HSP90AA1 (heat shock protein 90 alpha family class A member 1)

基因基本信息

基因基本信息

symbol:
HSP90AA1
locus group:
protein-coding gene
location:
14q32.31
gene_family:
Heat shock 90kDa proteins
alias symbol:
Hsp89|Hsp90|FLJ31884|HSP90N
alias name:
None
entrez id:
3320
ensembl gene id:
ENSG00000080824
ucsc gene id:
uc001yku.5
refseq accession:
NM_005348
hgnc_id:
HGNC:5253
approved reserved:
1990-06-27

基因染色体位置

基因染色体位置

14q32.31
基因染色体位置图

基因简述

基因简述

HSP90AA1是热休克蛋白90（HSP90）家族的重要成员之一，属于分子伴侣蛋白家族。HSP90家族包括HSP90AA1（诱导型）、HSP90AB1（组成型）和HSP90B1（内质网型）等亚型，它们共同的特点是能够帮助蛋白质正确折叠、维持蛋白质稳定性并参与细胞应激反应。HSP90AA1主要在细胞质中表达，其表达水平在热应激或其他环境压力下显著升高。该基因编码的HSP90蛋白通过与客户蛋白（如激酶、转录因子和类固醇激素受体）结合，协助它们完成构象成熟和功能激活。HSP90AA1在多种细胞过程中发挥关键作用，包括信号转导、细胞周期调控、凋亡抑制和免疫应答。突变或异常表达可能严重影响其功能，例如某些突变会削弱其与ATP或客户蛋白的结合能力，导致蛋白质错误折叠和聚集，这可能引发神经退行性疾病或癌症。HSP90AA1的过表达常见于多种肿瘤，如乳腺癌、肺癌和前列腺癌，因为它能稳定致癌蛋白（如HER2、AKT和突变型p53），促进肿瘤细胞存活和增殖。相反，降低HSP90AA1表达或使用其抑制剂（如格尔德霉素）可诱导客户蛋白降解，抑制肿瘤生长。此外，HSP90AA1还参与病毒感染和炎症反应，例如在流感病毒复制中起辅助作用。该基因的表达水平受热休克因子1（HSF1）调控，在应激条件下HSF1激活并上调HSP90AA1表达。HSP90家族蛋白均依赖ATP水解来驱动构象变化，完成客户蛋白的折叠循环。由于其在疾病中的重要作用，HSP90AA1已成为癌症治疗的研究靶点，但其广泛功能也使得靶向治疗需谨慎以避免副作用。

None

无

OMIM数据库中对HSP90AA1基因的介绍     Wikipedia数据库中对HSP90AA1基因的介绍

基因序列

基因序列

HSP90AA1基因的碱基序列：[NCBI]
Loading Gene Browser...

基因突变

基因突变

HSP90AA1基因的碱基突变：           仅显示部分snp
rs4947       rs745313       rs1058078       rs1059623       rs1059629       rs1190587       rs1190588       rs1190589       rs1190590       rs1190591       rs1190592       rs1190593       rs1190594       rs1190595       rs1190596       rs1190597       rs1190598      

基因表达

基因表达

HSP90AA1基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向Tm值
反向引物序列
反向Tm值
评分
GCTTGGAATACACGAAGACTC
59
TGTGTAGTACCTTAACAGCTC
57
TATATCACAGGTGAGACCAAGG
59
GATCACTTCTAAGCCATGTTTCC
59
CCTTTCAGGCAGAAATTGC
58
GACCCATAGGTTCACATCTG
58
TTTCTGAGAAGGGCACCTG
60
GTAGAGTGGTGGATCCAGAC
59
CAATAACCTTGGTGAACCTATGG
60
TCCTCCAAGTACTCAGTTTGG
60
CTGTGAGGAGCTAATCCCTG
60
GATCCTCCGAGTCTACCAC
59
TTCAGACAGAGCCAAGGTG
60
TTTCCTCAGGCATCAGTAGC
60
AGACACAGGTGAACCTATGG
59
TCGTTCCTCCAAGTACTCAG
59
GATGCGGTGAAGCTTACAG
59
AAGTGCTCTAGCTTGTTCC
58
AACTGGCGGAAGATAAAGAG
58
TTGAGAGTCTTCGTGTATTCCA
59

转录因子

转录因子

转录因子
影响基因
影响类型
参考文献链接（PubMed）
POU4F1
HSP90AA1
Activation
15818685
POU4F2
HSP90AA1
Activation
15818685
STAT1
HSP90AA1
Repression
12940076

基因本体信息

HSP90AA1基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 质膜
  • 细胞质
  • 细胞外
  • 高尔基体
  • 囊泡
  • 细胞骨架
  • 内质网
  • 细胞核
  • 内体
  • 溶酶体
  • 线粒体

HSP90AA1基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0005524
G3V2J8 (UniProtKB)
IEA
GO:0006457
G3V2J8 (UniProtKB)
IEA
GO:0006950
G3V2J8 (UniProtKB)
IEA
GO:0051082
G3V2J8 (UniProtKB)
IEA
GO:0005524
H0YJF5 (UniProtKB)
IEA
GO:0006457
H0YJF5 (UniProtKB)
IEA
GO:0006950
H0YJF5 (UniProtKB)
IEA
GO:0051082
H0YJF5 (UniProtKB)
IEA
GO:0000086
P07900 (UniProtKB)
TAS
GO:0000166
P07900 (UniProtKB)
TAS
GO:0001764
P07900 (UniProtKB)
IEA
GO:0002134
P07900 (UniProtKB)
IEA
GO:0002135
P07900 (UniProtKB)
IEA
GO:0003009
P07900 (UniProtKB)
IEA
GO:0003729
P07900 (UniProtKB)
IEA
GO:0004713
P07900 (UniProtKB)
EXP
GO:0005515
P07900 (UniProtKB)
IPI
GO:0005515
P07900 (UniProtKB)
IPI
GO:0005515
P07900 (UniProtKB)
IPI
GO:0005515
P07900 (UniProtKB)
IPI
GO:0005515
P07900 (UniProtKB)
IPI
GO:0005515
P07900 (UniProtKB)
IPI
GO:0005515
P07900 (UniProtKB)
IPI
GO:0005515
P07900 (UniProtKB)
IPI
GO:0005515
P07900 (UniProtKB)
IPI
GO:0005515
P07900 (UniProtKB)
IPI
GO:0005515
P07900 (UniProtKB)
IPI
GO:0005515
P07900 (UniProtKB)
IPI
GO:0005515
P07900 (UniProtKB)
IPI
GO:0005515
P07900 (UniProtKB)
IPI
GO:0005515
P07900 (UniProtKB)
IPI
GO:0005515
P07900 (UniProtKB)
IPI
GO:0005515
P07900 (UniProtKB)
IPI
GO:0005515
P07900 (UniProtKB)
IPI
GO:0005515
P07900 (UniProtKB)
IPI
GO:0005515
P07900 (UniProtKB)
IPI
GO:0005515
P07900 (UniProtKB)
IPI
GO:0005515
P07900 (UniProtKB)
IPI
GO:0005515
P07900 (UniProtKB)
IPI
GO:0005515
P07900 (UniProtKB)
IPI
GO:0005515
P07900 (UniProtKB)
IPI
GO:0005515
P07900 (UniProtKB)
IPI
GO:0005515
P07900 (UniProtKB)
IPI
GO:0005515
P07900 (UniProtKB)
IPI
GO:0005515
P07900 (UniProtKB)
IPI
GO:0005515
P07900 (UniProtKB)
IPI
GO:0005515
P07900 (UniProtKB)
IPI
GO:0005515
P07900 (UniProtKB)
IPI
GO:0005515
P07900 (UniProtKB)
IPI
GO:0005515
P07900 (UniProtKB)
IPI
GO:0005515
P07900 (UniProtKB)
IPI
GO:0005515
P07900 (UniProtKB)
IPI
GO:0005515
P07900 (UniProtKB)
IPI
GO:0005515
P07900 (UniProtKB)
IPI
GO:0005515
P07900 (UniProtKB)
IPI
GO:0005515
P07900 (UniProtKB)
IPI
GO:0005515
P07900 (UniProtKB)
IPI
GO:0005515
P07900 (UniProtKB)
IPI
GO:0005515
P07900 (UniProtKB)
IPI
GO:0005515
P07900 (UniProtKB)
IPI
GO:0005515
P07900 (UniProtKB)
IPI
GO:0005515
P07900 (UniProtKB)
IPI
GO:0005515
P07900 (UniProtKB)
IPI
GO:0005515
P07900 (UniProtKB)
IPI
GO:0005515
P07900 (UniProtKB)
IPI
GO:0005515
P07900 (UniProtKB)
IPI
GO:0005515
P07900 (UniProtKB)
IPI
GO:0005515
P07900 (UniProtKB)
IPI
GO:0005515
P07900 (UniProtKB)
IPI
GO:0005515
P07900 (UniProtKB)
IPI
GO:0005515
P07900 (UniProtKB)
IPI
GO:0005515
P07900 (UniProtKB)
IPI
GO:0005515
P07900 (UniProtKB)
IPI
GO:0005515
P07900 (UniProtKB)
IPI
GO:0005515
P07900 (UniProtKB)
IPI
GO:0005515
P07900 (UniProtKB)
IPI
GO:0005515
P07900 (UniProtKB)
IPI
GO:0005515
P07900 (UniProtKB)
IPI
GO:0005515
P07900 (UniProtKB)
IPI
GO:0005515
P07900 (UniProtKB)
IPI
GO:0005515
P07900 (UniProtKB)
IPI
GO:0005515
P07900 (UniProtKB)
IPI
GO:0005515
P07900 (UniProtKB)
IPI
GO:0005515
P07900 (UniProtKB)
IPI
GO:0005515
P07900 (UniProtKB)
IPI
GO:0005515
P07900 (UniProtKB)
IPI
GO:0005515
P07900 (UniProtKB)
IPI
GO:0005515
P07900 (UniProtKB)
IPI
GO:0005524
P07900 (UniProtKB)
TAS
GO:0005525
P07900 (UniProtKB)
IEA
GO:0005576
P07900 (UniProtKB)
TAS
GO:0005634
P07900 (UniProtKB)
ISS
GO:0005634
P07900 (UniProtKB)
IDA
GO:0005654
P07900 (UniProtKB)
IDA
GO:0005654
P07900 (UniProtKB)
TAS
GO:0005654
P07900 (UniProtKB)
TAS
GO:0005654
P07900 (UniProtKB)
TAS
GO:0005737
P07900 (UniProtKB)
ISS
GO:0005737
P07900 (UniProtKB)
IDA
GO:0005829
P07900 (UniProtKB)
NAS
GO:0005829
P07900 (UniProtKB)
TAS
GO:0005829
P07900 (UniProtKB)
TAS
GO:0005829
P07900 (UniProtKB)
TAS
GO:0005829
P07900 (UniProtKB)
TAS
GO:0005829
P07900 (UniProtKB)
TAS
GO:0005829
P07900 (UniProtKB)
TAS
GO:0005829
P07900 (UniProtKB)
TAS
GO:0005829
P07900 (UniProtKB)
TAS
GO:0005829
P07900 (UniProtKB)
TAS
GO:0005829
P07900 (UniProtKB)
TAS
GO:0005829
P07900 (UniProtKB)
TAS
GO:0005829
P07900 (UniProtKB)
TAS
GO:0005829
P07900 (UniProtKB)
TAS
GO:0005829
P07900 (UniProtKB)
TAS
GO:0005829
P07900 (UniProtKB)
TAS
GO:0005829
P07900 (UniProtKB)
TAS
GO:0005829
P07900 (UniProtKB)
TAS
GO:0005829
P07900 (UniProtKB)
TAS
GO:0005829
P07900 (UniProtKB)
TAS
GO:0005829
P07900 (UniProtKB)
TAS
GO:0005829
P07900 (UniProtKB)
TAS
GO:0005829
P07900 (UniProtKB)
TAS
GO:0005829
P07900 (UniProtKB)
TAS
GO:0005829
P07900 (UniProtKB)
TAS
GO:0005829
P07900 (UniProtKB)
TAS
GO:0005829
P07900 (UniProtKB)
TAS
GO:0005829
P07900 (UniProtKB)
TAS
GO:0005829
P07900 (UniProtKB)
TAS
GO:0005829
P07900 (UniProtKB)
TAS
GO:0005829
P07900 (UniProtKB)
TAS
GO:0005829
P07900 (UniProtKB)
TAS
GO:0005829
P07900 (UniProtKB)
TAS
GO:0005829
P07900 (UniProtKB)
TAS
GO:0005829
P07900 (UniProtKB)
TAS
GO:0005829
P07900 (UniProtKB)
TAS
GO:0005829
P07900 (UniProtKB)
TAS
GO:0005829
P07900 (UniProtKB)
TAS
GO:0005829
P07900 (UniProtKB)
TAS
GO:0005829
P07900 (UniProtKB)
TAS
GO:0005829
P07900 (UniProtKB)
TAS
GO:0005829
P07900 (UniProtKB)
TAS
GO:0005829
P07900 (UniProtKB)
TAS
GO:0005829
P07900 (UniProtKB)
TAS
GO:0005829
P07900 (UniProtKB)
TAS
GO:0005829
P07900 (UniProtKB)
TAS
GO:0005829
P07900 (UniProtKB)
TAS
GO:0005829
P07900 (UniProtKB)
TAS
GO:0005829
P07900 (UniProtKB)
TAS
GO:0005829
P07900 (UniProtKB)
TAS
GO:0005829
P07900 (UniProtKB)
TAS
GO:0005829
P07900 (UniProtKB)
TAS
GO:0005829
P07900 (UniProtKB)
TAS
GO:0005829
P07900 (UniProtKB)
TAS
GO:0005829
P07900 (UniProtKB)
TAS
GO:0005829
P07900 (UniProtKB)
TAS
GO:0005829
P07900 (UniProtKB)
TAS
GO:0005829
P07900 (UniProtKB)
TAS
GO:0005829
P07900 (UniProtKB)
TAS
GO:0005829
P07900 (UniProtKB)
TAS
GO:0005829
P07900 (UniProtKB)
TAS
GO:0005829
P07900 (UniProtKB)
TAS
GO:0005829
P07900 (UniProtKB)
TAS
GO:0005829
P07900 (UniProtKB)
TAS
GO:0005829
P07900 (UniProtKB)
TAS
GO:0005829
P07900 (UniProtKB)
TAS
GO:0005829
P07900 (UniProtKB)
TAS
GO:0005829
P07900 (UniProtKB)
TAS
GO:0005829
P07900 (UniProtKB)
TAS
GO:0005829
P07900 (UniProtKB)
TAS
GO:0005829
P07900 (UniProtKB)
TAS
GO:0005829
P07900 (UniProtKB)
TAS
GO:0005829
P07900 (UniProtKB)
TAS
GO:0005829
P07900 (UniProtKB)
TAS
GO:0005829
P07900 (UniProtKB)
TAS
GO:0005829
P07900 (UniProtKB)
TAS
GO:0005829
P07900 (UniProtKB)
TAS
GO:0005829
P07900 (UniProtKB)
TAS
GO:0005829
P07900 (UniProtKB)
TAS
GO:0005829
P07900 (UniProtKB)
TAS
GO:0005829
P07900 (UniProtKB)
TAS
GO:0005829
P07900 (UniProtKB)
TAS
GO:0005829
P07900 (UniProtKB)
TAS
GO:0005886
P07900 (UniProtKB)
TAS
GO:0005886
P07900 (UniProtKB)
TAS
GO:0005886
P07900 (UniProtKB)
TAS
GO:0005886
P07900 (UniProtKB)
TAS
GO:0006839
P07900 (UniProtKB)
TAS
GO:0006898
P07900 (UniProtKB)
TAS
GO:0006986
P07900 (UniProtKB)
NAS
GO:0007165
P07900 (UniProtKB)
NAS
GO:0009408
P07900 (UniProtKB)
ISS
GO:0009409
P07900 (UniProtKB)
ISS
GO:0009651
P07900 (UniProtKB)
IEA
GO:0009986
P07900 (UniProtKB)
IEA
GO:0010592
P07900 (UniProtKB)
IEA
GO:0010659
P07900 (UniProtKB)
IEA
GO:0016020
P07900 (UniProtKB)
IDA
GO:0016323
P07900 (UniProtKB)
IEA
GO:0016324
P07900 (UniProtKB)
IEA
GO:0016887
P07900 (UniProtKB)
IDA
GO:0017098
P07900 (UniProtKB)
IEA
GO:0018108
P07900 (UniProtKB)
IEA
GO:0019901
P07900 (UniProtKB)
IEA
GO:0019903
P07900 (UniProtKB)
IEA
GO:0023026
P07900 (UniProtKB)
IDA
GO:0030235
P07900 (UniProtKB)
IDA
GO:0030911
P07900 (UniProtKB)
TAS
GO:0030911
P07900 (UniProtKB)
IDA
GO:0031012
P07900 (UniProtKB)
IEA
GO:0031396
P07900 (UniProtKB)
IDA
GO:0031526
P07900 (UniProtKB)
IEA
GO:0032564
P07900 (UniProtKB)
IEA
GO:0032587
P07900 (UniProtKB)
IEA
GO:0033160
P07900 (UniProtKB)
IEA
GO:0038096
P07900 (UniProtKB)
TAS
GO:0038128
P07900 (UniProtKB)
TAS
GO:0042026
P07900 (UniProtKB)
TAS
GO:0042470
P07900 (UniProtKB)
IEA
GO:0042802
P07900 (UniProtKB)
IPI
GO:0042802
P07900 (UniProtKB)
IPI
GO:0042802
P07900 (UniProtKB)
IPI
GO:0042802
P07900 (UniProtKB)
IPI
GO:0042803
P07900 (UniProtKB)
TAS
GO:0042826
P07900 (UniProtKB)
IPI
GO:0043005
P07900 (UniProtKB)
IEA
GO:0043025
P07900 (UniProtKB)
IEA
GO:0043202
P07900 (UniProtKB)
TAS
GO:0043209
P07900 (UniProtKB)
IEA
GO:0043209
P07900 (UniProtKB)
IEA
GO:0043234
P07900 (UniProtKB)
IEA
GO:0043254
P07900 (UniProtKB)
NAS
GO:0043335
P07900 (UniProtKB)
NAS
GO:0043627
P07900 (UniProtKB)
IEA
GO:0044325
P07900 (UniProtKB)
IEA
GO:0044822
P07900 (UniProtKB)
IDA
GO:0044822
P07900 (UniProtKB)
IDA
GO:0045040
P07900 (UniProtKB)
IDA
GO:0045429
P07900 (UniProtKB)
ISS
GO:0045793
P07900 (UniProtKB)
IEA
GO:0046677
P07900 (UniProtKB)
ISS
GO:0048010
P07900 (UniProtKB)
TAS
GO:0048471
P07900 (UniProtKB)
IEA
GO:0050821
P07900 (UniProtKB)
TAS
GO:0050999
P07900 (UniProtKB)
TAS
GO:0050999
P07900 (UniProtKB)
TAS
GO:0051020
P07900 (UniProtKB)
IPI
GO:0051022
P07900 (UniProtKB)
IEA
GO:0051082
P07900 (UniProtKB)
IEA
GO:0051131
P07900 (UniProtKB)
IDA
GO:0060452
P07900 (UniProtKB)
IEA
GO:0061684
P07900 (UniProtKB)
TAS
GO:0070062
P07900 (UniProtKB)
IDA
GO:0070062
P07900 (UniProtKB)
IDA
GO:0070062
P07900 (UniProtKB)
IDA
GO:0070062
P07900 (UniProtKB)
IDA
GO:0070062
P07900 (UniProtKB)
IDA
GO:0070062
P07900 (UniProtKB)
IDA
GO:0070062
P07900 (UniProtKB)
IDA
GO:0071682
P07900 (UniProtKB)
TAS
GO:1900034
P07900 (UniProtKB)
TAS

基因相关microRNA

基因相关microRNA

可能调控 HSP90AA1基因的相关microRNA：     

基因相互作用关系

基因相互作用关系

Reactome

MINT

BioGrid

IntAct

mentha

String

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因通路

基因通路

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Mammary Neoplasms 0.201357209 7 0 BeFree_CTD_human_RGD
Neoplasm Metastasis 0.123528744 14 0 BeFree_CTD_human
HIV Infections 0.121085767 5 0 BeFree_CTD_human
Ki-1+ Anaplastic Large Cell Lymphoma 0.120542884 3 0 BeFree_CTD_human
Contact Dermatitis 0.12 1 0 CTD_human
Hypertension, Portal 0.08 1 0 RGD
Diabetes Mellitus, Experimental 0.08 1 0 RGD
Malignant neoplasm of breast 0.012138939 37 0 BeFree_GAD
Breast Carcinoma 0.010043349 37 0 BeFree
melanoma 0.008977445 14 0 BeFree_LHGDN

基因相关服务

基因相关服务

联系方式

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