CHN2 (chimerin 2)

基因基本信息

基因基本信息

symbol:
CHN2
locus group:
protein-coding gene
location:
7p14.3
gene_family:
Rho GTPase activating proteins|SH2 domain containing
alias symbol:
ARHGAP3|RhoGAP3
alias name:
beta chimerin|chimaerin 2
entrez id:
1124
ensembl gene id:
ENSG00000106069
ucsc gene id:
uc003szz.4
refseq accession:
NM_004067
hgnc_id:
HGNC:1944
approved reserved:
1997-08-28

基因染色体位置

基因染色体位置

7p14.3
基因染色体位置图

基因简述

基因简述

This gene encodes a guanosine triphosphate (GTP)-metabolizing protein that contains a phorbol-ester/diacylglycerol (DAG)-type zinc finger, a Rho-GAP domain, and an SH2 domain. The encoded protein translocates from the cytosol to the Golgi apparatus membrane upon binding by diacylglycerol (DAG). Activity of this protein is important in cell proliferation and migration, and expression changes in this gene have been detected in cancers. A mutation in this gene has also been associated with schizophrenia in men. Alternative transcript splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, May 2014]

None

OMIM数据库中对CCND1基因的介绍     Wikipedia数据库中对CCND1基因的介绍

基因序列

基因序列

CCND1基因的碱基序列：[NCBI]
Loading Gene Browser...

基因突变

基因突变

CHN2基因的碱基突变：           仅显示部分snp
rs446       rs12611       rs28467       rs39047       rs39048       rs39049       rs39050       rs39051       rs39052       rs39053       rs39054       rs39055       rs39056       rs39057       rs39058       rs39059       rs39060      

基因表达

基因表达

CHN2基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向Tm值
反向引物序列
反向Tm值
评分
GGCATTTGACAGAGATGGTG
59
TACAGTTTAAGGGCTCCAGTG
60
AATACCAGCCTCCTATATGGA
58
CTGTTAAATTTCTCCCGAGGA
58
TCATATCAATGGCTGGGCT
59
CTGCTGTTAAATTTCTGTTCCC
58
ATGAGATCCTGGGACAACC
59
GATTAGCAGAAACCAAGGGC
59
CGATGCTGAAGAATACCAGC
59
GAGATGATCCCATGAAACTCTC
58
AAAGAGCAGGGACAGAGTC
59
ATGCCATGACTGTGTCCTC
60
GGCATTTGACAGAGATGGTG
59
TACAGTTTAAGGGCTCCAGTG
60
ACAAATAAATAGCGGCGGC
59
ATTCTTCAGCATCGGAGGA
59
CCATTCAGATGCTGAAGAATACC
60
ATTCTCTTGGGACGAGGTG
59
CATGCTGGAAGAAGCAAGC
60
CTTGCAAGTAAGTCCTGAATGG
60

转录因子

转录因子

      尚未收录相关数据

基因本体信息

CHN2基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 质膜
  • 细胞质
  • 细胞外
  • 高尔基体
  • 囊泡
  • 细胞骨架
  • 内质网
  • 细胞核
  • 内体
  • 溶酶体
  • 线粒体

CHN2基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0007165
A0A0A0MTI3 (UniProtKB)
IEA
GO:0005622
B3VCF4 (UniProtKB)
IEA
GO:0035556
B3VCF4 (UniProtKB)
IEA
GO:0005622
B3VCF5 (UniProtKB)
IEA
GO:0035556
B3VCF5 (UniProtKB)
IEA
GO:0046872
B3VCF5 (UniProtKB)
IEA
GO:0005622
B3VCF6 (UniProtKB)
IEA
GO:0035556
B3VCF6 (UniProtKB)
IEA
GO:0046872
B3VCF6 (UniProtKB)
IEA
GO:0007165
B3VCG2 (UniProtKB)
IEA
GO:0007165
B3VCG4 (UniProtKB)
IEA
GO:0005622
H7C0V3 (UniProtKB)
IEA
GO:0035556
H7C0V3 (UniProtKB)
IEA
GO:0046872
H7C0V3 (UniProtKB)
IEA
GO:0007165
H7C138 (UniProtKB)
IEA
GO:0005070
P52757 (UniProtKB)
TAS
GO:0005096
P52757 (UniProtKB)
TAS
GO:0005515
P52757 (UniProtKB)
IPI
GO:0005737
P52757 (UniProtKB)
IBA
GO:0005829
P52757 (UniProtKB)
TAS
GO:0009967
P52757 (UniProtKB)
IEA
GO:0016020
P52757 (UniProtKB)
IEA
GO:0035556
P52757 (UniProtKB)
IEA
GO:0043547
P52757 (UniProtKB)
IEA
GO:0046872
P52757 (UniProtKB)
IEA
GO:0051056
P52757 (UniProtKB)
TAS

基因相关microRNA

基因相关microRNA

可能调控 CHN2基因的相关microRNA：     

基因相互作用关系

基因相互作用关系

Reactome

MINT

BioGrid

IntAct

mentha

String

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因通路

基因通路

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Precancerous Conditions 0.12 1 0 CTD_human
Liver neoplasms 0.12 1 0 CTD_human
Tobacco Use Disorder 0.004734064 2 0 GAD
Mammary Neoplasms 0.00272435 1 0 LHGDN
Diabetes Mellitus, Non-Insulin-Dependent 0.002638474 2 1 BeFree_GAD
Asthma 0.002367032 1 0 GAD
Diabetic Retinopathy 0.000542884 2 1 BeFree
Neuroblastoma 0.000271442 1 0 BeFree
Acquired CJD 0.000271442 1 0 BeFree
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma 0.000271442 1 0 BeFree

基因相关服务

基因相关服务

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