CENPF (centromere protein F)

基因基本信息

基因基本信息

symbol:
CENPF
locus group:
protein-coding gene
location:
1q41
gene_family:
alias symbol:
hcp-1
alias name:
mitosin
entrez id:
1063
ensembl gene id:
ENSG00000117724
ucsc gene id:
uc001hkm.4
refseq accession:
NM_016343
hgnc_id:
HGNC:1857
approved reserved:
1994-07-04

基因染色体位置

基因染色体位置

1q41
基因染色体位置图

基因简述

基因简述

This gene encodes a protein that associates with the centromere-kinetochore complex. The protein is a component of the nuclear matrix during the G2 phase of interphase. In late G2 the protein associates with the kinetochore and maintains this association through early anaphase. It localizes to the spindle midzone and the intracellular bridge in late anaphase and telophase, respectively, and is thought to be subsequently degraded. The localization of this protein suggests that it may play a role in chromosome segregation during mitotis. It is thought to form either a homodimer or heterodimer. Autoantibodies against this protein have been found in patients with cancer or graft versus host disease. [provided by RefSeq, Jul 2008]

None

OMIM数据库中对CCND1基因的介绍     Wikipedia数据库中对CCND1基因的介绍

基因序列

基因序列

CCND1基因的碱基序列：[NCBI]
Loading Gene Browser...

基因突变

基因突变

CENPF基因的碱基突变：           仅显示部分snp
rs7289       rs14284       rs179813       rs335522       rs335523       rs335524       rs335525       rs335526       rs335527       rs335528       rs369801       rs374934       rs376776       rs377293       rs380023       rs387535       rs388355      

基因表达

基因表达

CENPF基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向Tm值
反向引物序列
反向Tm值
评分
CTGTAAACAGCTGGAAGAGG
58
TTGGTATCCATAACAGTACCTG
57
CAAGAAGAACTCAGTGGAGAG
58
CCTTCAATTGATCTTTGCTGC
58
CACGGACTCACACTTTAGG
57
ATTCTTCCAAAGCCCAGCT
59
GAATTAGACTCTGGGCTCC
57
GTAAATAAACTTGCTCTCGGG
57
ATTAGACTCTGGGCTCCAG
58
TGTAAATAAACTTGCTCTCGGG
58
TGTAAACAGCTGGAAGAGGA
58
CTTGGTATCCATAACAGTACCTG
58
CAAGAAGAACTCAGTGGAGAG
58
CTTCAATTGATCTTTGCTGCTC
58
ACGGACTCACACTTTAGGG
59
CATTCTTCCAAAGCCCAGC
59
AATTAGACTCTGGGCTCCA
57
GTAAATAAACTTGCTCTCGGG
57
TGTAAACAGCTGGAAGAGG
57
TTGGTATCCATAACAGTACCTG
57

转录因子

转录因子

      尚未收录相关数据

基因本体信息

CENPF基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 质膜
  • 细胞质
  • 细胞外
  • 高尔基体
  • 囊泡
  • 细胞骨架
  • 内质网
  • 细胞核
  • 内体
  • 溶酶体
  • 线粒体

CENPF基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0000278
P49454 (UniProtKB)
IMP
GO:0000775
P49454 (UniProtKB)
IDA
GO:0000775
P49454 (UniProtKB)
IDA
GO:0000775
P49454 (UniProtKB)
IDA
GO:0000776
P49454 (UniProtKB)
IDA
GO:0000776
P49454 (UniProtKB)
IDA
GO:0000922
P49454 (UniProtKB)
IDA
GO:0000940
P49454 (UniProtKB)
TAS
GO:0000940
P49454 (UniProtKB)
IDA
GO:0000940
P49454 (UniProtKB)
IDA
GO:0000940
P49454 (UniProtKB)
IDA
GO:0001822
P49454 (UniProtKB)
IMP
GO:0003682
P49454 (UniProtKB)
NAS
GO:0005515
P49454 (UniProtKB)
IPI
GO:0005515
P49454 (UniProtKB)
IPI
GO:0005515
P49454 (UniProtKB)
IPI
GO:0005515
P49454 (UniProtKB)
IPI
GO:0005515
P49454 (UniProtKB)
IPI
GO:0005515
P49454 (UniProtKB)
IPI
GO:0005515
P49454 (UniProtKB)
IPI
GO:0005515
P49454 (UniProtKB)
IPI
GO:0005515
P49454 (UniProtKB)
IPI
GO:0005515
P49454 (UniProtKB)
IPI
GO:0005634
P49454 (UniProtKB)
IDA
GO:0005634
P49454 (UniProtKB)
IDA
GO:0005634
P49454 (UniProtKB)
IDA
GO:0005634
P49454 (UniProtKB)
IDA
GO:0005635
P49454 (UniProtKB)
IDA
GO:0005654
P49454 (UniProtKB)
IDA
GO:0005737
P49454 (UniProtKB)
IDA
GO:0005813
P49454 (UniProtKB)
IEA
GO:0005819
P49454 (UniProtKB)
IDA
GO:0005829
P49454 (UniProtKB)
TAS
GO:0005829
P49454 (UniProtKB)
TAS
GO:0005829
P49454 (UniProtKB)
TAS
GO:0005829
P49454 (UniProtKB)
TAS
GO:0005829
P49454 (UniProtKB)
TAS
GO:0005829
P49454 (UniProtKB)
TAS
GO:0005829
P49454 (UniProtKB)
TAS
GO:0005829
P49454 (UniProtKB)
TAS
GO:0005829
P49454 (UniProtKB)
TAS
GO:0005829
P49454 (UniProtKB)
TAS
GO:0005829
P49454 (UniProtKB)
TAS
GO:0005930
P49454 (UniProtKB)
IEA
GO:0007059
P49454 (UniProtKB)
IMP
GO:0007059
P49454 (UniProtKB)
NAS
GO:0007062
P49454 (UniProtKB)
TAS
GO:0007067
P49454 (UniProtKB)
IEA
GO:0007094
P49454 (UniProtKB)
NAS
GO:0007517
P49454 (UniProtKB)
IEA
GO:0008022
P49454 (UniProtKB)
IPI
GO:0008134
P49454 (UniProtKB)
IPI
GO:0008283
P49454 (UniProtKB)
NAS
GO:0008283
P49454 (UniProtKB)
NAS
GO:0010389
P49454 (UniProtKB)
IMP
GO:0010389
P49454 (UniProtKB)
IMP
GO:0015031
P49454 (UniProtKB)
IDA
GO:0015031
P49454 (UniProtKB)
IMP
GO:0016202
P49454 (UniProtKB)
ISS
GO:0016363
P49454 (UniProtKB)
IDA
GO:0021591
P49454 (UniProtKB)
IMP
GO:0030154
P49454 (UniProtKB)
IEA
GO:0030496
P49454 (UniProtKB)
IDA
GO:0036064
P49454 (UniProtKB)
IEA
GO:0042493
P49454 (UniProtKB)
NAS
GO:0042803
P49454 (UniProtKB)
IPI
GO:0045120
P49454 (UniProtKB)
IEA
GO:0045502
P49454 (UniProtKB)
IDA
GO:0045892
P49454 (UniProtKB)
IDA
GO:0048471
P49454 (UniProtKB)
IEA
GO:0051301
P49454 (UniProtKB)
IEA
GO:0051310
P49454 (UniProtKB)
IDA
GO:0051382
P49454 (UniProtKB)
NAS
GO:0051726
P49454 (UniProtKB)
TAS
GO:0071897
P49454 (UniProtKB)
IEA
GO:0097539
P49454 (UniProtKB)
IMP
GO:0000785
P49454 (UniProtKB)
NAS

基因相关microRNA

基因相关microRNA

可能调控 CENPF基因的相关microRNA：     

基因相互作用关系

基因相互作用关系

Reactome

MINT

BioGrid

IntAct

mentha

String

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因通路

基因通路

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Mammary Neoplasms 0.12272435 2 0 CTD_human_LHGDN
IGA Glomerulonephritis 0.12 1 0 CTD_human
Malignant neoplasm of breast 0.002909916 2 0 BeFree_GAD
Chronic Lymphocytic Leukemia 0.002367032 1 1 GAD
Neoplasm Metastasis 0.001357209 5 0 BeFree
Breast Carcinoma 0.000542884 2 0 BeFree
Prostate carcinoma 0.000542884 2 0 BeFree
Tumor Progression 0.000542884 2 3 BeFree
Malignant neoplasm of prostate 0.000542884 2 0 BeFree
Benign Neoplasm 0.000271442 1 0 BeFree

基因相关服务

基因相关服务

联系方式

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