FOS基因详情-基因数据库-基因云馆

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FOS (Fos proto-oncogene, AP-1 transcription factor subunit)

symbol:: FOS
locus group:: protein-coding gene
location:: 14q24.3
gene_family:: Basic leucine zipper proteins
alias symbol:: c-fos|AP-1
alias name:: None
entrez id:: 2353
ensembl gene id:: ENSG00000170345
ucsc gene id:: uc001xrn.4
refseq accession:: NM_005252
hgnc_id:: HGNC:3796
approved reserved:: 2001-06-22

14q24.3

FOS基因是一种早期即刻反应基因，属于FOS基因家族（包括FOS、FOSB、FOSL1和FOSL2），该家族成员编码亮氨酸拉链转录因子，通常与JUN家族蛋白形成异源二聚体AP-1（激活蛋白-1）复合物，参与调控细胞增殖、分化、凋亡和应激反应等过程。FOS蛋白作为转录因子，通过结合DNA特定序列调控下游靶基因表达，在细胞对外界刺激（如生长因子、细胞因子、紫外线或氧化应激）的快速响应中起核心作用。FOS基因的突变可能导致其功能异常，例如丧失DNA结合能力或无法与JUN蛋白形成复合物，进而影响细胞周期调控和应激反应，与多种疾病相关，包括癌症（如骨肉瘤、乳腺癌）、神经退行性疾病和心血管疾病。FOS过表达会异常激活AP-1依赖的基因转录，促进细胞增殖和转化，增加肿瘤发生风险；而敲除或低表达FOS可能导致发育缺陷、免疫功能异常或对氧化应激的敏感性增加。FOS基因家族成员的共性是均含有保守的亮氨酸拉链结构域，能够形成二聚体并结合DNA，但各成员在不同组织和应激条件下的表达模式及功能存在差异。例如，FOSL1（FRA-1）在侵袭性癌症中高表达，而FOSB的剪接变体ΔFOSB与成瘾行为相关。FOS的调控异常还与炎症性疾病和骨代谢紊乱（如骨质疏松）有关，因其参与破骨细胞分化和炎症因子（如IL-6、TNF-α）的转录调控。在神经系统，FOS的瞬时表达被广泛用作神经元激活的标志物，反映神经环路的活动变化。

The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. In some cases, expression of the FOS gene has also been associated with apoptotic cell death. [provided by RefSeq, Jul 2008]

果寡糖基因家族由4名成员：FOS，FOSB，FOSL1和FOSL2。这些基因编码亮氨酸拉链蛋白可与君家的蛋白质二聚化，由此形成的转录因子复合的AP-1。因此，FOS蛋白质有牵连的细胞增殖，分化和转型的监管。在一些情况下，FOS基因的表达也与细胞凋亡相关联。 [由RefSeq的，2008年7月提供]

OMIM数据库中对FOS基因的介绍 Wikipedia数据库中对FOS基因的介绍

FOS基因的碱基序列：[NCBI]

Loading Gene Browser...

FOS基因的碱基突变：仅显示部分snp

rs7101 rs14371 rs932257 rs1046117 rs1063169 rs2229024 rs2234706 rs2239615 rs3180688 rs3216792 rs4645847 rs4645848 rs4645849 rs4645850 rs4645851 rs4645852 rs4645853

FOS基因在不同组织中的表达： [UniProt]

正向引物序列

正向Tm值

反向引物序列

反向Tm值

评分

GACTCCTTCTCCAGCATGG

ATTCTTACTATGGCAAGCGTG

GACTCCTTCTCCAGCATGG

GAATGAAGTTGGCACTGGAG

TGAAGACCATGACAGGAGG

CTTTCCCTTCGGATTCTCC

GTGAAGACCATGACAGGAG

TTCTTCTGTTCCACCTTGC

ATACACTCCAAGCGGAGAC

TTTCCTTCTCCTTCAGCAGG

GAAAGGAATAAGATGGCTGCAG

CTAGTTGGTCTGTCTCCGC

GAAAGGAATAAGATGGCTGCAG

CTAGTTGGTCTGTCTCCGC

CTTCAACGCAGACTACGAG

GGGAATGAAGTTGGCACTG

GTGGAACAGGAGACAGACC

TTTCCTTCTCCTTCAGCAGG

AGGTGGAACAGTTATCTCCA

TATCAGTCAGCTCCCTCCT

转录因子

影响基因

影响类型

参考文献链接（PubMed）

AHR

FOS

Unknown

10478842

ARNT

FOS

Repression

21544813

BRCA1

FOS

Unknown

11313879

CREB1

FOS

Unknown

12432566

CREM

FOS

Repression

21757709

DACH1

FOS

Repression

17182846

ELK1

FOS

Unknown

11313879; 11846562; 20682780

ELK4

FOS

Activation

9734357

ELK4

FOS

Unknown

11846562

ESR1

FOS

Unknown

10037443

FOS基因（以及对应的蛋白质）的细胞分布位置：

[UniProt] [GenomeNet]

质膜
细胞质
细胞外
高尔基体
囊泡
细胞骨架
内质网
细胞核
内体
溶酶体
线粒体

FOS基因的本体（GO）信息：

GO库代码

对应的蛋白质

来源代码

GO:0003677

G3V289 (UniProtKB)

IEA

GO:0003700

G3V289 (UniProtKB)

IEA

GO:0005667

G3V289 (UniProtKB)

IEA

GO:0006357

G3V289 (UniProtKB)

IEA

GO:0003700

G3V2V7 (UniProtKB)

IEA

GO:0005667

G3V2V7 (UniProtKB)

IEA

GO:0006357

G3V2V7 (UniProtKB)

IEA

GO:0043565

G3V2V7 (UniProtKB)

IEA

GO:0003700

G3V5J9 (UniProtKB)

IEA

GO:0005667

G3V5J9 (UniProtKB)

IEA

GO:0006357

G3V5J9 (UniProtKB)

IEA

GO:0043565

G3V5J9 (UniProtKB)

IEA

GO:0003677

G3V5N7 (UniProtKB)

IEA

GO:0003700

G3V5N7 (UniProtKB)

IEA

GO:0005667

G3V5N7 (UniProtKB)

IEA

GO:0006357

G3V5N7 (UniProtKB)

IEA

GO:0003677

G3V5N9 (UniProtKB)

IEA

GO:0003700

G3V5N9 (UniProtKB)

IEA

GO:0005667

G3V5N9 (UniProtKB)

IEA

GO:0006357

G3V5N9 (UniProtKB)

IEA

GO:0003700

H0YJM3 (UniProtKB)

IEA

GO:0005667

H0YJM3 (UniProtKB)

IEA

GO:0006357

H0YJM3 (UniProtKB)

IEA

GO:0043565

H0YJM3 (UniProtKB)

IEA

GO:0000978

P01100 (UniProtKB)

IBA

GO:0000979

P01100 (UniProtKB)

IEA

GO:0000982

P01100 (UniProtKB)

IBA

GO:0001077

P01100 (UniProtKB)

IEA

GO:0001661

P01100 (UniProtKB)

IEA

GO:0003682

P01100 (UniProtKB)

IEA

GO:0003700

P01100 (UniProtKB)

IDA

GO:0005515

P01100 (UniProtKB)

IPI

GO:0005515

P01100 (UniProtKB)

IPI

GO:0005515

P01100 (UniProtKB)

IPI

GO:0005515

P01100 (UniProtKB)

IPI

GO:0005515

P01100 (UniProtKB)

IPI

GO:0005515

P01100 (UniProtKB)

IPI

GO:0005515

P01100 (UniProtKB)

IPI

GO:0005515

P01100 (UniProtKB)

IPI

GO:0005515

P01100 (UniProtKB)

IPI

GO:0005515

P01100 (UniProtKB)

IPI

GO:0005515

P01100 (UniProtKB)

IPI

GO:0005515

P01100 (UniProtKB)

IPI

GO:0005515

P01100 (UniProtKB)

IPI

GO:0005515

P01100 (UniProtKB)

IPI

GO:0005515

P01100 (UniProtKB)

IPI

GO:0005515

P01100 (UniProtKB)

IPI

GO:0005515

P01100 (UniProtKB)

IPI

GO:0005515

P01100 (UniProtKB)

IPI

GO:0005515

P01100 (UniProtKB)

IPI

GO:0005515

P01100 (UniProtKB)

IPI

GO:0005515

P01100 (UniProtKB)

IPI

GO:0005515

P01100 (UniProtKB)

IPI

GO:0005515

P01100 (UniProtKB)

IPI

GO:0005515

P01100 (UniProtKB)

IPI

GO:0005515

P01100 (UniProtKB)

IPI

GO:0005515

P01100 (UniProtKB)

IPI

GO:0005515

P01100 (UniProtKB)

IPI

GO:0005515

P01100 (UniProtKB)

IPI

GO:0005515

P01100 (UniProtKB)

IPI

GO:0005515

P01100 (UniProtKB)

IPI

GO:0005515

P01100 (UniProtKB)

IPI

GO:0005515

P01100 (UniProtKB)

IPI

GO:0005515

P01100 (UniProtKB)

IPI

GO:0005515

P01100 (UniProtKB)

IPI

GO:0005515

P01100 (UniProtKB)

IPI

GO:0005515

P01100 (UniProtKB)

IPI

GO:0005634

P01100 (UniProtKB)

IDA

GO:0005654

P01100 (UniProtKB)

IDA

GO:0005654

P01100 (UniProtKB)

TAS

GO:0005654

P01100 (UniProtKB)

TAS

GO:0005654

P01100 (UniProtKB)

TAS

GO:0005654

P01100 (UniProtKB)

TAS

GO:0005654

P01100 (UniProtKB)

TAS

GO:0005654

P01100 (UniProtKB)

TAS

GO:0005667

P01100 (UniProtKB)

IEA

GO:0005783

P01100 (UniProtKB)

IEA

GO:0005829

P01100 (UniProtKB)

IEA

GO:0006306

P01100 (UniProtKB)

TAS

GO:0006357

P01100 (UniProtKB)

TAS

GO:0006366

P01100 (UniProtKB)

IEA

GO:0006954

P01100 (UniProtKB)

TAS

GO:0007179

P01100 (UniProtKB)

IDA

GO:0007399

P01100 (UniProtKB)

IEA

GO:0007565

P01100 (UniProtKB)

IEA

GO:0007568

P01100 (UniProtKB)

IEA

GO:0008134

P01100 (UniProtKB)

IPI

GO:0009409

P01100 (UniProtKB)

IEA

GO:0009416

P01100 (UniProtKB)

IEA

GO:0009629

P01100 (UniProtKB)

IEA

GO:0009636

P01100 (UniProtKB)

IEA

GO:0016020

P01100 (UniProtKB)

IEA

GO:0030431

P01100 (UniProtKB)

IEA

GO:0031668

P01100 (UniProtKB)

IEA

GO:0032496

P01100 (UniProtKB)

IEA

GO:0032570

P01100 (UniProtKB)

IEA

GO:0032870

P01100 (UniProtKB)

IEA

GO:0034097

P01100 (UniProtKB)

IEA

GO:0034614

P01100 (UniProtKB)

IDA

GO:0035902

P01100 (UniProtKB)

IEA

GO:0035914

P01100 (UniProtKB)

IEA

GO:0035994

P01100 (UniProtKB)

IEA

GO:0038095

P01100 (UniProtKB)

TAS

GO:0042493

P01100 (UniProtKB)

IEA

GO:0042493

P01100 (UniProtKB)

IEA

GO:0043005

P01100 (UniProtKB)

IEA

GO:0044212

P01100 (UniProtKB)

IDA

GO:0045672

P01100 (UniProtKB)

IEA

GO:0045893

P01100 (UniProtKB)

IDA

GO:0045944

P01100 (UniProtKB)

IGI

GO:0046982

P01100 (UniProtKB)

IEA

GO:0051090

P01100 (UniProtKB)

TAS

GO:0051412

P01100 (UniProtKB)

IEA

GO:0051591

P01100 (UniProtKB)

IEA

GO:0060395

P01100 (UniProtKB)

IDA

GO:0070412

P01100 (UniProtKB)

IPI

GO:0071277

P01100 (UniProtKB)

IEA

GO:1902895

P01100 (UniProtKB)

ISS

可能调控 FOS基因的相关microRNA：

hsa-miR-192 hsa-miR-335 hsa-miR-101 hsa-miR-10a hsa-miR-10a* hsa-miR-130a hsa-miR-130a* hsa-miR-135b* hsa-miR-138 hsa-miR-143

Reactome

MINT

BioGrid

IntAct

mentha

String

序号	作用方式	资源库来源/分值	基因名称	基因名称

KEGG
Reactomepathway

名称
4010 MAPK signaling pathway [PATH:hsa04010]
4668 TNF signaling pathway [PATH:hsa04668]
4024 cAMP signaling pathway [PATH:hsa04024]
4620 Toll-like receptor signaling pathway [PATH:hsa04620]
4660 T cell receptor signaling pathway [PATH:hsa04660]
4662 B cell receptor signaling pathway [PATH:hsa04662]
4915 Estrogen signaling pathway [PATH:hsa04915]
4917 Prolactin signaling pathway [PATH:hsa04917]
4921 Oxytocin signaling pathway [PATH:hsa04921]
4725 Cholinergic synapse [PATH:hsa04725]
4728 Dopaminergic synapse [PATH:hsa04728]
4380 Osteoclast differentiation [PATH:hsa04380]
4713 Circadian entrainment [PATH:hsa04713]
5200 Pathways in cancer [PATH:hsa05200]
5231 Choline metabolism in cancer [PATH:hsa05231]
5210 Colorectal cancer [PATH:hsa05210]
5323 Rheumatoid arthritis [PATH:hsa05323]
5031 Amphetamine addiction [PATH:hsa05031]
5132 Salmonella infection [PATH:hsa05132]
5133 Pertussis [PATH:hsa05133]
5166 HTLV-I infection [PATH:hsa05166]
5161 Hepatitis B [PATH:hsa05161]
5168 Herpes simplex infection [PATH:hsa05168]
5140 Leishmaniasis [PATH:hsa05140]
5142 Chagas disease (American trypanosomiasis) [PATH:hsa05142]

名称
Activated TLR4 signalling
Activation of the AP-1 family of transcription factors
Cellular responses to stress
Cellular Senescence
Fc epsilon receptor (FCERI) signaling
FCERI mediated MAPK activation
Immune System
Innate Immune System
MAP kinase activation in TLR cascade
MAPK targets/ Nuclear events mediated by MAP kinases
MyD88 cascade initiated on plasma membrane
MyD88 dependent cascade initiated on endosome
MyD88-independent TLR3/TLR4 cascade
MyD88:Mal cascade initiated on plasma membrane
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
Toll Like Receptor 10 (TLR10) Cascade
Toll Like Receptor 2 (TLR2) Cascade
Toll Like Receptor 3 (TLR3) Cascade
Toll Like Receptor 4 (TLR4) Cascade
Toll Like Receptor 5 (TLR5) Cascade
Toll Like Receptor 7/8 (TLR7/8) Cascade
Toll Like Receptor 9 (TLR9) Cascade
Toll Like Receptor TLR1:TLR2 Cascade
Toll Like Receptor TLR6:TLR2 Cascade
Toll-Like Receptors Cascades
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
TRAF6 Mediated Induction of proinflammatory cytokines
TRIF-mediated TLR3/TLR4 signaling

疾病名称

关系值

NofPmids

NofSnps

来源

疾病名称	关系值	NofPmids	NofSnps	来源
Hypertensive disease	0.200271442	3	0	BeFree_CTD_human_RGD
Reperfusion Injury	0.2	2	0	CTD_human_RGD
Liver carcinoma	0.126253095	14	0	BeFree_CTD_human_LHGDN
Mammary Neoplasms	0.123538676	5	0	BeFree_CTD_human_LHGDN
Endometriosis	0.122995792	3	0	BeFree_CTD_human_LHGDN
Anxiety Disorders	0.120271442	2	0	BeFree_CTD_human
Hyperactive behavior	0.12	1	0	CTD_human
Lipoatrophic Diabetes Mellitus	0.12	0	0	ORPHANET
Status Epilepticus	0.12	4	0	CTD_human
Lung Neoplasms	0.12	1	0	CTD_human

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更新于2天前

FOS (Fos proto-oncogene, AP-1 transcription factor subunit)

基因基本信息

基因基本信息

基因染色体位置

基因染色体位置

基因简述

基因简述

基因序列

基因序列

基因突变

基因突变

基因表达

基因表达

基因引物

基因引物

转录因子

转录因子

基因本体信息

基因相关microRNA

基因相关microRNA

基因相互作用关系

基因相互作用关系

基因通路

基因通路

基因相关疾病

基因相关疾病

基因相关服务

基因相关服务

联系方式

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