HLA-DPB1 (major histocompatibility complex, class II, DP beta 1)

基因基本信息

基因基本信息

symbol:
HLA-DPB1
locus group:
protein-coding gene
location:
6p21.32
gene_family:
Histocompatibility complex|C1-set domain containing
alias symbol:
None
alias name:
None
entrez id:
3115
ensembl gene id:
ENSG00000223865
ucsc gene id:
uc063zjq.1
refseq accession:
NM_002121
hgnc_id:
HGNC:4940
approved reserved:
2001-06-22

基因染色体位置

基因染色体位置

6p21.32
基因染色体位置图

基因简述

基因简述

HLA-DPB1是人类白细胞抗原（HLA）系统中的一个重要基因，属于HLA II类基因家族，该家族还包括HLA-DQ和HLA-DR等基因。HLA II类基因家族的主要共性是编码细胞表面的糖蛋白，这些蛋白在免疫系统中起关键作用，负责将外来抗原呈递给CD4+ T细胞，从而激活适应性免疫应答。HLA-DPB1基因位于第6号染色体上，编码HLA-DP β链，与HLA-DP α链结合形成HLA-DP异二聚体，参与抗原呈递过程。HLA-DPB1具有高度多态性，不同等位基因可能导致个体对某些疾病易感性或抵抗性的差异。该基因的突变可能影响其抗原结合能力或与T细胞受体的相互作用，从而削弱免疫应答或导致自身免疫疾病。HLA-DPB1与多种疾病相关，包括类风湿性关节炎、系统性红斑狼疮、1型糖尿病和某些感染性疾病如结核病。此外，HLA-DPB1在造血干细胞移植中尤为重要，供体与受体之间的HLA-DPB1不匹配可能导致移植物抗宿主病（GVHD）或移植排斥。HLA-DPB1过表达可能增强抗原呈递效率，但过度激活免疫系统也可能增加自身免疫疾病风险；而降低表达可能导致免疫应答减弱，增加感染风险或肿瘤逃避免疫监视的能力。由于HLA-DPB1的多态性，不同个体对特定病原体或疫苗的反应可能存在差异，这使得它在个性化医疗和疫苗开发中具有重要研究价值。

HLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules. [provided by RefSeq, Jul 2008]

None

OMIM数据库中对CCND1基因的介绍     Wikipedia数据库中对CCND1基因的介绍

基因序列

基因序列

CCND1基因的碱基序列：[NCBI]
Loading Gene Browser...

基因突变

基因突变

HLA-DPB1基因的碱基突变：           仅显示部分snp
rs707958       rs707958       rs707958       rs707958       rs707958       rs707958       rs707958       rs928976       rs928976       rs928976       rs928976       rs928976       rs928976       rs928976       rs987870       rs1042117       rs1042117      

基因表达

基因表达

HLA-DPB1基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向Tm值
反向引物序列
反向Tm值
评分
AGGGAGATGTCTACACCTG
57
GAATCAGACTGTGCCTTCC
58
GTGCAGACACAACTACGAG
58
CATTCACCCTAGGCTGGAC
59
TAGTGATCACTCAGTGCCC
58
GGTAATTCTCGAGTTCTGTGG
58
CCTAAGGGACCTTAGTGCC
59
TTTCCTCTTTCCTTGTGCG
58
GCCACTCCAGAGAATTACCT
59
CTCCCGGTTGTAGATGTATCTC
59
CTAAGGGACCTTAGTGCCG
59
TTTCCTCTTTCCTTGTGCG
58
CAGACACAACTACGAGCTG
58
CATTCACCCTAGGCTGGAC
59
CAGGGAGATGTCTACACCTG
59
ATCAGACTGTGCCTTCCAC
59
GCCACTCCAGAGAATTACCT
59
TCCCGGTTGTAGATGTATCTC
58
CCACAGAACTCGAGAATTACC
58
TCCCGGTTGTAGATGTATCTC
58

转录因子

转录因子

转录因子
影响基因
影响类型
参考文献链接（PubMed）
CIITA
HLA-DPB1
Unknown
11889043
RFX1
HLA-DPB1
Unknown
11889043
RFX5
HLA-DPB1
Unknown
11258423
RFXANK
HLA-DPB1
Unknown
11258423
RFXAP
HLA-DPB1
Unknown
11258423

基因本体信息

HLA-DPB1基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 质膜
  • 细胞质
  • 细胞外
  • 高尔基体
  • 囊泡
  • 细胞骨架
  • 内质网
  • 细胞核
  • 内体
  • 溶酶体
  • 线粒体

HLA-DPB1基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0002504
A0A0G2JII1 (UniProtKB)
IEA
GO:0006955
A0A0G2JII1 (UniProtKB)
IEA
GO:0016021
A0A0G2JII1 (UniProtKB)
IEA
GO:0042613
A0A0G2JII1 (UniProtKB)
IEA
GO:0002504
A0A0G2JJV3 (UniProtKB)
IEA
GO:0006955
A0A0G2JJV3 (UniProtKB)
IEA
GO:0016021
A0A0G2JJV3 (UniProtKB)
IEA
GO:0042613
A0A0G2JJV3 (UniProtKB)
IEA
GO:0006955
A0A140T8Z3 (UniProtKB)
IEA
GO:0019882
A0A140T8Z3 (UniProtKB)
IEA
GO:0042613
A0A140T8Z3 (UniProtKB)
IEA
GO:0006955
A0A140T8Z7 (UniProtKB)
IEA
GO:0019882
A0A140T8Z7 (UniProtKB)
IEA
GO:0042613
A0A140T8Z7 (UniProtKB)
IEA
GO:0006955
A0A140T915 (UniProtKB)
IEA
GO:0019882
A0A140T915 (UniProtKB)
IEA
GO:0042613
A0A140T915 (UniProtKB)
IEA
GO:0006955
A0A140T928 (UniProtKB)
IEA
GO:0019882
A0A140T928 (UniProtKB)
IEA
GO:0042613
A0A140T928 (UniProtKB)
IEA
GO:0006955
A0A140T966 (UniProtKB)
IEA
GO:0019882
A0A140T966 (UniProtKB)
IEA
GO:0042613
A0A140T966 (UniProtKB)
IEA
GO:0006955
A0A140T976 (UniProtKB)
IEA
GO:0019882
A0A140T976 (UniProtKB)
IEA
GO:0042613
A0A140T976 (UniProtKB)
IEA
GO:0006955
A0A140T9A5 (UniProtKB)
IEA
GO:0019882
A0A140T9A5 (UniProtKB)
IEA
GO:0042613
A0A140T9A5 (UniProtKB)
IEA
GO:0006955
A0A140T9I3 (UniProtKB)
IEA
GO:0019882
A0A140T9I3 (UniProtKB)
IEA
GO:0042613
A0A140T9I3 (UniProtKB)
IEA
GO:0006955
A0A140T9P1 (UniProtKB)
IEA
GO:0019882
A0A140T9P1 (UniProtKB)
IEA
GO:0042613
A0A140T9P1 (UniProtKB)
IEA
GO:0006955
A0A140T9P7 (UniProtKB)
IEA
GO:0019882
A0A140T9P7 (UniProtKB)
IEA
GO:0042613
A0A140T9P7 (UniProtKB)
IEA
GO:0006955
A0A140T9Q1 (UniProtKB)
IEA
GO:0019882
A0A140T9Q1 (UniProtKB)
IEA
GO:0042613
A0A140T9Q1 (UniProtKB)
IEA
GO:0006955
A0A140T9T6 (UniProtKB)
IEA
GO:0019882
A0A140T9T6 (UniProtKB)
IEA
GO:0042613
A0A140T9T6 (UniProtKB)
IEA
GO:0006955
A0A140T9Y0 (UniProtKB)
IEA
GO:0019882
A0A140T9Y0 (UniProtKB)
IEA
GO:0042613
A0A140T9Y0 (UniProtKB)
IEA
GO:0006955
A0A140T9Y2 (UniProtKB)
IEA
GO:0019882
A0A140T9Y2 (UniProtKB)
IEA
GO:0042613
A0A140T9Y2 (UniProtKB)
IEA
GO:0002504
H0Y5P2 (UniProtKB)
IEA
GO:0006955
H0Y5P2 (UniProtKB)
IEA
GO:0016021
H0Y5P2 (UniProtKB)
IEA
GO:0042613
H0Y5P2 (UniProtKB)
IEA
GO:0002504
H0Y7G7 (UniProtKB)
IEA
GO:0006955
H0Y7G7 (UniProtKB)
IEA
GO:0016021
H0Y7G7 (UniProtKB)
IEA
GO:0042613
H0Y7G7 (UniProtKB)
IEA
GO:0000139
P04440 (UniProtKB)
TAS
GO:0000139
P04440 (UniProtKB)
TAS
GO:0005765
P04440 (UniProtKB)
TAS
GO:0005765
P04440 (UniProtKB)
TAS
GO:0005765
P04440 (UniProtKB)
TAS
GO:0005765
P04440 (UniProtKB)
TAS
GO:0005765
P04440 (UniProtKB)
TAS
GO:0005765
P04440 (UniProtKB)
TAS
GO:0005765
P04440 (UniProtKB)
TAS
GO:0005765
P04440 (UniProtKB)
TAS
GO:0005886
P04440 (UniProtKB)
TAS
GO:0005886
P04440 (UniProtKB)
TAS
GO:0005886
P04440 (UniProtKB)
TAS
GO:0005886
P04440 (UniProtKB)
TAS
GO:0005886
P04440 (UniProtKB)
TAS
GO:0005886
P04440 (UniProtKB)
TAS
GO:0005886
P04440 (UniProtKB)
TAS
GO:0005886
P04440 (UniProtKB)
TAS
GO:0005886
P04440 (UniProtKB)
TAS
GO:0005886
P04440 (UniProtKB)
TAS
GO:0005886
P04440 (UniProtKB)
TAS
GO:0005886
P04440 (UniProtKB)
TAS
GO:0005886
P04440 (UniProtKB)
TAS
GO:0005886
P04440 (UniProtKB)
TAS
GO:0005886
P04440 (UniProtKB)
TAS
GO:0005886
P04440 (UniProtKB)
TAS
GO:0005886
P04440 (UniProtKB)
TAS
GO:0009986
P04440 (UniProtKB)
IMP
GO:0010008
P04440 (UniProtKB)
IEA
GO:0012507
P04440 (UniProtKB)
TAS
GO:0012507
P04440 (UniProtKB)
TAS
GO:0016020
P04440 (UniProtKB)
IDA
GO:0019886
P04440 (UniProtKB)
IMP
GO:0019886
P04440 (UniProtKB)
TAS
GO:0030658
P04440 (UniProtKB)
TAS
GO:0030658
P04440 (UniProtKB)
TAS
GO:0030666
P04440 (UniProtKB)
TAS
GO:0030666
P04440 (UniProtKB)
TAS
GO:0030669
P04440 (UniProtKB)
TAS
GO:0030669
P04440 (UniProtKB)
TAS
GO:0031295
P04440 (UniProtKB)
TAS
GO:0032588
P04440 (UniProtKB)
TAS
GO:0032588
P04440 (UniProtKB)
TAS
GO:0032588
P04440 (UniProtKB)
TAS
GO:0032588
P04440 (UniProtKB)
TAS
GO:0032588
P04440 (UniProtKB)
TAS
GO:0032729
P04440 (UniProtKB)
IMP
GO:0042102
P04440 (UniProtKB)
IMP
GO:0042605
P04440 (UniProtKB)
IDA
GO:0042613
P04440 (UniProtKB)
IDA
GO:0050852
P04440 (UniProtKB)
TAS
GO:0050870
P04440 (UniProtKB)
IMP
GO:0060333
P04440 (UniProtKB)
TAS
GO:0071556
P04440 (UniProtKB)
TAS
GO:0071556
P04440 (UniProtKB)
TAS
GO:0071556
P04440 (UniProtKB)
TAS
GO:0071556
P04440 (UniProtKB)
TAS

基因相关microRNA

基因相关microRNA

可能调控 HLA-DPB1基因的相关microRNA：     

基因相互作用关系

基因相互作用关系

Reactome

MINT

BioGrid

IntAct

mentha

String

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因通路

基因通路

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Asthma 0.267185251 14 1 BeFree_CTD_human_GAD_GWASCAT_LHGDN
Hepatitis B, Chronic 0.250901282 18 5 BeFree_CTD_human_GAD_GWASCAT
Multiple Sclerosis 0.147199064 22 0 BeFree_CTD_human_GAD
Systemic Scleroderma 0.135830843 9 1 BeFree_GAD_GWASCAT
Hepatitis B 0.132334436 29 5 BeFree_GAD_GWASCAT
Berylliosis 0.13183516 9 0 CTD_human_GAD
Celiac Disease 0.131444166 20 0 BeFree_CTD_human_GAD
Rheumatoid Arthritis 0.130434343 25 0 BeFree_CTD_human_GAD
Chronic berylliosis 0.127057489 26 0 BeFree_ORPHANET
Sarcoidosis 0.126634157 9 0 BeFree_CTD_human_GAD

基因相关服务

基因相关服务

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