
TAS
GO:0005576
P05231 (UniProtKB)
TAS
GO:0005576
P05231 (UniProtKB)
TAS
GO:0005576
P05231 (UniProtKB)
TAS
GO:0005615
P05231 (UniProtKB)
IDA
GO:0005615
P05231 (UniProtKB)
IDA
GO:0005615
P05231 (UniProtKB)
IDA
GO:0005737
P05231 (UniProtKB)
IEA
GO:0005896
P05231 (UniProtKB)
IDA
GO:0005896
P05231 (UniProtKB)
IDA
GO:0006469
P05231 (UniProtKB)
IEA
GO:0006953
P05231 (UniProtKB)
TAS
GO:0006954
P05231 (UniProtKB)
IDA
GO:0006959
P05231 (UniProtKB)
IC
GO:0007568
P05231 (UniProtKB)
IEA
GO:0008083
P05231 (UniProtKB)
IDA
GO:0008083
P05231 (UniProtKB)
IDA
GO:0008284
P05231 (UniProtKB)
IMP
GO:0008284
P05231 (UniProtKB)
IDA
GO:0008285
P05231 (UniProtKB)
IEA
GO:0008360
P05231 (UniProtKB)
IEA
GO:0009408
P05231 (UniProtKB)
IEA
GO:0009409
P05231 (UniProtKB)
IEA
GO:0009897
P05231 (UniProtKB)
IEA
GO:0010574
P05231 (UniProtKB)
IDA
GO:0010628
P05231 (UniProtKB)
IDA
GO:0010888
P05231 (UniProtKB)
NAS
GO:0010996
P05231 (UniProtKB)
IEA
GO:0016049
P05231 (UniProtKB)
IEA
GO:0019221
P05231 (UniProtKB)
IDA
GO:0019221
P05231 (UniProtKB)
IDA
GO:0030168
P05231 (UniProtKB)
TAS
GO:0031000
P05231 (UniProtKB)
IEA
GO:0031018
P05231 (UniProtKB)
ISS
GO:0031175
P05231 (UniProtKB)
IMP
GO:0031667
P05231 (UniProtKB)
IEA
GO:0032494
P05231 (UniProtKB)
NAS
GO:0032722
P05231 (UniProtKB)
IDA
GO:0032722
P05231 (UniProtKB)
NAS
GO:0032755
P05231 (UniProtKB)
IDA
GO:0032868
P05231 (UniProtKB)
IEA
GO:0032966
P05231 (UniProtKB)
IDA
GO:0033138
P05231 (UniProtKB)
IDA
GO:0033160
P05231 (UniProtKB)
IEA
GO:0035729
P05231 (UniProtKB)
IEA
GO:0042102
P05231 (UniProtKB)
IDA
GO:0042493
P05231 (UniProtKB)
IEA
GO:0042517
P05231 (UniProtKB)
IDA
GO:0042517
P05231 (UniProtKB)
IDA
GO:0042593
P05231 (UniProtKB)
IEA
GO:0042832
P05231 (UniProtKB)
IEA
GO:0043065
P05231 (UniProtKB)
IDA
GO:0043066
P05231 (UniProtKB)
IDA
GO:0043154
P05231 (UniProtKB)
IEA
GO:0043200
P05231 (UniProtKB)
IEA
GO:0043410
P05231 (UniProtKB)
IDA
GO:0043410
P05231 (UniProtKB)
IDA
GO:0045079
P05231 (UniProtKB)
ISS
GO:0045188
P05231 (UniProtKB)
IEA
GO:0045429
P05231 (UniProtKB)
IEA
GO:0045454
P05231 (UniProtKB)
IEA
GO:0045599
P05231 (UniProtKB)
NAS
GO:0045630
P05231 (UniProtKB)
IEA
GO:0045666
P05231 (UniProtKB)
IEA
GO:0045669
P05231 (UniProtKB)
TAS
GO:0045721
P05231 (UniProtKB)
IEA
GO:0045727
P05231 (UniProtKB)
IDA
GO:0045740
P05231 (UniProtKB)
IEA
GO:0045765
P05231 (UniProtKB)
IC
GO:0045893
P05231 (UniProtKB)
IDA
GO:0045944
P05231 (UniProtKB)
ISS
GO:0045944
P05231 (UniProtKB)
IDA
GO:0045944
P05231 (UniProtKB)
IDA
GO:0045944
P05231 (UniProtKB)
IDA
GO:0046427
P05231 (UniProtKB)
IDA
GO:0046427
P05231 (UniProtKB)
IDA
GO:0046427
P05231 (UniProtKB)
IDA
GO:0046677
P05231 (UniProtKB)
IEA
GO:0046716
P05231 (UniProtKB)
IEA
GO:0046849
P05231 (UniProtKB)
IEA
GO:0046888
P05231 (UniProtKB)
IEA
GO:0048635
P05231 (UniProtKB)
IEA
GO:0048661
P05231 (UniProtKB)
IDA
GO:0050679
P05231 (UniProtKB)
IEA
GO:0050710
P05231 (UniProtKB)
IEA
GO:0050731
P05231 (UniProtKB)
IDA
GO:0050829
P05231 (UniProtKB)
TAS
GO:0050830
P05231 (UniProtKB)
TAS
GO:0050871
P05231 (UniProtKB)
IDA
GO:0051024
P05231 (UniProtKB)
IDA
GO:0051091
P05231 (UniProtKB)
IDA
GO:0051384
P05231 (UniProtKB)
IDA
GO:0051592
P05231 (UniProtKB)
IEA
GO:0051602
P05231 (UniProtKB)
IEA
GO:0051607
P05231 (UniProtKB)
IDA
GO:0051897
P05231 (UniProtKB)
IEA
GO:0051971
P05231 (UniProtKB)
IEA
GO:0060445
P05231 (UniProtKB)
IEA
GO:0060664
P05231 (UniProtKB)
IEA
GO:0070091
P05231 (UniProtKB)
ISS
GO:0070102
P05231 (UniProtKB)
IDA
GO:0070102
P05231 (UniProtKB)
IDA
GO:0070301
P05231 (UniProtKB)
IDA
GO:0070374
P05231 (UniProtKB)
IEA
GO:0071222
P05231 (UniProtKB)
IMP
GO:0071347
P05231 (UniProtKB)
IEA
GO:0071347
P05231 (UniProtKB)
IEA
GO:0071356
P05231 (UniProtKB)
IEA
GO:0071356
P05231 (UniProtKB)
IEA
GO:0071549
P05231 (UniProtKB)
IEA
GO:0071864
P05231 (UniProtKB)
IEA
GO:0072540
P05231 (UniProtKB)
ISS
GO:1901215
P05231 (UniProtKB)
IEA
GO:2000366
P05231 (UniProtKB)
IC
GO:2000676
P05231 (UniProtKB)
TAS
GO:0051092
P05231 (UniProtKB)
IDA
GO:0005138
P05231 (UniProtKB)
IPI

基因相关microRNA

基因相关microRNA

可能调控 IL6基因的相关microRNA：     

基因相互作用关系

基因相互作用关系

Reactome

BioGrid

IntAct

mentha

String

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因通路

基因通路

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Diabetes Mellitus, Non-Insulin-Dependent 0.420661594 76 2 BeFree_CLINVAR_CTD_human_GAD_LHGDN_RGD
Obesity 0.289229902 116 5 BeFree_CTD_human_GAD_RGD
Rheumatoid Arthritis, Systemic Juvenile 0.240271442 1 0 BeFree_CTD_human_ORPHANET
Multiple Myeloma 0.225615597 239 1 BeFree_CTD_human_GAD_LHGDN
Inflammation 0.219070452 70 0 CTD_human_GAD_LHGDN
Rheumatoid Arthritis 0.212623944 187 5 BeFree_CTD_human_GAD_LHGDN
Heart failure 0.205081451 15 0 BeFree_CTD_human_GAD_RGD
Depressive disorder 0.203800186 15 0 BeFree_CTD_human_RGD
Reperfusion Injury 0.202367032 7 0 CTD_human_GAD_RGD
Diabetes Mellitus, Experimental 0.2 4 0 CTD_human_RGD

基因相关服务

基因相关服务

联系方式

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