This gene is a member of the Abd-B homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded nuclear protein functions as a sequence-specific transcription factor that is involved in cell proliferation and differentiation. Increased expression of this gene is associated with some cases of leukemia, prostate cancer and lung cancer. [provided by RefSeq, Jul 2008]
此基因是阿布德-B同源盒家族的成员,并且编码蛋白质有同源DNA结合结构域。它被包括在位于17号染色??体上的编码核蛋白质的功能作为参与细胞增殖和分化序列特异性转录因子同源b基因序列的簇。该基因的表达增加与白血病,前列腺癌和肺癌的某些情况下,相关联。 [由RefSeq的,2008年7月提供]
HOXB9基因(以及对应的蛋白质)的细胞分布位置:
HOXB9基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Hodgkin Disease | 0.002995792 | 1 | 0 | BeFree_LHGDN |
Malignant neoplasm of breast | 0.001085767 | 4 | 0 | BeFree |
Breast Carcinoma | 0.001085767 | 4 | 0 | BeFree |
Neoplasm Metastasis | 0.001085767 | 4 | 0 | BeFree |
Tumor Progression | 0.000814326 | 3 | 0 | BeFree |
Hip Dislocation, Congenital | 0.000542884 | 2 | 0 | BeFree |
Secondary malignant neoplasm of lung | 0.000542884 | 2 | 0 | BeFree |
Embryonal Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Liver carcinoma | 0.000542884 | 2 | 0 | BeFree |
CAMPOMELIC DYSPLASIA | 0.000542884 | 2 | 0 | BeFree |
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