HPN (hepsin)
- symbol:
- HPN
- locus group:
- protein-coding gene
- location:
- 19q13.11
- gene_family:
- Proteases, serine
- alias symbol:
- TMPRSS1
- alias name:
- transmembrane protease, serine 1
- entrez id:
- 3249
- ensembl gene id:
- ENSG00000105707
- ucsc gene id:
- uc002nxq.3
- refseq accession:
- NM_002151
- hgnc_id:
- HGNC:5155
- approved reserved:
- 1992-12-07
This gene encodes a type II transmembrane serine protease that may be involved in diverse cellular functions, including blood coagulation and the maintenance of cell morphology. Expression of the encoded protein is associated with the growth and progression of cancers, particularly prostate cancer. The protein is cleaved into a catalytic serine protease chain and a non-catalytic scavenger receptor cysteine-rich chain, which associate via a single disulfide bond. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
这个基因编码II型跨膜丝氨酸蛋白酶可参与多种细胞功能，包括血液凝固和细胞形态的维护。所编码的蛋白质的表达在与癌症的生长和进展，特别是前列腺癌有关。该蛋白被裂解成催化丝氨酸蛋白酶链和非催化清道夫受体富含半胱氨酸的链，经由单个二硫键哪些联系人。选择性剪接结果在多个抄本变形。 [由RefSeq的，2013年1月提供]
基因本体信息
HPN基因（以及对应的蛋白质）的细胞分布位置：
- 质膜
- 细胞质
- 细胞外
- 高尔基体
- 囊泡
- 细胞骨架
- 内质网
- 细胞核
- 内体
- 溶酶体
- 线粒体
HPN基因的本体（GO）信息：
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Prostatic Neoplasms | 0.13225461 | 9 | 0 | BeFree_CTD_human_LHGDN |
| Lipoidosis | 0.12 | 2 | 0 | CTD_human |
| Malignant neoplasm of prostate | 0.012529933 | 21 | 0 | BeFree_GAD |
| Prostate carcinoma | 0.005428837 | 20 | 0 | BeFree |
| Neoplasm Metastasis | 0.002442977 | 9 | 0 | BeFree |
| Tumor Progression | 0.001357209 | 5 | 0 | BeFree |
| Ovarian Carcinoma | 0.000814326 | 3 | 0 | BeFree |
| Liver carcinoma | 0.000814326 | 3 | 0 | BeFree |
| Malignant neoplasm of ovary | 0.000814326 | 3 | 0 | BeFree |
| Liver neoplasms | 0.000542884 | 2 | 0 | BeFree |
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