CHEK1 (checkpoint kinase 1)

基因基本信息

基因基本信息

symbol:
CHEK1
locus group:
protein-coding gene
location:
11q24.2
gene_family:
alias symbol:
CHK1
alias name:
None
entrez id:
1111
ensembl gene id:
ENSG00000149554
ucsc gene id:
uc001qcf.5
refseq accession:
NM_001274
hgnc_id:
HGNC:1925
approved reserved:
1998-04-21

基因染色体位置

基因染色体位置

11q24.2
基因染色体位置图

基因简述

基因简述

CHEK1（检查点激酶1）是一种关键的细胞周期调控基因，属于丝氨酸/苏氨酸激酶家族，与DNA损伤应答和细胞周期检查点密切相关。它主要在G2/M检查点发挥作用，当DNA受损时，CHEK1被上游激酶ATR磷酸化激活，进而磷酸化下游靶蛋白如CDC25C，阻止细胞进入有丝分裂，为DNA修复争取时间。CHEK1还参与S期检查点调控，确保DNA复制顺利完成。该基因的突变可能导致检查点功能缺陷，使细胞在DNA损伤情况下仍继续分裂，增加基因组不稳定性，与多种癌症如乳腺癌、卵巢癌和结直肠癌的发生发展相关。CHEK1过表达常见于某些肿瘤，可能导致对DNA损伤药物的耐药性，而降低表达则使细胞对辐射和化疗药物更敏感，因此它成为癌症治疗的潜在靶点。CHEK1属于检查点激酶家族，该家族还包括CHEK2，它们共同特点是参与DNA损伤应答，但CHEK1主要响应复制压力，而CHEK2更多参与双链断裂修复。CHEK1在胚胎发育中也很重要，完全敲除会导致小鼠胚胎致死，表明其对细胞存活不可或缺。此外，CHEK1与多种蛋白如BRCA1、p53等相互作用，形成复杂的调控网络。针对CHEK1的小分子抑制剂如MK-8776正在临床试验中，用于增强化疗效果。

The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2011]

None

OMIM数据库中对CHEK1基因的介绍     Wikipedia数据库中对CHEK1基因的介绍

基因序列

基因序列

CHEK1基因的碱基序列：[NCBI]
Loading Gene Browser...

基因突变

基因突变

CHEK1基因的碱基突变：           仅显示部分snp
rs479195       rs565435       rs2282535       rs4935924       rs11220181       rs11220182       rs11434532       rs17141326       rs36034937       rs74524543       rs76114742       rs76133534       rs76744140       rs77913417       rs79534074       rs80176214       rs80262452      

基因表达

基因表达

CHEK1基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向Tm值
反向引物序列
反向Tm值
评分
GTACTGTAGTGGAGGAGAGC
59
CCATGCAGATAAACCACCC
59
CAGGATCCTCACAGAACCC
60
CTCACAAGTCTCTTTCAGGC
59
ATTTGGATTCCTGCAGTGG
58
TGTCTGGCTTCTCCATAGG
59
CTATGGAGAAGTTCAACTTGCT
59
TTTCTGGACAGTCTACGGC
59
GAGAAGCCAGACATAGGCA
59
ATACCATGCAGATAAACCACC
58
GGTTTATCTGCATGGTATTGGA
59
TTGAGGTTATCCCTTTCATCCA
59
TATGGAGAAGTTCAACTTGCTG
59
CAATCTTCACTGCGACTGC
60
TTCCGGCTTTCTAAGGGTG
60
GGCTGCTCACAATATCAATCAG
60
CAGAATAGAGCCAGACATAGG
58
GAGTTATTCCAATACCATGCAG
57
GTTGATGTTTGGTCCTGTGG
60
TCCCATGGCAATTCTCCAG
60

转录因子

转录因子

转录因子
影响基因
影响类型
参考文献链接（PubMed）
BCL6
CHEK1
Repression
18346918
E2F1
CHEK1
Unknown
18660752
MYC
CHEK1
Activation
23269272
TP53
CHEK1
Repression
15016801
TP53
CHEK1
Unknown
11152453

基因本体信息

CHEK1基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 质膜
  • 细胞质
  • 细胞外
  • 高尔基体
  • 囊泡
  • 细胞骨架
  • 内质网
  • 细胞核
  • 内体
  • 溶酶体
  • 线粒体

CHEK1基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0004672
A0A087WT52 (UniProtKB)
IEA
GO:0005524
A0A087WT52 (UniProtKB)
IEA
GO:0006468
A0A087WT52 (UniProtKB)
IEA
GO:0004672
E7EPP6 (UniProtKB)
IEA
GO:0005524
E7EPP6 (UniProtKB)
IEA
GO:0005654
E7EPP6 (UniProtKB)
IDA
GO:0006468
E7EPP6 (UniProtKB)
IEA
GO:0043231
E7EPP6 (UniProtKB)
IDA
GO:0004674
E9PJI4 (UniProtKB)
IEA
GO:0005524
E9PJI4 (UniProtKB)
IEA
GO:0006468
E9PJI4 (UniProtKB)
IEA
GO:0004674
E9PKQ3 (UniProtKB)
IEA
GO:0005524
E9PKQ3 (UniProtKB)
IEA
GO:0006468
E9PKQ3 (UniProtKB)
IEA
GO:0004672
E9PM65 (UniProtKB)
IEA
GO:0005524
E9PM65 (UniProtKB)
IEA
GO:0006468
E9PM65 (UniProtKB)
IEA
GO:0004672
E9PPA5 (UniProtKB)
IEA
GO:0005524
E9PPA5 (UniProtKB)
IEA
GO:0006468
E9PPA5 (UniProtKB)
IEA
GO:0004672
E9PQW7 (UniProtKB)
IEA
GO:0005524
E9PQW7 (UniProtKB)
IEA
GO:0006468
E9PQW7 (UniProtKB)
IEA
GO:0004674
J3KN87 (UniProtKB)
IEA
GO:0005524
J3KN87 (UniProtKB)
IEA
GO:0005654
J3KN87 (UniProtKB)
IDA
GO:0006468
J3KN87 (UniProtKB)
IEA
GO:0043231
J3KN87 (UniProtKB)
IDA
GO:0000077
O14757 (UniProtKB)
IDA
GO:0000077
O14757 (UniProtKB)
IMP
GO:0000086
O14757 (UniProtKB)
IEA
GO:0000785
O14757 (UniProtKB)
ISS
GO:0000794
O14757 (UniProtKB)
IDA
GO:0004672
O14757 (UniProtKB)
IMP
GO:0004674
O14757 (UniProtKB)
IDA
GO:0004674
O14757 (UniProtKB)
TAS
GO:0004674
O14757 (UniProtKB)
TAS
GO:0004674
O14757 (UniProtKB)
TAS
GO:0004674
O14757 (UniProtKB)
TAS
GO:0005515
O14757 (UniProtKB)
IPI
GO:0005515
O14757 (UniProtKB)
IPI
GO:0005515
O14757 (UniProtKB)
IPI
GO:0005515
O14757 (UniProtKB)
IPI
GO:0005515
O14757 (UniProtKB)
IPI
GO:0005515
O14757 (UniProtKB)
IPI
GO:0005515
O14757 (UniProtKB)
IPI
GO:0005515
O14757 (UniProtKB)
IPI
GO:0005515
O14757 (UniProtKB)
IPI
GO:0005515
O14757 (UniProtKB)
IPI
GO:0005515
O14757 (UniProtKB)
IPI
GO:0005515
O14757 (UniProtKB)
IPI
GO:0005515
O14757 (UniProtKB)
IPI
GO:0005515
O14757 (UniProtKB)
IPI
GO:0005515
O14757 (UniProtKB)
IPI
GO:0005515
O14757 (UniProtKB)
IPI
GO:0005515
O14757 (UniProtKB)
IPI
GO:0005515
O14757 (UniProtKB)
IPI
GO:0005524
O14757 (UniProtKB)
IEA
GO:0005615
O14757 (UniProtKB)
IDA
GO:0005634
O14757 (UniProtKB)
IDA
GO:0005634
O14757 (UniProtKB)
IDA
GO:0005654
O14757 (UniProtKB)
IDA
GO:0005654
O14757 (UniProtKB)
TAS
GO:0005654
O14757 (UniProtKB)
TAS
GO:0005654
O14757 (UniProtKB)
TAS
GO:0005654
O14757 (UniProtKB)
TAS
GO:0005654
O14757 (UniProtKB)
TAS
GO:0005654
O14757 (UniProtKB)
TAS
GO:0005654
O14757 (UniProtKB)
TAS
GO:0005654
O14757 (UniProtKB)
TAS
GO:0005657
O14757 (UniProtKB)
IEA
GO:0005813
O14757 (UniProtKB)
IDA
GO:0005829
O14757 (UniProtKB)
TAS
GO:0006260
O14757 (UniProtKB)
TAS
GO:0006260
O14757 (UniProtKB)
TAS
GO:0006260
O14757 (UniProtKB)
TAS
GO:0006281
O14757 (UniProtKB)
IMP
GO:0006974
O14757 (UniProtKB)
IMP
GO:0006975
O14757 (UniProtKB)
IDA
GO:0010569
O14757 (UniProtKB)
IDA
GO:0010767
O14757 (UniProtKB)
ISS
GO:0016301
O14757 (UniProtKB)
TAS
GO:0018107
O14757 (UniProtKB)
IDA
GO:0031572
O14757 (UniProtKB)
IMP
GO:0035402
O14757 (UniProtKB)
IDA
GO:0035407
O14757 (UniProtKB)
IEA
GO:0042127
O14757 (UniProtKB)
IEA
GO:0043231
O14757 (UniProtKB)
IDA
GO:0045839
O14757 (UniProtKB)
IDA
GO:0046602
O14757 (UniProtKB)
IDA
GO:0048096
O14757 (UniProtKB)
ISS
GO:0071260
O14757 (UniProtKB)
IEP
GO:0090399
O14757 (UniProtKB)
NAS
GO:1901796
O14757 (UniProtKB)
TAS
GO:2000615
O14757 (UniProtKB)
ISS
GO:0000781
O14757 (UniProtKB)
IDA

基因相关microRNA

基因相关microRNA

可能调控 CHEK1基因的相关microRNA：     

基因相互作用关系

基因相互作用关系

Reactome

MINT

BioGrid

IntAct

mentha

String

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因通路

基因通路

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Mammary Neoplasms 0.120542884 3 0 BeFree_CTD_human
Polyploidy 0.12 1 0 CTD_human
Peripheral Neuropathy 0.12 1 0 CTD_human
IGA Glomerulonephritis 0.12 1 0 CTD_human
Malignant neoplasm of breast 0.020173913 28 1 BeFree_GAD
Fanconi Anemia 0.009801702 9 0 BeFree_LHGDN
Breast Carcinoma 0.006243163 23 1 BeFree
Malignant neoplasm of lung 0.006091273 7 0 BeFree_GAD
Colonic Neoplasms 0.005091382 1 0 GAD_LHGDN
DNA Damage 0.004734064 2 0 GAD

基因相关服务

基因相关服务

联系方式

山东省济南市章丘区文博路2号 齐鲁师范学院 genelibs生信实验室

山东省济南市高新区舜华路750号大学科技园北区F座4单元2楼

电话： 0531-88819269

E-mail: product@genelibs.com

微信公众号

关注微信订阅号，实时查看信息，关注医学生物学动态。

版权所有 © 2025.Genelibs 济南弘晖生物技术有限公司 鲁ICP备13024435号-2