HRAS基因详情-基因数据库-基因云馆

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HRAS (HRas proto-oncogene, GTPase)

symbol:: HRAS
locus group:: protein-coding gene
location:: 11p15.5
gene_family:: RAS type family GTPases
alias symbol:: None
alias name:: None
entrez id:: 3265
ensembl gene id:: ENSG00000174775
ucsc gene id:: uc010qvx.3
refseq accession:: NM_176795
hgnc_id:: HGNC:5173
approved reserved:: 2001-06-22

11p15.5

This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, mental retardation, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identified for this gene. [provided by RefSeq, Jul 2008]

该基因属于ras癌基因家族，其成员都涉及到哺乳动物肉瘤逆转录病毒的基因转化。由这些基因编码的产品中的信号转导途径发挥作用。这些蛋白质能结合GTP和GDP，他们有内在的GTP酶活性。这种蛋白质经受德和重新棕榈，调控其质膜和高尔基体之间的快速交换的一个连续的循环。突变该基因引起科斯特洛综合征的疾病特征在于通过在产前阶段增加的生长，生长缺陷在产后阶段，易感性肿瘤的形成，智力低下，皮肤和肌肉骨骼异常，独特的面部外观和心血管异常。在这个基因的缺陷涉及各种癌症，包括膀胱癌，甲状腺滤泡状癌和口腔鳞状细胞癌的。多个转录变异体，其编码不同同种型，已经确定了该基因。 [由RefSeq的，2008年7月提供]

OMIM数据库中对CCND1基因的介绍 Wikipedia数据库中对CCND1基因的介绍

CCND1基因的碱基序列：[NCBI]

Loading Gene Browser...

HRAS基因的碱基突变：仅显示部分snp

rs12628 rs12628 rs3730376 rs3730376 rs7938775 rs7938775 rs7939028 rs7939028 rs8176330 rs8176330 rs8176331 rs8176331 rs8176332 rs8176332 rs8176333 rs8176333 rs8176334

HRAS基因在不同组织中的表达： [UniProt]

正向引物序列

正向Tm值

反向引物序列

反向Tm值

评分

GGTCATTAAGAGCAAGTGGG

ATATTCCGTCATCGCTCCTC

TGAACCCTCCTGATGAGAG

TCCATGTCCTGAGCTTGTG

GAACATCCCAAATGCCACC

TACTGTGATCCCATCTGTGC

CGGAATATAAGCTGGTGGTG

CGGTAGGAATCCTCTATAGTGG

TTGGACATCCTGGATACCG

TTGATCTGCTCCCTGTACTG

TTGGACATCCTGGATACCG

TGATCTGCTCCCTGTACTG

TGAACATCCCAAATGCCAC

ACTGTGATCCCATCTGTGC

ACGGAATATAAGCTGGTGGT

GGTAGGAATCCTCTATAGTGGG

GGTCATTAAGAGCAAGTGGG

ATATTCCGTCATCGCTCCT

GAACCCTCCTGATGAGAGTG

TCCATGTCCTGAGCTTGTG

转录因子

影响基因

影响类型

参考文献链接（PubMed）

BTG2

HRAS

Repression

20197462

MAZ

HRAS

Activation

21931711

SP1

HRAS

Activation

21931711

SP1

HRAS

Unknown

3012774

TP53

HRAS

Unknown

11127813

HRAS基因（以及对应的蛋白质）的细胞分布位置：

[UniProt] [GenomeNet]

质膜
细胞质
细胞外
高尔基体
囊泡
细胞骨架
内质网
细胞核
内体
溶酶体
线粒体

HRAS基因的本体（GO）信息：

GO库代码

对应的蛋白质

来源代码

GO:0000139

P01112 (UniProtKB)

IEA

GO:0000165

P01112 (UniProtKB)

TAS

GO:0001934

P01112 (UniProtKB)

IDA

GO:0002223

P01112 (UniProtKB)

TAS

GO:0003924

P01112 (UniProtKB)

IDA

GO:0005515

P01112 (UniProtKB)

IPI

GO:0005515

P01112 (UniProtKB)

IPI

GO:0005515

P01112 (UniProtKB)

IPI

GO:0005515

P01112 (UniProtKB)

IPI

GO:0005515

P01112 (UniProtKB)

IPI

GO:0005515

P01112 (UniProtKB)

IPI

GO:0005515

P01112 (UniProtKB)

IPI

GO:0005515

P01112 (UniProtKB)

IPI

GO:0005515

P01112 (UniProtKB)

IPI

GO:0005515

P01112 (UniProtKB)

IPI

GO:0005515

P01112 (UniProtKB)

IPI

GO:0005515

P01112 (UniProtKB)

IPI

GO:0005515

P01112 (UniProtKB)

IPI

GO:0005515

P01112 (UniProtKB)

IPI

GO:0005515

P01112 (UniProtKB)

IPI

GO:0005515

P01112 (UniProtKB)

IPI

GO:0005515

P01112 (UniProtKB)

IPI

GO:0005515

P01112 (UniProtKB)

IPI

GO:0005515

P01112 (UniProtKB)

IPI

GO:0005515

P01112 (UniProtKB)

IPI

GO:0005515

P01112 (UniProtKB)

IPI

GO:0005515

P01112 (UniProtKB)

IPI

GO:0005515

P01112 (UniProtKB)

IPI

GO:0005515

P01112 (UniProtKB)

IPI

GO:0005515

P01112 (UniProtKB)

IPI

GO:0005515

P01112 (UniProtKB)

IPI

GO:0005515

P01112 (UniProtKB)

IPI

GO:0005515

P01112 (UniProtKB)

IPI

GO:0005515

P01112 (UniProtKB)

IPI

GO:0005515

P01112 (UniProtKB)

IPI

GO:0005515

P01112 (UniProtKB)

IPI

GO:0005515

P01112 (UniProtKB)

IPI

GO:0005515

P01112 (UniProtKB)

IPI

GO:0005515

P01112 (UniProtKB)

IPI

GO:0005515

P01112 (UniProtKB)

IPI

GO:0005515

P01112 (UniProtKB)

IPI

GO:0005515

P01112 (UniProtKB)

IPI

GO:0005515

P01112 (UniProtKB)

IPI

GO:0005515

P01112 (UniProtKB)

IPI

GO:0005525

P01112 (UniProtKB)

IDA

GO:0005525

P01112 (UniProtKB)

IDA

GO:0005634

P01112 (UniProtKB)

IEA

GO:0005737

P01112 (UniProtKB)

TAS

GO:0005794

P01112 (UniProtKB)

IDA

GO:0005794

P01112 (UniProtKB)

IDA

GO:0005829

P01112 (UniProtKB)

TAS

GO:0005829

P01112 (UniProtKB)

TAS

GO:0005829

P01112 (UniProtKB)

TAS

GO:0005886

P01112 (UniProtKB)

IDA

GO:0005886

P01112 (UniProtKB)

IDA

GO:0005886

P01112 (UniProtKB)

IDA

GO:0005886

P01112 (UniProtKB)

TAS

GO:0005886

P01112 (UniProtKB)

TAS

GO:0005886

P01112 (UniProtKB)

TAS

GO:0005886

P01112 (UniProtKB)

TAS

GO:0005886

P01112 (UniProtKB)

TAS

GO:0005886

P01112 (UniProtKB)

TAS

GO:0005886

P01112 (UniProtKB)

TAS

GO:0005886

P01112 (UniProtKB)

TAS

GO:0005886

P01112 (UniProtKB)

TAS

GO:0005886

P01112 (UniProtKB)

TAS

GO:0005886

P01112 (UniProtKB)

TAS

GO:0005886

P01112 (UniProtKB)

TAS

GO:0005886

P01112 (UniProtKB)

TAS

GO:0005886

P01112 (UniProtKB)

TAS

GO:0005886

P01112 (UniProtKB)

TAS

GO:0005886

P01112 (UniProtKB)

TAS

GO:0005886

P01112 (UniProtKB)

TAS

GO:0005886

P01112 (UniProtKB)

TAS

GO:0005886

P01112 (UniProtKB)

TAS

GO:0005886

P01112 (UniProtKB)

TAS

GO:0005886

P01112 (UniProtKB)

TAS

GO:0005886

P01112 (UniProtKB)

TAS

GO:0005886

P01112 (UniProtKB)

TAS

GO:0005886

P01112 (UniProtKB)

TAS

GO:0005886

P01112 (UniProtKB)

TAS

GO:0005886

P01112 (UniProtKB)

TAS

GO:0005886

P01112 (UniProtKB)

TAS

GO:0005886

P01112 (UniProtKB)

TAS

GO:0005886

P01112 (UniProtKB)

TAS

GO:0005886

P01112 (UniProtKB)

TAS

GO:0005886

P01112 (UniProtKB)

TAS

GO:0005886

P01112 (UniProtKB)

TAS

GO:0005886

P01112 (UniProtKB)

TAS

GO:0005886

P01112 (UniProtKB)

TAS

GO:0005886

P01112 (UniProtKB)

TAS

GO:0005886

P01112 (UniProtKB)

TAS

GO:0005886

P01112 (UniProtKB)

TAS

GO:0005886

P01112 (UniProtKB)

TAS

GO:0005886

P01112 (UniProtKB)

TAS

GO:0005886

P01112 (UniProtKB)

TAS

GO:0005886

P01112 (UniProtKB)

TAS

GO:0005886

P01112 (UniProtKB)

TAS

GO:0005886

P01112 (UniProtKB)

TAS

GO:0005886

P01112 (UniProtKB)

TAS

GO:0005886

P01112 (UniProtKB)

TAS

GO:0005886

P01112 (UniProtKB)

TAS

GO:0005886

P01112 (UniProtKB)

TAS

GO:0005886

P01112 (UniProtKB)

TAS

GO:0005886

P01112 (UniProtKB)

TAS

GO:0006897

P01112 (UniProtKB)

IEA

GO:0006935

P01112 (UniProtKB)

TAS

GO:0007050

P01112 (UniProtKB)

IDA

GO:0007050

P01112 (UniProtKB)

IMP

GO:0007093

P01112 (UniProtKB)

IDA

GO:0007165

P01112 (UniProtKB)

NAS

GO:0007166

P01112 (UniProtKB)

TAS

GO:0007173

P01112 (UniProtKB)

TAS

GO:0007265

P01112 (UniProtKB)

IDA

GO:0007265

P01112 (UniProtKB)

TAS

GO:0007411

P01112 (UniProtKB)

TAS

GO:0008022

P01112 (UniProtKB)

IPI

GO:0008283

P01112 (UniProtKB)

IEA

GO:0008284

P01112 (UniProtKB)

IDA

GO:0008285

P01112 (UniProtKB)

IDA

GO:0009887

P01112 (UniProtKB)

TAS

GO:0010629

P01112 (UniProtKB)

IDA

GO:0030335

P01112 (UniProtKB)

IDA

GO:0032729

P01112 (UniProtKB)

IEA

GO:0034260

P01112 (UniProtKB)

IDA

GO:0035176

P01112 (UniProtKB)

IEA

GO:0038095

P01112 (UniProtKB)

TAS

GO:0038128

P01112 (UniProtKB)

TAS

GO:0042088

P01112 (UniProtKB)

IEA

GO:0042832

P01112 (UniProtKB)

IEA

GO:0043406

P01112 (UniProtKB)

IDA

GO:0043410

P01112 (UniProtKB)

IDA

GO:0043524

P01112 (UniProtKB)

IEA

GO:0043547

P01112 (UniProtKB)

IDA

GO:0045740

P01112 (UniProtKB)

IDA

GO:0045944

P01112 (UniProtKB)

IDA

GO:0045944

P01112 (UniProtKB)

IDA

GO:0046330

P01112 (UniProtKB)

IDA

GO:0046579

P01112 (UniProtKB)

IEA

GO:0048013

P01112 (UniProtKB)

TAS

GO:0048169

P01112 (UniProtKB)

IEA

GO:0048471

P01112 (UniProtKB)

IEA

GO:0050679

P01112 (UniProtKB)

IMP

GO:0050852

P01112 (UniProtKB)

IEA

GO:0050900

P01112 (UniProtKB)

TAS

GO:0051291

P01112 (UniProtKB)

IEA

GO:0070374

P01112 (UniProtKB)

IDA

GO:0090303

P01112 (UniProtKB)

IDA

GO:0090398

P01112 (UniProtKB)

IDA

GO:0097193

P01112 (UniProtKB)

IEA

GO:1900029

P01112 (UniProtKB)

IDA

GO:2000251

P01112 (UniProtKB)

IDA

GO:2000630

P01112 (UniProtKB)

IDA

可能调控 HRAS基因的相关microRNA：

hsa-let-7a hsa-miR-143 hsa-miR-181a hsa-miR-181d hsa-miR-615-3p

Reactome

MINT

BioGrid

IntAct

mentha

String

序号	作用方式	资源库来源/分值	基因名称	基因名称

KEGG
Reactomepathway

名称
4014 Ras signaling pathway [PATH:hsa04014]
4015 Rap1 signaling pathway [PATH:hsa04015]
4010 MAPK signaling pathway [PATH:hsa04010]
4012 ErbB signaling pathway [PATH:hsa04012]
4370 VEGF signaling pathway [PATH:hsa04370]
4068 FoxO signaling pathway [PATH:hsa04068]
4071 Sphingolipid signaling pathway [PATH:hsa04071]
4151 PI3K-Akt signaling pathway [PATH:hsa04151]
4144 Endocytosis [PATH:hsa04144]
4810 Regulation of actin cytoskeleton [PATH:hsa04810]
4510 Focal adhesion [PATH:hsa04510]
4530 Tight junction [PATH:hsa04530]
4540 Gap junction [PATH:hsa04540]
4550 Signaling pathways regulating pluripotency of stem cells [PATH:hsa04550]
4650 Natural killer cell mediated cytotoxicity [PATH:hsa04650]
4660 T cell receptor signaling pathway [PATH:hsa04660]
4662 B cell receptor signaling pathway [PATH:hsa04662]
4664 Fc epsilon RI signaling pathway [PATH:hsa04664]
4062 Chemokine signaling pathway [PATH:hsa04062]
4910 Insulin signaling pathway [PATH:hsa04910]
4912 GnRH signaling pathway [PATH:hsa04912]
4915 Estrogen signaling pathway [PATH:hsa04915]
4917 Prolactin signaling pathway [PATH:hsa04917]
4921 Oxytocin signaling pathway [PATH:hsa04921]
4919 Thyroid hormone signaling pathway [PATH:hsa04919]
4916 Melanogenesis [PATH:hsa04916]
4725 Cholinergic synapse [PATH:hsa04725]
4726 Serotonergic synapse [PATH:hsa04726]
4720 Long-term potentiation [PATH:hsa04720]
4730 Long-term depression [PATH:hsa04730]
4722 Neurotrophin signaling pathway [PATH:hsa04722]
4360 Axon guidance [PATH:hsa04360]
5200 Pathways in cancer [PATH:hsa05200]
5230 Central carbon metabolism in cancer [PATH:hsa05230]
5231 Choline metabolism in cancer [PATH:hsa05231]
5206 MicroRNAs in cancer [PATH:hsa05206]
5205 Proteoglycans in cancer [PATH:hsa05205]
5203 Viral carcinogenesis [PATH:hsa05203]
5214 Glioma [PATH:hsa05214]
5216 Thyroid cancer [PATH:hsa05216]
5221 Acute myeloid leukemia [PATH:hsa05221]
5220 Chronic myeloid leukemia [PATH:hsa05220]
5218 Melanoma [PATH:hsa05218]
5211 Renal cell carcinoma [PATH:hsa05211]
5219 Bladder cancer [PATH:hsa05219]
5215 Prostate cancer [PATH:hsa05215]
5213 Endometrial cancer [PATH:hsa05213]
5223 Non-small cell lung cancer [PATH:hsa05223]
5034 Alcoholism [PATH:hsa05034]
5166 HTLV-I infection [PATH:hsa05166]
5161 Hepatitis B [PATH:hsa05161]
5160 Hepatitis C [PATH:hsa05160]

名称
Activation of NMDA receptor upon glutamate binding and postsynaptic events
Activation of RAS in B cells
Adaptive Immune System
ARMS-mediated activation
Axon guidance
C-type lectin receptors (CLRs)
CD209 (DC-SIGN) signaling
Cell surface interactions at the vascular wall
Constitutive Signaling by EGFRvIII
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
CREB phosphorylation through the activation of Ras
Cytokine Signaling in Immune system
DAP12 interactions
DAP12 signaling
Developmental Biology
Disease
Diseases of signal transduction
Downstream signal transduction
Downstream signaling events of B Cell Receptor (BCR)
Downstream signaling of activated FGFR1
Downstream signaling of activated FGFR2
Downstream signaling of activated FGFR3
Downstream signaling of activated FGFR4
EGFR Transactivation by Gastrin
EPH-Ephrin signaling
EPHB-mediated forward signaling
Fc epsilon receptor (FCERI) signaling
FCERI mediated MAPK activation
FRS-mediated FGFR1 signaling
FRS-mediated FGFR2 signaling
FRS-mediated FGFR3 signaling
Frs2-mediated activation
FRS2-mediated FGFR4 signaling
Gastrin-CREB signalling pathway via PKC and MAPK
GRB2 events in EGFR signaling
GRB2 events in ERBB2 signaling
Hemostasis
IGF1R signaling cascade
Immune System
Innate Immune System
Insulin receptor signalling cascade
Interleukin receptor SHC signaling
Interleukin-2 signaling
Interleukin-3, 5 and GM-CSF signaling
IRS-mediated signalling
IRS-related events
IRS-related events triggered by IGF1R
MEK activation
NCAM signaling for neurite out-growth
Neuronal System
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
NGF signalling via TRKA from the plasma membrane
p38MAPK events
Post NMDA receptor activation events
Prolonged ERK activation events
RAF activation
RAF phosphorylates MEK
RAF/MAP kinase cascade
Ras activation uopn Ca2+ infux through NMDA receptor
SHC-mediated cascade:FGFR1
SHC-mediated cascade:FGFR2
SHC-mediated cascade:FGFR3
SHC-mediated cascade:FGFR4
SHC-mediated signalling
SHC-related events
SHC-related events triggered by IGF1R
SHC1 events in EGFR signaling
SHC1 events in ERBB2 signaling
SHC1 events in ERBB4 signaling
Signal Transduction
Signaling by EGFR
Signaling by EGFR in Cancer
Signaling by EGFRvIII in Cancer
Signaling by ERBB2
Signaling by ERBB4
Signaling by FGFR
Signaling by FGFR in disease
Signaling by FGFR1
Signaling by FGFR1 in disease
Signaling by FGFR1 mutants
Signaling by FGFR2
Signaling by FGFR2 in disease
Signaling by FGFR2 mutants
Signaling by FGFR3
Signaling by FGFR3 in disease
Signaling by FGFR3 mutants
Signaling by FGFR4
Signaling by FGFR4 in disease
Signaling by FGFR4 mutants
Signaling by GPCR
Signaling by Insulin receptor
Signaling by Interleukins
Signaling by Leptin
Signaling by Ligand-Responsive EGFR Variants in Cancer
Signaling by PDGF
Signaling by SCF-KIT
Signaling by the B Cell Receptor (BCR)
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
Signaling by VEGF
Signalling by NGF
Signalling to ERKs
Signalling to p38 via RIT and RIN
Signalling to RAS
SOS-mediated signalling
Tie2 Signaling
Transmission across Chemical Synapses
VEGFA-VEGFR2 Pathway
VEGFR2 mediated cell proliferation

疾病名称

关系值

NofPmids

NofSnps

来源

疾病名称	关系值	NofPmids	NofSnps	来源
Costello syndrome (disorder)	0.454657861	60	5	BeFree_CTD_human_MGD_ORPHANET_UNIPROT
Nevus sebaceous	0.36	1	0	CTD_human_ORPHANET_UNIPROT
Mouth Neoplasms	0.202367032	3	0	CTD_human_GAD_RGD
Mammary Neoplasms, Experimental	0.2	3	0	CTD_human_RGD
Thyroid Neoplasm	0.135731154	10	0	BeFree_CTD_human_GAD_LHGDN
Squamous cell carcinoma	0.130867606	31	0	BeFree_CTD_human_LHGDN
Mammary Neoplasms	0.127620235	14	0	BeFree_CTD_human_LHGDN
Papilloma	0.125710211	12	0	BeFree_CTD_human_LHGDN
Bladder Neoplasm	0.124538567	12	1	BeFree_CTD_human_GAD
Carcinoma, Transitional Cell	0.123452799	6	0	BeFree_CTD_human_GAD