This gene encodes a WD repeat-containing protein that interacts with the COP9 signalosome, a macromolecular complex that interacts with cullin-RING E3 ligases and regulates their activity by hydrolyzing cullin-Nedd8 conjugates. [provided by RefSeq, Jul 2009]
该基因编码与COP9 signalosome,与滞-RING E3连接酶相互作用,通过水解滞-NED??D8结合物调节其活性的大分子复杂交互的WD重复含蛋白质。 [由RefSeq的,2009年7月提供]
DCAF12基因(以及对应的蛋白质)的细胞分布位置:
DCAF12基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Prostate carcinoma | 0.000271442 | 1 | 0 | BeFree |
Carcinoma of lung | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of lung | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of prostate | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of testis | 0.000271442 | 1 | 0 | BeFree |
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