FYN (FYN proto-oncogene, Src family tyrosine kinase)
- symbol:
- FYN
- locus group:
- protein-coding gene
- location:
- 6q21
- gene_family:
- SH2 domain containing
- alias symbol:
- SYN|SLK|MGC45350
- alias name:
- None
- entrez id:
- 2534
- ensembl gene id:
- ENSG00000010810
- ucsc gene id:
- uc003pvk.3
- refseq accession:
- NM_001370529
- hgnc_id:
- HGNC:4037
- approved reserved:
- 1988-08-19
FYN是一种属于SRC家族的非受体型酪氨酸激酶基因，在细胞信号传导中发挥重要作用。该基因编码的Fyn蛋白广泛分布于多种组织中，尤其在神经系统和免疫系统中表达丰富。Fyn蛋白通过其SH2和SH3结构域与其他蛋白质相互作用，参与调控T细胞受体信号通路、神经元发育、突触可塑性以及细胞黏附等关键生物学过程。在免疫系统中，Fyn与Lck协同作用，参与T细胞激活的早期信号事件。在神经系统中，Fyn通过调节NMDA受体和髓鞘形成影响学习记忆功能。FYN基因突变可能导致多种疾病，包括神经系统疾病如阿尔茨海默病（通过影响tau蛋白磷酸化）和免疫系统异常。FYN过表达与某些癌症如乳腺癌和前列腺癌的进展相关，可能促进肿瘤细胞迁移和侵袭；而表达降低则可能损害T细胞功能导致免疫缺陷。FYN属于SRC基因家族，该家族成员均含有SH2、SH3结构域和激酶结构域，通过酪氨酸磷酸化参与细胞信号转导，在细胞生长、分化、存活和运动等过程中起调控作用。SRC家族激酶通常通过与细胞膜受体结合而被激活，其活性异常与多种癌症发生密切相关。
This gene is a member of the protein-tyrosine kinase oncogene family. It encodes a membrane-associated tyrosine kinase that has been implicated in the control of cell growth. The protein associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. Alternatively spliced transcript variants encoding distinct isoforms exist. [provided by RefSeq, Jul 2008]
该基??因是蛋白质 - 酪氨酸激酶致癌基因家族的一个成员。它编码已在细胞生长的控制被牵连的膜相关的酪氨酸激酶。与磷脂酰肌醇3激酶的P85亚基蛋白联营公司及与菲英岛结合蛋白相互作用。存在选择性剪接转录变异体的编码不同的亚型。 [由RefSeq的，2008年7月提供]
正向引物序列
正向Tm值
反向引物序列
反向Tm值
评分
CTCTTCATCACAGGGAAGGA
59
AGCCACATAATTGCTGGGA
59
AAGGACTCACCGTCTTTGG
60
AAGAGTGTCACTCCTGTTCC
59
TGGATACTACATTACCACCCG
59
AAACCATCAGCTTTCTCTGAG
58
TATTGAACAGCTCGGAAGG
57
CATAATTGCTGGGAATGTAACC
57
TGGATACTACATTACCACCCG
59
AAACCATCAGCTTTCTCTGAG
58
AAGGACTCACCGTCTTTGG
60
AAGAGTGTCACTCCTGTTCC
59
TATTGAACAGCTCGGAAGG
57
CATAATTGCTGGGAATGTAACC
58
CGACAGCTATTGTCCTTTGG
59
AAAGTGAATAGGCACCTTTGG
59
TATCCAGGCAGAAGAGTGG
59
TCTTGGGTTTCCAAAGGAC
58
AAGGACTCACCGTCTTTGG
59
AAGAGTGTCACTCCTGTTCC
59
基因本体信息
FYN基因（以及对应的蛋白质）的细胞分布位置：
- 质膜
- 细胞质
- 细胞外
- 高尔基体
- 囊泡
- 细胞骨架
- 内质网
- 细胞核
- 内体
- 溶酶体
- 线粒体
FYN基因的本体（GO）信息：
GO库代码
对应的蛋白质
来源代码
GO:0000165
P06241 (UniProtKB)
TAS
GO:0001664
P06241 (UniProtKB)
IEA
GO:0001764
P06241 (UniProtKB)
IEA
GO:0001948
P06241 (UniProtKB)
IPI
GO:0002223
P06241 (UniProtKB)
TAS
GO:0002250
P06241 (UniProtKB)
IEA
GO:0004713
P06241 (UniProtKB)
EXP
GO:0004713
P06241 (UniProtKB)
EXP
GO:0004713
P06241 (UniProtKB)
EXP
GO:0004713
P06241 (UniProtKB)
EXP
GO:0004713
P06241 (UniProtKB)
EXP
GO:0004713
P06241 (UniProtKB)
EXP
GO:0004713
P06241 (UniProtKB)
IMP
GO:0004713
P06241 (UniProtKB)
EXP
GO:0004713
P06241 (UniProtKB)
EXP
GO:0004713
P06241 (UniProtKB)
EXP
GO:0004713
P06241 (UniProtKB)
TAS
GO:0004713
P06241 (UniProtKB)
TAS
GO:0004713
P06241 (UniProtKB)
TAS
GO:0004713
P06241 (UniProtKB)
TAS
GO:0004713
P06241 (UniProtKB)
TAS
GO:0004713
P06241 (UniProtKB)
TAS
GO:0004713
P06241 (UniProtKB)
TAS
GO:0004713
P06241 (UniProtKB)
TAS
GO:0004713
P06241 (UniProtKB)
TAS
GO:0004715
P06241 (UniProtKB)
IBA
GO:0004715
P06241 (UniProtKB)
NAS
GO:0005088
P06241 (UniProtKB)
TAS
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005515
P06241 (UniProtKB)
IPI
GO:0005524
P06241 (UniProtKB)
IEA
GO:0005634
P06241 (UniProtKB)
IEA
GO:0005739
P06241 (UniProtKB)
IEA
GO:0005768
P06241 (UniProtKB)
IDA
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005829
P06241 (UniProtKB)
TAS
GO:0005884
P06241 (UniProtKB)
IEA
GO:0005886
P06241 (UniProtKB)
IDA
GO:0005886
P06241 (UniProtKB)
IDA
GO:0006468
P06241 (UniProtKB)
NAS
GO:0006816
P06241 (UniProtKB)
NAS
GO:0007169
P06241 (UniProtKB)
IBA
GO:0007411
P06241 (UniProtKB)
TAS
GO:0007417
P06241 (UniProtKB)
IBA
GO:0007596
P06241 (UniProtKB)
TAS
GO:0007612
P06241 (UniProtKB)
TAS
GO:0007631
P06241 (UniProtKB)
TAS
GO:0008360
P06241 (UniProtKB)
IEA
GO:0010629
P06241 (UniProtKB)
IEA
GO:0010976
P06241 (UniProtKB)
IEA
GO:0014066
P06241 (UniProtKB)
TAS
GO:0014068
P06241 (UniProtKB)
IEA
GO:0014069
P06241 (UniProtKB)
IEA
GO:0015631
P06241 (UniProtKB)
IEA
GO:0016032
P06241 (UniProtKB)
IEA
GO:0016477
P06241 (UniProtKB)
IBA
GO:0018108
P06241 (UniProtKB)
IMP
GO:0030154
P06241 (UniProtKB)
IBA
GO:0030168
P06241 (UniProtKB)
TAS
GO:0030900
P06241 (UniProtKB)
IEA
GO:0031234
P06241 (UniProtKB)
IBA
GO:0031295
P06241 (UniProtKB)
TAS
GO:0031295
P06241 (UniProtKB)
TAS
GO:0031397
P06241 (UniProtKB)
IEA
GO:0035556
P06241 (UniProtKB)
TAS
GO:0036120
P06241 (UniProtKB)
IEA
GO:0038083
P06241 (UniProtKB)
IBA
GO:0038096
P06241 (UniProtKB)
TAS
GO:0042110
P06241 (UniProtKB)
IBA
GO:0042127
P06241 (UniProtKB)
IBA
GO:0042177
P06241 (UniProtKB)
IEA
GO:0042493
P06241 (UniProtKB)
IEA
GO:0042523
P06241 (UniProtKB)
IEA
GO:0042608
P06241 (UniProtKB)
IEA
GO:0042609
P06241 (UniProtKB)
IEA
GO:0042610
P06241 (UniProtKB)
IEA
GO:0042981
P06241 (UniProtKB)
IBA
GO:0043123
P06241 (UniProtKB)
IEA
GO:0043524
P06241 (UniProtKB)
IEA
GO:0043547
P06241 (UniProtKB)
IEA
GO:0043548
P06241 (UniProtKB)
IEA
GO:0044325
P06241 (UniProtKB)
IEA
GO:0045087
P06241 (UniProtKB)
IBA
GO:0045471
P06241 (UniProtKB)
IEA
GO:0046854
P06241 (UniProtKB)
IEA
GO:0046872
P06241 (UniProtKB)
IEA
GO:0046875
P06241 (UniProtKB)
IPI
GO:0046934
P06241 (UniProtKB)
TAS
GO:0048010
P06241 (UniProtKB)
TAS
GO:0048013
P06241 (UniProtKB)
TAS
GO:0048015
P06241 (UniProtKB)
TAS
GO:0048813
P06241 (UniProtKB)
IEA
GO:0050690
P06241 (UniProtKB)
TAS
GO:0050798
P06241 (UniProtKB)
IEA
GO:0050852
P06241 (UniProtKB)
IDA
GO:0050900
P06241 (UniProtKB)
TAS
GO:0050966
P06241 (UniProtKB)
IEA
GO:0051428
P06241 (UniProtKB)
IEA
GO:0070851
P06241 (UniProtKB)
IPI
GO:0071375
P06241 (UniProtKB)
IEA
GO:0071560
P06241 (UniProtKB)
IEA
GO:1900182
P06241 (UniProtKB)
IEA
GO:2001240
P06241 (UniProtKB)
IEA
GO:0045121
P06241 (UniProtKB)
IDA
| 名称 |
|---|
| 4071 Sphingolipid signaling pathway [PATH:hsa04071] |
| 4510 Focal adhesion [PATH:hsa04510] |
| 4520 Adherens junction [PATH:hsa04520] |
| 4611 Platelet activation [PATH:hsa04611] |
| 4650 Natural killer cell mediated cytotoxicity [PATH:hsa04650] |
| 4660 T cell receptor signaling pathway [PATH:hsa04660] |
| 4664 Fc epsilon RI signaling pathway [PATH:hsa04664] |
| 4725 Cholinergic synapse [PATH:hsa04725] |
| 4360 Axon guidance [PATH:hsa04360] |
| 4380 Osteoclast differentiation [PATH:hsa04380] |
| 5020 Prion diseases [PATH:hsa05020] |
| 5416 Viral myocarditis [PATH:hsa05416] |
| 5130 Pathogenic Escherichia coli infection [PATH:hsa05130] |
| 5162 Measles [PATH:hsa05162] |
| 名称 |
|---|
| Adaptive Immune System |
| Antigen activates B Cell Receptor (BCR) leading to generation of second messengers |
| Axon guidance |
| C-type lectin receptors (CLRs) |
| CD209 (DC-SIGN) signaling |
| CD28 co-stimulation |
| CD28 dependent PI3K/Akt signaling |
| CD28 dependent Vav1 pathway |
| Cell surface interactions at the vascular wall |
| Cell-Cell communication |
| Constitutive Signaling by Aberrant PI3K in Cancer |
| Costimulation by the CD28 family |
| CRMPs in Sema3A signaling |
| CTLA4 inhibitory signaling |
| Cytokine Signaling in Immune system |
| DAP12 interactions |
| DAP12 signaling |
| DCC mediated attractive signaling |
| Dectin-2 family |
| Developmental Biology |
| Disease |
| Diseases of signal transduction |
| Downstream signal transduction |
| Downstream signaling events of B Cell Receptor (BCR) |
| Downstream signaling of activated FGFR1 |
| Downstream signaling of activated FGFR2 |
| Downstream signaling of activated FGFR3 |
| Downstream signaling of activated FGFR4 |
| EPH-ephrin mediated repulsion of cells |
| EPH-Ephrin signaling |
| EPHA-mediated growth cone collapse |
| EPHB-mediated forward signaling |
| Ephrin signaling |
| Fc epsilon receptor (FCERI) signaling |
| Fcgamma receptor (FCGR) dependent phagocytosis |
| FCGR activation |
| GAB1 signalosome |
| GPVI-mediated activation cascade |
| Hemostasis |
| HIV Infection |
| Host Interactions of HIV factors |
| Immune System |
| Infectious disease |
| Innate Immune System |
| Interleukin-3, 5 and GM-CSF signaling |
| NCAM signaling for neurite out-growth |
| Nef and signal transduction |
| Nephrin interactions |
| Netrin mediated repulsion signals |
| Netrin-1 signaling |
| NGF signalling via TRKA from the plasma membrane |
| PECAM1 interactions |
| PI-3K cascade:FGFR1 |
| PI-3K cascade:FGFR2 |
| PI-3K cascade:FGFR3 |
| PI-3K cascade:FGFR4 |
| PI3K events in ERBB2 signaling |
| PI3K events in ERBB4 signaling |
| PI3K/AKT activation |
| PI3K/AKT Signaling in Cancer |
| PIP3 activates AKT signaling |
| Platelet activation, signaling and aggregation |
| Platelet Adhesion to exposed collagen |
| Regulation of KIT signaling |
| Regulation of signaling by CBL |
| Role of LAT2/NTAL/LAB on calcium mobilization |
| Sema3A PAK dependent Axon repulsion |
| SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
| Semaphorin interactions |
| Signal Transduction |
| Signaling by EGFR |
| Signaling by ERBB2 |
| Signaling by ERBB4 |
| Signaling by FGFR |
| Signaling by FGFR1 |
| Signaling by FGFR2 |
| Signaling by FGFR3 |
| Signaling by FGFR4 |
| Signaling by Interleukins |
| Signaling by PDGF |
| Signaling by SCF-KIT |
| Signaling by the B Cell Receptor (BCR) |
| Signaling by VEGF |
| Signalling by NGF |
| The role of Nef in HIV-1 replication and disease pathogenesis |
| VEGFA-VEGFR2 Pathway |
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Peripheral T-Cell Lymphoma | 0.120271442 | 1 | 0 | BeFree_CTD_human |
| Stomach Neoplasms | 0.12 | 1 | 0 | CTD_human |
| Catalepsy | 0.12 | 1 | 0 | CTD_human |
| Adult T-Cell Lymphoma/Leukemia | 0.12 | 1 | 0 | CTD_human |
| Sepsis | 0.08 | 1 | 0 | RGD |
| Epilepsy, Temporal Lobe | 0.08 | 1 | 0 | RGD |
| Alzheimer's Disease | 0.010454206 | 5 | 0 | BeFree_GAD_LHGDN |
| Asthma | 0.005634266 | 2 | 5 | BeFree_GAD_LHGDN |
| Schizophrenia | 0.00554839 | 5 | 0 | BeFree_GAD |
| Bipolar Disorder | 0.005276948 | 2 | 0 | BeFree_GAD |
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