GSK3B (glycogen synthase kinase 3 beta)

基因基本信息

基因基本信息

symbol:
GSK3B
locus group:
protein-coding gene
location:
3q13.33
gene_family:
alias symbol:
None
alias name:
None
entrez id:
2932
ensembl gene id:
ENSG00000082701
ucsc gene id:
uc003edn.4
refseq accession:
NM_001146156
hgnc_id:
HGNC:4617
approved reserved:
1997-05-15

基因染色体位置

基因染色体位置

3q13.33
基因染色体位置图

基因简述

基因简述

GSK3B（糖原合成酶激酶3β）是一种丝氨酸/苏氨酸蛋白激酶，属于GSK3基因家族，该家族还包括GSK3A。GSK3家族成员在多种细胞信号通路中发挥关键作用，特别是参与Wnt、Hedgehog和胰岛素信号通路，调控细胞增殖、分化、代谢和凋亡等过程。GSK3B的主要作用位点包括磷酸化多种底物蛋白，如糖原合成酶、β-catenin、Tau蛋白等，从而影响糖原代谢、基因转录和细胞骨架稳定性。GSK3B的活性通常受上游信号分子（如AKT）的抑制性磷酸化调控。GSK3B突变可能导致其功能异常，与多种疾病相关，如阿尔茨海默病（通过异常磷酸化Tau蛋白形成神经纤维缠结）、2型糖尿病（影响胰岛素信号通路和糖代谢）以及多种癌症（如通过β-catenin的异常积累促进肿瘤发生）。GSK3B过表达可能导致细胞凋亡增加、炎症反应加剧以及神经退行性病变，而降低表达则可能促进细胞增殖和肿瘤发展，同时影响葡萄糖稳态。在神经系统中，GSK3B活性过高与抑郁症和精神分裂症有关，而抑制其活性可能具有神经保护作用。GSK3B还与炎症反应和免疫调节相关，影响NF-κB等信号通路。药物开发中，GSK3B抑制剂（如锂盐）被研究用于治疗神经退行性疾病和情绪障碍。该基因的多功能性使其成为多种病理过程的关键调控因子，但其具体作用高度依赖细胞类型和上下文环境。

The protein encoded by this gene is a serine-threonine kinase, belonging to the glycogen synthase kinase subfamily. It is involved in energy metabolism, neuronal cell development, and body pattern formation. Polymorphisms in this gene have been implicated in modifying risk of Parkinson disease, and studies in mice show that overexpression of this gene may be relevant to the pathogenesis of Alzheimer disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]

由该基因编码的蛋白质是一种丝氨酸 - 苏氨酸激酶，属于糖原合酶激酶亚家族。它是参与能量代谢，神经细胞的发育和身体图案形成。在这种基因多态性有牵连修改帕金森病的风险，和在小鼠中的研究表明，该基因的过度表达可能与阿尔茨海默病的发病机制。另外剪接转录变体编码不同亚型也发现了这种基因。[由RefSeq的，2009年09月提供]

OMIM数据库中对GSK3B基因的介绍     Wikipedia数据库中对GSK3B基因的介绍

基因序列

基因序列

GSK3B基因的碱基序列：[NCBI]
Loading Gene Browser...

基因突变

基因突变

GSK3B基因的碱基突变：           仅显示部分snp
rs182839       rs334533       rs334534       rs334535       rs334536       rs334551       rs334552       rs334553       rs334554       rs334555       rs334557       rs334558       rs334559       rs334560       rs334561       rs334562       rs334563      

基因表达

基因表达

GSK3B基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向Tm值
反向引物序列
反向Tm值
评分
CACTCAAGATGCTAATACTGGAG
59
ACTGTTCAGGTGGAGTTGG
60
TATTCCTCCTCATGCTCGG
59
TCTCCAGTATTAGCATCTGACG
60
GATCATGAGAAAGCTAGATCACTG
59
ACCTCATCTTTCTTCTCACCA
59
TCCTTGGACTAAGGTCTTCC
59
GTTGGTGTATACTCCAGCAG
58
TATTCCTCCTCATGCTCGG
59
TCTCCAGTATTAGCATCTGACG
60
GCAAATCAGAGAAATGAACCC
58
CCTGACGAATCCTTAGTCC
57
CCTTGGACTAAGGTCTTCCG
60
AGTTGGTGTATACTCCAGCAG
60
CCACTCAAGATGCTAATACTGG
59
CTGTTCAGGTGGAGTTGGA
59
AGCAAATCAGAGAAATGAACCC
59
TGACGAATCCTTAGTCCAAGG
60
ATCTGTTCTCGGTACTATAGGG
58
AGCAGACCATACATCTATACTAGAG
59

转录因子

转录因子

转录因子
影响基因
影响类型
参考文献链接（PubMed）
CDX2
GSK3B
Unknown
24501326
CREB1
GSK3B
Unknown
11579131
NFKB1
GSK3B
Unknown
11579131
TFCP2
GSK3B
Unknown
16973241

基因本体信息

GSK3B基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 质膜
  • 细胞质
  • 细胞外
  • 高尔基体
  • 囊泡
  • 细胞骨架
  • 内质网
  • 细胞核
  • 内体
  • 溶酶体
  • 线粒体

GSK3B基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0000320
P49841 (UniProtKB)
IEA
GO:0001085
P49841 (UniProtKB)
IPI
GO:0001837
P49841 (UniProtKB)
IMP
GO:0001954
P49841 (UniProtKB)
IMP
GO:0002039
P49841 (UniProtKB)
IDA
GO:0004672
P49841 (UniProtKB)
TAS
GO:0004672
P49841 (UniProtKB)
TAS
GO:0004674
P49841 (UniProtKB)
ISS
GO:0004674
P49841 (UniProtKB)
IDA
GO:0004674
P49841 (UniProtKB)
IDA
GO:0004674
P49841 (UniProtKB)
IDA
GO:0004674
P49841 (UniProtKB)
IDA
GO:0004674
P49841 (UniProtKB)
IDA
GO:0004674
P49841 (UniProtKB)
IDA
GO:0004674
P49841 (UniProtKB)
IDA
GO:0004674
P49841 (UniProtKB)
IDA
GO:0004674
P49841 (UniProtKB)
TAS
GO:0004674
P49841 (UniProtKB)
TAS
GO:0004674
P49841 (UniProtKB)
TAS
GO:0004674
P49841 (UniProtKB)
TAS
GO:0005178
P49841 (UniProtKB)
IEA
GO:0005515
P49841 (UniProtKB)
IPI
GO:0005515
P49841 (UniProtKB)
IPI
GO:0005515
P49841 (UniProtKB)
IPI
GO:0005515
P49841 (UniProtKB)
IPI
GO:0005515
P49841 (UniProtKB)
IPI
GO:0005515
P49841 (UniProtKB)
IPI
GO:0005515
P49841 (UniProtKB)
IPI
GO:0005515
P49841 (UniProtKB)
IPI
GO:0005515
P49841 (UniProtKB)
IPI
GO:0005515
P49841 (UniProtKB)
IPI
GO:0005515
P49841 (UniProtKB)
IPI
GO:0005515
P49841 (UniProtKB)
IPI
GO:0005515
P49841 (UniProtKB)
IPI
GO:0005515
P49841 (UniProtKB)
IPI
GO:0005515
P49841 (UniProtKB)
IPI
GO:0005515
P49841 (UniProtKB)
IPI
GO:0005515
P49841 (UniProtKB)
IPI
GO:0005515
P49841 (UniProtKB)
IPI
GO:0005515
P49841 (UniProtKB)
IPI
GO:0005515
P49841 (UniProtKB)
IPI
GO:0005515
P49841 (UniProtKB)
IPI
GO:0005515
P49841 (UniProtKB)
IPI
GO:0005515
P49841 (UniProtKB)
IPI
GO:0005515
P49841 (UniProtKB)
IPI
GO:0005515
P49841 (UniProtKB)
IPI
GO:0005515
P49841 (UniProtKB)
IPI
GO:0005515
P49841 (UniProtKB)
IPI
GO:0005515
P49841 (UniProtKB)
IPI
GO:0005515
P49841 (UniProtKB)
IPI
GO:0005515
P49841 (UniProtKB)
IPI
GO:0005515
P49841 (UniProtKB)
IPI
GO:0005515
P49841 (UniProtKB)
IPI
GO:0005515
P49841 (UniProtKB)
IPI
GO:0005515
P49841 (UniProtKB)
IPI
GO:0005515
P49841 (UniProtKB)
IPI
GO:0005515
P49841 (UniProtKB)
IPI
GO:0005515
P49841 (UniProtKB)
IPI
GO:0005515
P49841 (UniProtKB)
IPI
GO:0005515
P49841 (UniProtKB)
IPI
GO:0005515
P49841 (UniProtKB)
IPI
GO:0005515
P49841 (UniProtKB)
IPI
GO:0005515
P49841 (UniProtKB)
IPI
GO:0005515
P49841 (UniProtKB)
IPI
GO:0005515
P49841 (UniProtKB)
IPI
GO:0005515
P49841 (UniProtKB)
IPI
GO:0005515
P49841 (UniProtKB)
IPI
GO:0005515
P49841 (UniProtKB)
IPI
GO:0005515
P49841 (UniProtKB)
IPI
GO:0005515
P49841 (UniProtKB)
IPI
GO:0005515
P49841 (UniProtKB)
IPI
GO:0005515
P49841 (UniProtKB)
IPI
GO:0005515
P49841 (UniProtKB)
IPI
GO:0005515
P49841 (UniProtKB)
IPI
GO:0005515
P49841 (UniProtKB)
IPI
GO:0005515
P49841 (UniProtKB)
IPI
GO:0005515
P49841 (UniProtKB)
IPI
GO:0005515
P49841 (UniProtKB)
IPI
GO:0005515
P49841 (UniProtKB)
IPI
GO:0005515
P49841 (UniProtKB)
IPI
GO:0005515
P49841 (UniProtKB)
IPI
GO:0005515
P49841 (UniProtKB)
IPI
GO:0005515
P49841 (UniProtKB)
IPI
GO:0005515
P49841 (UniProtKB)
IPI
GO:0005515
P49841 (UniProtKB)
IPI
GO:0005515
P49841 (UniProtKB)
IPI
GO:0005515
P49841 (UniProtKB)
IPI
GO:0005515
P49841 (UniProtKB)
IPI
GO:0005515
P49841 (UniProtKB)
IPI
GO:0005515
P49841 (UniProtKB)
IPI
GO:0005515
P49841 (UniProtKB)
IPI
GO:0005515
P49841 (UniProtKB)
IPI
GO:0005515
P49841 (UniProtKB)
IPI
GO:0005515
P49841 (UniProtKB)
IPI
GO:0005515
P49841 (UniProtKB)
IPI
GO:0005515
P49841 (UniProtKB)
IPI
GO:0005515
P49841 (UniProtKB)
IPI
GO:0005524
P49841 (UniProtKB)
IEA
GO:0005634
P49841 (UniProtKB)
IDA
GO:0005634
P49841 (UniProtKB)
IDA
GO:0005634
P49841 (UniProtKB)
IDA
GO:0005737
P49841 (UniProtKB)
IDA
GO:0005737
P49841 (UniProtKB)
IDA
GO:0005737
P49841 (UniProtKB)
IDA
GO:0005737
P49841 (UniProtKB)
IDA
GO:0005737
P49841 (UniProtKB)
IDA
GO:0005739
P49841 (UniProtKB)
IEA
GO:0005813
P49841 (UniProtKB)
IDA
GO:0005829
P49841 (UniProtKB)
TAS
GO:0005829
P49841 (UniProtKB)
TAS
GO:0005829
P49841 (UniProtKB)
TAS
GO:0005829
P49841 (UniProtKB)
TAS
GO:0005829
P49841 (UniProtKB)
TAS
GO:0005829
P49841 (UniProtKB)
TAS
GO:0005829
P49841 (UniProtKB)
TAS
GO:0005829
P49841 (UniProtKB)
TAS
GO:0005829
P49841 (UniProtKB)
TAS
GO:0005829
P49841 (UniProtKB)
TAS
GO:0005829
P49841 (UniProtKB)
TAS
GO:0005829
P49841 (UniProtKB)
TAS
GO:0005829
P49841 (UniProtKB)
TAS
GO:0005829
P49841 (UniProtKB)
TAS
GO:0005829
P49841 (UniProtKB)
TAS
GO:0005829
P49841 (UniProtKB)
TAS
GO:0005829
P49841 (UniProtKB)
TAS
GO:0005829
P49841 (UniProtKB)
TAS
GO:0005829
P49841 (UniProtKB)
TAS
GO:0005829
P49841 (UniProtKB)
TAS
GO:0005829
P49841 (UniProtKB)
TAS
GO:0005829
P49841 (UniProtKB)
TAS
GO:0005829
P49841 (UniProtKB)
TAS
GO:0005829
P49841 (UniProtKB)
TAS
GO:0005829
P49841 (UniProtKB)
TAS
GO:0005829
P49841 (UniProtKB)
TAS
GO:0005829
P49841 (UniProtKB)
TAS
GO:0005829
P49841 (UniProtKB)
TAS
GO:0005829
P49841 (UniProtKB)
TAS
GO:0005829
P49841 (UniProtKB)
TAS
GO:0005886
P49841 (UniProtKB)
IDA
GO:0005977
P49841 (UniProtKB)
IDA
GO:0006349
P49841 (UniProtKB)
IEA
GO:0006468
P49841 (UniProtKB)
IDA
GO:0006468
P49841 (UniProtKB)
IDA
GO:0006468
P49841 (UniProtKB)
IDA
GO:0006611
P49841 (UniProtKB)
IEA
GO:0006983
P49841 (UniProtKB)
IDA
GO:0007212
P49841 (UniProtKB)
NAS
GO:0007409
P49841 (UniProtKB)
IEA
GO:0007520
P49841 (UniProtKB)
IEA
GO:0007568
P49841 (UniProtKB)
IEA
GO:0007623
P49841 (UniProtKB)
ISS
GO:0008013
P49841 (UniProtKB)
IPI
GO:0009887
P49841 (UniProtKB)
IEA
GO:0010614
P49841 (UniProtKB)
IEA
GO:0010800
P49841 (UniProtKB)
IEA
GO:0010918
P49841 (UniProtKB)
IEA
GO:0014043
P49841 (UniProtKB)
IEA
GO:0014823
P49841 (UniProtKB)
IEA
GO:0016055
P49841 (UniProtKB)
TAS
GO:0016301
P49841 (UniProtKB)
IDA
GO:0016301
P49841 (UniProtKB)
IDA
GO:0016301
P49841 (UniProtKB)
TAS
GO:0016301
P49841 (UniProtKB)
TAS
GO:0016301
P49841 (UniProtKB)
TAS
GO:0016477
P49841 (UniProtKB)
IEA
GO:0018105
P49841 (UniProtKB)
IDA
GO:0018105
P49841 (UniProtKB)
IDA
GO:0018105
P49841 (UniProtKB)
IDA
GO:0018105
P49841 (UniProtKB)
IDA
GO:0018107
P49841 (UniProtKB)
IDA
GO:0019901
P49841 (UniProtKB)
IPI
GO:0021766
P49841 (UniProtKB)
IMP
GO:0030010
P49841 (UniProtKB)
IEA
GO:0030424
P49841 (UniProtKB)
IEA
GO:0030426
P49841 (UniProtKB)
IEA
GO:0030529
P49841 (UniProtKB)
IEA
GO:0030877
P49841 (UniProtKB)
TAS
GO:0030877
P49841 (UniProtKB)
IDA
GO:0030877
P49841 (UniProtKB)
IDA
GO:0030877
P49841 (UniProtKB)
TAS
GO:0030877
P49841 (UniProtKB)
IDA
GO:0030877
P49841 (UniProtKB)
IDA
GO:0031333
P49841 (UniProtKB)
IMP
GO:0031334
P49841 (UniProtKB)
IDA
GO:0031625
P49841 (UniProtKB)
IPI
GO:0032091
P49841 (UniProtKB)
IDA
GO:0032092
P49841 (UniProtKB)
ISS
GO:0032092
P49841 (UniProtKB)
ISS
GO:0032355
P49841 (UniProtKB)
IEA
GO:0032436
P49841 (UniProtKB)
IC
GO:0032868
P49841 (UniProtKB)
IEA
GO:0032886
P49841 (UniProtKB)
IMP
GO:0033138
P49841 (UniProtKB)
IEA
GO:0034236
P49841 (UniProtKB)
IPI
GO:0034392
P49841 (UniProtKB)
IEA
GO:0035255
P49841 (UniProtKB)
IEA
GO:0035372
P49841 (UniProtKB)
IEA
GO:0035556
P49841 (UniProtKB)
IDA
GO:0035729
P49841 (UniProtKB)
IEA
GO:0036016
P49841 (UniProtKB)
ISS
GO:0036018
P49841 (UniProtKB)
IEA
GO:0042493
P49841 (UniProtKB)
IEA
GO:0043025
P49841 (UniProtKB)
IEA
GO:0043066
P49841 (UniProtKB)
IDA
GO:0043161
P49841 (UniProtKB)
TAS
GO:0043197
P49841 (UniProtKB)
IEA
GO:0043198
P49841 (UniProtKB)
IEA
GO:0043407
P49841 (UniProtKB)
IEA
GO:0043525
P49841 (UniProtKB)
IEA
GO:0043547
P49841 (UniProtKB)
IMP
GO:0044027
P49841 (UniProtKB)
IEA
GO:0044337
P49841 (UniProtKB)
IEA
GO:0045121
P49841 (UniProtKB)
IEA
GO:0045444
P49841 (UniProtKB)
IEA
GO:0045719
P49841 (UniProtKB)
TAS
GO:0045732
P49841 (UniProtKB)
IC
GO:0045773
P49841 (UniProtKB)
IEA
GO:0045944
P49841 (UniProtKB)
IEA
GO:0046777
P49841 (UniProtKB)
IDA
GO:0046827
P49841 (UniProtKB)
IDA
GO:0048156
P49841 (UniProtKB)
IEA
GO:0048168
P49841 (UniProtKB)
IEA
GO:0048471
P49841 (UniProtKB)
IEA
GO:0048661
P49841 (UniProtKB)
IEA
GO:0050321
P49841 (UniProtKB)
IDA
GO:0050321
P49841 (UniProtKB)
IDA
GO:0050774
P49841 (UniProtKB)
IEA
GO:0051001
P49841 (UniProtKB)
IEA
GO:0051059
P49841 (UniProtKB)
IPI
GO:0051534
P49841 (UniProtKB)
IMP
GO:0060070
P49841 (UniProtKB)
IDA
GO:0060070
P49841 (UniProtKB)
IC
GO:0070059
P49841 (UniProtKB)
IEA
GO:0070301
P49841 (UniProtKB)
IEA
GO:0071109
P49841 (UniProtKB)
IMP
GO:0071260
P49841 (UniProtKB)
IEA
GO:0071282
P49841 (UniProtKB)
IEA
GO:0071285
P49841 (UniProtKB)
IEA
GO:0071871
P49841 (UniProtKB)
IEA
GO:0090090
P49841 (UniProtKB)
IC
GO:0090090
P49841 (UniProtKB)
TAS
GO:0097192
P49841 (UniProtKB)
ISS
GO:0097481
P49841 (UniProtKB)
IEA
GO:0099565
P49841 (UniProtKB)
NAS
GO:1900034
P49841 (UniProtKB)
TAS
GO:1900181
P49841 (UniProtKB)
ISS
GO:1901030
P49841 (UniProtKB)
ISS
GO:1901216
P49841 (UniProtKB)
IDA
GO:1902065
P49841 (UniProtKB)
IEA
GO:1903351
P49841 (UniProtKB)
IEA
GO:1904339
P49841 (UniProtKB)
TAS
GO:1904885
P49841 (UniProtKB)
TAS
GO:1904886
P49841 (UniProtKB)
TAS
GO:1990418
P49841 (UniProtKB)
IEA
GO:1990478
P49841 (UniProtKB)
IEA
GO:1990776
P49841 (UniProtKB)
IEA
GO:1990909
P49841 (UniProtKB)
TAS
GO:2000077
P49841 (UniProtKB)
TAS
GO:2000463
P49841 (UniProtKB)
IEA
GO:2000466
P49841 (UniProtKB)
TAS
GO:2000573
P49841 (UniProtKB)
IEA
GO:2000738
P49841 (UniProtKB)
IEA
GO:2001223
P49841 (UniProtKB)
IEA

基因相关microRNA

基因相关microRNA

可能调控 GSK3B基因的相关microRNA：     

基因相互作用关系

基因相互作用关系

Reactome

MINT

BioGrid

IntAct

mentha

String

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因通路

基因通路

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Alzheimer's Disease 0.225718421 22 0 BeFree_CTD_human_GAD_LHGDN_RGD
Schizophrenia 0.223794584 18 0 BeFree_CTD_human_GAD_LHGDN_RGD
Depressive disorder 0.200271442 4 0 BeFree_CTD_human_RGD
Cardiomegaly 0.2 2 0 CTD_human_RGD
Myocardial Infarction 0.2 2 0 CTD_human_RGD
Bipolar Disorder 0.140183845 18 0 BeFree_CTD_human_GAD_LHGDN
Prostatic Neoplasms 0.128444493 5 0 BeFree_CTD_human_LHGDN
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse 0.12272435 1 0 CTD_human_LHGDN
Peritonitis 0.12 1 0 CTD_human
Heart failure 0.12 1 0 CTD_human

基因相关服务

基因相关服务

联系方式

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