CES3 (carboxylesterase 3)
- symbol:
- CES3
- locus group:
- protein-coding gene
- location:
- 16q22.1
- gene_family:
- Carboxylesterases
- alias symbol:
- FLJ21736|ES31
- alias name:
- esterase 31|brain carboxylesterase…
- entrez id:
- 23491
- ensembl gene id:
- ENSG00000172828
- ucsc gene id:
- uc002eqt.4
- refseq accession:
- NM_024922
- hgnc_id:
- HGNC:1865
- approved reserved:
- 1999-12-14
This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This gene is expressed in several tissues, particularly in colon, trachea and in brain, and the protein participates in colon and neural drug metabolism. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported, but the biological validity and/or full-length nature of some variants have not been determined.[provided by RefSeq, Jun 2010]
None
基因本体信息
CES3基因（以及对应的蛋白质）的细胞分布位置：
- 质膜
- 细胞质
- 细胞外
- 高尔基体
- 囊泡
- 细胞骨架
- 内质网
- 细胞核
- 内体
- 溶酶体
- 线粒体
CES3基因的本体（GO）信息：
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Liver Cirrhosis, Experimental | 0.12 | 1 | 0 | CTD_human |
| Myocardial Ischemia | 0.12 | 1 | 0 | CTD_human |
| Arteriosclerosis | 0.000271442 | 1 | 0 | BeFree |
| Atherosclerosis | 0.000271442 | 1 | 0 | BeFree |
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