FCRLA (Fc receptor like A)
- symbol:
- FCRLA
- locus group:
- protein-coding gene
- location:
- 1q23.3
- gene_family:
- Immunoglobulin-like domain containing
- alias symbol:
- MGC4595|FCRLc2|FCRLb|FCRLc1|FCRLd|FCRLe|FCRL|FREB|FCRLX
- alias name:
- None
- entrez id:
- 84824
- ensembl gene id:
- ENSG00000132185
- ucsc gene id:
- uc001gbd.4
- refseq accession:
- NM_032738
- hgnc_id:
- HGNC:18504
- approved reserved:
- 2005-05-10
This gene encodes a protein similar to receptors for the Fc fragment of gamma immunoglobulin (IgG). These receptors, referred to as FCGRs, mediate the destruction of IgG-coated antigens and of cells induced by antibodies. This encoded protein is selectively expressed in B cells, and may be involved in their development. This protein may also be involved in the development of lymphomas. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
这个基因编码类似受体的γ免疫球蛋白（IgG）的的Fc片段的蛋白质。这些受体称为FCGRs，调解IgG包被抗原，并通过抗体诱导的细胞的破坏。这个编码的蛋白质是在B细胞中选择性表达，并且可能参与在其发展。这种蛋白可能也参与淋巴瘤的发展。编码不同蛋白同种型的多个可变剪接转录物变体已被用于这个基因说明。 [由RefSeq的，2011年8月提供]
基因本体信息
FCRLA基因（以及对应的蛋白质）的细胞分布位置：
- 质膜
- 细胞质
- 细胞外
- 高尔基体
- 囊泡
- 细胞骨架
- 内质网
- 细胞核
- 内体
- 溶酶体
- 线粒体
FCRLA基因的本体（GO）信息：
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| melanoma | 0.003267234 | 2 | 0 | BeFree_LHGDN |
| Rheumatoid Arthritis | 0.00272435 | 1 | 0 | LHGDN |
| B-Cell Lymphomas | 0.000271442 | 1 | 0 | BeFree |
| Pigmentation Disorders | 0.000271442 | 1 | 0 | BeFree |
| Graves Disease | 0.000271442 | 1 | 0 | BeFree |
| Chronic Lymphocytic Leukemia | 0.000271442 | 1 | 0 | BeFree |
| IGA Glomerulonephritis | 0.000271442 | 1 | 0 | BeFree |
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