HMOX1 (heme oxygenase 1)

基因基本信息

基因基本信息

symbol:
HMOX1
locus group:
protein-coding gene
location:
22q12.3
gene_family:
alias symbol:
bK286B10|HO-1
alias name:
None
entrez id:
3162
ensembl gene id:
ENSG00000100292
ucsc gene id:
uc003ant.3
refseq accession:
NM_002133
hgnc_id:
HGNC:5013
approved reserved:
1992-10-15

基因染色体位置

基因染色体位置

22q12.3
基因染色体位置图

基因简述

基因简述

HMOX1（血红素加氧酶1）是一种关键的抗氧化和抗炎基因，主要功能是催化血红素降解为胆绿素、一氧化碳（CO）和游离铁。胆绿素随后被转化为胆红素，两者都是强效的抗氧化剂，而CO具有抗炎和血管舒张作用。HMOX1在多种组织中表达，尤其在肝脏、脾脏和巨噬细胞中活性较高，其主要作用位点包括内质网和线粒体，参与细胞应激反应和氧化损伤修复。HMOX1的诱导表达通常由氧化应激、炎症、重金属或紫外线等刺激触发，通过Nrf2/ARE信号通路激活。突变或功能缺失可能导致血红素代谢异常，引发贫血、铁过载或炎症性疾病，而某些突变可能增加对氧化应激的敏感性，与神经退行性疾病（如阿尔茨海默病）和心血管疾病相关。HMOX1过表达通常具有保护作用，可减轻氧化损伤和炎症，但过度表达可能导致铁蓄积和细胞毒性；反之，表达降低会削弱抗氧化防御，加剧组织损伤。HMOX1属于血红素加氧酶家族，该家族还包括HMOX2，两者均参与血红素降解，但HMOX1为诱导型，受应激调控，而HMOX2是组成型表达，主要维持基础生理功能。HMOX1与多种疾病相关，如慢性肾病、动脉粥样硬化和癌症，在某些肿瘤中高表达可能促进癌细胞存活，而在其他情况下其抗炎特性可能抑制肿瘤发展。

Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family. [provided by RefSeq, Jul 2008]

血红素氧合酶，血红素代谢，裂解血红素的重要的酶，以形成胆绿素，其随后由胆绿素还原酶和一氧化碳，推定的神经递质转换为胆红素。血红素加氧酶的活性是通过其衬底血红素和通过各种非血红素物质诱导的。血红素加氧酶的发生是由于2同功酶，一种可诱导血红素加氧酶1和组成型血红素加氧酶2。 HMOX1和HMOX2属于血红素加氧酶家族。 [由RefSeq的，2008年7月提供]

OMIM数据库中对HMOX1基因的介绍     Wikipedia数据库中对HMOX1基因的介绍

基因序列

基因序列

HMOX1基因的碱基序列：[NCBI]
Loading Gene Browser...

基因突变

基因突变

HMOX1基因的碱基突变：           仅显示部分snp
rs2003038       rs2071746       rs2071747       rs2071748       rs2071749       rs2269533       rs2269534       rs2285112       rs2413346       rs3216831       rs3761439       rs4820192       rs5750103       rs5750104       rs5755712       rs5755717       rs5755718      

基因表达

基因表达

HMOX1基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向Tm值
反向引物序列
反向Tm值
评分
ACAAAGTGCAAGATTCTGCC
60
GTGTAAGGACCCATCGGAG
60
GAACTTTCAGAAGGGCCAG
59
CATAGATGTGGTACAGGGAGG
60
TGAACTCCCTGGAGATGAC
58
CTCAAAGAGCTGGATGTTGAG
59
TGAACTCCCTGGAGATGAC
58
CTCAAAGAGCTGGATGTTGAG
59
CTGGCATCCTGCTTTATGTG
59
CATATGACCCTGTGAGGGT
59
GAACTCCCTGGAGATGACTC
59
CTCAAAGAGCTGGATGTTGAG
59
GAACTTTCAGAAGGGCCAG
59
ATAGATGTGGTACAGGGAGG
58
AAAGTGCAAGATTCTGCCC
59
GAGTGTAAGGACCCATCGG
60
TGGCATCCTGCTTTATGTG
58
TCATATGACCCTGTGAGGG
58
GAACTCCCTGGAGATGACTC
59
CTCAAAGAGCTGGATGTTGAG
59

转录因子

转录因子

转录因子
影响基因
影响类型
参考文献链接（PubMed）
AR
HMOX1
Activation
11965035
BACH1
HMOX1
Activation
17942419
BACH1
HMOX1
Repression
17409198; 18550526; 21982894
CREB1
HMOX1
Repression
14523007
ERG
HMOX1
Unknown
10022513
ETS1
HMOX1
Unknown
10022513
FLI1
HMOX1
Unknown
10022513
NFE2L2
HMOX1
Activation
16551619; 21982894; 22484158
NFE2L2
HMOX1
Repression
22459801
NFE2L2
HMOX1
Unknown
17942419; 24035498

基因本体信息

HMOX1基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 质膜
  • 细胞质
  • 细胞外
  • 高尔基体
  • 囊泡
  • 细胞骨架
  • 内质网
  • 细胞核
  • 内体
  • 溶酶体
  • 线粒体

HMOX1基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0004392
B1AHA8 (UniProtKB)
IEA
GO:0006788
B1AHA8 (UniProtKB)
IEA
GO:0046872
B1AHA8 (UniProtKB)
IEA
GO:0001525
P09601 (UniProtKB)
TAS
GO:0001935
P09601 (UniProtKB)
TAS
GO:0002246
P09601 (UniProtKB)
IMP
GO:0002686
P09601 (UniProtKB)
TAS
GO:0004392
P09601 (UniProtKB)
IDA
GO:0004392
P09601 (UniProtKB)
IMP
GO:0004392
P09601 (UniProtKB)
TAS
GO:0004630
P09601 (UniProtKB)
IEA
GO:0004871
P09601 (UniProtKB)
IMP
GO:0005515
P09601 (UniProtKB)
IPI
GO:0005515
P09601 (UniProtKB)
IPI
GO:0005615
P09601 (UniProtKB)
TAS
GO:0005634
P09601 (UniProtKB)
ISS
GO:0005730
P09601 (UniProtKB)
IEA
GO:0005783
P09601 (UniProtKB)
ISS
GO:0005783
P09601 (UniProtKB)
IDA
GO:0005783
P09601 (UniProtKB)
IDA
GO:0005789
P09601 (UniProtKB)
TAS
GO:0005829
P09601 (UniProtKB)
IEA
GO:0005901
P09601 (UniProtKB)
IEA
GO:0006788
P09601 (UniProtKB)
IDA
GO:0006879
P09601 (UniProtKB)
IMP
GO:0006879
P09601 (UniProtKB)
TAS
GO:0006979
P09601 (UniProtKB)
IMP
GO:0007264
P09601 (UniProtKB)
IEA
GO:0007588
P09601 (UniProtKB)
IC
GO:0008217
P09601 (UniProtKB)
IEA
GO:0008219
P09601 (UniProtKB)
ISS
GO:0008630
P09601 (UniProtKB)
IEA
GO:0010656
P09601 (UniProtKB)
IEA
GO:0014806
P09601 (UniProtKB)
TAS
GO:0016020
P09601 (UniProtKB)
TAS
GO:0019899
P09601 (UniProtKB)
ISS
GO:0020037
P09601 (UniProtKB)
IDA
GO:0031670
P09601 (UniProtKB)
IEA
GO:0032764
P09601 (UniProtKB)
IEA
GO:0034101
P09601 (UniProtKB)
IMP
GO:0034383
P09601 (UniProtKB)
TAS
GO:0034395
P09601 (UniProtKB)
IEA
GO:0034605
P09601 (UniProtKB)
IMP
GO:0035094
P09601 (UniProtKB)
IDA
GO:0035556
P09601 (UniProtKB)
TAS
GO:0042167
P09601 (UniProtKB)
IDA
GO:0042167
P09601 (UniProtKB)
TAS
GO:0042542
P09601 (UniProtKB)
ISS
GO:0042803
P09601 (UniProtKB)
IDA
GO:0043123
P09601 (UniProtKB)
IMP
GO:0043305
P09601 (UniProtKB)
IEA
GO:0043392
P09601 (UniProtKB)
IEA
GO:0043433
P09601 (UniProtKB)
IEA
GO:0043524
P09601 (UniProtKB)
IEA
GO:0043619
P09601 (UniProtKB)
ISS
GO:0043627
P09601 (UniProtKB)
IEA
GO:0045080
P09601 (UniProtKB)
TAS
GO:0045765
P09601 (UniProtKB)
TAS
GO:0045766
P09601 (UniProtKB)
IEA
GO:0045909
P09601 (UniProtKB)
IC
GO:0046872
P09601 (UniProtKB)
IEA
GO:0048471
P09601 (UniProtKB)
IDA
GO:0048661
P09601 (UniProtKB)
IDA
GO:0048662
P09601 (UniProtKB)
IDA
GO:0051090
P09601 (UniProtKB)
ISS
GO:0051260
P09601 (UniProtKB)
IDA
GO:0055072
P09601 (UniProtKB)
IDA
GO:0055072
P09601 (UniProtKB)
IMP
GO:0071243
P09601 (UniProtKB)
IEA
GO:0071276
P09601 (UniProtKB)
IEA
GO:0071456
P09601 (UniProtKB)
IEP
GO:1902042
P09601 (UniProtKB)
IMP

基因相关microRNA

基因相关microRNA

可能调控 HMOX1基因的相关microRNA：     

基因相互作用关系

基因相互作用关系

Reactome

MINT

BioGrid

IntAct

mentha

String

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因通路

基因通路

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Hypertensive disease 0.212539865 15 0 BeFree_CTD_human_GAD_LHGDN_RGD
Myocardial Ischemia 0.205634266 4 0 BeFree_CTD_human_GAD_LHGDN_RGD
Reperfusion Injury 0.20272435 11 0 CTD_human_LHGDN_RGD
Colitis 0.200814326 6 0 BeFree_CTD_human_RGD
Diabetes Mellitus, Experimental 0.2 5 0 CTD_human_RGD
Liver Cirrhosis, Experimental 0.2 4 0 CTD_human_RGD
Status Epilepticus 0.2 1 0 CTD_human_RGD
Coronary Artery Disease 0.144437157 17 0 BeFree_CTD_human_GAD_LHGDN
Alzheimer's Disease 0.140627039 16 0 BeFree_CTD_human_GAD_LHGDN
Diabetes Mellitus, Non-Insulin-Dependent 0.137002487 13 0 BeFree_CTD_human_GAD_LHGDN

基因相关服务

基因相关服务

联系方式

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