DICER1 (dicer 1, ribonuclease III)

基因基本信息

基因基本信息

symbol:
DICER1
locus group:
protein-coding gene
location:
14q32.13
gene_family:
alias symbol:
Dicer|KIAA0928|K12H4.8-LIKE|HERNA
alias name:
dicer 1, double-stranded RNA-speci…
entrez id:
23405
ensembl gene id:
ENSG00000100697
ucsc gene id:
uc001ydw.3
refseq accession:
NM_030621
hgnc_id:
HGNC:17098
approved reserved:
2002-05-09

基因染色体位置

基因染色体位置

14q32.13
基因染色体位置图

基因简述

基因简述

DICER1是一种编码Dicer酶的基因，属于RNA酶III家族（RNase III family），在RNA干扰（RNAi）和小RNA生成过程中起核心作用。Dicer酶的主要功能是将双链RNA（dsRNA）或前体microRNA（pre-miRNA）切割成短的小干扰RNA（siRNA）或成熟的microRNA（miRNA），这些小RNA随后参与基因表达的调控，影响细胞分化、增殖和凋亡等关键生物学过程。DICER1基因的表达产物主要在细胞质中发挥作用，其作用位点涉及RNA的加工和沉默复合体（RISC）的形成。DICER1突变会导致Dicer酶功能丧失或减弱，影响小RNA的生成，进而破坏正常的基因调控网络，可能导致发育异常或肿瘤发生。DICER1突变与多种疾病相关，包括胸膜肺母细胞瘤（PPB）、甲状腺癌、卵巢性索间质肿瘤等，这些疾病统称为DICER1综合征（DICER1 syndrome）。DICER1过表达可能增强RNA干扰效率，但过度的小RNA生成可能干扰正常的基因表达平衡，导致细胞功能紊乱；而DICER1表达降低则会导致小RNA生成不足，影响基因沉默和细胞稳态，可能促进肿瘤发展。DICER1属于RNA酶III基因家族，该家族的共性是通过切割RNA分子参与基因表达的调控，成员通常具有保守的RNA酶III结构域和双链RNA结合域。DICER1的功能异常不仅影响自身调控的基因网络，还可能干扰其他依赖小RNA的生物学过程，如免疫应答和病毒感染防御。

This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2010]

该基因编码具有包含在其氨基末端具有DEXH框和羧基末端的RNA基序的RNA解旋酶基序的蛋白。所编码的蛋白质的功能作为核糖核酸酶，并通过RNA干扰和小颞RNA（stRNA）的途径需要，以产生抑制基因表达的活性的小RNA组分。选择性剪接结果在多个抄本变形。 [由RefSeq的，2010年9月提供]

OMIM数据库中对DICER1基因的介绍     Wikipedia数据库中对DICER1基因的介绍

基因序列

基因序列

DICER1基因的碱基序列：[NCBI]
Loading Gene Browser...

基因突变

基因突变

DICER1基因的碱基突变：           仅显示部分snp
rs3742331       rs6575499       rs6575500       rs7148441       rs10137181       rs10137198       rs10149088       rs11851369       rs12323634       rs12323635       rs12882291       rs73331574       rs73331576       rs73331578       rs73331584       rs76098598       rs78294544      

基因表达

基因表达

DICER1基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向Tm值
反向引物序列
反向Tm值
评分
TAATCAACCTCAGCTGTGGG
60
ATATGAGACACCTCTGCTCAG
59
AGGTCAGCAACTGTAATCTG
58
AATATTGACACCACCATGCG
59
AACTGCCAAATTTAGCCCG
59
CGACCAACACCTTTAAATTTCC
59
TTACTAAGCACCAGGTTCTC
57
TGTCTGACAGTGATAAGTAACC
58
CCATTGGACACATCAATAGATACTG
60
TCTCGGGTTCTGCATTTAGG
60
CGCTTCCTTTAAGCAGTGC
60
AGAGTTCTGGAACCAGTATCTG
59
AAGCGCTTCCTTTAAGCAG
59
GAGTTCTGGAACCAGTATCTG
58
ATGGCATTGGGAAGAATCAG
58
GAACATAGGATCGATATTCTCTTCC
59
ACCCATACCTCAGATTCCAC
59
CCAGACTTCTTCAACTCAATGG
59
ACCCATACCTCAGATTCCAC
59
CCAGACTTCTTCAACTCAATGG
59

转录因子

转录因子

转录因子
影响基因
影响类型
参考文献链接（PubMed）
GATA1
DICER1
Activation
23426981
SOX4
DICER1
Unknown
22098624

基因本体信息

DICER1基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 质膜
  • 细胞质
  • 细胞外
  • 高尔基体
  • 囊泡
  • 细胞骨架
  • 内质网
  • 细胞核
  • 内体
  • 溶酶体
  • 线粒体

DICER1基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0003723
H0YJZ6 (UniProtKB)
IEA
GO:0004525
H0YJZ6 (UniProtKB)
IEA
GO:0006396
H0YJZ6 (UniProtKB)
IEA
GO:0090502
H0YJZ6 (UniProtKB)
IEA
GO:0000122
Q9UPY3 (UniProtKB)
ISS
GO:0003725
Q9UPY3 (UniProtKB)
IDA
GO:0003725
Q9UPY3 (UniProtKB)
IMP
GO:0004386
Q9UPY3 (UniProtKB)
IEA
GO:0004521
Q9UPY3 (UniProtKB)
IMP
GO:0004521
Q9UPY3 (UniProtKB)
IMP
GO:0004521
Q9UPY3 (UniProtKB)
TAS
GO:0004521
Q9UPY3 (UniProtKB)
IDA
GO:0004525
Q9UPY3 (UniProtKB)
EXP
GO:0004525
Q9UPY3 (UniProtKB)
EXP
GO:0004525
Q9UPY3 (UniProtKB)
EXP
GO:0004525
Q9UPY3 (UniProtKB)
EXP
GO:0004525
Q9UPY3 (UniProtKB)
IDA
GO:0004525
Q9UPY3 (UniProtKB)
IDA
GO:0004530
Q9UPY3 (UniProtKB)
IBA
GO:0005515
Q9UPY3 (UniProtKB)
IPI
GO:0005515
Q9UPY3 (UniProtKB)
IPI
GO:0005515
Q9UPY3 (UniProtKB)
IPI
GO:0005515
Q9UPY3 (UniProtKB)
IPI
GO:0005515
Q9UPY3 (UniProtKB)
IPI
GO:0005515
Q9UPY3 (UniProtKB)
IPI
GO:0005515
Q9UPY3 (UniProtKB)
IPI
GO:0005515
Q9UPY3 (UniProtKB)
IPI
GO:0005515
Q9UPY3 (UniProtKB)
IPI
GO:0005515
Q9UPY3 (UniProtKB)
IPI
GO:0005515
Q9UPY3 (UniProtKB)
IPI
GO:0005515
Q9UPY3 (UniProtKB)
IPI
GO:0005515
Q9UPY3 (UniProtKB)
IPI
GO:0005515
Q9UPY3 (UniProtKB)
IPI
GO:0005515
Q9UPY3 (UniProtKB)
IPI
GO:0005515
Q9UPY3 (UniProtKB)
IPI
GO:0005515
Q9UPY3 (UniProtKB)
IPI
GO:0005515
Q9UPY3 (UniProtKB)
IPI
GO:0005515
Q9UPY3 (UniProtKB)
IPI
GO:0005515
Q9UPY3 (UniProtKB)
IPI
GO:0005515
Q9UPY3 (UniProtKB)
IPI
GO:0005515
Q9UPY3 (UniProtKB)
IPI
GO:0005515
Q9UPY3 (UniProtKB)
IPI
GO:0005515
Q9UPY3 (UniProtKB)
IPI
GO:0005515
Q9UPY3 (UniProtKB)
IPI
GO:0005515
Q9UPY3 (UniProtKB)
IPI
GO:0005515
Q9UPY3 (UniProtKB)
IPI
GO:0005515
Q9UPY3 (UniProtKB)
IPI
GO:0005515
Q9UPY3 (UniProtKB)
IPI
GO:0005515
Q9UPY3 (UniProtKB)
IPI
GO:0005515
Q9UPY3 (UniProtKB)
IPI
GO:0005515
Q9UPY3 (UniProtKB)
IPI
GO:0005524
Q9UPY3 (UniProtKB)
IEA
GO:0005634
Q9UPY3 (UniProtKB)
IBA
GO:0005737
Q9UPY3 (UniProtKB)
IBA
GO:0005793
Q9UPY3 (UniProtKB)
IEA
GO:0005829
Q9UPY3 (UniProtKB)
TAS
GO:0005829
Q9UPY3 (UniProtKB)
TAS
GO:0005829
Q9UPY3 (UniProtKB)
TAS
GO:0005829
Q9UPY3 (UniProtKB)
TAS
GO:0005829
Q9UPY3 (UniProtKB)
TAS
GO:0005829
Q9UPY3 (UniProtKB)
TAS
GO:0006309
Q9UPY3 (UniProtKB)
IBA
GO:0010626
Q9UPY3 (UniProtKB)
ISS
GO:0014040
Q9UPY3 (UniProtKB)
ISS
GO:0014040
Q9UPY3 (UniProtKB)
ISS
GO:0019904
Q9UPY3 (UniProtKB)
IPI
GO:0021675
Q9UPY3 (UniProtKB)
ISS
GO:0030422
Q9UPY3 (UniProtKB)
IDA
GO:0030422
Q9UPY3 (UniProtKB)
IDA
GO:0030422
Q9UPY3 (UniProtKB)
IDA
GO:0030423
Q9UPY3 (UniProtKB)
IMP
GO:0030423
Q9UPY3 (UniProtKB)
IMP
GO:0030424
Q9UPY3 (UniProtKB)
IEA
GO:0030425
Q9UPY3 (UniProtKB)
IEA
GO:0030426
Q9UPY3 (UniProtKB)
IEA
GO:0031047
Q9UPY3 (UniProtKB)
TAS
GO:0031054
Q9UPY3 (UniProtKB)
IDA
GO:0031054
Q9UPY3 (UniProtKB)
IDA
GO:0031054
Q9UPY3 (UniProtKB)
IDA
GO:0031054
Q9UPY3 (UniProtKB)
IDA
GO:0031054
Q9UPY3 (UniProtKB)
IDA
GO:0031643
Q9UPY3 (UniProtKB)
ISS
GO:0031643
Q9UPY3 (UniProtKB)
ISS
GO:0032290
Q9UPY3 (UniProtKB)
ISS
GO:0033167
Q9UPY3 (UniProtKB)
IC
GO:0033168
Q9UPY3 (UniProtKB)
IMP
GO:0035087
Q9UPY3 (UniProtKB)
IDA
GO:0035196
Q9UPY3 (UniProtKB)
ISS
GO:0035196
Q9UPY3 (UniProtKB)
IDA
GO:0035196
Q9UPY3 (UniProtKB)
IDA
GO:0035197
Q9UPY3 (UniProtKB)
IDA
GO:0035280
Q9UPY3 (UniProtKB)
IDA
GO:0036404
Q9UPY3 (UniProtKB)
IMP
GO:0046872
Q9UPY3 (UniProtKB)
IEA
GO:0048812
Q9UPY3 (UniProtKB)
ISS
GO:0070578
Q9UPY3 (UniProtKB)
IDA
GO:0070578
Q9UPY3 (UniProtKB)
IDA
GO:0070578
Q9UPY3 (UniProtKB)
IDA
GO:0070578
Q9UPY3 (UniProtKB)
IDA
GO:0070883
Q9UPY3 (UniProtKB)
IDA
GO:0070883
Q9UPY3 (UniProtKB)
IDA
GO:0090502
Q9UPY3 (UniProtKB)
IDA
GO:0090502
Q9UPY3 (UniProtKB)
IDA
GO:0016442
Q9UPY3 (UniProtKB)
IDA
GO:0070883
Q9UPY3 (UniProtKB)
IDA

基因相关microRNA

基因相关microRNA

可能调控 DICER1基因的相关microRNA：     

基因相互作用关系

基因相互作用关系

Reactome

MINT

BioGrid

IntAct

mentha

String

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因通路

基因通路

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Pleuropulmonary blastoma 0.486243163 23 4 BeFree_CLINVAR_CTD_human_ORPHANET_UNIPROT
Euthyroid Goiter 0.240271442 2 0 BeFree_ORPHANET_UNIPROT
Endometriosis 0.120271442 1 0 BeFree_CTD_human
Gynandroblastoma 0.12 0 0 ORPHANET
Granulosa Cell Cancer 0.12 0 0 ORPHANET
Rhabdomyosarcoma, Embryonal, 2 0.12 0 0 CLINVAR
Malignant Granulosa Cell Tumor 0.12 0 0 ORPHANET
Endemic goiter 0.12 0 1 CLINVAR
Oligospermia 0.12 1 0 CTD_human
IGA Glomerulonephritis 0.12 1 0 CTD_human

基因相关服务

基因相关服务

联系方式

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