The increased expression level of this gene is associated with HER-2/neu proto-oncogene overexpression. Amplification and resulting overexpression of this proto-oncogene are found in approximately 30% of human breast and 20% of human ovarian cancers. Alternatively spliced variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Dec 2010]
该基因的表达增加水平与HER-2 / neu原癌基因过表达有关。扩增和这个原癌基因的过度表达导致在人乳腺癌的约30%,人卵巢癌的20%,被发现。编码不同同种型的可变剪接变体已被确定为这个基因。 [由RefSeq的,2010年12月提供]
GOLM2基因(以及对应的蛋白质)的细胞分布位置:
GOLM2基因的本体(GO)信息:
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