EP300基因详情-基因数据库-基因云馆

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EP300 (E1A binding protein p300)

symbol:: EP300
locus group:: protein-coding gene
location:: 22q13.2
gene_family:: K(lysine) acetyltransferases
alias symbol:: p300|KAT3B
alias name:: histone acetyltransferase p300
entrez id:: 2033
ensembl gene id:: ENSG00000100393
ucsc gene id:: uc003azl.6
refseq accession:: NM_001429
hgnc_id:: HGNC:3373
approved reserved:: 1998-07-31

22q13.2

EP300（也称为p300）是一种重要的转录辅激活因子，属于CREB结合蛋白（CBP）/p300基因家族。这个家族的成员在调控基因表达、染色质重塑和细胞信号转导中发挥核心作用。EP300通过其组蛋白乙酰转移酶（HAT）活性修饰染色质结构，促进转录因子与DNA的结合，从而激活多种基因的表达。它参与多种生物学过程，包括细胞增殖、分化、凋亡、DNA修复和免疫反应。EP300与多种转录因子（如p53、NF-κB和STAT3）相互作用，调控细胞周期和应激反应。EP300的突变或功能异常与多种疾病相关，包括癌症（如结直肠癌、乳腺癌和白血病）、神经发育障碍（如Rubinstein-Taybi综合征）和心血管疾病。突变可能导致其HAT活性丧失或与转录因子的结合能力下降，从而影响基因表达调控。EP300过表达可能促进肿瘤发生，因其可激活促增殖和抗凋亡基因；而表达降低可能导致发育缺陷或免疫功能障碍，因其参与胚胎发育和免疫细胞活化。EP300与CBP功能高度相似，两者在胚胎发育中部分冗余，但某些特定功能不可替代。该基因家族成员均含有多个功能域，如HAT域、溴结构域和蛋白相互作用域，介导其广泛的调控作用。

None

无

OMIM数据库中对EP300基因的介绍 Wikipedia数据库中对EP300基因的介绍

EP300基因的碱基序列：[NCBI]

Loading Gene Browser...

EP300基因的碱基突变：仅显示部分snp

rs20551 rs20552 rs20553 rs20554 rs79540 rs130086 rs136393 rs730811 rs738628 rs738629 rs738630 rs738631 rs738632 rs766314 rs1033611 rs1033612 rs1046088

EP300基因在不同组织中的表达： [UniProt]

正向引物序列

正向Tm值

反向引物序列

反向Tm值

评分

CATGAAAGCAAGGTTTGTGG

TCTTCAAAGGCAAAGAGGG

GATGCCCAATGTATCTAACGAC

CGGATCACAAAGAAGACCTC

GATGCCCAATGTATCTAACGA

CGGATCACAAAGAAGACCTC

转录因子

影响基因

影响类型

参考文献链接（PubMed）

EP300

Activation

22334658

BRCA1

EP300

Activation

11782371

BRCA1

EP300

Unknown

11405179

CREBBP

EP300

Unknown

15154850

EGR1

EP300

Activation

18798221; 20414733

EGR1

EP300

Unknown

15635605

EP300

ABCB1

Unknown

22154511

EP300

ALOX15

Activation

12517954

EP300

BIRC5

Activation

19102934

EP300

BIRC5

Repression

19102934

EP300基因（以及对应的蛋白质）的细胞分布位置：

[UniProt] [GenomeNet]

质膜
细胞质
细胞外
高尔基体
囊泡
细胞骨架
内质网
细胞核
内体
溶酶体
线粒体

EP300基因的本体（GO）信息：

GO库代码

对应的蛋白质

来源代码

GO:0003712

A0A0U1RQG3 (UniProtKB)

IEA

GO:0006355

A0A0U1RQG3 (UniProtKB)

IEA

GO:0003712

A0A0U1RR87 (UniProtKB)

IEA

GO:0006355

A0A0U1RR87 (UniProtKB)

IEA

GO:0000122

Q09472 (UniProtKB)

IDA

GO:0000123

Q09472 (UniProtKB)

IEA

GO:0000785

Q09472 (UniProtKB)

IEA

GO:0000978

Q09472 (UniProtKB)

IEA

GO:0000979

Q09472 (UniProtKB)

IEA

GO:0001047

Q09472 (UniProtKB)

IDA

GO:0001102

Q09472 (UniProtKB)

IPI

GO:0001228

Q09472 (UniProtKB)

IEA

GO:0001666

Q09472 (UniProtKB)

IDA

GO:0001666

Q09472 (UniProtKB)

IDA

GO:0001756

Q09472 (UniProtKB)

IEA

GO:0001889

Q09472 (UniProtKB)

IEA

GO:0001934

Q09472 (UniProtKB)

IEA

GO:0002039

Q09472 (UniProtKB)

IEA

GO:0002039

Q09472 (UniProtKB)

IEA

GO:0002223

Q09472 (UniProtKB)

TAS

GO:0003677

Q09472 (UniProtKB)

IDA

GO:0003682

Q09472 (UniProtKB)

IMP

GO:0003682

Q09472 (UniProtKB)

IDA

GO:0003684

Q09472 (UniProtKB)

IDA

GO:0003713

Q09472 (UniProtKB)

IDA

GO:0003713

Q09472 (UniProtKB)

IDA

GO:0003713

Q09472 (UniProtKB)

IDA

GO:0003713

Q09472 (UniProtKB)

IDA

GO:0004402

Q09472 (UniProtKB)

IDA

GO:0004402

Q09472 (UniProtKB)

IDA

GO:0004402

Q09472 (UniProtKB)

IDA

GO:0004402

Q09472 (UniProtKB)

TAS

GO:0004468

Q09472 (UniProtKB)

IDA

GO:0005515

Q09472 (UniProtKB)

IPI

GO:0005515

Q09472 (UniProtKB)

IPI

GO:0005515

Q09472 (UniProtKB)

IPI

GO:0005515

Q09472 (UniProtKB)

IPI

GO:0005515

Q09472 (UniProtKB)

IPI

GO:0005515

Q09472 (UniProtKB)

IPI

GO:0005515

Q09472 (UniProtKB)

IPI

GO:0005515

Q09472 (UniProtKB)

IPI

GO:0005515

Q09472 (UniProtKB)

IPI

GO:0005515

Q09472 (UniProtKB)

IPI

GO:0005515

Q09472 (UniProtKB)

IPI

GO:0005515

Q09472 (UniProtKB)

IPI

GO:0005515

Q09472 (UniProtKB)

IPI

GO:0005515

Q09472 (UniProtKB)

IPI

GO:0005515

Q09472 (UniProtKB)

IPI

GO:0005515

Q09472 (UniProtKB)

IPI

GO:0005515

Q09472 (UniProtKB)

IPI

GO:0005515

Q09472 (UniProtKB)

IPI

GO:0005515

Q09472 (UniProtKB)

IPI

GO:0005515

Q09472 (UniProtKB)

IPI

GO:0005515

Q09472 (UniProtKB)

IPI

GO:0005515

Q09472 (UniProtKB)

IPI

GO:0005515

Q09472 (UniProtKB)

IPI

GO:0005515

Q09472 (UniProtKB)

IPI

GO:0005515

Q09472 (UniProtKB)

IPI

GO:0005515

Q09472 (UniProtKB)

IPI

GO:0005515

Q09472 (UniProtKB)

IPI

GO:0005515

Q09472 (UniProtKB)

IPI

GO:0005515

Q09472 (UniProtKB)

IPI

GO:0005515

Q09472 (UniProtKB)

IPI

GO:0005515

Q09472 (UniProtKB)

IPI

GO:0005515

Q09472 (UniProtKB)

IPI

GO:0005515

Q09472 (UniProtKB)

IPI

GO:0005515

Q09472 (UniProtKB)

IPI

GO:0005515

Q09472 (UniProtKB)

IPI

GO:0005515

Q09472 (UniProtKB)

IPI

GO:0005515

Q09472 (UniProtKB)

IPI

GO:0005515

Q09472 (UniProtKB)

IPI

GO:0005515

Q09472 (UniProtKB)

IPI

GO:0005515

Q09472 (UniProtKB)

IPI

GO:0005515

Q09472 (UniProtKB)

IPI

GO:0005515

Q09472 (UniProtKB)

IPI

GO:0005515

Q09472 (UniProtKB)

IPI

GO:0005515

Q09472 (UniProtKB)

IPI

GO:0005515

Q09472 (UniProtKB)

IPI

GO:0005515

Q09472 (UniProtKB)

IPI

GO:0005515

Q09472 (UniProtKB)

IPI

GO:0005515

Q09472 (UniProtKB)

IPI

GO:0005515

Q09472 (UniProtKB)

IPI

GO:0005515

Q09472 (UniProtKB)

IPI

GO:0005515

Q09472 (UniProtKB)

IPI

GO:0005515

Q09472 (UniProtKB)

IPI

GO:0005515

Q09472 (UniProtKB)

IPI

GO:0005515

Q09472 (UniProtKB)

IPI

GO:0005515

Q09472 (UniProtKB)

IPI

GO:0005515

Q09472 (UniProtKB)

IPI

GO:0005515

Q09472 (UniProtKB)

IPI

GO:0005515

Q09472 (UniProtKB)

IPI

GO:0005515

Q09472 (UniProtKB)

IPI

GO:0005515

Q09472 (UniProtKB)

IPI

GO:0005515

Q09472 (UniProtKB)

IPI

GO:0005515

Q09472 (UniProtKB)

IPI

GO:0005515

Q09472 (UniProtKB)

IPI

GO:0005515

Q09472 (UniProtKB)

IPI

GO:0005515

Q09472 (UniProtKB)

IPI

GO:0005515

Q09472 (UniProtKB)

IPI

GO:0005515

Q09472 (UniProtKB)

IPI

GO:0005515

Q09472 (UniProtKB)

IPI

GO:0005515

Q09472 (UniProtKB)

IPI

GO:0005515

Q09472 (UniProtKB)

IPI

GO:0005515

Q09472 (UniProtKB)

IPI

GO:0005515

Q09472 (UniProtKB)

IPI

GO:0005515

Q09472 (UniProtKB)

IPI

GO:0005515

Q09472 (UniProtKB)

IPI

GO:0005515

Q09472 (UniProtKB)

IPI

GO:0005515

Q09472 (UniProtKB)

IPI

GO:0005515

Q09472 (UniProtKB)

IPI

GO:0005515

Q09472 (UniProtKB)

IPI

GO:0005515

Q09472 (UniProtKB)

IPI

GO:0005515

Q09472 (UniProtKB)

IPI

GO:0005515

Q09472 (UniProtKB)

IPI

GO:0005515

Q09472 (UniProtKB)

IPI

GO:0005515

Q09472 (UniProtKB)

IPI

GO:0005515

Q09472 (UniProtKB)

IPI

GO:0005515

Q09472 (UniProtKB)

IPI

GO:0005515

Q09472 (UniProtKB)

IPI

GO:0005515

Q09472 (UniProtKB)

IPI

GO:0005515

Q09472 (UniProtKB)

IPI

GO:0005515

Q09472 (UniProtKB)

IPI

GO:0005515

Q09472 (UniProtKB)

IPI

GO:0005515

Q09472 (UniProtKB)

IPI

GO:0005515

Q09472 (UniProtKB)

IPI

GO:0005515

Q09472 (UniProtKB)

IPI

GO:0005515

Q09472 (UniProtKB)

IPI

GO:0005515

Q09472 (UniProtKB)

IPI

GO:0005515

Q09472 (UniProtKB)

IPI

GO:0005515

Q09472 (UniProtKB)

IPI

GO:0005515

Q09472 (UniProtKB)

IPI

GO:0005515

Q09472 (UniProtKB)

IPI

GO:0005515

Q09472 (UniProtKB)

IPI

GO:0005515

Q09472 (UniProtKB)

IPI

GO:0005515

Q09472 (UniProtKB)

IPI

GO:0005515

Q09472 (UniProtKB)

IPI

GO:0005515

Q09472 (UniProtKB)

IPI

GO:0005515

Q09472 (UniProtKB)

IPI

GO:0005515

Q09472 (UniProtKB)

IPI

GO:0005515

Q09472 (UniProtKB)

IPI

GO:0005515

Q09472 (UniProtKB)

IPI

GO:0005515

Q09472 (UniProtKB)

IPI

GO:0005515

Q09472 (UniProtKB)

IPI

GO:0005515

Q09472 (UniProtKB)

IPI

GO:0005515

Q09472 (UniProtKB)

IPI

GO:0005515

Q09472 (UniProtKB)

IPI

GO:0005634

Q09472 (UniProtKB)

IDA

GO:0005634

Q09472 (UniProtKB)

IDA

GO:0005634

Q09472 (UniProtKB)

IDA

GO:0005654

Q09472 (UniProtKB)

IDA

GO:0005654

Q09472 (UniProtKB)

TAS

GO:0005654

Q09472 (UniProtKB)

TAS

GO:0005654

Q09472 (UniProtKB)

TAS

GO:0005654

Q09472 (UniProtKB)

TAS

GO:0005654

Q09472 (UniProtKB)

TAS

GO:0005654

Q09472 (UniProtKB)

TAS

GO:0005654

Q09472 (UniProtKB)

TAS

GO:0005654

Q09472 (UniProtKB)

TAS

GO:0005654

Q09472 (UniProtKB)

TAS

GO:0005654

Q09472 (UniProtKB)

TAS

GO:0005654

Q09472 (UniProtKB)

TAS

GO:0005654

Q09472 (UniProtKB)

TAS

GO:0005654

Q09472 (UniProtKB)

TAS

GO:0005654

Q09472 (UniProtKB)

TAS

GO:0005654

Q09472 (UniProtKB)

TAS

GO:0005654

Q09472 (UniProtKB)

TAS

GO:0005654

Q09472 (UniProtKB)

TAS

GO:0005654

Q09472 (UniProtKB)

TAS

GO:0005654

Q09472 (UniProtKB)

TAS

GO:0005654

Q09472 (UniProtKB)

TAS

GO:0005654

Q09472 (UniProtKB)

TAS

GO:0005654

Q09472 (UniProtKB)

TAS

GO:0005654

Q09472 (UniProtKB)

TAS

GO:0005654

Q09472 (UniProtKB)

TAS

GO:0005654

Q09472 (UniProtKB)

TAS

GO:0005654

Q09472 (UniProtKB)

TAS

GO:0005654

Q09472 (UniProtKB)

TAS

GO:0005654

Q09472 (UniProtKB)

TAS

GO:0005654

Q09472 (UniProtKB)

TAS

GO:0005654

Q09472 (UniProtKB)

TAS

GO:0005654

Q09472 (UniProtKB)

TAS

GO:0005654

Q09472 (UniProtKB)

TAS

GO:0005654

Q09472 (UniProtKB)

TAS

GO:0005654

Q09472 (UniProtKB)

TAS

GO:0005654

Q09472 (UniProtKB)

TAS

GO:0005654

Q09472 (UniProtKB)

TAS

GO:0005654

Q09472 (UniProtKB)

TAS

GO:0005654

Q09472 (UniProtKB)

TAS

GO:0005654

Q09472 (UniProtKB)

TAS

GO:0005654

Q09472 (UniProtKB)

TAS

GO:0005654

Q09472 (UniProtKB)

TAS

GO:0005654

Q09472 (UniProtKB)

TAS

GO:0005654

Q09472 (UniProtKB)

TAS

GO:0005654

Q09472 (UniProtKB)

TAS

GO:0005654

Q09472 (UniProtKB)

TAS

GO:0005654

Q09472 (UniProtKB)

TAS

GO:0005667

Q09472 (UniProtKB)

IEA

GO:0005737

Q09472 (UniProtKB)

IDA

GO:0006283

Q09472 (UniProtKB)

TAS

GO:0006355

Q09472 (UniProtKB)

IDA

GO:0006366

Q09472 (UniProtKB)

IEA

GO:0006473

Q09472 (UniProtKB)

IDA

GO:0006473

Q09472 (UniProtKB)

TAS

GO:0006473

Q09472 (UniProtKB)

IDA

GO:0006475

Q09472 (UniProtKB)

IDA

GO:0006915

Q09472 (UniProtKB)

IMP

GO:0006977

Q09472 (UniProtKB)

TAS

GO:0006990

Q09472 (UniProtKB)

ISS

GO:0007219

Q09472 (UniProtKB)

TAS

GO:0007399

Q09472 (UniProtKB)

TAS

GO:0007507

Q09472 (UniProtKB)

IEA

GO:0007519

Q09472 (UniProtKB)

IEA

GO:0007613

Q09472 (UniProtKB)

IEA

GO:0007623

Q09472 (UniProtKB)

ISS

GO:0008013

Q09472 (UniProtKB)

IPI

GO:0008022

Q09472 (UniProtKB)

IDA

GO:0008134

Q09472 (UniProtKB)

IPI

GO:0008134

Q09472 (UniProtKB)

IPI

GO:0008134

Q09472 (UniProtKB)

IPI

GO:0008270

Q09472 (UniProtKB)

IEA

GO:0009887

Q09472 (UniProtKB)

IEA

GO:0010506

Q09472 (UniProtKB)

TAS

GO:0010560

Q09472 (UniProtKB)

IEA

GO:0010942

Q09472 (UniProtKB)

IEA

GO:0014737

Q09472 (UniProtKB)

IEA

GO:0016032

Q09472 (UniProtKB)

IEA

GO:0016407

Q09472 (UniProtKB)

IMP

GO:0016407

Q09472 (UniProtKB)

EXP

GO:0016407

Q09472 (UniProtKB)

EXP

GO:0016407

Q09472 (UniProtKB)

IDA

GO:0016407

Q09472 (UniProtKB)

EXP

GO:0016407

Q09472 (UniProtKB)

IDA

GO:0016746

Q09472 (UniProtKB)

IDA

GO:0018076

Q09472 (UniProtKB)

IDA

GO:0018393

Q09472 (UniProtKB)

IDA

GO:0030183

Q09472 (UniProtKB)

IEA

GO:0030220

Q09472 (UniProtKB)

IEA

GO:0030324

Q09472 (UniProtKB)

IEA

GO:0031490

Q09472 (UniProtKB)

IEA

GO:0031490

Q09472 (UniProtKB)

IEA

GO:0032025

Q09472 (UniProtKB)

IEA

GO:0032092

Q09472 (UniProtKB)

IEA

GO:0032403

Q09472 (UniProtKB)

IEA

GO:0032481

Q09472 (UniProtKB)

TAS

GO:0032967

Q09472 (UniProtKB)

IEA

GO:0032993

Q09472 (UniProtKB)

IEA

GO:0033160

Q09472 (UniProtKB)

IEA

GO:0033613

Q09472 (UniProtKB)

IPI

GO:0034212

Q09472 (UniProtKB)

TAS

GO:0034612

Q09472 (UniProtKB)

IEA

GO:0034644

Q09472 (UniProtKB)

IDA

GO:0035066

Q09472 (UniProtKB)

IEA

GO:0035257

Q09472 (UniProtKB)

IPI

GO:0035259

Q09472 (UniProtKB)

IEA

GO:0035690

Q09472 (UniProtKB)

IEA

GO:0035855

Q09472 (UniProtKB)

IEA

GO:0035984

Q09472 (UniProtKB)

IEA

GO:0042771

Q09472 (UniProtKB)

IDA

GO:0042975

Q09472 (UniProtKB)

IEA

GO:0043154

Q09472 (UniProtKB)

IEA

GO:0043388

Q09472 (UniProtKB)

IEA

GO:0043425

Q09472 (UniProtKB)

IEA

GO:0043491

Q09472 (UniProtKB)

IEA

GO:0043627

Q09472 (UniProtKB)

IDA

GO:0043923

Q09472 (UniProtKB)

IDA

GO:0043966

Q09472 (UniProtKB)

IEA

GO:0043967

Q09472 (UniProtKB)

IMP

GO:0043969

Q09472 (UniProtKB)

IDA

GO:0045444

Q09472 (UniProtKB)

ISS

GO:0045471

Q09472 (UniProtKB)

IEA

GO:0045727

Q09472 (UniProtKB)

IEA

GO:0045773

Q09472 (UniProtKB)

IEA

GO:0045793

Q09472 (UniProtKB)

IEA

GO:0045815

Q09472 (UniProtKB)

TAS

GO:0045862

Q09472 (UniProtKB)

IEA

GO:0045944

Q09472 (UniProtKB)

IDA

GO:0045944

Q09472 (UniProtKB)

IMP

GO:0045944

Q09472 (UniProtKB)

IDA

GO:0046332

Q09472 (UniProtKB)

IEA

GO:0048565

Q09472 (UniProtKB)

IEA

GO:0050681

Q09472 (UniProtKB)

IPI

GO:0050714

Q09472 (UniProtKB)

IEA

GO:0050821

Q09472 (UniProtKB)

ISS

GO:0051019

Q09472 (UniProtKB)

IEA

GO:0051059

Q09472 (UniProtKB)

IEA

GO:0051091

Q09472 (UniProtKB)

IDA

GO:0051592

Q09472 (UniProtKB)

IEA

GO:0051726

Q09472 (UniProtKB)

TAS

GO:0060177

Q09472 (UniProtKB)

IEA

GO:0060298

Q09472 (UniProtKB)

IEA

GO:0060765

Q09472 (UniProtKB)

IDA

GO:0061418

Q09472 (UniProtKB)

TAS

GO:0065004

Q09472 (UniProtKB)

IEA

GO:0070301

Q09472 (UniProtKB)

IEA

GO:0070542

Q09472 (UniProtKB)

IEA

GO:0071300

Q09472 (UniProtKB)

IEA

GO:0071320

Q09472 (UniProtKB)

IEA

GO:0071333

Q09472 (UniProtKB)

IEA

GO:0071389

Q09472 (UniProtKB)

IEA

GO:0071549

Q09472 (UniProtKB)

IEA

GO:0090043

Q09472 (UniProtKB)

IDA

GO:0097157

Q09472 (UniProtKB)

IEA

GO:1900034

Q09472 (UniProtKB)

TAS

GO:1901796

Q09472 (UniProtKB)

TAS

GO:1904837

Q09472 (UniProtKB)

TAS

GO:1990090

Q09472 (UniProtKB)

IEA

GO:1990405

Q09472 (UniProtKB)

IEA

GO:2000629

Q09472 (UniProtKB)

IEA

GO:0003713

Q09472 (UniProtKB)

IDA

可能调控 EP300基因的相关microRNA：

hsa-miR-9 hsa-miR-125b hsa-miR-132* hsa-miR-182 hsa-miR-182* hsa-miR-200b hsa-miR-200b* hsa-miR-200c hsa-miR-200c* hsa-miR-26b

Reactome

MINT

BioGrid

IntAct

mentha

String

序号	作用方式	资源库来源/分值	基因名称	基因名称

KEGG
Reactomepathway

名称
4310 Wnt signaling pathway [PATH:hsa04310]
4330 Notch signaling pathway [PATH:hsa04330]
4350 TGF-beta signaling pathway [PATH:hsa04350]
4630 Jak-STAT signaling pathway [PATH:hsa04630]
4066 HIF-1 signaling pathway [PATH:hsa04066]
4068 FoxO signaling pathway [PATH:hsa04068]
4024 cAMP signaling pathway [PATH:hsa04024]
4110 Cell cycle [PATH:hsa04110]
4520 Adherens junction [PATH:hsa04520]
4922 Glucagon signaling pathway [PATH:hsa04922]
4919 Thyroid hormone signaling pathway [PATH:hsa04919]
4916 Melanogenesis [PATH:hsa04916]
4720 Long-term potentiation [PATH:hsa04720]
5200 Pathways in cancer [PATH:hsa05200]
5206 MicroRNAs in cancer [PATH:hsa05206]
5203 Viral carcinogenesis [PATH:hsa05203]
5211 Renal cell carcinoma [PATH:hsa05211]
5215 Prostate cancer [PATH:hsa05215]
5016 Huntington's disease [PATH:hsa05016]
5152 Tuberculosis [PATH:hsa05152]
5166 HTLV-I infection [PATH:hsa05166]
5164 Influenza A [PATH:hsa05164]
5161 Hepatitis B [PATH:hsa05161]
5168 Herpes simplex infection [PATH:hsa05168]
5169 Epstein-Barr virus infection [PATH:hsa05169]

名称
Attenuation phase
BMAL1:CLOCK,NPAS2 activates circadian gene expression
C-type lectin receptors (CLRs)
CD209 (DC-SIGN) signaling
Cell Cycle
Cell Cycle, Mitotic
Cellular response to heat stress
Cellular response to hypoxia
Cellular responses to stress
Chromatin modifying enzymes
Chromatin organization
Circadian Clock
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Cytosolic sensors of pathogen-associated DNA
Developmental Biology
Disease
Diseases of signal transduction
Factors involved in megakaryocyte development and platelet production
Fatty acid, triacylglycerol, and ketone body metabolism
formation of the beta-catenin:TCF transactivating complex
G2/M Transition
HATs acetylate histones
Hemostasis
HSF1-dependent transactivation
Immune System
Innate Immune System
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production
Metabolism
Metabolism of lipids and lipoproteins
Mitotic G2-G2/M phases
NOTCH1 Intracellular Domain Regulates Transcription
NOTCH2 intracellular domain regulates transcription
Polo-like kinase mediated events
PPARA activates gene expression
Pre-NOTCH Expression and Processing
Pre-NOTCH Transcription and Translation
Regulation of gene expression by Hypoxia-inducible Factor
Regulation of Hypoxia-inducible Factor (HIF) by oxygen
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
RORA activates gene expression
Signal Transduction
Signaling by NOTCH
Signaling by NOTCH1
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
Signaling by NOTCH1 in Cancer
Signaling by NOTCH1 PEST Domain Mutants in Cancer
Signaling by NOTCH2
Signaling by Wnt
TCF dependent signaling in response to WNT
TRAF3-dependent IRF activation pathway
TRAF6 mediated IRF7 activation
Transcriptional regulation of white adipocyte differentiation

疾病名称

关系值

NofPmids

NofSnps

来源

疾病名称	关系值	NofPmids	NofSnps	来源
RUBINSTEIN-TAYBI SYNDROME 2	0.24	0	5	CLINVAR_ORPHANET
Rubinstein-Taybi Syndrome	0.129248887	14	0	BeFree_CTD_human_LHGDN
Mammary Neoplasms	0.12272435	2	0	CTD_human_LHGDN
Endometrial Neoplasms	0.12272435	2	0	CTD_human_LHGDN
Colon Carcinoma	0.120814326	3	2	BeFree_CLINVAR
melanoma	0.120271442	1	0	BeFree_CTD_human
Carcinoma, Transitional Cell	0.120271442	2	0	BeFree_CTD_human
Obesity	0.120271442	2	0	BeFree_CTD_human
Stevens-Johnson Syndrome	0.12	1	0	CTD_human
Squamous cell carcinoma of esophagus	0.12	2	0	CTD_human

联系方式

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更新于2天前

EP300 (E1A binding protein p300)

基因基本信息

基因基本信息

基因染色体位置

基因染色体位置

基因简述

基因简述

基因序列

基因序列

基因突变

基因突变

基因表达

基因表达

基因引物

基因引物

转录因子

转录因子

基因本体信息

基因相关microRNA

基因相关microRNA

基因相互作用关系

基因相互作用关系

基因通路

基因通路

基因相关疾病

基因相关疾病

基因相关服务

基因相关服务

联系方式

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