EGFR基因详情-基因数据库-基因云馆

登录系统

EGFR (epidermal growth factor receptor)

symbol:: EGFR
locus group:: protein-coding gene
location:: 7p11.2
gene_family:: Receptor Tyrosine Kinases
alias symbol:: ERBB1|ERRP
alias name:: erythroblastic leukemia viral (v-e…
entrez id:: 1956
ensembl gene id:: ENSG00000146648
ucsc gene id:: uc003tqk.4
refseq accession:: NM_005228
hgnc_id:: HGNC:3236
approved reserved:: 1986-01-01

7p11.2

EGFR（表皮生长因子受体）是一种重要的跨膜蛋白，属于受体酪氨酸激酶（RTK）家族中的ErbB家族（也称为HER家族），该家族包括EGFR（HER1/ErbB1）、HER2（ErbB2）、HER3（ErbB3）和HER4（ErbB4）。这些家族成员在细胞生长、增殖、分化和存活等过程中发挥关键作用，通过结合特定的生长因子（如EGF、TGF-α等）激活下游信号通路，如RAS-RAF-MAPK和PI3K-AKT通路。EGFR主要在上皮细胞、成纤维细胞和胶质细胞等细胞表面表达，其正常功能对组织发育和修复至关重要。EGFR的突变或异常表达与多种疾病密切相关，尤其是癌症。常见的EGFR突变（如外显子19缺失或L858R点突变）会导致受体持续激活，促进细胞不受控制的增殖，与非小细胞肺癌（NSCLC）、结直肠癌、头颈癌和胶质母细胞瘤等恶性肿瘤的发生发展相关。针对EGFR的靶向药物（如吉非替尼、厄洛替尼和奥希替尼）已广泛应用于临床治疗。EGFR过表达会增强下游信号通路的活性，导致细胞过度增殖和肿瘤形成，同时还可能影响其他基因的表达，如上调 cyclin D1 促进细胞周期进展或抑制凋亡相关基因（如 BAX）。相反，EGFR表达降低或功能缺失可能影响组织修复和细胞存活，导致发育异常或组织功能障碍。此外，EGFR与其他家族成员（如HER2）可形成异源二聚体，进一步放大信号传导，在癌症中常见HER2过表达与EGFR协同作用的情况。EGFR基因的遗传变异也可能影响个体对靶向药物的敏感性或耐药性，例如T790M突变会导致对一代EGFR抑制剂的耐药性。总之，EGFR作为细胞信号传导的核心分子，其功能异常对疾病发生和治疗具有深远影响，深入研究其机制有助于开发更有效的抗癌策略。

None

无

OMIM数据库中对EGFR基因的介绍 Wikipedia数据库中对EGFR基因的介绍

EGFR基因的碱基序列：[NCBI]

Loading Gene Browser...

EGFR基因的碱基突变：仅显示部分snp

rs741153 rs759163 rs845555 rs845556 rs845557 rs845558 rs845559 rs845560 rs845561 rs845562 rs940805 rs1050171 rs1076452 rs1554718 rs1861002 rs1861003 rs1861004

EGFR基因在不同组织中的表达： [UniProt]

正向引物序列

正向Tm值

反向引物序列

反向Tm值

评分

TCCTGGAGAAAGGAGAACG

TATCATCCAGCACTTGACCA

CATGAGAAATTTACAGGGCCA

TTTCTGGCAGTTCTCCTCTC

TTTACAGGAAATCCTGCATGG

AGTCACTGCTGACTATGTCC

GTGTGCCCACTACATTGAC

TATGTAGCTTCCATTCGTTGGA

GACCAAGCAACATGGTCAG

CTTATCTCCTTGAGGGAGCG

AGTATTGATCGGGAGAGCC

TAGAAAGTCCAGGCAAAGG

TTTACAGGAAATCCTGCATGG

AGTCACTGCTGACTATGTCC

GACCAAGCAACATGGTCAG

CTTATCTCCTTGAGGGAGCG

AGTGCCTGAATACATAAACCAG

CAGAGGCTGATTGTGATAGAC

AGTGCCTGAATACATAAACCAG

CAGAGGCTGATTGTGATAGAC

转录因子

影响基因

影响类型

参考文献链接（PubMed）

EGFR

Activation

11556855; 21613411

BCL3

EGFR

Activation

17881446

BRCA1

EGFR

Repression

21396117

CREBBP

EGFR

Unknown

21464950

EGR1

EGFR

Activation

11830539

ESR1

EGFR

Unknown

12421825

HDAC1

EGFR

Repression

22025675

HDAC3

EGFR

Unknown

21464950

HOXB7

EGFR

Activation

21690342

JUN

EGFR

Activation

10803405

EGFR基因（以及对应的蛋白质）的细胞分布位置：

[UniProt] [GenomeNet]

质膜
细胞质
细胞外
高尔基体
囊泡
细胞骨架
内质网
细胞核
内体
溶酶体
线粒体

EGFR基因的本体（GO）信息：

GO库代码

对应的蛋白质

来源代码

GO:0004714

A0A0B4J1Y5 (UniProtKB)

IEA

GO:0005524

A0A0B4J1Y5 (UniProtKB)

IEA

GO:0007169

A0A0B4J1Y5 (UniProtKB)

IEA

GO:0016020

A0A0B4J1Y5 (UniProtKB)

IEA

GO:0018108

A0A0B4J1Y5 (UniProtKB)

IEA

GO:0004714

E9PFD7 (UniProtKB)

IEA

GO:0005524

E9PFD7 (UniProtKB)

IEA

GO:0007169

E9PFD7 (UniProtKB)

IEA

GO:0016021

E9PFD7 (UniProtKB)

IEA

GO:0018108

E9PFD7 (UniProtKB)

IEA

GO:0018108

E9PFD7 (UniProtKB)

IEA

GO:0000139

P00533 (UniProtKB)

IEA

GO:0000165

P00533 (UniProtKB)

TAS

GO:0000186

P00533 (UniProtKB)

IEA

GO:0000902

P00533 (UniProtKB)

IEA

GO:0001503

P00533 (UniProtKB)

NAS

GO:0001892

P00533 (UniProtKB)

IEA

GO:0001934

P00533 (UniProtKB)

IDA

GO:0001942

P00533 (UniProtKB)

IEA

GO:0003682

P00533 (UniProtKB)

IDA

GO:0003690

P00533 (UniProtKB)

NAS

GO:0004709

P00533 (UniProtKB)

NAS

GO:0004713

P00533 (UniProtKB)

IMP

GO:0004713

P00533 (UniProtKB)

TAS

GO:0004713

P00533 (UniProtKB)

IDA

GO:0004713

P00533 (UniProtKB)

EXP

GO:0004713

P00533 (UniProtKB)

IDA

GO:0004713

P00533 (UniProtKB)

TAS

GO:0004713

P00533 (UniProtKB)

TAS

GO:0004713

P00533 (UniProtKB)

TAS

GO:0004713

P00533 (UniProtKB)

TAS

GO:0004713

P00533 (UniProtKB)

TAS

GO:0004713

P00533 (UniProtKB)

TAS

GO:0004713

P00533 (UniProtKB)

TAS

GO:0004714

P00533 (UniProtKB)

TAS

GO:0004716

P00533 (UniProtKB)

IEA

GO:0004888

P00533 (UniProtKB)

IDA

GO:0005006

P00533 (UniProtKB)

IDA

GO:0005006

P00533 (UniProtKB)

IDA

GO:0005006

P00533 (UniProtKB)

NAS

GO:0005006

P00533 (UniProtKB)

NAS

GO:0005088

P00533 (UniProtKB)

TAS

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005515

P00533 (UniProtKB)

IPI

GO:0005524

P00533 (UniProtKB)

IEA

GO:0005615

P00533 (UniProtKB)

NAS

GO:0005634

P00533 (UniProtKB)

IDA

GO:0005634

P00533 (UniProtKB)

IDA

GO:0005634

P00533 (UniProtKB)

IDA

GO:0005737

P00533 (UniProtKB)

IDA

GO:0005737

P00533 (UniProtKB)

IDA

GO:0005768

P00533 (UniProtKB)

IDA

GO:0005768

P00533 (UniProtKB)

IDA

GO:0005789

P00533 (UniProtKB)

IEA

GO:0005886

P00533 (UniProtKB)

IDA

GO:0005886

P00533 (UniProtKB)

IDA

GO:0005886

P00533 (UniProtKB)

TAS

GO:0005886

P00533 (UniProtKB)

TAS

GO:0005886

P00533 (UniProtKB)

TAS

GO:0005886

P00533 (UniProtKB)

TAS

GO:0005886

P00533 (UniProtKB)

TAS

GO:0005886

P00533 (UniProtKB)

TAS

GO:0005886

P00533 (UniProtKB)

TAS

GO:0005886

P00533 (UniProtKB)

TAS

GO:0005886

P00533 (UniProtKB)

TAS

GO:0005886

P00533 (UniProtKB)

TAS

GO:0005886

P00533 (UniProtKB)

TAS

GO:0005886

P00533 (UniProtKB)

TAS

GO:0005886

P00533 (UniProtKB)

TAS

GO:0005886

P00533 (UniProtKB)

TAS

GO:0005886

P00533 (UniProtKB)

TAS

GO:0005886

P00533 (UniProtKB)

TAS

GO:0005886

P00533 (UniProtKB)

TAS

GO:0005886

P00533 (UniProtKB)

TAS

GO:0005886

P00533 (UniProtKB)

TAS

GO:0005886

P00533 (UniProtKB)

TAS

GO:0005886

P00533 (UniProtKB)

TAS

GO:0005886

P00533 (UniProtKB)

TAS

GO:0005886

P00533 (UniProtKB)

TAS

GO:0005886

P00533 (UniProtKB)

TAS

GO:0005886

P00533 (UniProtKB)

TAS

GO:0005886

P00533 (UniProtKB)

TAS

GO:0005886

P00533 (UniProtKB)

TAS

GO:0005886

P00533 (UniProtKB)

TAS

GO:0005886

P00533 (UniProtKB)

TAS

GO:0005886

P00533 (UniProtKB)

TAS

GO:0005886

P00533 (UniProtKB)

TAS

GO:0005886

P00533 (UniProtKB)

TAS

GO:0005886

P00533 (UniProtKB)

TAS

GO:0005886

P00533 (UniProtKB)

TAS

GO:0005886

P00533 (UniProtKB)

TAS

GO:0005886

P00533 (UniProtKB)

TAS

GO:0005886

P00533 (UniProtKB)

TAS

GO:0005886

P00533 (UniProtKB)

TAS

GO:0005886

P00533 (UniProtKB)

TAS

GO:0005886

P00533 (UniProtKB)

TAS

GO:0005886

P00533 (UniProtKB)

TAS

GO:0005886

P00533 (UniProtKB)

TAS

GO:0005886

P00533 (UniProtKB)

TAS

GO:0005886

P00533 (UniProtKB)

TAS

GO:0005886

P00533 (UniProtKB)

TAS

GO:0005886

P00533 (UniProtKB)

TAS

GO:0005886

P00533 (UniProtKB)

TAS

GO:0005886

P00533 (UniProtKB)

TAS

GO:0005886

P00533 (UniProtKB)

TAS

GO:0005886

P00533 (UniProtKB)

TAS

GO:0005886

P00533 (UniProtKB)

TAS

GO:0005886

P00533 (UniProtKB)

TAS

GO:0005886

P00533 (UniProtKB)

TAS

GO:0005886

P00533 (UniProtKB)

TAS

GO:0005886

P00533 (UniProtKB)

TAS

GO:0005886

P00533 (UniProtKB)

TAS

GO:0005886

P00533 (UniProtKB)

TAS

GO:0005886

P00533 (UniProtKB)

TAS

GO:0005886

P00533 (UniProtKB)

TAS

GO:0005886

P00533 (UniProtKB)

TAS

GO:0005886

P00533 (UniProtKB)

TAS

GO:0005886

P00533 (UniProtKB)

TAS

GO:0005886

P00533 (UniProtKB)

TAS

GO:0005886

P00533 (UniProtKB)

TAS

GO:0005886

P00533 (UniProtKB)

TAS

GO:0005886

P00533 (UniProtKB)

TAS

GO:0005886

P00533 (UniProtKB)

TAS

GO:0005886

P00533 (UniProtKB)

TAS

GO:0005886

P00533 (UniProtKB)

TAS

GO:0005886

P00533 (UniProtKB)

TAS

GO:0005886

P00533 (UniProtKB)

TAS

GO:0005886

P00533 (UniProtKB)

TAS

GO:0005886

P00533 (UniProtKB)

TAS

GO:0005886

P00533 (UniProtKB)

TAS

GO:0005886

P00533 (UniProtKB)

TAS

GO:0005886

P00533 (UniProtKB)

TAS

GO:0005886

P00533 (UniProtKB)

TAS

GO:0005886

P00533 (UniProtKB)

TAS

GO:0005886

P00533 (UniProtKB)

TAS

GO:0005886

P00533 (UniProtKB)

TAS

GO:0005886

P00533 (UniProtKB)

TAS

GO:0005886

P00533 (UniProtKB)

TAS

GO:0005886

P00533 (UniProtKB)

TAS

GO:0005886

P00533 (UniProtKB)

TAS

GO:0005886

P00533 (UniProtKB)

TAS

GO:0005886

P00533 (UniProtKB)

TAS

GO:0005886

P00533 (UniProtKB)

TAS

GO:0005886

P00533 (UniProtKB)

TAS

GO:0005886

P00533 (UniProtKB)

TAS

GO:0005886

P00533 (UniProtKB)

TAS

GO:0005886

P00533 (UniProtKB)

TAS

GO:0005886

P00533 (UniProtKB)

TAS

GO:0005886

P00533 (UniProtKB)

TAS

GO:0005886

P00533 (UniProtKB)

TAS

GO:0005886

P00533 (UniProtKB)

TAS

GO:0005886

P00533 (UniProtKB)

TAS

GO:0005886

P00533 (UniProtKB)

TAS

GO:0005886

P00533 (UniProtKB)

TAS

GO:0005886

P00533 (UniProtKB)

TAS

GO:0005886

P00533 (UniProtKB)

TAS

GO:0005886

P00533 (UniProtKB)

TAS

GO:0005886

P00533 (UniProtKB)

TAS

GO:0005886

P00533 (UniProtKB)

TAS

GO:0005886

P00533 (UniProtKB)

TAS

GO:0005886

P00533 (UniProtKB)

TAS

GO:0005886

P00533 (UniProtKB)

TAS

GO:0005886

P00533 (UniProtKB)

TAS

GO:0005886

P00533 (UniProtKB)

TAS

GO:0005886

P00533 (UniProtKB)

TAS

GO:0005925

P00533 (UniProtKB)

IDA

GO:0006950

P00533 (UniProtKB)

NAS

GO:0007165

P00533 (UniProtKB)

IDA

GO:0007165

P00533 (UniProtKB)

TAS

GO:0007166

P00533 (UniProtKB)

IDA

GO:0007173

P00533 (UniProtKB)

IDA

GO:0007173

P00533 (UniProtKB)

IDA

GO:0007173

P00533 (UniProtKB)

TAS

GO:0007202

P00533 (UniProtKB)

TAS

GO:0007435

P00533 (UniProtKB)

IEA

GO:0007611

P00533 (UniProtKB)

ISS

GO:0008283

P00533 (UniProtKB)

IDA

GO:0008284

P00533 (UniProtKB)

IDA

GO:0009986

P00533 (UniProtKB)

IDA

GO:0010008

P00533 (UniProtKB)

IDA

GO:0014066

P00533 (UniProtKB)

TAS

GO:0016020

P00533 (UniProtKB)

IDA

GO:0016021

P00533 (UniProtKB)

IEA

GO:0016323

P00533 (UniProtKB)

IDA

GO:0016337

P00533 (UniProtKB)

IMP

GO:0018108

P00533 (UniProtKB)

IEA

GO:0018108

P00533 (UniProtKB)

IEA

GO:0019899

P00533 (UniProtKB)

IPI

GO:0019903

P00533 (UniProtKB)

IPI

GO:0021795

P00533 (UniProtKB)

IEA

GO:0030307

P00533 (UniProtKB)

IDA

GO:0030335

P00533 (UniProtKB)

IMP

GO:0031625

P00533 (UniProtKB)

IPI

GO:0031625

P00533 (UniProtKB)

IPI

GO:0031659

P00533 (UniProtKB)

IDA

GO:0031901

P00533 (UniProtKB)

IDA

GO:0031965

P00533 (UniProtKB)

IEA

GO:0035413

P00533 (UniProtKB)

IMP

GO:0038128

P00533 (UniProtKB)

TAS

GO:0042059

P00533 (UniProtKB)

TAS

GO:0042177

P00533 (UniProtKB)

IDA

GO:0042327

P00533 (UniProtKB)

IDA

GO:0042802

P00533 (UniProtKB)

IPI

GO:0042802

P00533 (UniProtKB)

IPI

GO:0042802

P00533 (UniProtKB)

IPI

GO:0042802

P00533 (UniProtKB)

IPI

GO:0042802

P00533 (UniProtKB)

IPI

GO:0042802

P00533 (UniProtKB)

IPI

GO:0042802

P00533 (UniProtKB)

IPI

GO:0042802

P00533 (UniProtKB)

IPI

GO:0042802

P00533 (UniProtKB)

IPI

GO:0042802

P00533 (UniProtKB)

IPI

GO:0042802

P00533 (UniProtKB)

IPI

GO:0042802

P00533 (UniProtKB)

IPI

GO:0042802

P00533 (UniProtKB)

IPI

GO:0043006

P00533 (UniProtKB)

TAS

GO:0043066

P00533 (UniProtKB)

IMP

GO:0043235

P00533 (UniProtKB)

IDA

GO:0043406

P00533 (UniProtKB)

IDA

GO:0043547

P00533 (UniProtKB)

IEA

GO:0045121

P00533 (UniProtKB)

IDA

GO:0045429

P00533 (UniProtKB)

IDA

GO:0045739

P00533 (UniProtKB)

IDA

GO:0045740

P00533 (UniProtKB)

IDA

GO:0045944

P00533 (UniProtKB)

IDA

GO:0046777

P00533 (UniProtKB)

IMP

GO:0046854

P00533 (UniProtKB)

IEA

GO:0046934

P00533 (UniProtKB)

TAS

GO:0046982

P00533 (UniProtKB)

IDA

GO:0048015

P00533 (UniProtKB)

TAS

GO:0048146

P00533 (UniProtKB)

IEA

GO:0048471

P00533 (UniProtKB)

IEA

GO:0048546

P00533 (UniProtKB)

IEA

GO:0050679

P00533 (UniProtKB)

IDA

GO:0050730

P00533 (UniProtKB)

IMP

GO:0050999

P00533 (UniProtKB)

IDA

GO:0051015

P00533 (UniProtKB)

IDA

GO:0051205

P00533 (UniProtKB)

TAS

GO:0051897

P00533 (UniProtKB)

IMP

GO:0060571

P00533 (UniProtKB)

IEA

GO:0061029

P00533 (UniProtKB)

IEA

GO:0070141

P00533 (UniProtKB)

IDA

GO:0070374

P00533 (UniProtKB)

IDA

GO:0070374

P00533 (UniProtKB)

IMP

GO:0070435

P00533 (UniProtKB)

ISS

GO:0071230

P00533 (UniProtKB)

IEA

GO:0071364

P00533 (UniProtKB)

ISS

GO:0071392

P00533 (UniProtKB)

IDA

GO:0097489

P00533 (UniProtKB)

IDA

GO:1903800

P00533 (UniProtKB)

IMP

GO:2000145

P00533 (UniProtKB)

TAS

GO:0030122

P00533 (UniProtKB)

TAS

GO:0030235

P00533 (UniProtKB)

IDA

GO:0004714

Q504U8 (UniProtKB)

IEA

GO:0005524

Q504U8 (UniProtKB)

IEA

GO:0006898

Q504U8 (UniProtKB)

IDA

GO:0007169

Q504U8 (UniProtKB)

IEA

GO:0016021

Q504U8 (UniProtKB)

IEA

GO:0018108

Q504U8 (UniProtKB)

IEA

GO:0018108

Q504U8 (UniProtKB)

IEA

可能调控 EGFR基因的相关microRNA：

hsa-miR-1 hsa-miR-146a hsa-mir-146b hsa-miR-155 hsa-miR-16 hsa-miR-21 hsa-miR-30a hsa-miR-335 hsa-miR-7 hsa-let-7a

Reactome

MINT

BioGrid

IntAct

mentha

String

序号	作用方式	资源库来源/分值	基因名称	基因名称

KEGG
Reactomepathway

名称
4014 Ras signaling pathway [PATH:hsa04014]
4015 Rap1 signaling pathway [PATH:hsa04015]
4010 MAPK signaling pathway [PATH:hsa04010]
4012 ErbB signaling pathway [PATH:hsa04012]
4066 HIF-1 signaling pathway [PATH:hsa04066]
4068 FoxO signaling pathway [PATH:hsa04068]
4020 Calcium signaling pathway [PATH:hsa04020]
4151 PI3K-Akt signaling pathway [PATH:hsa04151]
4060 Cytokine-cytokine receptor interaction [PATH:hsa04060]
4144 Endocytosis [PATH:hsa04144]
4810 Regulation of actin cytoskeleton [PATH:hsa04810]
4510 Focal adhesion [PATH:hsa04510]
4520 Adherens junction [PATH:hsa04520]
4540 Gap junction [PATH:hsa04540]
4912 GnRH signaling pathway [PATH:hsa04912]
4915 Estrogen signaling pathway [PATH:hsa04915]
4921 Oxytocin signaling pathway [PATH:hsa04921]
4320 Dorso-ventral axis formation [PATH:hsa04320]
5200 Pathways in cancer [PATH:hsa05200]
5230 Central carbon metabolism in cancer [PATH:hsa05230]
5231 Choline metabolism in cancer [PATH:hsa05231]
5206 MicroRNAs in cancer [PATH:hsa05206]
5205 Proteoglycans in cancer [PATH:hsa05205]
5212 Pancreatic cancer [PATH:hsa05212]
5214 Glioma [PATH:hsa05214]
5218 Melanoma [PATH:hsa05218]
5219 Bladder cancer [PATH:hsa05219]
5215 Prostate cancer [PATH:hsa05215]
5213 Endometrial cancer [PATH:hsa05213]
5223 Non-small cell lung cancer [PATH:hsa05223]
5120 Epithelial cell signaling in Helicobacter pylori infection [PATH:hsa05120]
5160 Hepatitis C [PATH:hsa05160]

名称
Adaptive Immune System
Axon guidance
Constitutive Signaling by Aberrant PI3K in Cancer
Constitutive Signaling by EGFRvIII
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
DAP12 interactions
DAP12 signaling
Developmental Biology
Disease
Diseases of signal transduction
Downstream signal transduction
Downstream signaling events of B Cell Receptor (BCR)
Downstream signaling of activated FGFR1
Downstream signaling of activated FGFR2
Downstream signaling of activated FGFR3
Downstream signaling of activated FGFR4
EGFR downregulation
EGFR interacts with phospholipase C-gamma
EGFR Transactivation by Gastrin
Fc epsilon receptor (FCERI) signaling
GAB1 signalosome
Gastrin-CREB signalling pathway via PKC and MAPK
GRB2 events in EGFR signaling
GRB2 events in ERBB2 signaling
Immune System
Inhibition of Signaling by Overexpressed EGFR
Innate Immune System
L1CAM interactions
NGF signalling via TRKA from the plasma membrane
PI-3K cascade:FGFR1
PI-3K cascade:FGFR2
PI-3K cascade:FGFR3
PI-3K cascade:FGFR4
PI3K events in ERBB2 signaling
PI3K events in ERBB4 signaling
PI3K/AKT activation
PI3K/AKT Signaling in Cancer
PIP3 activates AKT signaling
PLCG1 events in ERBB2 signaling
Role of LAT2/NTAL/LAB on calcium mobilization
SHC1 events in EGFR signaling
SHC1 events in ERBB2 signaling
Signal Transduction
Signal transduction by L1
Signaling by EGFR
Signaling by EGFR in Cancer
Signaling by EGFRvIII in Cancer
Signaling by ERBB2
Signaling by ERBB4
Signaling by FGFR
Signaling by FGFR1
Signaling by FGFR2
Signaling by FGFR3
Signaling by FGFR4
Signaling by GPCR
Signaling by Ligand-Responsive EGFR Variants in Cancer
Signaling by Overexpressed Wild-Type EGFR in Cancer
Signaling by PDGF
Signaling by SCF-KIT
Signaling by the B Cell Receptor (BCR)
Signalling by NGF

疾病名称

关系值

NofPmids

NofSnps

来源

疾病名称	关系值	NofPmids	NofSnps	来源
Non-Small Cell Lung Carcinoma	0.384981818	1698	11	BeFree_CLINVAR_CTD_human_GAD_LHGDN
Adenocarcinoma	0.36	600	6	BeFree_CTD_human_GAD_LHGDN
Lung Neoplasms	0.298458047	212	2	BeFree_CTD_human_GAD_LHGDN
Squamous cell carcinoma	0.276687359	254	3	BeFree_CTD_human_GAD_LHGDN
Glioblastoma	0.255782082	390	3	BeFree_CTD_human_GAD_LHGDN
Neoplasm Metastasis	0.229100734	280	3	BeFree_CTD_human_GAD_LHGDN
Glioma	0.222572316	245	9	BeFree_GAD_GWASCAT_LHGDN
Mammary Neoplasms	0.215396242	86	0	BeFree_CTD_human_GAD_LHGDN
Cardiomyopathy, Dilated	0.202638474	3	0	BeFree_CTD_human_GAD_RGD
Acute kidney injury	0.2	2	0	CTD_human_RGD

联系地址

山东省济南市章丘区文博路2号

齐鲁师范学院 genelibs生信实验室

山东省济南市高新区舜华路750号

大学科技园北区F座4单元2楼

电话： 0531-88819269

微信公众号

关注微信订阅号，实时查看信息，关注医学生物学动态。

商务邮箱

E-mail: product@genelibs.com

EGFR (epidermal growth factor receptor)

基因基本信息

基因基本信息

基因染色体位置

基因染色体位置

基因简述

基因简述

基因序列

基因序列

基因突变

基因突变

基因表达

基因表达

基因引物

基因引物

转录因子

转录因子

基因本体信息

基因相关microRNA

基因相关microRNA

基因相互作用关系

基因相互作用关系

基因通路

基因通路

基因相关疾病

基因相关疾病

基因相关服务

基因相关服务

联系地址

微信公众号