ERCC6-PGBD3 (ERCC6-PGBD3 readthrough)
- symbol:
- ERCC6-PGBD3
- locus group:
- other
- location:
- 10q11.23
- gene_family:
- alias symbol:
- alias name:
- entrez id:
- 101243544
- ensembl gene id:
- ENSG00000258838
- ucsc gene id:
- refseq accession:
- NM_001277058
- hgnc_id:
- HGNC:48347
- approved reserved:
- 2013-05-10T00:00:00Z
None
This locus represents naturally-occurring readthrough transcription between the neighboring ERCC6 (excision repair cross-complementing rodent repair deficiency, complementation group 6) and PGBD (piggyBac transposable element derived 3) genes on chromosome 10. The readthrough transcripts encode a fusion protein that shares sequence with the product of each individual gene. The encoded protein may function in DNA repair and in the innate immune response. It binds to MER85 sequences in DNA, and may interact with transcription factors to modulate gene expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2013]
这一位点代表天然邻近ERCC6（切除修复交叉互补灭鼠修复缺陷，互补组6）和PGBD（piggyBac转座子衍生3）10号染色体的基因的转录通读编码融合之间通读转录蛋白与每个基因的产物共享序列。所编码的蛋白质可在DNA修复和先天免疫应答的作用。它结合到MER85序列的DNA，并且可以与转录因子相互作用，以调节基因表达。选择性剪接结果在多个抄本变形。 [由RefSeq的，2013年2月提供]
基因本体信息
ERCC6-PGBD3基因（以及对应的蛋白质）的细胞分布位置：
- 质膜
- 细胞质
- 细胞外
- 高尔基体
- 囊泡
- 细胞骨架
- 内质网
- 细胞核
- 内体
- 溶酶体
- 线粒体
ERCC6-PGBD3基因的本体（GO）信息：
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