DAB2IP (DAB2 interacting protein)

基因基本信息

基因基本信息

symbol:
DAB2IP
locus group:
protein-coding gene
location:
9q33.2
gene_family:
C2 and RasGAP domain containing
alias symbol:
AF9Q34|DIP1/2|KIAA1743|AIP1
alias name:
nGAP-like protein|DOC-2/DAB2 inter…
entrez id:
153090
ensembl gene id:
ENSG00000136848
ucsc gene id:
uc004bln.5
refseq accession:
NM_032552
hgnc_id:
HGNC:17294
approved reserved:
2002-01-23

基因染色体位置

基因染色体位置

9q33.2
基因染色体位置图

基因简述

基因简述

DAB2IP（Disabled homolog 2-interacting protein）是一种重要的抑癌基因，属于RAS GTP酶激活蛋白（RAS GAP）家族成员，该家族共性是通过促进RAS蛋白从活性状态（GTP结合）转变为非活性状态（GDP结合），负调控RAS/MAPK信号通路，从而抑制细胞增殖和肿瘤发生。DAB2IP编码的蛋白包含多个功能域，包括PH域（介导膜定位）、C2域（参与钙依赖性膜结合）和GAP域（发挥RAS抑制作用），其生物学功能涉及调控细胞凋亡、抑制迁移侵袭、维持基因组稳定性及血管生成等。该基因主要作用位点包括细胞质和细胞膜，通过与DAB2、ASPP1等蛋白相互作用影响TGF-β、NF-κB和PI3K/AKT通路。突变或表观遗传沉默（如启动子甲基化）会导致DAB2IP功能丧失，与前列腺癌、乳腺癌、肝癌等多种恶性肿瘤的进展、转移和不良预后相关，同时可能促进炎症反应和纤维化疾病。过表达DAB2IP可抑制肿瘤细胞生长、增强化疗敏感性，并通过下调VEGF抑制血管生成；而低表达时则导致RAS/ERK和PI3K/AKT通路过度激活，加速细胞恶性转化，还可能通过上调MMP-9促进转移。该基因家族（RAS GAPs）的共性是通过负调控RAS超家族蛋白（如HRAS、KRAS）的活性，维持细胞稳态，其成员变异常与发育异常和肿瘤发生密切相关。

DAB2IP is a Ras (MIM 190020) GTPase-activating protein (GAP) that acts as a tumor suppressor. The DAB2IP gene is inactivated by methylation in prostate and breast cancers (Yano et al., 2005 [PubMed 15386433]).[supplied by OMIM, May 2010]

DAB2IP是一个的Ras（MIM 190020）GTP酶激活蛋白（GAP），它作为一种肿瘤抑制基因。该DAB2IP基因被甲基化在前列腺和乳腺癌灭活（Yano等人，2005 [搜索PubMed 15386433]）。[由OMIM，2010年5月供给]

OMIM数据库中对CCND1基因的介绍     Wikipedia数据库中对CCND1基因的介绍

基因序列

基因序列

CCND1基因的碱基序列：[NCBI]
Loading Gene Browser...

基因突变

基因突变

DAB2IP基因的碱基突变：           仅显示部分snp
rs476807       rs476951       rs480270       rs480935       rs481137       rs490396       rs501001       rs514823       rs518973       rs519379       rs520198       rs520204       rs520341       rs520529       rs520533       rs521394       rs537143      

基因表达

基因表达

DAB2IP基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向Tm值
反向引物序列
反向Tm值
评分
ACTACTGCTTCGAGGTGAC
59
AGGTTCTCCATCCACTTATCC
59
AGGTGAAGGACTTCCTGAC
59
TGTTCTCCCGGAAGATGAG
59
TGTGACCTGGATGTCATGG
59
GTCCATTTCCTCATCTGTCCT
60
GTGACCTGGATGTCATGGT
59
GTCCATTTCCTCATCTGTCCT
60
AAGGTGAAGGACTTCCTGAC
59
GTTCTCCCGGAAGATGAGG
60
ACTACTGCTTCGAGGTGAC
59
TTCTCCATCCACTTATCCCG
59
ACTACTGCTTCGAGGTGAC
59
TCTCCATCCACTTATCCCG
58
AGGTGAAGGACTTCCTGAC
59
GTTCTCCCGGAAGATGAGG
60
TGTGACCTGGATGTCATGG
59
TCCATTTCCTCATCTGTCCTC
59

转录因子

转录因子

      尚未收录相关数据

基因本体信息

DAB2IP基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 质膜
  • 细胞质
  • 细胞外
  • 高尔基体
  • 囊泡
  • 细胞骨架
  • 内质网
  • 细胞核
  • 内体
  • 溶酶体
  • 线粒体

DAB2IP基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0005096
F6R503 (UniProtKB)
IEA
GO:0008285
F6R503 (UniProtKB)
IEA
GO:0016525
F6R503 (UniProtKB)
IEA
GO:0030948
F6R503 (UniProtKB)
IEA
GO:0038026
F6R503 (UniProtKB)
IEA
GO:0043065
F6R503 (UniProtKB)
IEA
GO:0043547
F6R503 (UniProtKB)
IEA
GO:0005096
F8WA47 (UniProtKB)
IEA
GO:0008285
F8WA47 (UniProtKB)
IEA
GO:0016525
F8WA47 (UniProtKB)
IEA
GO:0030948
F8WA47 (UniProtKB)
IEA
GO:0038026
F8WA47 (UniProtKB)
IEA
GO:0043065
F8WA47 (UniProtKB)
IEA
GO:0043547
F8WA47 (UniProtKB)
IEA
GO:0005096
H0Y3A3 (UniProtKB)
IEA
GO:0008285
H0Y3A3 (UniProtKB)
IEA
GO:0016525
H0Y3A3 (UniProtKB)
IEA
GO:0030948
H0Y3A3 (UniProtKB)
IEA
GO:0038026
H0Y3A3 (UniProtKB)
IEA
GO:0043065
H0Y3A3 (UniProtKB)
IEA
GO:0043547
H0Y3A3 (UniProtKB)
IEA
GO:0000122
Q5VWQ8 (UniProtKB)
IDA
GO:0000122
Q5VWQ8 (UniProtKB)
IMP
GO:0000165
Q5VWQ8 (UniProtKB)
TAS
GO:0000185
Q5VWQ8 (UniProtKB)
IDA
GO:0001525
Q5VWQ8 (UniProtKB)
IEA
GO:0001933
Q5VWQ8 (UniProtKB)
ISS
GO:0001933
Q5VWQ8 (UniProtKB)
IMP
GO:0005096
Q5VWQ8 (UniProtKB)
IBA
GO:0005123
Q5VWQ8 (UniProtKB)
IPI
GO:0005515
Q5VWQ8 (UniProtKB)
IPI
GO:0005515
Q5VWQ8 (UniProtKB)
IPI
GO:0005515
Q5VWQ8 (UniProtKB)
IPI
GO:0005515
Q5VWQ8 (UniProtKB)
IPI
GO:0005515
Q5VWQ8 (UniProtKB)
IPI
GO:0005515
Q5VWQ8 (UniProtKB)
IPI
GO:0005515
Q5VWQ8 (UniProtKB)
IPI
GO:0005737
Q5VWQ8 (UniProtKB)
IDA
GO:0005737
Q5VWQ8 (UniProtKB)
IDA
GO:0005829
Q5VWQ8 (UniProtKB)
TAS
GO:0005829
Q5VWQ8 (UniProtKB)
TAS
GO:0005886
Q5VWQ8 (UniProtKB)
IDA
GO:0005886
Q5VWQ8 (UniProtKB)
IDA
GO:0006927
Q5VWQ8 (UniProtKB)
TAS
GO:0006954
Q5VWQ8 (UniProtKB)
IEA
GO:0006987
Q5VWQ8 (UniProtKB)
TAS
GO:0007049
Q5VWQ8 (UniProtKB)
IEA
GO:0007252
Q5VWQ8 (UniProtKB)
ISS
GO:0007257
Q5VWQ8 (UniProtKB)
IDA
GO:0008285
Q5VWQ8 (UniProtKB)
IDA
GO:0008625
Q5VWQ8 (UniProtKB)
IMP
GO:0010596
Q5VWQ8 (UniProtKB)
IMP
GO:0010633
Q5VWQ8 (UniProtKB)
IMP
GO:0010633
Q5VWQ8 (UniProtKB)
TAS
GO:0010719
Q5VWQ8 (UniProtKB)
IMP
GO:0010719
Q5VWQ8 (UniProtKB)
IDA
GO:0010976
Q5VWQ8 (UniProtKB)
ISS
GO:0014067
Q5VWQ8 (UniProtKB)
IDA
GO:0016525
Q5VWQ8 (UniProtKB)
IDA
GO:0017124
Q5VWQ8 (UniProtKB)
IDA
GO:0017124
Q5VWQ8 (UniProtKB)
IDA
GO:0019900
Q5VWQ8 (UniProtKB)
IPI
GO:0019901
Q5VWQ8 (UniProtKB)
IDA
GO:0019901
Q5VWQ8 (UniProtKB)
IPI
GO:0021814
Q5VWQ8 (UniProtKB)
ISS
GO:0021819
Q5VWQ8 (UniProtKB)
ISS
GO:0030139
Q5VWQ8 (UniProtKB)
IDA
GO:0030424
Q5VWQ8 (UniProtKB)
ISS
GO:0030425
Q5VWQ8 (UniProtKB)
IEA
GO:0030948
Q5VWQ8 (UniProtKB)
IMP
GO:0031235
Q5VWQ8 (UniProtKB)
IBA
GO:0031434
Q5VWQ8 (UniProtKB)
IPI
GO:0031435
Q5VWQ8 (UniProtKB)
IPI
GO:0032088
Q5VWQ8 (UniProtKB)
IMP
GO:0032266
Q5VWQ8 (UniProtKB)
IDA
GO:0032403
Q5VWQ8 (UniProtKB)
IDA
GO:0032809
Q5VWQ8 (UniProtKB)
ISS
GO:0034144
Q5VWQ8 (UniProtKB)
IDA
GO:0034260
Q5VWQ8 (UniProtKB)
ISS
GO:0034260
Q5VWQ8 (UniProtKB)
IMP
GO:0035148
Q5VWQ8 (UniProtKB)
IMP
GO:0035414
Q5VWQ8 (UniProtKB)
ISS
GO:0035591
Q5VWQ8 (UniProtKB)
IDA
GO:0035924
Q5VWQ8 (UniProtKB)
ISS
GO:0035924
Q5VWQ8 (UniProtKB)
IDA
GO:0036312
Q5VWQ8 (UniProtKB)
IDA
GO:0036324
Q5VWQ8 (UniProtKB)
ISS
GO:0038026
Q5VWQ8 (UniProtKB)
IEA
GO:0040008
Q5VWQ8 (UniProtKB)
IEA
GO:0042059
Q5VWQ8 (UniProtKB)
ISS
GO:0042802
Q5VWQ8 (UniProtKB)
IPI
GO:0042803
Q5VWQ8 (UniProtKB)
IPI
GO:0043025
Q5VWQ8 (UniProtKB)
ISS
GO:0043065
Q5VWQ8 (UniProtKB)
IDA
GO:0043065
Q5VWQ8 (UniProtKB)
IDA
GO:0043087
Q5VWQ8 (UniProtKB)
ISS
GO:0043122
Q5VWQ8 (UniProtKB)
ISS
GO:0043124
Q5VWQ8 (UniProtKB)
IDA
GO:0043124
Q5VWQ8 (UniProtKB)
IDA
GO:0043184
Q5VWQ8 (UniProtKB)
IPI
GO:0043254
Q5VWQ8 (UniProtKB)
IDA
GO:0043407
Q5VWQ8 (UniProtKB)
IDA
GO:0043407
Q5VWQ8 (UniProtKB)
IMP
GO:0043410
Q5VWQ8 (UniProtKB)
IDA
GO:0043497
Q5VWQ8 (UniProtKB)
IDA
GO:0043507
Q5VWQ8 (UniProtKB)
IDA
GO:0043547
Q5VWQ8 (UniProtKB)
IEA
GO:0043548
Q5VWQ8 (UniProtKB)
IDA
GO:0043553
Q5VWQ8 (UniProtKB)
IDA
GO:0044257
Q5VWQ8 (UniProtKB)
IDA
GO:0044300
Q5VWQ8 (UniProtKB)
ISS
GO:0044301
Q5VWQ8 (UniProtKB)
ISS
GO:0045087
Q5VWQ8 (UniProtKB)
IEA
GO:0045732
Q5VWQ8 (UniProtKB)
ISS
GO:0045892
Q5VWQ8 (UniProtKB)
IMP
GO:0045944
Q5VWQ8 (UniProtKB)
IDA
GO:0045944
Q5VWQ8 (UniProtKB)
IDA
GO:0046330
Q5VWQ8 (UniProtKB)
IDA
GO:0046330
Q5VWQ8 (UniProtKB)
IDA
GO:0046580
Q5VWQ8 (UniProtKB)
IBA
GO:0046580
Q5VWQ8 (UniProtKB)
IC
GO:0048147
Q5VWQ8 (UniProtKB)
ISS
GO:0048812
Q5VWQ8 (UniProtKB)
ISS
GO:0050680
Q5VWQ8 (UniProtKB)
IMP
GO:0051721
Q5VWQ8 (UniProtKB)
IDA
GO:0070059
Q5VWQ8 (UniProtKB)
ISS
GO:0070062
Q5VWQ8 (UniProtKB)
IDA
GO:0070273
Q5VWQ8 (UniProtKB)
IDA
GO:0070317
Q5VWQ8 (UniProtKB)
IDA
GO:0070373
Q5VWQ8 (UniProtKB)
IDA
GO:0071158
Q5VWQ8 (UniProtKB)
IDA
GO:0071222
Q5VWQ8 (UniProtKB)
IDA
GO:0071347
Q5VWQ8 (UniProtKB)
IDA
GO:0071356
Q5VWQ8 (UniProtKB)
IDA
GO:0071356
Q5VWQ8 (UniProtKB)
IDA
GO:0071356
Q5VWQ8 (UniProtKB)
IDA
GO:0071364
Q5VWQ8 (UniProtKB)
ISS
GO:0071889
Q5VWQ8 (UniProtKB)
IDA
GO:0071901
Q5VWQ8 (UniProtKB)
IDA
GO:0071901
Q5VWQ8 (UniProtKB)
IMP
GO:0071902
Q5VWQ8 (UniProtKB)
IDA
GO:0071902
Q5VWQ8 (UniProtKB)
IMP
GO:0072577
Q5VWQ8 (UniProtKB)
TAS
GO:0090090
Q5VWQ8 (UniProtKB)
IMP
GO:0090129
Q5VWQ8 (UniProtKB)
ISS
GO:1900006
Q5VWQ8 (UniProtKB)
ISS
GO:1900744
Q5VWQ8 (UniProtKB)
ISS
GO:1900747
Q5VWQ8 (UniProtKB)
ISS
GO:1901800
Q5VWQ8 (UniProtKB)
IMP
GO:1903896
Q5VWQ8 (UniProtKB)
TAS
GO:1990032
Q5VWQ8 (UniProtKB)
ISS
GO:1990597
Q5VWQ8 (UniProtKB)
IDA
GO:2000599
Q5VWQ8 (UniProtKB)
IDA
GO:2001224
Q5VWQ8 (UniProtKB)
ISS
GO:2001235
Q5VWQ8 (UniProtKB)
IDA
GO:0035662
Q5VWQ8 (UniProtKB)
IDA

基因相关microRNA

基因相关microRNA

可能调控 DAB2IP基因的相关microRNA：     

基因相互作用关系

基因相互作用关系

BioGrid

IntAct

mentha

String

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因通路

基因通路

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Aortic Aneurysm, Abdominal 0.242638474 1 1 BeFree_CTD_human_GAD_GWASCAT
Prostatic Neoplasms 0.128444493 3 0 BeFree_CTD_human_LHGDN
Lung Neoplasms 0.12272435 2 0 CTD_human_LHGDN
Myocardial Infarction 0.122367032 1 0 CTD_human_GAD
Pulmonary Embolism 0.12 1 0 CTD_human
Peripheral Vascular Diseases 0.12 1 0 CTD_human
Malignant neoplasm of prostate 0.015363904 18 0 BeFree_GAD
Prostate carcinoma 0.003528744 13 0 BeFree
Carcinoma, Transitional Cell 0.002995792 2 0 BeFree_LHGDN
Mammary Neoplasms 0.00272435 1 0 LHGDN

基因相关服务

基因相关服务

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