ERBB3 (erb-b2 receptor tyrosine kinase 3)

基因基本信息

基因基本信息

symbol:
ERBB3
locus group:
protein-coding gene
location:
12q13.2
gene_family:
Receptor Tyrosine Kinases
alias symbol:
HER3
alias name:
human epidermal growth factor rece…
entrez id:
2065
ensembl gene id:
ENSG00000065361
ucsc gene id:
uc001sjh.4
refseq accession:
NM_001982
hgnc_id:
HGNC:3431
approved reserved:
1990-07-15

基因染色体位置

基因染色体位置

12q13.2
基因染色体位置图

基因简述

基因简述

This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. [provided by RefSeq, Jul 2008]

该基因编码的表皮生长因子受体（EGFR）家族的受体酪氨酸激酶的成员。这种膜结合蛋白具有神经调节蛋白结合结构域，但不活性激酶结构域。因此，它可以结合这种配位体，但通过蛋白磷酸化不是信号传送到细胞中。但是，它确实形式的异源二聚体与其它EGF受体家族成员确实具有激酶活性。异二聚导致通路从而导致细胞增殖或分化的激活。此基因和/或它的蛋白质的过表达的扩增已经报道在许多癌症，包括前列腺癌，膀胱癌，和乳房肿瘤。替代转录剪接变异体编码不同亚型进行了表征。一种同种型缺乏膜间区域和被分泌到细胞外。这种形式的作用以调节膜结合形式的活性。附加剪接变体也有报道，但还没有被充分表征。 [由RefSeq的，2008年7月提供]

OMIM数据库中对CCND1基因的介绍     Wikipedia数据库中对CCND1基因的介绍

基因序列

基因序列

CCND1基因的碱基序列：[NCBI]
Loading Gene Browser...

基因突变

基因突变

ERBB3基因的碱基突变：           仅显示部分snp
rs705696       rs705708       rs773116       rs773122       rs773123       rs798829       rs812826       rs877636       rs984896       rs1088696       rs1088697       rs1508211       rs2229045       rs2229046       rs2271188       rs2271189       rs2271194      

基因表达

基因表达

ERBB3基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向Tm值
反向引物序列
反向Tm值
评分
GGAAGTTTGCCATCTTCGTC
60
ACAGAATCTCGGTGAGCTG
60
GACTATGTCCCAAAGCCTG
58
CACAAATCCATCAATGTTGCTC
59
CCAGACCTGCTAGAGAAGG
59
CAATCATCCAACACTTGACCA
59
ATGCTGAGATAGTGGTGAAGG
60
TTGCAAACCTCATGACAGG
58
GACAATGGCAGAAGCTGTC
59
GTCTTCTGATCCAGGACCC
59
TCTACGAGAGGTGTGAGGT
59
TTCTCGAATCCACTGCAGG
60
TAAGTGGATGGCCCTTGAG
59
CAAACTGTCACACCATAGCTC
59
CGGGAGATCACAGGTTACC
60
CTCCAATGGTTGTCAAATTGGA
60
GGAAGTTTGCCATCTTCGTC
60
ACAGAATCTCGGTGAGCTG
60
CAGAGCTTCAAGACTGTTTAGG
59
AGAGGCTCTATGCTCTCAC
58

转录因子

转录因子

转录因子
影响基因
影响类型
参考文献链接（PubMed）
AR
ERBB3
Activation
21741601
TWIST1
ERBB3
Repression
19051271
TWIST2
ERBB3
Repression
19051271
YBX1
ERBB3
Activation
19648825

基因本体信息

ERBB3基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 质膜
  • 细胞质
  • 细胞外
  • 高尔基体
  • 囊泡
  • 细胞骨架
  • 内质网
  • 细胞核
  • 内体
  • 溶酶体
  • 线粒体

ERBB3基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0004672
B3KWG5 (UniProtKB)
IEA
GO:0006468
B3KWG5 (UniProtKB)
IEA
GO:0004714
B4DGQ7 (UniProtKB)
IEA
GO:0005524
B4DGQ7 (UniProtKB)
IEA
GO:0007169
B4DGQ7 (UniProtKB)
IEA
GO:0016021
B4DGQ7 (UniProtKB)
IEA
GO:0018108
B4DGQ7 (UniProtKB)
IEA
GO:0004672
F8VW56 (UniProtKB)
IEA
GO:0005524
F8VW56 (UniProtKB)
IEA
GO:0006468
F8VW56 (UniProtKB)
IEA
GO:0004713
F8VYK4 (UniProtKB)
IEA
GO:0016021
F8VYK4 (UniProtKB)
IEA
GO:0018108
F8VYK4 (UniProtKB)
IEA
GO:0000165
P21860 (UniProtKB)
TAS
GO:0003197
P21860 (UniProtKB)
IEA
GO:0004713
P21860 (UniProtKB)
TAS
GO:0004713
P21860 (UniProtKB)
TAS
GO:0004888
P21860 (UniProtKB)
ISS
GO:0005088
P21860 (UniProtKB)
TAS
GO:0005515
P21860 (UniProtKB)
IPI
GO:0005515
P21860 (UniProtKB)
IPI
GO:0005515
P21860 (UniProtKB)
IPI
GO:0005515
P21860 (UniProtKB)
IPI
GO:0005515
P21860 (UniProtKB)
IPI
GO:0005515
P21860 (UniProtKB)
IPI
GO:0005515
P21860 (UniProtKB)
IPI
GO:0005515
P21860 (UniProtKB)
IPI
GO:0005515
P21860 (UniProtKB)
IPI
GO:0005515
P21860 (UniProtKB)
IPI
GO:0005515
P21860 (UniProtKB)
IPI
GO:0005515
P21860 (UniProtKB)
IPI
GO:0005515
P21860 (UniProtKB)
IPI
GO:0005515
P21860 (UniProtKB)
IPI
GO:0005515
P21860 (UniProtKB)
IPI
GO:0005515
P21860 (UniProtKB)
IPI
GO:0005515
P21860 (UniProtKB)
IPI
GO:0005515
P21860 (UniProtKB)
IPI
GO:0005515
P21860 (UniProtKB)
IPI
GO:0005515
P21860 (UniProtKB)
IPI
GO:0005515
P21860 (UniProtKB)
IPI
GO:0005515
P21860 (UniProtKB)
IPI
GO:0005515
P21860 (UniProtKB)
IPI
GO:0005515
P21860 (UniProtKB)
IPI
GO:0005515
P21860 (UniProtKB)
IPI
GO:0005515
P21860 (UniProtKB)
IPI
GO:0005515
P21860 (UniProtKB)
IPI
GO:0005515
P21860 (UniProtKB)
IPI
GO:0005515
P21860 (UniProtKB)
IPI
GO:0005515
P21860 (UniProtKB)
IPI
GO:0005515
P21860 (UniProtKB)
IPI
GO:0005515
P21860 (UniProtKB)
IPI
GO:0005515
P21860 (UniProtKB)
IPI
GO:0005515
P21860 (UniProtKB)
IPI
GO:0005515
P21860 (UniProtKB)
IPI
GO:0005515
P21860 (UniProtKB)
IPI
GO:0005515
P21860 (UniProtKB)
IPI
GO:0005515
P21860 (UniProtKB)
IPI
GO:0005515
P21860 (UniProtKB)
IPI
GO:0005515
P21860 (UniProtKB)
IPI
GO:0005515
P21860 (UniProtKB)
IPI
GO:0005515
P21860 (UniProtKB)
IPI
GO:0005515
P21860 (UniProtKB)
IPI
GO:0005515
P21860 (UniProtKB)
IPI
GO:0005515
P21860 (UniProtKB)
IPI
GO:0005515
P21860 (UniProtKB)
IPI
GO:0005515
P21860 (UniProtKB)
IPI
GO:0005515
P21860 (UniProtKB)
IPI
GO:0005515
P21860 (UniProtKB)
IPI
GO:0005515
P21860 (UniProtKB)
IPI
GO:0005515
P21860 (UniProtKB)
IPI
GO:0005515
P21860 (UniProtKB)
IPI
GO:0005515
P21860 (UniProtKB)
IPI
GO:0005515
P21860 (UniProtKB)
IPI
GO:0005515
P21860 (UniProtKB)
IPI
GO:0005515
P21860 (UniProtKB)
IPI
GO:0005515
P21860 (UniProtKB)
IPI
GO:0005515
P21860 (UniProtKB)
IPI
GO:0005515
P21860 (UniProtKB)
IPI
GO:0005515
P21860 (UniProtKB)
IPI
GO:0005515
P21860 (UniProtKB)
IPI
GO:0005515
P21860 (UniProtKB)
IPI
GO:0005515
P21860 (UniProtKB)
IPI
GO:0005515
P21860 (UniProtKB)
IPI
GO:0005524
P21860 (UniProtKB)
IEA
GO:0005615
P21860 (UniProtKB)
IDA
GO:0005622
P21860 (UniProtKB)
IEA
GO:0005622
P21860 (UniProtKB)
IEA
GO:0005622
P21860 (UniProtKB)
IEA
GO:0005886
P21860 (UniProtKB)
TAS
GO:0005886
P21860 (UniProtKB)
TAS
GO:0005886
P21860 (UniProtKB)
TAS
GO:0005886
P21860 (UniProtKB)
TAS
GO:0005886
P21860 (UniProtKB)
TAS
GO:0005886
P21860 (UniProtKB)
TAS
GO:0005886
P21860 (UniProtKB)
TAS
GO:0005886
P21860 (UniProtKB)
TAS
GO:0005886
P21860 (UniProtKB)
TAS
GO:0005886
P21860 (UniProtKB)
TAS
GO:0005886
P21860 (UniProtKB)
TAS
GO:0005886
P21860 (UniProtKB)
TAS
GO:0005886
P21860 (UniProtKB)
TAS
GO:0005886
P21860 (UniProtKB)
TAS
GO:0005886
P21860 (UniProtKB)
TAS
GO:0005886
P21860 (UniProtKB)
TAS
GO:0005886
P21860 (UniProtKB)
TAS
GO:0005886
P21860 (UniProtKB)
TAS
GO:0005886
P21860 (UniProtKB)
TAS
GO:0005886
P21860 (UniProtKB)
TAS
GO:0005886
P21860 (UniProtKB)
TAS
GO:0005886
P21860 (UniProtKB)
TAS
GO:0005886
P21860 (UniProtKB)
TAS
GO:0005886
P21860 (UniProtKB)
TAS
GO:0005886
P21860 (UniProtKB)
TAS
GO:0005887
P21860 (UniProtKB)
TAS
GO:0007162
P21860 (UniProtKB)
IDA
GO:0007165
P21860 (UniProtKB)
IDA
GO:0007169
P21860 (UniProtKB)
ISS
GO:0007422
P21860 (UniProtKB)
ISS
GO:0007507
P21860 (UniProtKB)
ISS
GO:0009968
P21860 (UniProtKB)
IDA
GO:0014037
P21860 (UniProtKB)
ISS
GO:0014065
P21860 (UniProtKB)
IDA
GO:0014066
P21860 (UniProtKB)
TAS
GO:0014068
P21860 (UniProtKB)
TAS
GO:0016323
P21860 (UniProtKB)
IDA
GO:0016324
P21860 (UniProtKB)
IEA
GO:0016328
P21860 (UniProtKB)
IEA
GO:0018108
P21860 (UniProtKB)
IEA
GO:0019838
P21860 (UniProtKB)
IPI
GO:0019838
P21860 (UniProtKB)
ISS
GO:0021545
P21860 (UniProtKB)
ISS
GO:0030296
P21860 (UniProtKB)
IDA
GO:0038128
P21860 (UniProtKB)
TAS
GO:0038132
P21860 (UniProtKB)
IDA
GO:0042060
P21860 (UniProtKB)
NAS
GO:0042127
P21860 (UniProtKB)
IDA
GO:0042802
P21860 (UniProtKB)
IPI
GO:0042802
P21860 (UniProtKB)
IPI
GO:0042803
P21860 (UniProtKB)
NAS
GO:0043235
P21860 (UniProtKB)
IDA
GO:0043235
P21860 (UniProtKB)
ISS
GO:0043524
P21860 (UniProtKB)
ISS
GO:0043547
P21860 (UniProtKB)
IEA
GO:0046854
P21860 (UniProtKB)
IEA
GO:0046934
P21860 (UniProtKB)
TAS
GO:0046982
P21860 (UniProtKB)
IDA
GO:0046982
P21860 (UniProtKB)
IPI
GO:0048015
P21860 (UniProtKB)
TAS
GO:0051048
P21860 (UniProtKB)
IDA
GO:0051402
P21860 (UniProtKB)
IMP
GO:0061098
P21860 (UniProtKB)
IMP
GO:0070886
P21860 (UniProtKB)
IEA
GO:0097192
P21860 (UniProtKB)
IMP
GO:2000145
P21860 (UniProtKB)
TAS
GO:0004713
P21860 (UniProtKB)
IDA

基因相关microRNA

基因相关microRNA

可能调控 ERBB3基因的相关microRNA：     

基因相互作用关系

基因相互作用关系

Reactome

MINT

BioGrid

IntAct

mentha

String

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因通路

基因通路

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Lethal Congenital Contracture Syndrome 2 0.36 0 0 CLINVAR_CTD_human_ORPHANET
Diabetes Mellitus, Insulin-Dependent 0.160315489 20 3 BeFree_GAD_GWASCAT
Mammary Neoplasms 0.137964821 21 0 BeFree_CTD_human_LHGDN
Prostatic Neoplasms 0.133621751 5 0 CTD_human_LHGDN
Lung Neoplasms 0.128715934 5 1 BeFree_CTD_human_LHGDN
Disease Progression 0.125091382 3 0 CTD_human_GAD_LHGDN
Nasopharyngeal carcinoma 0.12 1 0 CTD_human
gallbladder neoplasm 0.12 1 0 CTD_human
Obesity 0.12 1 1 GWASCAT
Mouth Neoplasms 0.08 1 0 RGD

基因相关服务

基因相关服务

联系方式

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