FOLR2 (folate receptor beta)

基因基本信息

基因基本信息

symbol:
FOLR2
locus group:
protein-coding gene
location:
11q13.4
gene_family:
alias symbol:
FRβ
alias name:
None
entrez id:
2350
ensembl gene id:
ENSG00000165457
ucsc gene id:
uc001ose.5
refseq accession:
NM_000803
hgnc_id:
HGNC:3793
approved reserved:
1992-04-16

基因染色体位置

基因染色体位置

11q13.4
基因染色体位置图

基因简述

基因简述

The protein encoded by this gene is a member of the folate receptor (FOLR) family, and these genes exist in a cluster on chromosome 11. Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives, and they mediate delivery of 5-methyltetrahydrofolate to the interior of cells. This protein has a 68% and 79% sequence homology with the FOLR1 and FOLR3 proteins, respectively. Although this protein was originally thought to be specific to placenta, it can also exist in other tissues, and it may play a role in the transport of methotrexate in synovial macrophages in rheumatoid arthritis patients. Multiple transcript variants that encode the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

由该基因编码的蛋白质是叶酸受体（FOLR）家族的一个成员，并且这些基因在集群存在于11号染色体这个基因家族的成员具有对叶酸和对数减少的叶酸的高亲和性酸衍生物，和它们介导5-甲基递送至细胞内部。该蛋白质具有与FOLR1和FOLR3蛋白质68％和79％的序列同源性，分别为。虽然该蛋白最初被认为是特定的胎盘，它也可以存在于其它组织，并且它可以在甲氨蝶呤的滑膜巨噬细胞类风湿关节炎患者的运输中发挥作用。编码相同蛋白质的多个转录物变体已经发现这种基因。 [由RefSeq的，2008年7月提供]

OMIM数据库中对CCND1基因的介绍     Wikipedia数据库中对CCND1基因的介绍

基因序列

基因序列

CCND1基因的碱基序列：[NCBI]
Loading Gene Browser...

基因突变

基因突变

FOLR2基因的碱基突变：           仅显示部分snp
rs11268       rs13908       rs514933       rs651646       rs651933       rs1803567       rs1803569       rs2298444       rs2508202       rs11235469       rs11235470       rs11828061       rs12274520       rs12282143       rs59825932       rs60642813       rs71834554      

基因表达

基因表达

FOLR2基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向Tm值
反向引物序列
反向Tm值
评分
CTGCATGACCAATGCAGTC
60
TTAAAGTTGTACAGGCGGGA
59
TCCAGCAGGTGAATCAGAG
59
GGAGGTGTGACAATCCTCC
60
ATCCAGCAGGTGAATCAGAG
60
GAGGTGTGACAATCCTCCC
60
CTGCATGACCAATGCAGTC
60
TAAAGTTGTACAGGCGGGAG
60
CTGCATGACCAATGCAGTC
60
TAAAGTTGTACAGGCGGGA
59
TCCAGCAGGTGAATCAGAG
59
GAGGTGTGACAATCCTCCC
60

转录因子

转录因子

      尚未收录相关数据

基因本体信息

FOLR2基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 质膜
  • 细胞质
  • 细胞外
  • 高尔基体
  • 囊泡
  • 细胞骨架
  • 内质网
  • 细胞核
  • 内体
  • 溶酶体
  • 线粒体

FOLR2基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0005542
A0A087WWY2 (UniProtKB)
IEA
GO:0008517
A0A087WWY2 (UniProtKB)
IEA
GO:0015884
A0A087WWY2 (UniProtKB)
IEA
GO:0005542
E7EU04 (UniProtKB)
IEA
GO:0008517
E7EU04 (UniProtKB)
IEA
GO:0015884
E7EU04 (UniProtKB)
IEA
GO:0005542
F5GXV3 (UniProtKB)
IEA
GO:0008517
F5GXV3 (UniProtKB)
IEA
GO:0015884
F5GXV3 (UniProtKB)
IEA
GO:0005542
F5GZ45 (UniProtKB)
IEA
GO:0008517
F5GZ45 (UniProtKB)
IEA
GO:0015884
F5GZ45 (UniProtKB)
IEA
GO:0005542
F5H3Z4 (UniProtKB)
IEA
GO:0008517
F5H3Z4 (UniProtKB)
IEA
GO:0015884
F5H3Z4 (UniProtKB)
IEA
GO:0005542
F5H4Z6 (UniProtKB)
IEA
GO:0008517
F5H4Z6 (UniProtKB)
IEA
GO:0015884
F5H4Z6 (UniProtKB)
IEA
GO:0005542
F5H5L8 (UniProtKB)
IEA
GO:0008517
F5H5L8 (UniProtKB)
IEA
GO:0015884
F5H5L8 (UniProtKB)
IEA
GO:0005542
J3KQP4 (UniProtKB)
IEA
GO:0008517
J3KQP4 (UniProtKB)
IEA
GO:0015884
J3KQP4 (UniProtKB)
IEA
GO:0005542
J3KR13 (UniProtKB)
IEA
GO:0008517
J3KR13 (UniProtKB)
IEA
GO:0015884
J3KR13 (UniProtKB)
IEA
GO:0005542
P14207 (UniProtKB)
IDA
GO:0005542
P14207 (UniProtKB)
IDA
GO:0005542
P14207 (UniProtKB)
IDA
GO:0005576
P14207 (UniProtKB)
IEA
GO:0006898
P14207 (UniProtKB)
IC
GO:0006954
P14207 (UniProtKB)
NAS
GO:0008144
P14207 (UniProtKB)
IPI
GO:0008284
P14207 (UniProtKB)
IMP
GO:0008517
P14207 (UniProtKB)
IDA
GO:0009986
P14207 (UniProtKB)
IDA
GO:0015884
P14207 (UniProtKB)
IDA
GO:0016020
P14207 (UniProtKB)
TAS
GO:0031362
P14207 (UniProtKB)
IDA
GO:0050758
P14207 (UniProtKB)
IC
GO:0051870
P14207 (UniProtKB)
IDA
GO:0061714
P14207 (UniProtKB)
IC
GO:0071231
P14207 (UniProtKB)
IEA
GO:0002548
P14207 (UniProtKB)
IDA

基因相关microRNA

基因相关microRNA

可能调控 FOLR2基因的相关microRNA：     

基因相互作用关系

基因相互作用关系

String

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因通路

基因通路

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Neural Tube Defects 0.12 1 0 CTD_human
Spina Bifida 0.005005506 3 0 BeFree_GAD
Meningomyelocele 0.002638474 1 0 BeFree_GAD
Congenital Heart Defects 0.002367032 1 0 GAD
Hyperparathyroidism, Secondary 0.002367032 1 0 GAD
Cleft Palate 0.002367032 1 0 GAD
Cleft Lip 0.002367032 1 0 GAD
Leukemia, Myelocytic, Acute 0.000814326 3 0 BeFree
Rheumatoid Arthritis 0.000542884 2 0 BeFree
Rett Syndrome 0.000271442 1 0 BeFree

基因相关服务

基因相关服务

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