HDAC6 (histone deacetylase 6)

基因基本信息

基因基本信息

symbol:
HDAC6
locus group:
protein-coding gene
location:
Xp11.23
gene_family:
Protein phosphatase 1 regulatory subunits
alias symbol:
KIAA0901|JM21|HD6|FLJ16239|PPP1R90
alias name:
protein phosphatase 1, regulatory …
entrez id:
10013
ensembl gene id:
ENSG00000094631
ucsc gene id:
uc004dks.2
refseq accession:
NM_006044
hgnc_id:
HGNC:14064
approved reserved:
2000-11-28

基因染色体位置

基因染色体位置

Xp11.23
基因染色体位置图

基因简述

基因简述

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains which appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription. [provided by RefSeq, Jul 2008]

组蛋白中转录调节，细胞周期进程，并发育事件中起关键作用。组蛋白乙酰化/脱乙酰化改变染色体结构，影响到DNA的转录因子的访问。由该基因编码的蛋白质属于组蛋白脱乙酰/ ACUC / APHA家族的II级。它包含出现彼此独立地工作的两个催化域的内部重复。这种蛋白具有组蛋白去乙酰活性，抑制了转录。 [由RefSeq的，7月20日提供的08]

OMIM数据库中对CCND1基因的介绍     Wikipedia数据库中对CCND1基因的介绍

基因序列

基因序列

CCND1基因的碱基序列：[NCBI]
Loading Gene Browser...

基因突变

基因突变

HDAC6基因的碱基突变：           仅显示部分snp
rs782816419       rs782819209       rs782820336       rs782810859       rs782811110       rs782814101       rs782803339       rs782804500       rs782807715       rs782802842       rs782800530       rs782800939       rs782798063       rs782799645       rs782796954       rs782797482       rs782796374      

基因表达

基因表达

HDAC6基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向Tm值
反向引物序列
反向Tm值
评分
GTCTGGTCCTTTCCTGATCC
60
CACAGGAAACTGAAGCCTG
59
GCGGAGGTAAAGAAGAAAGG
58
GTTCAGATCCATCCCTTGC
58
GGGTCATGAAGGTAGAAGAC
57
TAACCTAGGTTTGGCTGGT
58
AGGATTCCACCACAACCAG
60
ATATTTCGCTTCGAAGTGACAC
60
ATCGTAGATTGGGATGTGC
57
GATGGAGAAATAGAGGACACTG
58
GATTGTGGATTGGGATGTCC
59
AGGGACACATATAGCACACTG
60
AGGATTCCACCACAACCAG
60
ATATTTCGCTTCGAAGTGACAC
60
ATCATTAGGCCTCCTGGAC
59
TGTTTCTGTTGAGCATAGCG
59
CTCTGGGATGACAGCTTCC
60
CTGTGAACCAACATCAGCTC
59
GGTCCTCAGCTACATCGAC
60
CTTCACATCTAGGAGAGCCTG
60

转录因子

转录因子

      尚未收录相关数据

基因本体信息

HDAC6基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 质膜
  • 细胞质
  • 细胞外
  • 高尔基体
  • 囊泡
  • 细胞骨架
  • 内质网
  • 细胞核
  • 内体
  • 溶酶体
  • 线粒体

HDAC6基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0000118
Q9UBN7 (UniProtKB)
IDA
GO:0000209
Q9UBN7 (UniProtKB)
IEA
GO:0001047
Q9UBN7 (UniProtKB)
IDA
GO:0003779
Q9UBN7 (UniProtKB)
IEA
GO:0004407
Q9UBN7 (UniProtKB)
IDA
GO:0004407
Q9UBN7 (UniProtKB)
IDA
GO:0004407
Q9UBN7 (UniProtKB)
IMP
GO:0005515
Q9UBN7 (UniProtKB)
IPI
GO:0005515
Q9UBN7 (UniProtKB)
IPI
GO:0005515
Q9UBN7 (UniProtKB)
IPI
GO:0005515
Q9UBN7 (UniProtKB)
IPI
GO:0005515
Q9UBN7 (UniProtKB)
IPI
GO:0005515
Q9UBN7 (UniProtKB)
IPI
GO:0005515
Q9UBN7 (UniProtKB)
IPI
GO:0005515
Q9UBN7 (UniProtKB)
IPI
GO:0005515
Q9UBN7 (UniProtKB)
IPI
GO:0005515
Q9UBN7 (UniProtKB)
IPI
GO:0005515
Q9UBN7 (UniProtKB)
IPI
GO:0005515
Q9UBN7 (UniProtKB)
IPI
GO:0005515
Q9UBN7 (UniProtKB)
IPI
GO:0005515
Q9UBN7 (UniProtKB)
IPI
GO:0005515
Q9UBN7 (UniProtKB)
IPI
GO:0005634
Q9UBN7 (UniProtKB)
ISS
GO:0005737
Q9UBN7 (UniProtKB)
ISS
GO:0005771
Q9UBN7 (UniProtKB)
TAS
GO:0005829
Q9UBN7 (UniProtKB)
ISS
GO:0005829
Q9UBN7 (UniProtKB)
TAS
GO:0005829
Q9UBN7 (UniProtKB)
TAS
GO:0005874
Q9UBN7 (UniProtKB)
IDA
GO:0005875
Q9UBN7 (UniProtKB)
IDA
GO:0005881
Q9UBN7 (UniProtKB)
IEA
GO:0005901
Q9UBN7 (UniProtKB)
IDA
GO:0006351
Q9UBN7 (UniProtKB)
IEA
GO:0006476
Q9UBN7 (UniProtKB)
IMP
GO:0006515
Q9UBN7 (UniProtKB)
IMP
GO:0006886
Q9UBN7 (UniProtKB)
IMP
GO:0006996
Q9UBN7 (UniProtKB)
TAS
GO:0007026
Q9UBN7 (UniProtKB)
IEA
GO:0008013
Q9UBN7 (UniProtKB)
IPI
GO:0008017
Q9UBN7 (UniProtKB)
ISS
GO:0008017
Q9UBN7 (UniProtKB)
IDA
GO:0008270
Q9UBN7 (UniProtKB)
IEA
GO:0009636
Q9UBN7 (UniProtKB)
IMP
GO:0009967
Q9UBN7 (UniProtKB)
IMP
GO:0010033
Q9UBN7 (UniProtKB)
IMP
GO:0010469
Q9UBN7 (UniProtKB)
IMP
GO:0010506
Q9UBN7 (UniProtKB)
TAS
GO:0010634
Q9UBN7 (UniProtKB)
IMP
GO:0010727
Q9UBN7 (UniProtKB)
IC
GO:0010870
Q9UBN7 (UniProtKB)
IMP
GO:0010870
Q9UBN7 (UniProtKB)
IMP
GO:0016234
Q9UBN7 (UniProtKB)
IDA
GO:0016235
Q9UBN7 (UniProtKB)
IDA
GO:0016236
Q9UBN7 (UniProtKB)
IMP
GO:0016575
Q9UBN7 (UniProtKB)
IDA
GO:0016575
Q9UBN7 (UniProtKB)
ISS
GO:0019899
Q9UBN7 (UniProtKB)
ISS
GO:0030424
Q9UBN7 (UniProtKB)
ISS
GO:0030425
Q9UBN7 (UniProtKB)
ISS
GO:0031252
Q9UBN7 (UniProtKB)
IDA
GO:0031593
Q9UBN7 (UniProtKB)
IDA
GO:0031625
Q9UBN7 (UniProtKB)
IPI
GO:0031647
Q9UBN7 (UniProtKB)
IMP
GO:0032041
Q9UBN7 (UniProtKB)
IEA
GO:0032418
Q9UBN7 (UniProtKB)
IMP
GO:0034983
Q9UBN7 (UniProtKB)
IMP
GO:0034983
Q9UBN7 (UniProtKB)
IMP
GO:0035967
Q9UBN7 (UniProtKB)
IMP
GO:0040029
Q9UBN7 (UniProtKB)
IMP
GO:0042826
Q9UBN7 (UniProtKB)
IPI
GO:0042903
Q9UBN7 (UniProtKB)
ISS
GO:0042903
Q9UBN7 (UniProtKB)
IDA
GO:0042903
Q9UBN7 (UniProtKB)
IDA
GO:0042903
Q9UBN7 (UniProtKB)
TAS
GO:0043014
Q9UBN7 (UniProtKB)
IDA
GO:0043162
Q9UBN7 (UniProtKB)
IEA
GO:0043204
Q9UBN7 (UniProtKB)
ISS
GO:0043241
Q9UBN7 (UniProtKB)
IEA
GO:0043242
Q9UBN7 (UniProtKB)
IMP
GO:0045598
Q9UBN7 (UniProtKB)
IEA
GO:0045861
Q9UBN7 (UniProtKB)
IMP
GO:0045892
Q9UBN7 (UniProtKB)
ISS
GO:0048156
Q9UBN7 (UniProtKB)
IDA
GO:0048471
Q9UBN7 (UniProtKB)
IDA
GO:0048487
Q9UBN7 (UniProtKB)
IEA
GO:0051354
Q9UBN7 (UniProtKB)
IC
GO:0051646
Q9UBN7 (UniProtKB)
IEA
GO:0051787
Q9UBN7 (UniProtKB)
EXP
GO:0051788
Q9UBN7 (UniProtKB)
IMP
GO:0051879
Q9UBN7 (UniProtKB)
IDA
GO:0060632
Q9UBN7 (UniProtKB)
IC
GO:0060765
Q9UBN7 (UniProtKB)
TAS
GO:0070201
Q9UBN7 (UniProtKB)
IEA
GO:0070301
Q9UBN7 (UniProtKB)
IMP
GO:0070840
Q9UBN7 (UniProtKB)
IDA
GO:0070842
Q9UBN7 (UniProtKB)
IMP
GO:0070845
Q9UBN7 (UniProtKB)
IMP
GO:0070846
Q9UBN7 (UniProtKB)
IMP
GO:0070848
Q9UBN7 (UniProtKB)
IMP
GO:0070932
Q9UBN7 (UniProtKB)
IEA
GO:0071218
Q9UBN7 (UniProtKB)
IEA
GO:0090035
Q9UBN7 (UniProtKB)
IMP
GO:0090042
Q9UBN7 (UniProtKB)
ISS
GO:0090042
Q9UBN7 (UniProtKB)
IDA
GO:0098779
Q9UBN7 (UniProtKB)
IGI
GO:1901300
Q9UBN7 (UniProtKB)
IDA
GO:1903146
Q9UBN7 (UniProtKB)
TAS
GO:0030286
Q9UBN7 (UniProtKB)
IDA

基因相关microRNA

基因相关microRNA

可能调控 HDAC6基因的相关microRNA：     

基因相互作用关系

基因相互作用关系

MINT

BioGrid

IntAct

mentha

String

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因通路

基因通路

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
CHONDRODYSPLASIA WITH PLATYSPONDYLY, DISTINCTIVE BRACHYDACTYLY, HYDROCEPHALY, AND MICROPHTHALMIA 0.24 0 1 CLINVAR_ORPHANET
melanoma 0.120542884 3 0 BeFree_CTD_human
Prostatic Neoplasms 0.12 1 0 CTD_human
ovarian neoplasm 0.12 1 0 CTD_human
Polycystic liver disease 0.08 1 0 RGD
Hypertensive disease 0.08 1 0 RGD
Polycystic Kidney Diseases 0.08 1 0 RGD
Sepsis 0.08 1 0 RGD
Mammary Neoplasms 0.008715934 5 0 BeFree_LHGDN
Lymphoma, T-Cell, Cutaneous 0.00272435 1 0 LHGDN

基因相关服务

基因相关服务

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