DUSP3 (dual specificity phosphatase 3)
- symbol:
- DUSP3
- locus group:
- protein-coding gene
- location:
- 17q21.31
- gene_family:
- Atypical dual specificity phosphatases
- alias symbol:
- None
- alias name:
- None
- entrez id:
- 1845
- ensembl gene id:
- ENSG00000108861
- ucsc gene id:
- uc002ied.5
- refseq accession:
- NM_004090
- hgnc_id:
- HGNC:3069
- approved reserved:
- 1994-05-19
DUSP3（双特异性磷酸酶3）属于双特异性磷酸酶（DUSP）基因家族，该家族成员能够去磷酸化并调控丝裂原活化蛋白激酶（MAPK）信号通路中的关键蛋白，如ERK、JNK和p38。DUSP3通过去磷酸化这些激酶参与细胞增殖、分化、凋亡和应激反应的调控。DUSP3主要定位于细胞核，在DNA损伤修复和细胞周期调控中发挥重要作用。突变或异常表达可能导致MAPK信号通路失调，进而影响细胞稳态。研究表明，DUSP3与多种癌症相关，例如在乳腺癌和肝癌中，DUSP3表达降低可能导致MAPK信号过度激活，促进肿瘤发生；而在某些白血病中，DUSP3过表达可能抑制细胞凋亡，支持癌细胞存活。DUSP3基因家族（DUSPs）的共性在于它们均含有保守的磷酸酶结构域，能够靶向MAPK通路成员，但不同成员具有组织特异性表达和底物偏好性。DUSP3过表达可能抑制MAPK信号，导致细胞增殖受阻或凋亡增加，而表达降低则可能增强MAPK活性，促进细胞异常增殖或炎症反应。此外，DUSP3还参与免疫调节，其表达变化可能影响T细胞或巨噬细胞的功能。该基因的调控异常与炎症性疾病、自身免疫病和癌症的发展密切相关，因此被视为潜在的治疗靶点。
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene maps in a region that contains the BRCA1 locus which confers susceptibility to breast and ovarian cancer. Although DUSP3 is expressed in both breast and ovarian tissues, mutation screening in breast cancer pedigrees and in sporadic tumors was negative, leading to the conclusion that this gene is not BRCA1. [provided by RefSeq, Jul 2008]
由该基因编码的蛋白是双重特异性蛋白磷酸酶亚家族的一个成员。这些通过磷酸酶脱磷酸化两个磷酸丝氨酸/苏氨酸和磷酸化酪氨酸残基的灭活他们的目标激酶。它们负调节有丝分裂原活化蛋白（MAP）激酶家族（MAPK / ERK，SAPK / JNK，p38的），其与细胞增殖和分化相关的成员。家庭双重特异性磷酸酶的不同成员显示各种MAP激酶，不同的组织分布和亚细胞定位，并通过细胞外刺激其表达诱导的不同模式不同的底物特异性。该基因映射在包含BRCA1基因座赋予的易感性乳腺癌和卵巢癌的区域。虽然DUSP3在乳腺癌和卵巢组织中表达，在乳腺癌家系和在散发性肿瘤突变筛查呈阴性，从而得出结论，该基因是不BRCA1。 [由RefSeq的，2008年7月提供]
基因本体信息
DUSP3基因（以及对应的蛋白质）的细胞分布位置：
- 质膜
- 细胞质
- 细胞外
- 高尔基体
- 囊泡
- 细胞骨架
- 内质网
- 细胞核
- 内体
- 溶酶体
- 线粒体
DUSP3基因的本体（GO）信息：
| 名称 |
|---|
| 4010 MAPK signaling pathway [PATH:hsa04010] |
| 名称 |
|---|
| Activated TLR4 signalling |
| ERK/MAPK targets |
| ERKs are inactivated |
| Immune System |
| Innate Immune System |
| MAP kinase activation in TLR cascade |
| MAPK targets/ Nuclear events mediated by MAP kinases |
| MyD88 cascade initiated on plasma membrane |
| MyD88 dependent cascade initiated on endosome |
| MyD88-independent TLR3/TLR4 cascade |
| MyD88:Mal cascade initiated on plasma membrane |
| NGF signalling via TRKA from the plasma membrane |
| Nuclear Events (kinase and transcription factor activation) |
| Signal Transduction |
| Signalling by NGF |
| Toll Like Receptor 10 (TLR10) Cascade |
| Toll Like Receptor 2 (TLR2) Cascade |
| Toll Like Receptor 3 (TLR3) Cascade |
| Toll Like Receptor 4 (TLR4) Cascade |
| Toll Like Receptor 5 (TLR5) Cascade |
| Toll Like Receptor 7/8 (TLR7/8) Cascade |
| Toll Like Receptor 9 (TLR9) Cascade |
| Toll Like Receptor TLR1:TLR2 Cascade |
| Toll Like Receptor TLR6:TLR2 Cascade |
| Toll-Like Receptors Cascades |
| TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation |
| TRAF6 Mediated Induction of proinflammatory cytokines |
| TRIF-mediated TLR3/TLR4 signaling |
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Non-Small Cell Lung Carcinoma | 0.120542884 | 3 | 0 | BeFree_CTD_human |
| Prostatic Neoplasms | 0.0054487 | 2 | 0 | LHGDN |
| Sepsis | 0.000271442 | 1 | 0 | BeFree |
| Ovarian Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Carcinogenesis | 0.000271442 | 1 | 0 | BeFree |
| Prostate carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Xenograft Model | 0.000271442 | 1 | 0 | BeFree |
| Septicemia | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of prostate | 0.000271442 | 1 | 0 | BeFree |
| Staphylococcus aureus infection | 0.000271442 | 1 | 0 | BeFree |
微信公众号
关注微信订阅号，实时查看信息，关注医学生物学动态。
版权所有 © 2025.Genelibs 济南弘晖生物技术有限公司 鲁ICP备13024435号-2
