CLCA2 (chloride channel accessory 2)

基因基本信息

基因基本信息

symbol:
CLCA2
locus group:
protein-coding gene
location:
1p22.3
gene_family:
Chloride channel accessory
alias symbol:
CLCRG2
alias name:
None
entrez id:
9635
ensembl gene id:
ENSG00000137975
ucsc gene id:
uc001dlr.5
refseq accession:
NM_006536
hgnc_id:
HGNC:2016
approved reserved:
1998-09-29

基因染色体位置

基因染色体位置

1p22.3
基因染色体位置图

基因简述

基因简述

The protein encoded by this gene belongs to the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same site on chromosome 1p31-p22 and share high degrees of homology in size, sequence and predicted structure, but differ significantly in their tissue distributions. Since this protein is expressed predominantly in trachea and lung, it is suggested to play a role in the complex pathogenesis of cystic fibrosis. It may also serve as adhesion molecule for lung metastatic cancer cells, mediating vascular arrest and colonization, and furthermore, it has been implicated to act as a tumor suppressor gene for breast cancer. [provided by RefSeq, Jul 2008]

None

OMIM数据库中对CCND1基因的介绍     Wikipedia数据库中对CCND1基因的介绍

基因序列

基因序列

CCND1基因的碱基序列：[NCBI]
Loading Gene Browser...

基因突变

基因突变

CLCA2基因的碱基突变：           仅显示部分snp
rs16908       rs883200       rs956499       rs969786       rs969787       rs969788       rs969789       rs969790       rs1052465       rs1158505       rs1158506       rs1158833       rs1334138       rs1334142       rs1334143       rs1334144       rs1334145      

基因表达

基因表达

CLCA2基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向Tm值
反向引物序列
反向Tm值
评分
AAGAAAGGATTTGAGGTGGT
57
CTTATCATCTCCGCTGGTC
58
TGCATGTCAATCACTCTCC
58
CTGAATATTACCGTTTGCTGTG
58
CTCATTCTGCACATACAGCA
58
ATAACATCAGCACCTGGCT
59
ATTATCACGTCTTACAGGAGGT
59
CTACTGAAAGCATCAATCATGC
58
CAGCTAAGCTTAGAAGATTCGC
60
ATGGCCAAGGCAATAAATCAG
59
CAACAATTCACTCCATTGCC
58
ACTTTAAACCTCCTGTAAGACG
58
GCATGTCAATCACTCTCCC
58
CTGAATATTACCGTTTGCTGTG
58
ACAGCTAAGCTTAGAAGATTCG
58
TGGCCAAGGCAATAAATCAG
59
TTTCATATCTGCCCACCAC
58
TTTCAACCACCTCAAATCCT
57
TCATTCTGCACATACAGCA
57
TATAACATCAGCACCTGGC
57

转录因子

转录因子

      尚未收录相关数据

基因本体信息

CLCA2基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 质膜
  • 细胞质
  • 细胞外
  • 高尔基体
  • 囊泡
  • 细胞骨架
  • 内质网
  • 细胞核
  • 内体
  • 溶酶体
  • 线粒体

CLCA2基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0004222
Q9UQC9 (UniProtKB)
TAS
GO:0005229
Q9UQC9 (UniProtKB)
IEA
GO:0005254
Q9UQC9 (UniProtKB)
TAS
GO:0005576
Q9UQC9 (UniProtKB)
IEA
GO:0005634
Q9UQC9 (UniProtKB)
IDA
GO:0005886
Q9UQC9 (UniProtKB)
TAS
GO:0005887
Q9UQC9 (UniProtKB)
TAS
GO:0006508
Q9UQC9 (UniProtKB)
IEA
GO:0006810
Q9UQC9 (UniProtKB)
TAS
GO:0007155
Q9UQC9 (UniProtKB)
IEA
GO:0009925
Q9UQC9 (UniProtKB)
IEA
GO:0015276
Q9UQC9 (UniProtKB)
IEA
GO:0030054
Q9UQC9 (UniProtKB)
IDA
GO:0034220
Q9UQC9 (UniProtKB)
TAS
GO:0046872
Q9UQC9 (UniProtKB)
IEA
GO:1902476
Q9UQC9 (UniProtKB)
IEA

基因相关microRNA

基因相关microRNA

可能调控 CLCA2基因的相关microRNA：     

基因相互作用关系

基因相互作用关系

BioGrid

IntAct

mentha

String

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因通路

基因通路

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Crohn Disease 0.12 1 1 GWASCAT
Malignant neoplasm of breast 0.005819831 5 0 BeFree_GAD
Breast Carcinoma 0.001085767 4 0 BeFree
Mammary Neoplasms 0.000814326 3 0 BeFree
Neoplasm Metastasis 0.000814326 3 0 BeFree
Erythema Nodosum 0.000271442 1 0 BeFree
Adenocarcinoma of lung (disorder) 0.000271442 1 0 BeFree
Adenocarcinoma 0.000271442 1 0 BeFree
Squamous cell carcinoma 0.000271442 1 0 BeFree
Malignant neoplasm of prostate 0.000271442 1 0 BeFree

基因相关服务

基因相关服务

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