GZMA (granzyme A)
- symbol:
- GZMA
- locus group:
- protein-coding gene
- location:
- 5q11.2
- gene_family:
- alias symbol:
- None
- alias name:
- CTL tryptase|Cytotoxic T-lymphocyt…
- entrez id:
- 3001
- ensembl gene id:
- ENSG00000145649
- ucsc gene id:
- uc003jpm.4
- refseq accession:
- NM_006144
- hgnc_id:
- HGNC:4708
- approved reserved:
- 1988-05-31
Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein described here is a T cell- and natural killer cell-specific serine protease that may function as a common component necessary for lysis of target cells by cytotoxic T lymphocytes and natural killer cells. [provided by RefSeq, Jul 2008]
细胞毒性T淋巴细胞（CTL）和自然杀伤（NK）细胞共同认识到，bind和裂解特定靶细胞的非凡能力。他们被认为通过裂解细胞轴承在其表面上“非己”抗原，通常肽或细胞内病原体感染导致的蛋白质来保护他们的主人。此处所描述的蛋白质是T细胞和天然杀伤细胞特异性的丝氨酸蛋白酶，可能根据需要对由细胞毒性T淋巴细胞和自然杀伤细胞的靶细胞的溶胞共同组成的作用。 [由RefSeq的，2008年7月提供]
基因本体信息
GZMA基因（以及对应的蛋白质）的细胞分布位置：
- 质膜
- 细胞质
- 细胞外
- 高尔基体
- 囊泡
- 细胞骨架
- 内质网
- 细胞核
- 内体
- 溶酶体
- 线粒体
GZMA基因的本体（GO）信息：
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Bronchiolitis, Viral | 0.004734064 | 2 | 1 | GAD |
| Respiratory Syncytial Virus Infections | 0.004734064 | 2 | 1 | GAD |
| Tuberculosis | 0.002995792 | 1 | 0 | BeFree_LHGDN |
| Chronic Obstructive Airway Disease | 0.002995792 | 1 | 0 | BeFree_LHGDN |
| Infection | 0.00272435 | 1 | 0 | LHGDN |
| Inflammation | 0.00272435 | 1 | 0 | LHGDN |
| Asthma | 0.002367032 | 1 | 0 | GAD |
| Rheumatoid Arthritis | 0.000542884 | 2 | 0 | BeFree |
| Scleroderma | 0.000542884 | 2 | 0 | BeFree |
| Systemic Scleroderma | 0.000542884 | 2 | 0 | BeFree |
微信公众号
关注微信订阅号，实时查看信息，关注医学生物学动态。
版权所有 © 2025.Genelibs 济南弘晖生物技术有限公司 鲁ICP备13024435号-2
