CES3 (carboxylesterase 3)
- symbol:
- CES3
- locus group:
- protein-coding gene
- location:
- 16q22.1
- gene_family:
- Carboxylesterases
- alias symbol:
- FLJ21736|ES31
- alias name:
- esterase 31|brain carboxylesterase…
- entrez id:
- 23491
- ensembl gene id:
- ENSG00000172828
- ucsc gene id:
- uc002eqt.4
- refseq accession:
- NM_024922
- hgnc_id:
- HGNC:1865
- approved reserved:
- 1999-12-14
CES3（羧酸酯酶3）属于羧酸酯酶（CES）基因家族，该家族主要编码水解酶，参与酯类、酰胺类和硫酯类化合物的代谢。CES3主要在肝脏和小肠中表达，其编码的蛋白在药物代谢、脂质代谢和解毒过程中发挥重要作用。CES3通过水解内源性和外源性酯类化合物，帮助机体清除毒素并参与脂质吸收与储存。该基因的突变可能导致酶活性改变，影响药物代谢效率或脂质代谢紊乱，与肥胖、糖尿病和某些药物不良反应相关。CES3过表达可能增强某些药物的代谢速率，降低药效，或干扰正常脂质代谢；而表达降低可能导致毒素积累或脂质代谢异常。CES基因家族的共性包括水解酶活性、参与药物和脂质代谢、在肝脏和肠道高表达。
This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This gene is expressed in several tissues, particularly in colon, trachea and in brain, and the protein participates in colon and neural drug metabolism. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported, but the biological validity and/or full-length nature of some variants have not been determined.[provided by RefSeq, Jun 2010]
None
基因本体信息
CES3基因（以及对应的蛋白质）的细胞分布位置：
- 质膜
- 细胞质
- 细胞外
- 高尔基体
- 囊泡
- 细胞骨架
- 内质网
- 细胞核
- 内体
- 溶酶体
- 线粒体
CES3基因的本体（GO）信息：
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Liver Cirrhosis, Experimental | 0.12 | 1 | 0 | CTD_human |
| Myocardial Ischemia | 0.12 | 1 | 0 | CTD_human |
| Arteriosclerosis | 0.000271442 | 1 | 0 | BeFree |
| Atherosclerosis | 0.000271442 | 1 | 0 | BeFree |
联系方式
山东省济南市章丘区文博路2号 齐鲁师范学院 genelibs生信实验室
山东省济南市高新区舜华路750号大学科技园北区F座4单元2楼
电话： 0531-88819269
E-mail: product@genelibs.com
微信公众号
关注微信订阅号，实时查看信息，关注医学生物学动态。
版权所有 © 2025.Genelibs 济南弘晖生物技术有限公司 鲁ICP备13024435号-2
