CLEC14A (C-type lectin domain containing 14A)
- symbol:
- CLEC14A
- locus group:
- protein-coding gene
- location:
- 14q21.1
- gene_family:
- C-type lectin domain family
- alias symbol:
- None
- alias name:
- None
- entrez id:
- 161198
- ensembl gene id:
- ENSG00000176435
- ucsc gene id:
- uc001wum.3
- refseq accession:
- NM_175060
- hgnc_id:
- HGNC:19832
- approved reserved:
- 2003-01-13
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. This family member plays a role in cell-cell adhesion and angiogenesis. It functions in filopodia formation, cell migration and tube formation. Due to its presence at higher levels in tumor endothelium than in normal tissue endothelium, it is considered to be a candidate for tumor vascular targeting. [provided by RefSeq, Jan 2012]
该基因编码超家族的C-型凝集素/ C-型凝集素样结构域（CTL / CTLD）的成员。这家人共享一个共同的蛋白折叠，并有不同的功能，例如细胞粘附，细胞 - 细胞信号传导，糖蛋白周转和角色在炎症和免疫反应的成员。该家族成员在细胞 - 细胞粘附和血管生成的作用。它的功能在丝状伪足形成，细胞迁移和管形成。由于其在肿瘤内皮更高水平比正常组织中的内皮的存在，它被认为是对肿瘤血管靶向的候选物。 [由RefSeq的，2012年1月提供]
基因本体信息
CLEC14A基因（以及对应的蛋白质）的细胞分布位置：
- 质膜
- 细胞质
- 细胞外
- 高尔基体
- 囊泡
- 细胞骨架
- 内质网
- 细胞核
- 内体
- 溶酶体
- 线粒体
CLEC14A基因的本体（GO）信息：
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Coronary Artery Vasospasm | 0.002367032 | 1 | 1 | GAD |
| Diabetes Mellitus, Non-Insulin-Dependent | 0.002367032 | 1 | 2 | GAD |
| tumor vasculature | 0.000271442 | 1 | 0 | BeFree |
| Solid tumour | 0.000271442 | 1 | 0 | BeFree |
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