GABARAP (GABA type A receptor-associated protein)

基因基本信息

基因基本信息

symbol:
GABARAP
locus group:
protein-coding gene
location:
17p13.1
gene_family:
alias symbol:
MM46|ATG8A
alias name:
None
entrez id:
11337
ensembl gene id:
ENSG00000170296
ucsc gene id:
uc002gfb.4
refseq accession:
NM_007278
hgnc_id:
HGNC:4067
approved reserved:
1999-09-29

基因染色体位置

基因染色体位置

17p13.1
基因染色体位置图

基因简述

基因简述

GABARAP（Gamma-aminobutyric acid receptor-associated protein）是一种重要的自噬相关蛋白，属于ATG8/LC3蛋白家族。它主要参与自噬过程，帮助细胞降解和回收受损的蛋白质和细胞器，维持细胞内稳态。GABARAP最初被发现与GABA(A)受体相互作用，调节神经递质受体的运输和定位，因此在神经系统中具有重要作用。GABARAP通过其C端的脂化修饰与自噬体膜结合，促进自噬体的形成和成熟。此外，它还参与囊泡运输、膜融合和细胞凋亡等过程。GABARAP的突变或表达异常可能导致自噬功能障碍，与多种疾病相关，如神经退行性疾病（阿尔茨海默病、帕金森病）、癌症和免疫疾病。过表达GABARAP可能增强自噬活性，有助于清除异常蛋白聚集，但过度自噬也可能导致细胞死亡。相反，降低GABARAP表达会抑制自噬，导致细胞内废物积累，可能引发疾病。GABARAP属于ATG8/LC3基因家族，该家族成员（如LC3、GABARAPL1、GABARAPL2）均含有高度保守的结构域，参与自噬过程，但在组织分布和功能上存在差异。GABARAP家族蛋白通常通过与其他蛋白相互作用来调节细胞内的膜动态变化和货物识别。

Gamma-aminobutyric acid A receptors [GABA(A) receptors] are ligand-gated chloride channels that mediate inhibitory neurotransmission. This gene encodes GABA(A) receptor-associated protein, which is highly positively charged in its N-terminus and shares sequence similarity with light chain-3 of microtubule-associated proteins 1A and 1B. This protein clusters neurotransmitter receptors by mediating interaction with the cytoskeleton. [provided by RefSeq, Jul 2008]

γ-氨基丁酸A受体[GABA（A）受体]是介导神经传递抑制配体门控氯离子通道。这个基因编码的GABA（A）的受体相关的蛋白质，这是高度在其N-末端和共享序列相似性轻链-3微管相关蛋白1A和1B的正电荷。该蛋白通过介导与细胞骨架相互作用聚类神经递质受体。 [由RefSeq的，2008年7月提供]

OMIM数据库中对GABARAP基因的介绍     Wikipedia数据库中对GABARAP基因的介绍

基因序列

基因序列

GABARAP基因的碱基序列：[NCBI]
Loading Gene Browser...

基因突变

基因突变

GABARAP基因的碱基突变：           仅显示部分snp
rs8930       rs1051449       rs16956625       rs16956628       rs16956630       rs34926505       rs115870530       rs116480846       rs140149853       rs140299496       rs142077609       rs146413480       rs150300133       rs181496422       rs181566600       rs184619830       rs189507174      

基因表达

基因表达

GABARAP基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向Tm值
反向引物序列
反向Tm值
评分
AAGAAGAGCATCCGTTCGA
59
TTCTACTATCACCGGCACC
59
TCAGCTGTACCAGGAACAC
59
GACACTTTCGTCACTGTAGG
58
ATTCATCTCCGAGCTGAGG
59
ATGGTGTTCCTGGTACAGC
60
AAGAAGAGCATCCGTTCGA
59
TTCTACTATCACCGGCACC
59
TCAGCTGTACCAGGAACAC
59
GACACTTTCGTCACTGTAGG
58
TCAGCTGTACCAGGAACAC
59
GACACTTTCGTCACTGTAGG
58
AAAGAAGAGCATCCGTTCGA
60
AGTAGAACTGACCAACGGC
60
TCAGCTGTACCAGGAACAC
59
CACTTTCGTCACTGTAGGC
59
TCAGCTGTACCAGGAACAC
59
CACTTTCGTCACTGTAGGC
59
AGAAGAGCATCCGTTCGAG
60
TTTCTACTATCACCGGCACC
60

转录因子

转录因子

      尚未收录相关数据

基因本体信息

GABARAP基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 质膜
  • 细胞质
  • 细胞外
  • 高尔基体
  • 囊泡
  • 细胞骨架
  • 内质网
  • 细胞核
  • 内体
  • 溶酶体
  • 线粒体

GABARAP基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0006914
H6UMI1 (UniProtKB)
IEA
GO:0006914
I3L236 (UniProtKB)
IEA
GO:0000139
O95166 (UniProtKB)
IEA
GO:0000226
O95166 (UniProtKB)
IEA
GO:0000421
O95166 (UniProtKB)
IDA
GO:0000421
O95166 (UniProtKB)
TAS
GO:0005515
O95166 (UniProtKB)
IPI
GO:0005515
O95166 (UniProtKB)
IPI
GO:0005515
O95166 (UniProtKB)
IPI
GO:0005515
O95166 (UniProtKB)
IPI
GO:0005515
O95166 (UniProtKB)
IPI
GO:0005515
O95166 (UniProtKB)
IPI
GO:0005515
O95166 (UniProtKB)
IPI
GO:0005515
O95166 (UniProtKB)
IPI
GO:0005515
O95166 (UniProtKB)
IPI
GO:0005515
O95166 (UniProtKB)
IPI
GO:0005515
O95166 (UniProtKB)
IPI
GO:0005515
O95166 (UniProtKB)
IPI
GO:0005515
O95166 (UniProtKB)
IPI
GO:0005515
O95166 (UniProtKB)
IPI
GO:0005515
O95166 (UniProtKB)
IPI
GO:0005515
O95166 (UniProtKB)
IPI
GO:0005515
O95166 (UniProtKB)
IPI
GO:0005515
O95166 (UniProtKB)
IPI
GO:0005515
O95166 (UniProtKB)
IPI
GO:0005515
O95166 (UniProtKB)
IPI
GO:0005515
O95166 (UniProtKB)
IPI
GO:0005515
O95166 (UniProtKB)
IPI
GO:0005515
O95166 (UniProtKB)
IPI
GO:0005515
O95166 (UniProtKB)
IPI
GO:0005515
O95166 (UniProtKB)
IPI
GO:0005515
O95166 (UniProtKB)
IPI
GO:0005515
O95166 (UniProtKB)
IPI
GO:0005515
O95166 (UniProtKB)
IPI
GO:0005515
O95166 (UniProtKB)
IPI
GO:0005515
O95166 (UniProtKB)
IPI
GO:0005515
O95166 (UniProtKB)
IPI
GO:0005515
O95166 (UniProtKB)
IPI
GO:0005515
O95166 (UniProtKB)
IPI
GO:0005515
O95166 (UniProtKB)
IPI
GO:0005515
O95166 (UniProtKB)
IPI
GO:0005515
O95166 (UniProtKB)
IPI
GO:0005515
O95166 (UniProtKB)
IPI
GO:0005515
O95166 (UniProtKB)
IPI
GO:0005515
O95166 (UniProtKB)
IPI
GO:0005515
O95166 (UniProtKB)
IPI
GO:0005515
O95166 (UniProtKB)
IPI
GO:0005515
O95166 (UniProtKB)
IPI
GO:0005515
O95166 (UniProtKB)
IPI
GO:0005515
O95166 (UniProtKB)
IPI
GO:0005515
O95166 (UniProtKB)
IPI
GO:0005515
O95166 (UniProtKB)
IPI
GO:0005515
O95166 (UniProtKB)
IPI
GO:0005515
O95166 (UniProtKB)
IPI
GO:0005515
O95166 (UniProtKB)
IPI
GO:0005515
O95166 (UniProtKB)
IPI
GO:0005515
O95166 (UniProtKB)
IPI
GO:0005515
O95166 (UniProtKB)
IPI
GO:0005515
O95166 (UniProtKB)
IPI
GO:0005515
O95166 (UniProtKB)
IPI
GO:0005515
O95166 (UniProtKB)
IPI
GO:0005515
O95166 (UniProtKB)
IPI
GO:0005515
O95166 (UniProtKB)
IPI
GO:0005515
O95166 (UniProtKB)
IPI
GO:0005515
O95166 (UniProtKB)
IPI
GO:0005515
O95166 (UniProtKB)
IPI
GO:0005515
O95166 (UniProtKB)
IPI
GO:0005515
O95166 (UniProtKB)
IPI
GO:0005515
O95166 (UniProtKB)
IPI
GO:0005515
O95166 (UniProtKB)
IPI
GO:0005764
O95166 (UniProtKB)
IEA
GO:0005776
O95166 (UniProtKB)
IDA
GO:0005790
O95166 (UniProtKB)
IEA
GO:0005829
O95166 (UniProtKB)
TAS
GO:0005829
O95166 (UniProtKB)
TAS
GO:0005829
O95166 (UniProtKB)
TAS
GO:0005829
O95166 (UniProtKB)
TAS
GO:0005829
O95166 (UniProtKB)
TAS
GO:0005829
O95166 (UniProtKB)
TAS
GO:0005829
O95166 (UniProtKB)
TAS
GO:0005829
O95166 (UniProtKB)
TAS
GO:0005874
O95166 (UniProtKB)
IEA
GO:0005875
O95166 (UniProtKB)
IEA
GO:0005886
O95166 (UniProtKB)
IEA
GO:0005930
O95166 (UniProtKB)
ISS
GO:0006605
O95166 (UniProtKB)
TAS
GO:0007268
O95166 (UniProtKB)
TAS
GO:0008017
O95166 (UniProtKB)
IEA
GO:0008625
O95166 (UniProtKB)
IDA
GO:0015629
O95166 (UniProtKB)
IEA
GO:0016236
O95166 (UniProtKB)
TAS
GO:0031410
O95166 (UniProtKB)
IEA
GO:0031625
O95166 (UniProtKB)
IPI
GO:0031625
O95166 (UniProtKB)
IPI
GO:0031625
O95166 (UniProtKB)
IPI
GO:0031625
O95166 (UniProtKB)
IPI
GO:0031625
O95166 (UniProtKB)
IPI
GO:0031625
O95166 (UniProtKB)
IPI
GO:0044297
O95166 (UniProtKB)
IEA
GO:0048471
O95166 (UniProtKB)
IEA
GO:0048487
O95166 (UniProtKB)
IDA
GO:0050811
O95166 (UniProtKB)
IPI
GO:0097225
O95166 (UniProtKB)
IEA

基因相关microRNA

基因相关microRNA

可能调控 GABARAP基因的相关microRNA：     

基因相互作用关系

基因相互作用关系

MINT

BioGrid

IntAct

mentha

String

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因通路

基因通路

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Carcinoma, Lobular 0.00272435 1 0 LHGDN
Mammary Neoplasms 0.00272435 1 0 LHGDN
Nicotine Dependence 0.002638474 1 0 BeFree_GAD
Epilepsy 0.000271442 1 0 BeFree
Developmental delay (disorder) 0.000271442 1 0 BeFree
Mesothelioma 0.000271442 1 0 BeFree
Schizophrenia 0.000271442 1 0 BeFree
Tumor Progression 0.000271442 1 0 BeFree

基因相关服务

基因相关服务

联系方式

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