IL1RAP (interleukin 1 receptor accessory protein)
- symbol:
- IL1RAP
- locus group:
- protein-coding gene
- location:
- 3q28
- gene_family:
- Immunoglobulin-like domain containing|Interleukin receptors
- alias symbol:
- IL-1RAcP|IL1R3|C3orf13
- alias name:
- None
- entrez id:
- 3556
- ensembl gene id:
- ENSG00000196083
- ucsc gene id:
- uc003fso.2
- refseq accession:
- NM_001167929
- hgnc_id:
- HGNC:5995
- approved reserved:
- 1997-10-09
Interleukin 1 induces synthesis of acute phase and proinflammatory proteins during infection, tissue damage, or stress, by forming a complex at the cell membrane with an interleukin 1 receptor and an accessory protein. This gene encodes the interleukin 1 receptor accessory protein. The protein is a necessary part of the interleukin 1 receptor complex which initiates signalling events that result in the activation of interleukin 1-responsive genes. Alternative splicing of this gene results in two transcript variants encoding two different isoforms, one membrane-bound and one soluble. The ratio of soluble to membrane-bound forms increases during acute-phase induction or stress. [provided by RefSeq, Nov 2009]
白细胞介素1诱导急性期和感染期间促炎蛋白，组织损伤，或应力的合成，通过用白介素1受体和辅助蛋白形成在细胞膜的复合物。该基因编码的白细胞介素1受体辅助蛋白。蛋白质是白细胞介素1受体配合物，其是发起信令导致的白介素1反应性基因的激活事件的必要组成部分。两个转录本基因导致选择性剪接变异体的编码两个不同的亚型，一是膜结合和一种可溶性。可溶性到膜结合形式的比率急性相感应或胁迫期间增加。 [由RefSeq的，2009年11月提供]
基因本体信息
IL1RAP基因（以及对应的蛋白质）的细胞分布位置：
- 质膜
- 细胞质
- 细胞外
- 高尔基体
- 囊泡
- 细胞骨架
- 内质网
- 细胞核
- 内体
- 溶酶体
- 线粒体
IL1RAP基因的本体（GO）信息：
| 名称 |
|---|
| 4060 Cytokine-cytokine receptor interaction [PATH:hsa04060] |
| 4210 Apoptosis [PATH:hsa04210] |
| 4750 Inflammatory mediator regulation of TRP channels [PATH:hsa04750] |
| 名称 |
|---|
| Cytokine Signaling in Immune system |
| Immune System |
| Interleukin-1 signaling |
| Signaling by Interleukins |
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Liver diseases | 0.12 | 1 | 0 | CTD_human |
| Inflammation | 0.007458414 | 3 | 0 | GAD_LHGDN |
| Premature Birth | 0.007101096 | 3 | 0 | GAD |
| Infection | 0.004734064 | 2 | 0 | GAD |
| Liver carcinoma | 0.002995792 | 2 | 0 | BeFree_LHGDN |
| Pregnancy Complications, Hematologic | 0.002367032 | 1 | 0 | GAD |
| Dermatologic disorders | 0.002367032 | 1 | 0 | GAD |
| Diabetes Mellitus, Insulin-Dependent | 0.002367032 | 1 | 0 | GAD |
| Fetal Diseases | 0.002367032 | 1 | 0 | GAD |
| Postoperative Complications | 0.002367032 | 1 | 0 | GAD |
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