FGFR2 (fibroblast growth factor receptor 2)

symbol:
FGFR2
locus group:
protein-coding gene
location:
10q26.13
gene_family:
Receptor Tyrosine Kinases|CD molecules|I-set domain containing
alias symbol:
CEK3|TK14|TK25|ECT1|K-SAM|CD332
alias name:
Crouzon syndrome|Pfeiffer syndrome
entrez id:
2263
ensembl gene id:
ENSG00000066468
ucsc gene id:
uc057wle.1
refseq accession:
NM_022976|NM_000141
hgnc_id:
HGNC:3689
approved reserved:
1991-05-09
10q26.13
基因染色体位置图

FGFR2(成纤维细胞生长因子受体2)属于FGFR基因家族,该家族包括FGFR1、FGFR2、FGFR3和FGFR4,这些基因编码的蛋白质都是跨膜酪氨酸激酶受体,主要通过与成纤维细胞生长因子(FGF)结合来调控细胞增殖、分化、迁移和存活等生物学过程。FGFR2在胚胎发育、骨骼形成、伤口愈合和组织修复中发挥关键作用,尤其在颅面发育和肢体形成过程中至关重要。FGFR2通过激活下游信号通路如RAS-MAPK、PI3K-AKT和PLCγ来传递信号。FGFR2的突变会显著影响其功能,例如某些错义突变可能导致受体持续激活,引发颅缝早闭综合征(如Apert综合征、Crouzon综合征和Pfeiffer综合征),这些疾病表现为颅骨异常融合、面部畸形和四肢发育异常。相反,功能丧失性突变可能导致骨骼发育不良或其他发育缺陷。FGFR2的过表达与多种癌症相关,包括乳腺癌、胃癌和子宫内膜癌,因为它能促进细胞增殖和存活;而表达降低则可能影响组织修复和再生能力。FGFR家族成员的共性是它们都含有细胞外FGF结合域、跨膜区和细胞内酪氨酸激酶域,通过二聚化激活下游信号通路。FGFR2的异常表达或突变不仅影响自身功能,还可能干扰其他FGFR家族成员或相关信号通路(如FGF配体或其他受体酪氨酸激酶)的平衡,从而对机体产生广泛影响。

None

FGFR2基因的碱基序列:[NCBI]
Loading Gene Browser...
FGFR2基因的碱基突变:           仅显示部分snp
rs751783       rs755793       rs1047057       rs1047074       rs1047076       rs1047077       rs1047078       rs1047082       rs1047083       rs1047087       rs1047088       rs1047090       rs1047095       rs1047100       rs1047101       rs1047102       rs1047111      

FGFR2基因在不同组织中的表达:    [UniProt]

基因在不同组织中的表达图
正向引物序列
正向Tm值
反向引物序列
反向Tm值
评分
ATGGTTGACAGTTCTGCCA
60
GCTATCTCCAGGTAGTCTGG
59
ATTGGAGGCTACAAGGTACG
60
GGTATAATTTCCCTTGTCAGATGG
59
GCCAGAAGAATGGCTTCTG
59
CCAGTCTCCCATTGGTCTC
60
TGGAAGTCAGGAATACTTGG
57
GAACAAGAACTTCTTGTGTCAG
58
CCTCTATGCTTGTACTGCC
58
GGATGAGATGGCATCTGTG
58
ATTAGAGCCAGAAGATGCCA
59
TGTTGTTACTGTTCTCACTGAC
59
GCTACAAGGTACGAAACCAG
59
CTACACAGGTATAATTTCCCTTGTC
59
CCTCTATGCTTGTACTGCC
58
GATGAGATGGCATCTGTGAC
59
TTAGAGCCAGAAGATGCCA
58
TGTTGTTACTGTTCTCACTGAC
59
GCCAGAAGAATGGCTTCTG
59
CAGTCTCCCATTGGTCTCC
60
      尚未收录相关数据

FGFR2基因(以及对应的蛋白质)的细胞分布位置:

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 质膜
  • 细胞质
  • 细胞外
  • 高尔基体
  • 囊泡
  • 细胞骨架
  • 内质网
  • 细胞核
  • 内体
  • 溶酶体
  • 线粒体

FGFR2基因的本体(GO)信息:

GO库代码
对应的蛋白质
来源代码
GO:0005007
A0A0A0MR25 (UniProtKB)
IEA
GO:0005524
A0A0A0MR25 (UniProtKB)
IEA
GO:0008284
A0A0A0MR25 (UniProtKB)
IEA
GO:0008543
A0A0A0MR25 (UniProtKB)
IEA
GO:0016021
A0A0A0MR25 (UniProtKB)
IEA
GO:0018108
A0A0A0MR25 (UniProtKB)
IEA
GO:0018108
A0A0A0MR25 (UniProtKB)
IEA
GO:0005007
D2CGD1 (UniProtKB)
IEA
GO:0005524
D2CGD1 (UniProtKB)
IEA
GO:0005654
D2CGD1 (UniProtKB)
IDA
GO:0008284
D2CGD1 (UniProtKB)
IEA
GO:0008543
D2CGD1 (UniProtKB)
IEA
GO:0016021
D2CGD1 (UniProtKB)
IEA
GO:0018108
D2CGD1 (UniProtKB)
IEA
GO:0018108
D2CGD1 (UniProtKB)
IEA
GO:0043231
D2CGD1 (UniProtKB)
IDA
GO:0005007
E7EVR7 (UniProtKB)
IEA
GO:0005524
E7EVR7 (UniProtKB)
IEA
GO:0008284
E7EVR7 (UniProtKB)
IEA
GO:0008543
E7EVR7 (UniProtKB)
IEA
GO:0016021
E7EVR7 (UniProtKB)
IEA
GO:0018108
E7EVR7 (UniProtKB)
IEA
GO:0018108
E7EVR7 (UniProtKB)
IEA
GO:0005007
H7BXU9 (UniProtKB)
IEA
GO:0005524
H7BXU9 (UniProtKB)
IEA
GO:0005654
H7BXU9 (UniProtKB)
IDA
GO:0008284
H7BXU9 (UniProtKB)
IEA
GO:0008543
H7BXU9 (UniProtKB)
IEA
GO:0016021
H7BXU9 (UniProtKB)
IEA
GO:0018108
H7BXU9 (UniProtKB)
IEA
GO:0043231
H7BXU9 (UniProtKB)
IDA
GO:0004713
H7C265 (UniProtKB)
IEA
GO:0005524
H7C265 (UniProtKB)
IEA
GO:0018108
H7C265 (UniProtKB)
IEA
GO:0000122
P21802 (UniProtKB)
ISS
GO:0000165
P21802 (UniProtKB)
TAS
GO:0001525
P21802 (UniProtKB)
ISS
GO:0001657
P21802 (UniProtKB)
ISS
GO:0001701
P21802 (UniProtKB)
ISS
GO:0001837
P21802 (UniProtKB)
IEA
GO:0002053
P21802 (UniProtKB)
ISS
GO:0003148
P21802 (UniProtKB)
ISS
GO:0003149
P21802 (UniProtKB)
ISS
GO:0004713
P21802 (UniProtKB)
NAS
GO:0004713
P21802 (UniProtKB)
TAS
GO:0004713
P21802 (UniProtKB)
TAS
GO:0004713
P21802 (UniProtKB)
TAS
GO:0004713
P21802 (UniProtKB)
TAS
GO:0004713
P21802 (UniProtKB)
TAS
GO:0004713
P21802 (UniProtKB)
TAS
GO:0005007
P21802 (UniProtKB)
IGI
GO:0005007
P21802 (UniProtKB)
NAS
GO:0005007
P21802 (UniProtKB)
IDA
GO:0005007
P21802 (UniProtKB)
NAS
GO:0005007
P21802 (UniProtKB)
IDA
GO:0005007
P21802 (UniProtKB)
NAS
GO:0005088
P21802 (UniProtKB)
TAS
GO:0005515
P21802 (UniProtKB)
IPI
GO:0005515
P21802 (UniProtKB)
IPI
GO:0005515
P21802 (UniProtKB)
IPI
GO:0005515
P21802 (UniProtKB)
IPI
GO:0005515
P21802 (UniProtKB)
IPI
GO:0005515
P21802 (UniProtKB)
IPI
GO:0005515
P21802 (UniProtKB)
IPI
GO:0005515
P21802 (UniProtKB)
IPI
GO:0005515
P21802 (UniProtKB)
IPI
GO:0005515
P21802 (UniProtKB)
IPI
GO:0005515
P21802 (UniProtKB)
IPI
GO:0005515
P21802 (UniProtKB)
IPI
GO:0005515
P21802 (UniProtKB)
IPI
GO:0005524
P21802 (UniProtKB)
IEA
GO:0005576
P21802 (UniProtKB)
IEA
GO:0005634
P21802 (UniProtKB)
IDA
GO:0005634
P21802 (UniProtKB)
IDA
GO:0005654
P21802 (UniProtKB)
IDA
GO:0005737
P21802 (UniProtKB)
IDA
GO:0005737
P21802 (UniProtKB)
IDA
GO:0005794
P21802 (UniProtKB)
IEA
GO:0005886
P21802 (UniProtKB)
TAS
GO:0005886
P21802 (UniProtKB)
TAS
GO:0005886
P21802 (UniProtKB)
TAS
GO:0005886
P21802 (UniProtKB)
TAS
GO:0005886
P21802 (UniProtKB)
TAS
GO:0005886
P21802 (UniProtKB)
TAS
GO:0005886
P21802 (UniProtKB)
TAS
GO:0005886
P21802 (UniProtKB)
TAS
GO:0005886
P21802 (UniProtKB)
TAS
GO:0005886
P21802 (UniProtKB)
TAS
GO:0005886
P21802 (UniProtKB)
TAS
GO:0005886
P21802 (UniProtKB)
TAS
GO:0005886
P21802 (UniProtKB)
TAS
GO:0005886
P21802 (UniProtKB)
TAS
GO:0005886
P21802 (UniProtKB)
TAS
GO:0005886
P21802 (UniProtKB)
TAS
GO:0005886
P21802 (UniProtKB)
TAS
GO:0005886
P21802 (UniProtKB)
TAS
GO:0005886
P21802 (UniProtKB)
TAS
GO:0005886
P21802 (UniProtKB)
TAS
GO:0005886
P21802 (UniProtKB)
TAS
GO:0005886
P21802 (UniProtKB)
TAS
GO:0005886
P21802 (UniProtKB)
TAS
GO:0005886
P21802 (UniProtKB)
TAS
GO:0005886
P21802 (UniProtKB)
TAS
GO:0005886
P21802 (UniProtKB)
TAS
GO:0005886
P21802 (UniProtKB)
TAS
GO:0005886
P21802 (UniProtKB)
TAS
GO:0005886
P21802 (UniProtKB)
TAS
GO:0005886
P21802 (UniProtKB)
TAS
GO:0005886
P21802 (UniProtKB)
TAS
GO:0005886
P21802 (UniProtKB)
TAS
GO:0005886
P21802 (UniProtKB)
TAS
GO:0005886
P21802 (UniProtKB)
TAS
GO:0005886
P21802 (UniProtKB)
TAS
GO:0005886
P21802 (UniProtKB)
TAS
GO:0005886
P21802 (UniProtKB)
TAS
GO:0005886
P21802 (UniProtKB)
TAS
GO:0005886
P21802 (UniProtKB)
TAS
GO:0005886
P21802 (UniProtKB)
TAS
GO:0005886
P21802 (UniProtKB)
TAS
GO:0005886
P21802 (UniProtKB)
TAS
GO:0005886
P21802 (UniProtKB)
TAS
GO:0005886
P21802 (UniProtKB)
TAS
GO:0005886
P21802 (UniProtKB)
TAS
GO:0005886
P21802 (UniProtKB)
TAS
GO:0005886
P21802 (UniProtKB)
TAS
GO:0005886
P21802 (UniProtKB)
TAS
GO:0005886
P21802 (UniProtKB)
TAS
GO:0005886
P21802 (UniProtKB)
TAS
GO:0005886
P21802 (UniProtKB)
TAS
GO:0005886
P21802 (UniProtKB)
TAS
GO:0005886
P21802 (UniProtKB)
TAS
GO:0005886
P21802 (UniProtKB)
TAS
GO:0005886
P21802 (UniProtKB)
TAS
GO:0005886
P21802 (UniProtKB)
TAS
GO:0005886
P21802 (UniProtKB)
TAS
GO:0005886
P21802 (UniProtKB)
TAS
GO:0005887
P21802 (UniProtKB)
IDA
GO:0005887
P21802 (UniProtKB)
IDA
GO:0005938
P21802 (UniProtKB)
IDA
GO:0006915
P21802 (UniProtKB)
IEA
GO:0007267
P21802 (UniProtKB)
ISS
GO:0007409
P21802 (UniProtKB)
ISS
GO:0008201
P21802 (UniProtKB)
IEA
GO:0008284
P21802 (UniProtKB)
IMP
GO:0008284
P21802 (UniProtKB)
IDA
GO:0008284
P21802 (UniProtKB)
IGI
GO:0008284
P21802 (UniProtKB)
IGI
GO:0008284
P21802 (UniProtKB)
IGI
GO:0008284
P21802 (UniProtKB)
IGI
GO:0008284
P21802 (UniProtKB)
IGI
GO:0008284
P21802 (UniProtKB)
IGI
GO:0008284
P21802 (UniProtKB)
IGI
GO:0008284
P21802 (UniProtKB)
IGI
GO:0008284
P21802 (UniProtKB)
IGI
GO:0008543
P21802 (UniProtKB)
IPI
GO:0008543
P21802 (UniProtKB)
IDA
GO:0008543
P21802 (UniProtKB)
IDA
GO:0008543
P21802 (UniProtKB)
IGI
GO:0008543
P21802 (UniProtKB)
IGI
GO:0008543
P21802 (UniProtKB)
IGI
GO:0008543
P21802 (UniProtKB)
IGI
GO:0008543
P21802 (UniProtKB)
IGI
GO:0008543
P21802 (UniProtKB)
IGI
GO:0008543
P21802 (UniProtKB)
IGI
GO:0008543
P21802 (UniProtKB)
IGI
GO:0008543
P21802 (UniProtKB)
IGI
GO:0008543
P21802 (UniProtKB)
TAS
GO:0008543
P21802 (UniProtKB)
TAS
GO:0008543
P21802 (UniProtKB)
TAS
GO:0008589
P21802 (UniProtKB)
ISS
GO:0009791
P21802 (UniProtKB)
ISS
GO:0009880
P21802 (UniProtKB)
ISS
GO:0009887
P21802 (UniProtKB)
ISS
GO:0009986
P21802 (UniProtKB)
IDA
GO:0010453
P21802 (UniProtKB)
ISS
GO:0010518
P21802 (UniProtKB)
IMP
GO:0014066
P21802 (UniProtKB)
TAS
GO:0016020
P21802 (UniProtKB)
NAS
GO:0016021
P21802 (UniProtKB)
NAS
GO:0016023
P21802 (UniProtKB)
IEA
GO:0016303
P21802 (UniProtKB)
TAS
GO:0016331
P21802 (UniProtKB)
ISS
GO:0017134
P21802 (UniProtKB)
IPI
GO:0017134
P21802 (UniProtKB)
IPI
GO:0017134
P21802 (UniProtKB)
IPI
GO:0017134
P21802 (UniProtKB)
IDA
GO:0018108
P21802 (UniProtKB)
IDA
GO:0018108
P21802 (UniProtKB)
IDA
GO:0021769
P21802 (UniProtKB)
ISS
GO:0021847
P21802 (UniProtKB)
ISS
GO:0021860
P21802 (UniProtKB)
ISS
GO:0022612
P21802 (UniProtKB)
ISS
GO:0030177
P21802 (UniProtKB)
ISS
GO:0030282
P21802 (UniProtKB)
ISS
GO:0030324
P21802 (UniProtKB)
ISS
GO:0030855
P21802 (UniProtKB)
ISS
GO:0030901
P21802 (UniProtKB)
ISS
GO:0030916
P21802 (UniProtKB)
ISS
GO:0031069
P21802 (UniProtKB)
ISS
GO:0032808
P21802 (UniProtKB)
ISS
GO:0033688
P21802 (UniProtKB)
TAS
GO:0035264
P21802 (UniProtKB)
ISS
GO:0035265
P21802 (UniProtKB)
ISS
GO:0035602
P21802 (UniProtKB)
ISS
GO:0035603
P21802 (UniProtKB)
ISS
GO:0035604
P21802 (UniProtKB)
ISS
GO:0035607
P21802 (UniProtKB)
ISS
GO:0036092
P21802 (UniProtKB)
IEA
GO:0040014
P21802 (UniProtKB)
ISS
GO:0040036
P21802 (UniProtKB)
ISS
GO:0042472
P21802 (UniProtKB)
ISS
GO:0042476
P21802 (UniProtKB)
ISS
GO:0042803
P21802 (UniProtKB)
IPI
GO:0043231
P21802 (UniProtKB)
IDA
GO:0043410
P21802 (UniProtKB)
IMP
GO:0043547
P21802 (UniProtKB)
IEA
GO:0045165
P21802 (UniProtKB)
ISS
GO:0045667
P21802 (UniProtKB)
TAS
GO:0045787
P21802 (UniProtKB)
ISS
GO:0045944
P21802 (UniProtKB)
ISS
GO:0046777
P21802 (UniProtKB)
IDA
GO:0046854
P21802 (UniProtKB)
IEA
GO:0046934
P21802 (UniProtKB)
TAS
GO:0048015
P21802 (UniProtKB)
TAS
GO:0048286
P21802 (UniProtKB)
ISS
GO:0048333
P21802 (UniProtKB)
IEA
GO:0048557
P21802 (UniProtKB)
ISS
GO:0048562
P21802 (UniProtKB)
ISS
GO:0048565
P21802 (UniProtKB)
ISS
GO:0048568
P21802 (UniProtKB)
ISS
GO:0048608
P21802 (UniProtKB)
ISS
GO:0048661
P21802 (UniProtKB)
IEA
GO:0048701
P21802 (UniProtKB)
IMP
GO:0048701
P21802 (UniProtKB)
IMP
GO:0048705
P21802 (UniProtKB)
TAS
GO:0048730
P21802 (UniProtKB)
ISS
GO:0048755
P21802 (UniProtKB)
ISS
GO:0048762
P21802 (UniProtKB)
ISS
GO:0050679
P21802 (UniProtKB)
ISS
GO:0050680
P21802 (UniProtKB)
IEA
GO:0051150
P21802 (UniProtKB)
ISS
GO:0051781
P21802 (UniProtKB)
ISS
GO:0055010
P21802 (UniProtKB)
ISS
GO:0060045
P21802 (UniProtKB)
ISS
GO:0060076
P21802 (UniProtKB)
ISS
GO:0060174
P21802 (UniProtKB)
ISS
GO:0060348
P21802 (UniProtKB)
ISS
GO:0060349
P21802 (UniProtKB)
ISS
GO:0060442
P21802 (UniProtKB)
ISS
GO:0060445
P21802 (UniProtKB)
ISS
GO:0060449
P21802 (UniProtKB)
ISS
GO:0060463
P21802 (UniProtKB)
ISS
GO:0060484
P21802 (UniProtKB)
ISS
GO:0060501
P21802 (UniProtKB)
ISS
GO:0060512
P21802 (UniProtKB)
ISS
GO:0060523
P21802 (UniProtKB)
ISS
GO:0060527
P21802 (UniProtKB)
ISS
GO:0060529
P21802 (UniProtKB)
ISS
GO:0060595
P21802 (UniProtKB)
ISS
GO:0060601
P21802 (UniProtKB)
ISS
GO:0060615
P21802 (UniProtKB)
ISS
GO:0060664
P21802 (UniProtKB)
ISS
GO:0060667
P21802 (UniProtKB)
ISS
GO:0060670
P21802 (UniProtKB)
ISS
GO:0060687
P21802 (UniProtKB)
ISS
GO:0060688
P21802 (UniProtKB)
ISS
GO:0060915
P21802 (UniProtKB)
ISS
GO:0060916
P21802 (UniProtKB)
ISS
GO:0070372
P21802 (UniProtKB)
ISS
GO:0070374
P21802 (UniProtKB)
ISS
GO:0090263
P21802 (UniProtKB)
ISS
GO:0031012
P21802 (UniProtKB)
IDA
GO:0004713
S4R381 (UniProtKB)
IEA
GO:0005524
S4R381 (UniProtKB)
IEA
GO:0016021
S4R381 (UniProtKB)
IEA
GO:0018108
S4R381 (UniProtKB)
IEA

可能调控 FGFR2基因的相关microRNA:     

Reactome

MINT

BioGrid

IntAct

mentha

String

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称
疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Cutis Gyrata Syndrome of Beare And Stevenson 0.561900093 8 2 BeFree_CLINVAR_CTD_human_MGD_ORPHANET_UNIPROT
JACKSON-WEISS SYNDROME 0.481085767 6 3 BeFree_CLINVAR_CTD_human_ORPHANET_UNIPROT
SCAPHOCEPHALY, MAXILLARY RETRUSION, AND MENTAL RETARDATION 0.48 1 1 CLINVAR_CTD_human_ORPHANET_UNIPROT
Apert syndrome 0.454657861 56 5 BeFree_CLINVAR_MGD_ORPHANET_UNIPROT
Antley-Bixler Syndrome, Autosomal Dominant 0.361900093 8 2 BeFree_CLINVAR_CTD_human_UNIPROT
BENT BONE DYSPLASIA SYNDROME 0.360271442 2 2 BeFree_CLINVAR_ORPHANET_UNIPROT
Lacrimoauriculodentodigital syndrome 0.36 1 0 CTD_human_ORPHANET_UNIPROT
Craniofacial dysostosis type 1 0.332486326 59 5 BeFree_MGD_ORPHANET_UNIPROT
Pfeiffer Syndrome 0.331867498 40 8 BeFree_CLINVAR_GAD_MGD_UNIPROT
Craniofacial Dysostosis 0.255482118 48 15 BeFree_CLINVAR_CTD_human_LHGDN

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