CIB1 (calcium and integrin binding 1)

基因基本信息

基因基本信息

symbol:
CIB1
locus group:
protein-coding gene
location:
15q26.1
gene_family:
EF-hand domain containing
alias symbol:
SIP2-28|CIB|KIP
alias name:
calmyrin
entrez id:
10519
ensembl gene id:
ENSG00000185043
ucsc gene id:
uc002bpb.5
refseq accession:
NM_001277764
hgnc_id:
HGNC:16920
approved reserved:
2002-05-08

基因染色体位置

基因染色体位置

15q26.1
基因染色体位置图

基因简述

基因简述

CIB1（Calcium and Integrin Binding protein 1）是一种钙离子结合蛋白，属于EF-hand蛋白家族，该家族成员通常具有钙离子结合结构域（EF-hand motif），参与细胞信号传导和钙依赖性调控。CIB1的主要功能包括调节细胞迁移、增殖和凋亡，尤其在血小板激活和血管形成中起关键作用。它通过与整合素（如整合素αIIbβ3）结合，调控细胞黏附和细胞外基质相互作用。CIB1还参与DNA损伤修复，与ATM/ATR激酶通路相关，影响细胞周期检查点。突变或异常表达可能导致血小板功能障碍、血栓形成异常或肿瘤发生。例如，CIB1缺失会损害血小板聚集，而过表达可能促进肿瘤细胞侵袭和转移。CIB1在乳腺癌、胶质瘤等癌症中常过表达，与不良预后相关。其表达水平变化还可能影响其他基因（如p53、Rac1）的功能，干扰细胞骨架重组或凋亡通路。CIB1基因家族（EF-hand家族）的共性是通过钙离子感应传递信号，成员包括钙调蛋白（Calmodulin）和S100蛋白等，均参与细胞代谢、运动及应激响应。专业术语解释：EF-hand指一种螺旋-环-螺旋结构的钙结合模体；整合素是跨膜受体，介导细胞与基质的黏附；ATM/ATR是DNA损伤应答中的关键激酶。若存在翻译争议，"EF-hand"可保留英文原名。

This gene encodes a member of the EF-hand domain-containing calcium-binding superfamily. The encoded protein interacts with many other proteins, including the platelet integrin alpha-IIb-beta-3, DNA-dependent protein kinase, presenilin-2, focal adhesion kinase, p21 activated kinase, and protein kinase D. The encoded protein may be involved in cell survival and proliferation, and is associated with several disease states including cancer and Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013]

该基因编码的EF手结构域的钙结合超家族的成员。所编码的蛋白质与许多其它蛋白质，包括血小板整联的α-IIB-β-3，DNA依赖性蛋白激酶，早老-2，粘着斑激酶，p21的活化激酶和蛋白激酶D。所编码的蛋白质可能参与相互作用在细胞存活和增殖，并与几种疾病状态，包括癌症和阿尔茨海默氏病相关联。选择性剪接结果在多个抄本变形。 [由RefSeq的，2013年4月提供]

OMIM数据库中对CCND1基因的介绍     Wikipedia数据库中对CCND1基因的介绍

基因序列

基因序列

CCND1基因的碱基序列：[NCBI]
Loading Gene Browser...

基因突变

基因突变

CIB1基因的碱基突变：           仅显示部分snp
rs3932       rs881341       rs881342       rs1044813       rs1104971       rs1105702       rs1127801       rs1533327       rs1969246       rs1996179       rs2016746       rs2048706       rs2048707       rs2063738       rs2063739       rs2063740       rs2063741      

基因表达

基因表达

CIB1基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向Tm值
反向引物序列
反向Tm值
评分
CATTGACAGGGATGGAACC
58
TTAAAGGAGCTGGCAAAGTC
58
AGGAGATCCTCCTTTCTGTG
59
TGTGTTCATTCCCACTCCT
59
CATTGACAGGGATGGAACC
58
TTAAAGGAGCTGGCAAAGTC
59
GGGATGGAACCATCAACCT
59
GGACAATCTTAAAGGAGCTGG
58
GGGATGGAACCATCAACCT
59
GGACAATCTTAAAGGAGCTGG
59
AGGAGATCCTCCTTTCTGTG
59
GTTCATTCCCACTCCTTGC
59
GGATGGAACCATCAACCTC
57
AGGACAATCTTAAAGGAGCTG
57
AGATCCTCCTTTCTGTGTACG
59
TGTGTTCATTCCCACTCCT
59
GGATGGAACCATCAACCTC
58
AGGACAATCTTAAAGGAGCTG
58

转录因子

转录因子

      尚未收录相关数据

基因本体信息

CIB1基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 质膜
  • 细胞质
  • 细胞外
  • 高尔基体
  • 囊泡
  • 细胞骨架
  • 内质网
  • 细胞核
  • 内体
  • 溶酶体
  • 线粒体

CIB1基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0001525
Q99828 (UniProtKB)
IEA
GO:0001933
Q99828 (UniProtKB)
ISS
GO:0001934
Q99828 (UniProtKB)
ISS
GO:0001954
Q99828 (UniProtKB)
ISS
GO:0002931
Q99828 (UniProtKB)
ISS
GO:0005509
Q99828 (UniProtKB)
IMP
GO:0005515
Q99828 (UniProtKB)
IPI
GO:0005515
Q99828 (UniProtKB)
IPI
GO:0005515
Q99828 (UniProtKB)
IPI
GO:0005515
Q99828 (UniProtKB)
IPI
GO:0005515
Q99828 (UniProtKB)
IPI
GO:0005515
Q99828 (UniProtKB)
IPI
GO:0005515
Q99828 (UniProtKB)
IPI
GO:0005515
Q99828 (UniProtKB)
IPI
GO:0005515
Q99828 (UniProtKB)
IPI
GO:0005515
Q99828 (UniProtKB)
IPI
GO:0005515
Q99828 (UniProtKB)
IPI
GO:0005515
Q99828 (UniProtKB)
IPI
GO:0005515
Q99828 (UniProtKB)
IPI
GO:0005515
Q99828 (UniProtKB)
IPI
GO:0005634
Q99828 (UniProtKB)
IDA
GO:0005654
Q99828 (UniProtKB)
IDA
GO:0005654
Q99828 (UniProtKB)
IMP
GO:0005737
Q99828 (UniProtKB)
IMP
GO:0005737
Q99828 (UniProtKB)
IDA
GO:0005737
Q99828 (UniProtKB)
IDA
GO:0005737
Q99828 (UniProtKB)
IDA
GO:0005737
Q99828 (UniProtKB)
IDA
GO:0005783
Q99828 (UniProtKB)
IMP
GO:0005794
Q99828 (UniProtKB)
IEA
GO:0005813
Q99828 (UniProtKB)
IDA
GO:0005886
Q99828 (UniProtKB)
IDA
GO:0005886
Q99828 (UniProtKB)
IDA
GO:0005886
Q99828 (UniProtKB)
IDA
GO:0006302
Q99828 (UniProtKB)
TAS
GO:0006915
Q99828 (UniProtKB)
IMP
GO:0006974
Q99828 (UniProtKB)
IDA
GO:0007026
Q99828 (UniProtKB)
IDA
GO:0007113
Q99828 (UniProtKB)
IDA
GO:0007155
Q99828 (UniProtKB)
IEA
GO:0007286
Q99828 (UniProtKB)
ISS
GO:0008022
Q99828 (UniProtKB)
IEA
GO:0008284
Q99828 (UniProtKB)
ISS
GO:0008285
Q99828 (UniProtKB)
IMP
GO:0008427
Q99828 (UniProtKB)
IMP
GO:0010977
Q99828 (UniProtKB)
IDA
GO:0016020
Q99828 (UniProtKB)
IDA
GO:0016324
Q99828 (UniProtKB)
IEA
GO:0017016
Q99828 (UniProtKB)
IPI
GO:0019901
Q99828 (UniProtKB)
IEA
GO:0030027
Q99828 (UniProtKB)
IDA
GO:0030220
Q99828 (UniProtKB)
ISS
GO:0030291
Q99828 (UniProtKB)
IDA
GO:0030307
Q99828 (UniProtKB)
ISS
GO:0030335
Q99828 (UniProtKB)
ISS
GO:0030424
Q99828 (UniProtKB)
IEA
GO:0030425
Q99828 (UniProtKB)
IEA
GO:0030426
Q99828 (UniProtKB)
IDA
GO:0031122
Q99828 (UniProtKB)
IMP
GO:0031982
Q99828 (UniProtKB)
IDA
GO:0032433
Q99828 (UniProtKB)
IDA
GO:0032587
Q99828 (UniProtKB)
IEA
GO:0033630
Q99828 (UniProtKB)
IDA
GO:0038163
Q99828 (UniProtKB)
ISS
GO:0042127
Q99828 (UniProtKB)
IMP
GO:0042383
Q99828 (UniProtKB)
IDA
GO:0043005
Q99828 (UniProtKB)
IDA
GO:0043025
Q99828 (UniProtKB)
IDA
GO:0043066
Q99828 (UniProtKB)
IMP
GO:0043085
Q99828 (UniProtKB)
ISS
GO:0043495
Q99828 (UniProtKB)
IGI
GO:0044325
Q99828 (UniProtKB)
IEA
GO:0045653
Q99828 (UniProtKB)
ISS
GO:0048471
Q99828 (UniProtKB)
IDA
GO:0051092
Q99828 (UniProtKB)
IMP
GO:0051301
Q99828 (UniProtKB)
IEA
GO:0051302
Q99828 (UniProtKB)
IMP
GO:0051898
Q99828 (UniProtKB)
ISS
GO:0070062
Q99828 (UniProtKB)
IDA
GO:0070062
Q99828 (UniProtKB)
IDA
GO:0070062
Q99828 (UniProtKB)
IDA
GO:0070062
Q99828 (UniProtKB)
IDA
GO:0070374
Q99828 (UniProtKB)
ISS
GO:0070886
Q99828 (UniProtKB)
IDA
GO:0071356
Q99828 (UniProtKB)
IMP
GO:0071363
Q99828 (UniProtKB)
ISS
GO:0071901
Q99828 (UniProtKB)
IEA
GO:0071902
Q99828 (UniProtKB)
ISS
GO:0071944
Q99828 (UniProtKB)
IDA
GO:0071944
Q99828 (UniProtKB)
IDA
GO:0090004
Q99828 (UniProtKB)
IGI
GO:0090050
Q99828 (UniProtKB)
ISS
GO:0090314
Q99828 (UniProtKB)
IMP
GO:0097191
Q99828 (UniProtKB)
TAS
GO:1900026
Q99828 (UniProtKB)
IDA
GO:1990090
Q99828 (UniProtKB)
IDA
GO:2000256
Q99828 (UniProtKB)
ISS

基因相关microRNA

基因相关microRNA

可能调控 CIB1基因的相关microRNA：     

基因相互作用关系

基因相互作用关系

MINT

BioGrid

IntAct

mentha

String

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因通路

基因通路

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Alzheimer's Disease 0.08 1 0 RGD
Malignant neoplasm of breast 0.009500466 35 0 BeFree
Breast Carcinoma 0.009229024 34 0 BeFree
Carcinogenesis 0.006514605 24 0 BeFree
Liver carcinoma 0.005700279 21 0 BeFree
Prostate carcinoma 0.005428837 20 0 BeFree
Malignant neoplasm of prostate 0.004885954 18 0 BeFree
Non-Small Cell Lung Carcinoma 0.003257302 12 0 BeFree
Colorectal Carcinoma 0.003257302 12 0 BeFree
Malignant neoplasm of stomach 0.002985861 11 0 BeFree

基因相关服务

基因相关服务

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