CDC42 (cell division cycle 42)

基因基本信息

基因基本信息

symbol:
CDC42
locus group:
protein-coding gene
location:
1p36.12
gene_family:
Rho family GTPases
alias symbol:
G25K|CDC42Hs
alias name:
GTP binding protein, 25kDa
entrez id:
998
ensembl gene id:
ENSG00000070831
ucsc gene id:
uc057ddl.1
refseq accession:
NM_001791
hgnc_id:
HGNC:1736
approved reserved:
1991-06-06

基因染色体位置

基因染色体位置

1p36.12
基因染色体位置图

基因简述

基因简述

CDC42（Cell Division Cycle 42）是一种小GTP酶，属于Rho家族（Rho family of GTPases）的成员。该家族主要参与调控细胞骨架重组、细胞迁移、细胞极性和细胞周期等过程。CDC42通过切换其活性状态（与GTP结合时为激活态，与GDP结合时为失活态）来调控下游信号通路。其表达产物是一种关键的信号转导蛋白，广泛分布于各种组织中，尤其在神经系统和免疫系统中发挥重要作用。CDC42的主要作用位点包括细胞膜、细胞质和细胞突起（如丝状伪足和片状伪足），通过与效应蛋白（如PAK、WASP和IQGAP）相互作用来调节肌动蛋白（actin）的动态组装。突变可能影响CDC42的功能，例如某些错义突变（如F28L和Y64C）会导致其持续激活或失活，进而引发疾病。CDC42功能异常与多种疾病相关，包括神经发育障碍（如智力障碍和自闭症）、癌症（如乳腺癌和结直肠癌）和免疫缺陷（如Wiskott-Aldrich综合征）。当CDC42过表达时，可能促进细胞迁移和侵袭，增加肿瘤转移风险；同时可能破坏细胞极性，影响组织形态发生。降低CDC42表达则可能导致细胞运动能力下降、细胞周期停滞或凋亡增加。在基因家族层面，Rho家族成员（如RhoA、Rac1）均通过调控细胞骨架和细胞黏附来影响细胞行为，但CDC42更侧重于细胞极性建立和膜运输的协调。专业术语解释：小GTP酶（small GTPase）是一类分子开关蛋白，通过结合GTP或GDP切换功能状态；肌动蛋白（actin）是细胞骨架的主要成分，参与细胞形态维持和运动；效应蛋白（effector proteins）是直接受GTP酶调控的下游信号分子。目前中文术语中"效应蛋白"有时也被称为"效应子"（effector）。

The protein encoded by this gene is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript variants. Pseudogenes of this gene have been identified on chromosomes 3, 4, 5, 7, 8 and 20. [provided by RefSeq, Apr 2013]

由该基因编码的蛋白质是的Rho-亚科，其调节信令控制多种细胞功能，包括细胞形态，迁移，内吞作用和细胞周期进展的途径的小GTP酶。该蛋白质是高度相似酿酒酵母中华网42，并且能够以补充酵母cdc42-1突变体。癌基因海湾干线的产物报特意从该蛋白催化GDP的解离。这种蛋白可以通过直接结合神经Wiskott-Aldrich公司综合征蛋白（N-WASP），随后激活Arp2 / 3复合调节肌动蛋白聚合。这个基因的选择性剪接的结果在多个转录变体。这个基因的假基因已被确定时，[通过的RefSeq，2013年4月提供]染色体3 4，5，7，8和20。

OMIM数据库中对CDC42基因的介绍     Wikipedia数据库中对CDC42基因的介绍

基因序列

基因序列

CDC42基因的碱基序列：[NCBI]
Loading Gene Browser...

基因突变

基因突变

CDC42基因的碱基突变：           仅显示部分snp
rs722697       rs725157       rs725158       rs763442       rs767399       rs909821       rs956944       rs1016493       rs1016494       rs1803269       rs1980475       rs2038101       rs2056974       rs2056975       rs2056976       rs2072921       rs2143104      

基因表达

基因表达

CDC42基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向Tm值
反向引物序列
反向Tm值
评分
CATCGGAATATGTACCGACTG
59
GTCATAATCCTCTTGCCCTG
58
CATCGGAATATGTACCGACTG
59
GTCATAATCCTCTTGCCCTG
58
TCTGCACTTACACAGAAAGG
58
TCTTCTTCGGTTCTGGAGG
59
GTACCGACTATCTTGACTTCTC
58
TTCTTGCAAACCCTGTGTC
59
TGACAACTATGCAGTCACAG
58
CATAATCCTCTTGCCCTGC
58
TCTGCACTTACACAGAAAGG
58
TCTTCTTCGGTTCTGGAGG
59
TGTACCGACTATCTTGACTTCTC
60
CTTGCAAACCCTGTGTCAC
60
CATCGGAATATGTACCGACTG
59
CATAATCCTCTTGCCCTGC
58
TTGACAACTATGCAGTCACAG
58
TAATCCTCTTGCCCTGCAG
59
GCACTTACACAGAAAGGCC
59
GCTCTTCTTCGGTTCTGGA
59

转录因子

转录因子

转录因子
影响基因
影响类型
参考文献链接（PubMed）
PTTG1
CDC42
Activation
22081074

基因本体信息

CDC42基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 质膜
  • 细胞质
  • 细胞外
  • 高尔基体
  • 囊泡
  • 细胞骨架
  • 内质网
  • 细胞核
  • 内体
  • 溶酶体
  • 线粒体

CDC42基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0000139
P60953 (UniProtKB)
ISS
GO:0000322
P60953 (UniProtKB)
IEA
GO:0002040
P60953 (UniProtKB)
IEA
GO:0003161
P60953 (UniProtKB)
IEA
GO:0003334
P60953 (UniProtKB)
IEA
GO:0003924
P60953 (UniProtKB)
TAS
GO:0005515
P60953 (UniProtKB)
IPI
GO:0005515
P60953 (UniProtKB)
IPI
GO:0005515
P60953 (UniProtKB)
IPI
GO:0005515
P60953 (UniProtKB)
IPI
GO:0005515
P60953 (UniProtKB)
IPI
GO:0005515
P60953 (UniProtKB)
IPI
GO:0005515
P60953 (UniProtKB)
IPI
GO:0005515
P60953 (UniProtKB)
IPI
GO:0005515
P60953 (UniProtKB)
IPI
GO:0005515
P60953 (UniProtKB)
IPI
GO:0005515
P60953 (UniProtKB)
IPI
GO:0005515
P60953 (UniProtKB)
IPI
GO:0005515
P60953 (UniProtKB)
IPI
GO:0005515
P60953 (UniProtKB)
IPI
GO:0005515
P60953 (UniProtKB)
IPI
GO:0005515
P60953 (UniProtKB)
IPI
GO:0005515
P60953 (UniProtKB)
IPI
GO:0005515
P60953 (UniProtKB)
IPI
GO:0005515
P60953 (UniProtKB)
IPI
GO:0005515
P60953 (UniProtKB)
IPI
GO:0005515
P60953 (UniProtKB)
IPI
GO:0005515
P60953 (UniProtKB)
IPI
GO:0005515
P60953 (UniProtKB)
IPI
GO:0005515
P60953 (UniProtKB)
IPI
GO:0005515
P60953 (UniProtKB)
IPI
GO:0005515
P60953 (UniProtKB)
IPI
GO:0005515
P60953 (UniProtKB)
IPI
GO:0005515
P60953 (UniProtKB)
IPI
GO:0005515
P60953 (UniProtKB)
IPI
GO:0005515
P60953 (UniProtKB)
IPI
GO:0005515
P60953 (UniProtKB)
IPI
GO:0005515
P60953 (UniProtKB)
IPI
GO:0005515
P60953 (UniProtKB)
IPI
GO:0005515
P60953 (UniProtKB)
IPI
GO:0005515
P60953 (UniProtKB)
IPI
GO:0005515
P60953 (UniProtKB)
IPI
GO:0005515
P60953 (UniProtKB)
IPI
GO:0005515
P60953 (UniProtKB)
IPI
GO:0005515
P60953 (UniProtKB)
IPI
GO:0005515
P60953 (UniProtKB)
IPI
GO:0005515
P60953 (UniProtKB)
IPI
GO:0005515
P60953 (UniProtKB)
IPI
GO:0005515
P60953 (UniProtKB)
IPI
GO:0005515
P60953 (UniProtKB)
IPI
GO:0005515
P60953 (UniProtKB)
IPI
GO:0005515
P60953 (UniProtKB)
IPI
GO:0005515
P60953 (UniProtKB)
IPI
GO:0005515
P60953 (UniProtKB)
IPI
GO:0005515
P60953 (UniProtKB)
IPI
GO:0005515
P60953 (UniProtKB)
IPI
GO:0005515
P60953 (UniProtKB)
IPI
GO:0005515
P60953 (UniProtKB)
IPI
GO:0005515
P60953 (UniProtKB)
IPI
GO:0005515
P60953 (UniProtKB)
IPI
GO:0005515
P60953 (UniProtKB)
IPI
GO:0005515
P60953 (UniProtKB)
IPI
GO:0005515
P60953 (UniProtKB)
IPI
GO:0005515
P60953 (UniProtKB)
IPI
GO:0005515
P60953 (UniProtKB)
IPI
GO:0005515
P60953 (UniProtKB)
IPI
GO:0005515
P60953 (UniProtKB)
IPI
GO:0005515
P60953 (UniProtKB)
IPI
GO:0005515
P60953 (UniProtKB)
IPI
GO:0005515
P60953 (UniProtKB)
IPI
GO:0005515
P60953 (UniProtKB)
IPI
GO:0005515
P60953 (UniProtKB)
IPI
GO:0005515
P60953 (UniProtKB)
IPI
GO:0005515
P60953 (UniProtKB)
IPI
GO:0005515
P60953 (UniProtKB)
IPI
GO:0005515
P60953 (UniProtKB)
IPI
GO:0005515
P60953 (UniProtKB)
IPI
GO:0005515
P60953 (UniProtKB)
IPI
GO:0005515
P60953 (UniProtKB)
IPI
GO:0005515
P60953 (UniProtKB)
IPI
GO:0005515
P60953 (UniProtKB)
IPI
GO:0005515
P60953 (UniProtKB)
IPI
GO:0005515
P60953 (UniProtKB)
IPI
GO:0005515
P60953 (UniProtKB)
IPI
GO:0005515
P60953 (UniProtKB)
IPI
GO:0005515
P60953 (UniProtKB)
IPI
GO:0005515
P60953 (UniProtKB)
IPI
GO:0005515
P60953 (UniProtKB)
IPI
GO:0005515
P60953 (UniProtKB)
IPI
GO:0005525
P60953 (UniProtKB)
IDA
GO:0005525
P60953 (UniProtKB)
IDA
GO:0005737
P60953 (UniProtKB)
IDA
GO:0005789
P60953 (UniProtKB)
TAS
GO:0005789
P60953 (UniProtKB)
TAS
GO:0005815
P60953 (UniProtKB)
IEA
GO:0005829
P60953 (UniProtKB)
TAS
GO:0005829
P60953 (UniProtKB)
TAS
GO:0005829
P60953 (UniProtKB)
TAS
GO:0005829
P60953 (UniProtKB)
TAS
GO:0005829
P60953 (UniProtKB)
TAS
GO:0005829
P60953 (UniProtKB)
TAS
GO:0005829
P60953 (UniProtKB)
TAS
GO:0005829
P60953 (UniProtKB)
TAS
GO:0005829
P60953 (UniProtKB)
TAS
GO:0005886
P60953 (UniProtKB)
IDA
GO:0005886
P60953 (UniProtKB)
TAS
GO:0005886
P60953 (UniProtKB)
TAS
GO:0005886
P60953 (UniProtKB)
TAS
GO:0005886
P60953 (UniProtKB)
TAS
GO:0005886
P60953 (UniProtKB)
TAS
GO:0005886
P60953 (UniProtKB)
TAS
GO:0005886
P60953 (UniProtKB)
TAS
GO:0005886
P60953 (UniProtKB)
TAS
GO:0005886
P60953 (UniProtKB)
TAS
GO:0005886
P60953 (UniProtKB)
TAS
GO:0005886
P60953 (UniProtKB)
TAS
GO:0005886
P60953 (UniProtKB)
TAS
GO:0005886
P60953 (UniProtKB)
TAS
GO:0005886
P60953 (UniProtKB)
TAS
GO:0005886
P60953 (UniProtKB)
TAS
GO:0005886
P60953 (UniProtKB)
TAS
GO:0005886
P60953 (UniProtKB)
TAS
GO:0005886
P60953 (UniProtKB)
TAS
GO:0005886
P60953 (UniProtKB)
TAS
GO:0005886
P60953 (UniProtKB)
TAS
GO:0005886
P60953 (UniProtKB)
TAS
GO:0005886
P60953 (UniProtKB)
TAS
GO:0005886
P60953 (UniProtKB)
TAS
GO:0005886
P60953 (UniProtKB)
TAS
GO:0005886
P60953 (UniProtKB)
TAS
GO:0005886
P60953 (UniProtKB)
TAS
GO:0005886
P60953 (UniProtKB)
TAS
GO:0005886
P60953 (UniProtKB)
TAS
GO:0005886
P60953 (UniProtKB)
TAS
GO:0005886
P60953 (UniProtKB)
TAS
GO:0005886
P60953 (UniProtKB)
TAS
GO:0005886
P60953 (UniProtKB)
TAS
GO:0005886
P60953 (UniProtKB)
TAS
GO:0005886
P60953 (UniProtKB)
TAS
GO:0005886
P60953 (UniProtKB)
TAS
GO:0005886
P60953 (UniProtKB)
TAS
GO:0005886
P60953 (UniProtKB)
TAS
GO:0005911
P60953 (UniProtKB)
IEA
GO:0005925
P60953 (UniProtKB)
IDA
GO:0007030
P60953 (UniProtKB)
ISS
GO:0007088
P60953 (UniProtKB)
IEA
GO:0007097
P60953 (UniProtKB)
IEA
GO:0007163
P60953 (UniProtKB)
TAS
GO:0007264
P60953 (UniProtKB)
IEA
GO:0007596
P60953 (UniProtKB)
TAS
GO:0010628
P60953 (UniProtKB)
IEA
GO:0010629
P60953 (UniProtKB)
IEA
GO:0016020
P60953 (UniProtKB)
IDA
GO:0016020
P60953 (UniProtKB)
IDA
GO:0016567
P60953 (UniProtKB)
IEA
GO:0019901
P60953 (UniProtKB)
IDA
GO:0019901
P60953 (UniProtKB)
IPI
GO:0021762
P60953 (UniProtKB)
IEP
GO:0030036
P60953 (UniProtKB)
IDA
GO:0030141
P60953 (UniProtKB)
IEA
GO:0030175
P60953 (UniProtKB)
IDA
GO:0030225
P60953 (UniProtKB)
TAS
GO:0030307
P60953 (UniProtKB)
IMP
GO:0030496
P60953 (UniProtKB)
IDA
GO:0030742
P60953 (UniProtKB)
IEA
GO:0031069
P60953 (UniProtKB)
IEA
GO:0031256
P60953 (UniProtKB)
IEA
GO:0031274
P60953 (UniProtKB)
IDA
GO:0031295
P60953 (UniProtKB)
TAS
GO:0031333
P60953 (UniProtKB)
IPI
GO:0031424
P60953 (UniProtKB)
IEA
GO:0031435
P60953 (UniProtKB)
IEA
GO:0031647
P60953 (UniProtKB)
IEA
GO:0031996
P60953 (UniProtKB)
IPI
GO:0032467
P60953 (UniProtKB)
IMP
GO:0033138
P60953 (UniProtKB)
IEA
GO:0034191
P60953 (UniProtKB)
IPI
GO:0034332
P60953 (UniProtKB)
IEA
GO:0034613
P60953 (UniProtKB)
IEA
GO:0035088
P60953 (UniProtKB)
IEA
GO:0035264
P60953 (UniProtKB)
IEA
GO:0036336
P60953 (UniProtKB)
IEA
GO:0036464
P60953 (UniProtKB)
IDA
GO:0038096
P60953 (UniProtKB)
TAS
GO:0042059
P60953 (UniProtKB)
TAS
GO:0042176
P60953 (UniProtKB)
IEA
GO:0042802
P60953 (UniProtKB)
IPI
GO:0043005
P60953 (UniProtKB)
IDA
GO:0043025
P60953 (UniProtKB)
IDA
GO:0043209
P60953 (UniProtKB)
IEA
GO:0043497
P60953 (UniProtKB)
IEA
GO:0043525
P60953 (UniProtKB)
IEA
GO:0043552
P60953 (UniProtKB)
IEA
GO:0045177
P60953 (UniProtKB)
IEA
GO:0045740
P60953 (UniProtKB)
IEA
GO:0045859
P60953 (UniProtKB)
IEA
GO:0046330
P60953 (UniProtKB)
IEA
GO:0046847
P60953 (UniProtKB)
IEA
GO:0048010
P60953 (UniProtKB)
TAS
GO:0048013
P60953 (UniProtKB)
TAS
GO:0048664
P60953 (UniProtKB)
IEA
GO:0051017
P60953 (UniProtKB)
IEA
GO:0051022
P60953 (UniProtKB)
IEA
GO:0051056
P60953 (UniProtKB)
TAS
GO:0051149
P60953 (UniProtKB)
TAS
GO:0051233
P60953 (UniProtKB)
IDA
GO:0051489
P60953 (UniProtKB)
IDA
GO:0051683
P60953 (UniProtKB)
ISS
GO:0051835
P60953 (UniProtKB)
IEA
GO:0051988
P60953 (UniProtKB)
IMP
GO:0060047
P60953 (UniProtKB)
IEA
GO:0060070
P60953 (UniProtKB)
IEA
GO:0060071
P60953 (UniProtKB)
NAS
GO:0060501
P60953 (UniProtKB)
IEA
GO:0060661
P60953 (UniProtKB)
IEA
GO:0060684
P60953 (UniProtKB)
IEA
GO:0060789
P60953 (UniProtKB)
IEA
GO:0061630
P60953 (UniProtKB)
IDA
GO:0070062
P60953 (UniProtKB)
IDA
GO:0070062
P60953 (UniProtKB)
IDA
GO:0070062
P60953 (UniProtKB)
IDA
GO:0070062
P60953 (UniProtKB)
IDA
GO:0070062
P60953 (UniProtKB)
IDA
GO:0071338
P60953 (UniProtKB)
IEA
GO:0072384
P60953 (UniProtKB)
ISS
GO:0072686
P60953 (UniProtKB)
IDA
GO:0090135
P60953 (UniProtKB)
IEA
GO:0090136
P60953 (UniProtKB)
IEA
GO:0090316
P60953 (UniProtKB)
IEA
GO:1900026
P60953 (UniProtKB)
IDA
GO:0005525
Q5JYX0 (UniProtKB)
IEA
GO:0005622
Q5JYX0 (UniProtKB)
IEA
GO:0007264
Q5JYX0 (UniProtKB)
IEA

基因相关microRNA

基因相关microRNA

可能调控 CDC42基因的相关microRNA：     

基因相互作用关系

基因相互作用关系

Reactome

MINT

BioGrid

IntAct

mentha

String

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因通路

基因通路

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
HIV Infections 0.123181358 5 0 BeFree_CTD_human_GAD
Animal Mammary Neoplasms 0.12 1 0 CTD_human
Adrenal Gland Neoplasms 0.12 1 0 CTD_human
Necrosis 0.12 1 0 CTD_human
Mammary Neoplasms, Experimental 0.12 1 0 CTD_human
Epilepsy, Temporal Lobe 0.08 1 0 RGD
Reperfusion Injury 0.08 1 0 RGD
Neoplasm Metastasis 0.006795978 16 0 BeFree_LHGDN
Mammary Neoplasms 0.003810118 5 0 BeFree_LHGDN
Malignant neoplasm of breast 0.003800186 14 0 BeFree

基因相关服务

基因相关服务

联系方式

山东省济南市章丘区文博路2号 齐鲁师范学院 genelibs生信实验室

山东省济南市高新区舜华路750号大学科技园北区F座4单元2楼

电话： 0531-88819269

E-mail: product@genelibs.com

微信公众号

关注微信订阅号，实时查看信息，关注医学生物学动态。

版权所有 © 2025.Genelibs 济南弘晖生物技术有限公司 鲁ICP备13024435号-2