CHUK (component of inhibitor of nuclear factor kappa B kinase complex)

基因基本信息

基因基本信息

symbol:
CHUK
locus group:
protein-coding gene
location:
10q24.31
gene_family:
alias symbol:
IKK1|IKK-alpha|IkBKA|NFKBIKA|IKKA
alias name:
inhibitor of nuclear factor kappa-…
entrez id:
1147
ensembl gene id:
ENSG00000213341
ucsc gene id:
uc001kqp.4
refseq accession:
NM_001278
hgnc_id:
HGNC:1974
approved reserved:
1995-03-15

基因染色体位置

基因染色体位置

10q24.31
基因染色体位置图

基因简述

基因简述

CHUK（也称为IKKα或IKK1）是IκB激酶（IKK）复合物的一个关键亚基，属于IKK蛋白激酶家族。该家族还包括IKKβ（IKK2）和IKKγ（NEMO），它们共同参与调控NF-κB信号通路，这是细胞中重要的炎症、免疫反应和细胞存活的调控途径。CHUK的主要功能是通过磷酸化IκB蛋白（NF-κB的抑制因子），促进IκB的降解，从而释放NF-κB进入细胞核激活靶基因的转录。CHUK不仅在经典NF-κB通路中发挥作用，还参与非经典NF-κB通路的激活，特别是在淋巴器官发育和表皮分化中起关键作用。CHUK的突变或功能异常与多种疾病相关，例如其功能丧失突变可能导致罕见的遗传性疾病，如外胚层发育不良伴免疫缺陷，表现为皮肤异常、毛发缺失和免疫系统功能受损。此外，CHUK的异常表达还与炎症性疾病、自身免疫疾病和某些癌症（如乳腺癌和鳞状细胞癌）的发生发展相关。CHUK过表达可能导致NF-κB信号通路的持续激活，进而促进炎症反应和细胞增殖，增加肿瘤发生的风险；而CHUK表达降低则可能削弱免疫反应和表皮屏障功能，导致感染易感性和皮肤病变。在基因家族中，IKK成员均含有激酶结构域，能够通过磷酸化作用调控下游信号分子，但CHUK与IKKβ在功能上有所分工，CHUK更侧重于非经典通路和发育调控，而IKKβ主要参与炎症和免疫反应的经典通路。研究CHUK的功能和调控机制对于理解炎症、免疫相关疾病及癌症的发病机制具有重要意义，同时也为开发靶向药物提供了潜在方向。

This gene encodes a member of the serine/threonine protein kinase family. The encoded protein, a component of a cytokine-activated protein complex that is an inhibitor of the essential transcription factor NF-kappa-B complex, phosphorylates sites that trigger the degradation of the inhibitor via the ubiquination pathway, thereby activating the transcription factor. [provided by RefSeq, Jul 2008]

该基因编码的丝氨酸/苏氨酸蛋白激酶家族的一个成员。编码的蛋白质，细胞因子活化的蛋白复合物，它是必不可少的转录因子NF-κ-B复合的抑制剂的组分，磷酸经由泛素化途径触发抑制剂的降解，从而激活转录因子的网站。 [由RefSeq的，2008年7月提供]

OMIM数据库中对CHUK基因的介绍     Wikipedia数据库中对CHUK基因的介绍

基因序列

基因序列

CHUK基因的碱基序列：[NCBI]
Loading Gene Browser...

基因突变

基因突变

CHUK基因的碱基突变：           仅显示部分snp
rs185855       rs986266       rs1138511       rs1138512       rs1138516       rs1260483       rs1324694       rs1327575       rs1327578       rs1408578       rs1823624       rs1827454       rs2230803       rs2230804       rs2274173       rs2274174       rs2274175      

基因表达

基因表达

CHUK基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向Tm值
反向引物序列
反向Tm值
评分
GACAATACTGTCATGTTCATGC
58
CAGAACTCTGTGTACAGGC
58
TCATGCAGTTGCACATTCTG
60
GAAGTCTCCCTGATATCAGCT
59
GAAGCAGTGCACTATGTGTC
59
AAGACTTAACATTGCTGCCC
59
TCTAGAAGGGAGACTTCAGC
58
CCTGTTCCTCATTTGCCTC
59
CATGATCATTCTCTGTCATGTG
57
TATCATTTGTGCTGAAGTCTCC
59
GCAGAACATGATCATTCTCTGTC
60
CATTTGTGCTGAAGTCTCCC
59
TTGCATGCTGAAATCATGGAG
60
ACGCTGTTCCAGAGATTCC
60
GCAGAACATGATCATTCTCTG
57
ATTTGTGCTGAAGTCTCCC
58
CAATACTGTCATGTTCATGCAG
58
GCAGAACTCTGTGTACAGG
58
CATGATCATTCTCTGTCATGTG
57
ATCATTTGTGCTGAAGTCTCC
59

转录因子

转录因子

转录因子
影响基因
影响类型
参考文献链接（PubMed）
ETS1
CHUK
Activation
15469934
TP53
CHUK
Repression
15469934

基因本体信息

CHUK基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 质膜
  • 细胞质
  • 细胞外
  • 高尔基体
  • 囊泡
  • 细胞骨架
  • 内质网
  • 细胞核
  • 内体
  • 溶酶体
  • 线粒体

CHUK基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0002223
O15111 (UniProtKB)
TAS
GO:0003009
O15111 (UniProtKB)
IEA
GO:0004672
O15111 (UniProtKB)
IDA
GO:0005515
O15111 (UniProtKB)
IPI
GO:0005515
O15111 (UniProtKB)
IPI
GO:0005515
O15111 (UniProtKB)
IPI
GO:0005515
O15111 (UniProtKB)
IPI
GO:0005515
O15111 (UniProtKB)
IPI
GO:0005515
O15111 (UniProtKB)
IPI
GO:0005515
O15111 (UniProtKB)
IPI
GO:0005515
O15111 (UniProtKB)
IPI
GO:0005515
O15111 (UniProtKB)
IPI
GO:0005515
O15111 (UniProtKB)
IPI
GO:0005515
O15111 (UniProtKB)
IPI
GO:0005515
O15111 (UniProtKB)
IPI
GO:0005515
O15111 (UniProtKB)
IPI
GO:0005515
O15111 (UniProtKB)
IPI
GO:0005515
O15111 (UniProtKB)
IPI
GO:0005515
O15111 (UniProtKB)
IPI
GO:0005515
O15111 (UniProtKB)
IPI
GO:0005515
O15111 (UniProtKB)
IPI
GO:0005515
O15111 (UniProtKB)
IPI
GO:0005515
O15111 (UniProtKB)
IPI
GO:0005515
O15111 (UniProtKB)
IPI
GO:0005515
O15111 (UniProtKB)
IPI
GO:0005515
O15111 (UniProtKB)
IPI
GO:0005515
O15111 (UniProtKB)
IPI
GO:0005515
O15111 (UniProtKB)
IPI
GO:0005515
O15111 (UniProtKB)
IPI
GO:0005515
O15111 (UniProtKB)
IPI
GO:0005515
O15111 (UniProtKB)
IPI
GO:0005515
O15111 (UniProtKB)
IPI
GO:0005515
O15111 (UniProtKB)
IPI
GO:0005515
O15111 (UniProtKB)
IPI
GO:0005515
O15111 (UniProtKB)
IPI
GO:0005515
O15111 (UniProtKB)
IPI
GO:0005515
O15111 (UniProtKB)
IPI
GO:0005515
O15111 (UniProtKB)
IPI
GO:0005515
O15111 (UniProtKB)
IPI
GO:0005515
O15111 (UniProtKB)
IPI
GO:0005515
O15111 (UniProtKB)
IPI
GO:0005515
O15111 (UniProtKB)
IPI
GO:0005515
O15111 (UniProtKB)
IPI
GO:0005515
O15111 (UniProtKB)
IPI
GO:0005515
O15111 (UniProtKB)
IPI
GO:0005515
O15111 (UniProtKB)
IPI
GO:0005515
O15111 (UniProtKB)
IPI
GO:0005515
O15111 (UniProtKB)
IPI
GO:0005515
O15111 (UniProtKB)
IPI
GO:0005515
O15111 (UniProtKB)
IPI
GO:0005515
O15111 (UniProtKB)
IPI
GO:0005515
O15111 (UniProtKB)
IPI
GO:0005515
O15111 (UniProtKB)
IPI
GO:0005515
O15111 (UniProtKB)
IPI
GO:0005515
O15111 (UniProtKB)
IPI
GO:0005515
O15111 (UniProtKB)
IPI
GO:0005515
O15111 (UniProtKB)
IPI
GO:0005515
O15111 (UniProtKB)
IPI
GO:0005515
O15111 (UniProtKB)
IPI
GO:0005515
O15111 (UniProtKB)
IPI
GO:0005515
O15111 (UniProtKB)
IPI
GO:0005515
O15111 (UniProtKB)
IPI
GO:0005515
O15111 (UniProtKB)
IPI
GO:0005515
O15111 (UniProtKB)
IPI
GO:0005515
O15111 (UniProtKB)
IPI
GO:0005515
O15111 (UniProtKB)
IPI
GO:0005515
O15111 (UniProtKB)
IPI
GO:0005515
O15111 (UniProtKB)
IPI
GO:0005515
O15111 (UniProtKB)
IPI
GO:0005515
O15111 (UniProtKB)
IPI
GO:0005515
O15111 (UniProtKB)
IPI
GO:0005515
O15111 (UniProtKB)
IPI
GO:0005515
O15111 (UniProtKB)
IPI
GO:0005515
O15111 (UniProtKB)
IPI
GO:0005515
O15111 (UniProtKB)
IPI
GO:0005515
O15111 (UniProtKB)
IPI
GO:0005524
O15111 (UniProtKB)
IEA
GO:0005654
O15111 (UniProtKB)
IDA
GO:0005737
O15111 (UniProtKB)
IDA
GO:0005829
O15111 (UniProtKB)
TAS
GO:0005829
O15111 (UniProtKB)
TAS
GO:0005829
O15111 (UniProtKB)
TAS
GO:0005829
O15111 (UniProtKB)
TAS
GO:0005829
O15111 (UniProtKB)
TAS
GO:0005829
O15111 (UniProtKB)
TAS
GO:0005829
O15111 (UniProtKB)
TAS
GO:0005829
O15111 (UniProtKB)
TAS
GO:0005829
O15111 (UniProtKB)
TAS
GO:0005829
O15111 (UniProtKB)
TAS
GO:0005829
O15111 (UniProtKB)
TAS
GO:0005829
O15111 (UniProtKB)
TAS
GO:0005829
O15111 (UniProtKB)
TAS
GO:0005829
O15111 (UniProtKB)
TAS
GO:0005829
O15111 (UniProtKB)
TAS
GO:0005829
O15111 (UniProtKB)
TAS
GO:0005829
O15111 (UniProtKB)
TAS
GO:0005829
O15111 (UniProtKB)
TAS
GO:0005829
O15111 (UniProtKB)
TAS
GO:0005829
O15111 (UniProtKB)
TAS
GO:0005829
O15111 (UniProtKB)
TAS
GO:0005829
O15111 (UniProtKB)
TAS
GO:0005829
O15111 (UniProtKB)
TAS
GO:0005829
O15111 (UniProtKB)
TAS
GO:0005829
O15111 (UniProtKB)
TAS
GO:0005829
O15111 (UniProtKB)
TAS
GO:0005829
O15111 (UniProtKB)
TAS
GO:0005829
O15111 (UniProtKB)
TAS
GO:0005829
O15111 (UniProtKB)
TAS
GO:0005829
O15111 (UniProtKB)
TAS
GO:0005829
O15111 (UniProtKB)
TAS
GO:0006468
O15111 (UniProtKB)
IDA
GO:0006954
O15111 (UniProtKB)
TAS
GO:0006955
O15111 (UniProtKB)
TAS
GO:0007249
O15111 (UniProtKB)
TAS
GO:0007249
O15111 (UniProtKB)
TAS
GO:0007252
O15111 (UniProtKB)
IEA
GO:0007266
O15111 (UniProtKB)
IEA
GO:0008384
O15111 (UniProtKB)
TAS
GO:0008385
O15111 (UniProtKB)
TAS
GO:0009615
O15111 (UniProtKB)
TAS
GO:0009636
O15111 (UniProtKB)
IEA
GO:0009653
O15111 (UniProtKB)
TAS
GO:0009898
O15111 (UniProtKB)
ISS
GO:0010034
O15111 (UniProtKB)
IEA
GO:0010803
O15111 (UniProtKB)
TAS
GO:0032496
O15111 (UniProtKB)
IEA
GO:0033194
O15111 (UniProtKB)
IEA
GO:0035631
O15111 (UniProtKB)
ISS
GO:0035666
O15111 (UniProtKB)
TAS
GO:0038061
O15111 (UniProtKB)
TAS
GO:0038095
O15111 (UniProtKB)
TAS
GO:0042493
O15111 (UniProtKB)
IEA
GO:0042803
O15111 (UniProtKB)
IDA
GO:0043123
O15111 (UniProtKB)
TAS
GO:0043200
O15111 (UniProtKB)
IEA
GO:0043231
O15111 (UniProtKB)
IDA
GO:0045087
O15111 (UniProtKB)
TAS
GO:0045944
O15111 (UniProtKB)
IDA
GO:0046982
O15111 (UniProtKB)
IDA
GO:0050852
O15111 (UniProtKB)
TAS
GO:0051092
O15111 (UniProtKB)
TAS
GO:0051092
O15111 (UniProtKB)
TAS
GO:0051146
O15111 (UniProtKB)
IEA
GO:0051403
O15111 (UniProtKB)
TAS
GO:0070423
O15111 (UniProtKB)
TAS
GO:0071356
O15111 (UniProtKB)
IDA
GO:0097110
O15111 (UniProtKB)
IDA

基因相关microRNA

基因相关microRNA

可能调控 CHUK基因的相关microRNA：     

基因相互作用关系

基因相互作用关系

Reactome

MINT

BioGrid

IntAct

mentha

String

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因通路

基因通路

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
COCOON SYNDROME 0.320271442 1 1 BeFree_CLINVAR_CTD_human_MGD
Bone Diseases, Developmental 0.12 1 0 CTD_human
Skin Abnormalities 0.12 3 0 CTD_human
Fetal Diseases 0.12 4 0 CTD_human
Cleft Palate 0.12 1 0 CTD_human
Limb Deformities, Congenital 0.12 4 0 CTD_human
IGA Glomerulonephritis 0.12 1 0 CTD_human
Muscular Atrophy 0.08 1 0 RGD
Colitis 0.08 1 0 RGD
Prostatic Neoplasms 0.0054487 2 0 LHGDN

基因相关服务

基因相关服务

联系方式

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