CDK9 (cyclin dependent kinase 9)
- symbol:
- CDK9
- locus group:
- protein-coding gene
- location:
- 9q34.11
- gene_family:
- Cyclin-dependent kinases
- alias symbol:
- PITALRE|C-2k|TAK
- alias name:
- None
- entrez id:
- 1025
- ensembl gene id:
- ENSG00000136807
- ucsc gene id:
- uc004bse.3
- refseq accession:
- NM_001261
- hgnc_id:
- HGNC:1780
- approved reserved:
- 1998-04-29
CDK9（细胞周期蛋白依赖性激酶9）是细胞周期蛋白依赖性激酶（CDK）家族的重要成员，属于转录调节CDK亚家族。CDK家族是一类丝氨酸/苏氨酸蛋白激酶，依赖细胞周期蛋白（Cyclin）激活，主要调控细胞周期和转录过程。CDK9的独特之处在于它不直接参与细胞周期调控，而是通过与Cyclin T1、T2或K组成复合物（称为P-TEFb）来调控RNA聚合酶II（Pol II）的转录延伸。具体来说，CDK9磷酸化Pol II的C端结构域（CTD），解除负性延伸因子（如DSIF和NELF）的抑制，促进mRNA合成。这一功能对基因表达、细胞分化、免疫应答及病毒感染（如HIV依赖CDK9完成转录）至关重要。CDK9突变或表达异常与多种疾病相关，例如其过度激活可能导致癌症（如白血病、乳腺癌），因它促进促生存基因和癌基因的转录；而CDK9抑制则可能诱发心肌病或神经退行性疾病，因其影响关键蛋白的表达。此外，CDK9是HIV复制的关键宿主因子，药物靶向抑制CDK9（如Flavopiridol）可抗病毒或抗癌。在基因家族中，CDK9与其他转录调节CDK（如CDK7、CDK12）共享保守的激酶结构域，但各自结合的Cyclin和底物特异性不同。降低CDK9表达会削弱转录延伸，导致全局基因表达下降，尤其影响即时早期基因（如c-Myc）；而过表达可能引发转录失调，促进肿瘤发生。CDK9的功能复杂性使其成为治疗癌症和病毒感染的重要靶点。
The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and known as important cell cycle regulators. This kinase was found to be a component of the multiprotein complex TAK/P-TEFb, which is an elongation factor for RNA polymerase II-directed transcription and functions by phosphorylating the C-terminal domain of the largest subunit of RNA polymerase II. This protein forms a complex with and is regulated by its regulatory subunit cyclin T or cyclin K. HIV-1 Tat protein was found to interact with this protein and cyclin T, which suggested a possible involvement of this protein in AIDS. [provided by RefSeq, Jul 2008]
由该基因编码的蛋白质是细胞周期蛋白依赖性蛋白激酶（CDK）家族的一个成员。 CDK家族成员是高度相似酿酒酵母CDC28的基因产物，和粟酒裂殖酵母CDC2，并称为重要的细胞周期调节。这种激酶被认为是该多蛋白复合物TAK / P-TEFB，它是RNA聚合酶II指导转录和通过磷酸化的RNA聚合酶II的最大亚基的C末端结构域的功能延伸因子的成分。该蛋白质形成复合带，由其调节亚基周期T或细胞周期蛋白K. HIV-1的Tat蛋白调节被发现与该蛋白和细胞周期蛋白T，它建议在艾滋病这种蛋白的一个可能参与相互作用。 [由RefSeq的，2008年7月提供]
基因本体信息
CDK9基因（以及对应的蛋白质）的细胞分布位置：
- 质膜
- 细胞质
- 细胞外
- 高尔基体
- 囊泡
- 细胞骨架
- 内质网
- 细胞核
- 内体
- 溶酶体
- 线粒体
CDK9基因的本体（GO）信息：
| 名称 |
|---|
| 5202 Transcriptional misregulation in cancers [PATH:hsa05202] |
| 名称 |
|---|
| Disease |
| Elongation arrest and recovery |
| Formation of HIV elongation complex in the absence of HIV Tat |
| Formation of HIV-1 elongation complex containing HIV-1 Tat |
| Formation of RNA Pol II elongation complex |
| Gene Expression |
| Generic Transcription Pathway |
| HIV elongation arrest and recovery |
| HIV Infection |
| HIV Life Cycle |
| HIV Transcription Elongation |
| Host Interactions of HIV factors |
| Infectious disease |
| Interactions of Tat with host cellular proteins |
| Late Phase of HIV Life Cycle |
| Pausing and recovery of HIV elongation |
| Pausing and recovery of Tat-mediated HIV elongation |
| RNA Polymerase II Pre-transcription Events |
| RNA Polymerase II Transcription |
| RNA Polymerase II Transcription Elongation |
| Signal Transduction |
| Signaling by TGF-beta Receptor Complex |
| SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
| Tat-mediated elongation of the HIV-1 transcript |
| Tat-mediated HIV elongation arrest and recovery |
| Transcription |
| Transcription of the HIV genome |
| Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer |
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Diabetes Mellitus, Experimental | 0.08 | 1 | 0 | RGD |
| HIV Infections | 0.00434307 | 16 | 0 | BeFree |
| Neuroblastoma | 0.002995792 | 1 | 0 | BeFree_LHGDN |
| Mammary Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
| Liver carcinoma | 0.000814326 | 3 | 0 | BeFree |
| leukemia | 0.000814326 | 3 | 0 | BeFree |
| Malignant neoplasm of breast | 0.000814326 | 3 | 0 | BeFree |
| Congestive heart failure | 0.000542884 | 2 | 0 | BeFree |
| Heart failure | 0.000542884 | 2 | 0 | BeFree |
| Breast Carcinoma | 0.000542884 | 2 | 0 | BeFree |
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