CDC26 (cell division cycle 26)
- symbol:
- CDC26
- locus group:
- protein-coding gene
- location:
- 9q32
- gene_family:
- Anaphase promoting complex subunits
- alias symbol:
- APC12|ANAPC12
- alias name:
- CDC26 subunit of anaphase promotin…
- entrez id:
- 246184
- ensembl gene id:
- ENSG00000176386
- ucsc gene id:
- uc004bgw.4
- refseq accession:
- NM_139286
- hgnc_id:
- HGNC:17839
- approved reserved:
- 2002-01-29
CDC26是后期促进复合物/环体（APC/C）的一个关键亚基，属于APC/C基因家族。APC/C是一个多亚基E3泛素连接酶复合物，主要调控细胞周期进程，通过泛素化降解细胞周期蛋白（如Cyclin B和Securin）和有丝分裂调控蛋白，确保细胞有序分裂。CDC26作为APC/C的支架蛋白，帮助维持复合物的稳定性，尤其在结合其他亚基（如APC2、APC11）时起重要作用。其功能位点集中在与APC/C核心亚基的相互作用区域，突变可能导致复合物组装缺陷，进而影响细胞周期调控。若CDC26功能丧失或表达降低，APC/C活性受损，会导致细胞周期蛋白异常积累，引发有丝分裂阻滞、染色体分离错误或基因组不稳定性，与癌症（如结直肠癌、乳腺癌）的发生密切相关。相反，过表达CDC26可能增强APC/C活性，加速细胞周期蛋白降解，但具体病理关联尚不明确。CDC26所属的APC/C基因家族成员均参与细胞周期调控，通过泛素-蛋白酶体系统精确控制靶蛋白降解，其共性包括保守的蛋白相互作用域和细胞周期依赖性表达模式。该家族的功能紊乱普遍与肿瘤、神经退行性疾病等病理过程相关。研究还发现CDC26与CDC16、CDC23等亚基协同作用，其表达异常可能间接影响纺锤体检查点功能或DNA损伤修复通路。
The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc26, a component of cell cycle anaphase-promoting complex (APC). APC is composed of a group of highly conserved proteins and functions as a cell cycle-regulated ubiquitin-protein ligase. APC thus is responsible for the cell cycle regulated proteolysis of various proteins. [provided by RefSeq, Jul 2008]
由该基因编码的蛋白质是高度类似于酿酒酵母Cdc26，细胞周期后期促进复合物（APC）的成分。 APC是由一组高度保守的蛋白和功能作为细胞周期调节的泛素 - 蛋白连接酶的。 APC从而负责各种蛋白质的细胞周期调节蛋白水解。 [由RefSeq的，2008年7月提供]
基因本体信息
CDC26基因（以及对应的蛋白质）的细胞分布位置：
- 质膜
- 细胞质
- 细胞外
- 高尔基体
- 囊泡
- 细胞骨架
- 内质网
- 细胞核
- 内体
- 溶酶体
- 线粒体
CDC26基因的本体（GO）信息：
| 名称 |
|---|
| 4120 Ubiquitin mediated proteolysis [PATH:hsa04120] |
| 4110 Cell cycle [PATH:hsa04110] |
| 4114 Oocyte meiosis [PATH:hsa04114] |
| 4914 Progesterone-mediated oocyte maturation [PATH:hsa04914] |
| 5166 HTLV-I infection [PATH:hsa05166] |
| 名称 |
|---|
| Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins |
| Adaptive Immune System |
| Antigen processing: Ubiquitination & Proteasome degradation |
| APC-Cdc20 mediated degradation of Nek2A |
| APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint |
| APC/C-mediated degradation of cell cycle proteins |
| APC/C:Cdc20 mediated degradation of Cyclin B |
| APC/C:Cdc20 mediated degradation of mitotic proteins |
| APC/C:Cdc20 mediated degradation of Securin |
| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 |
| Autodegradation of Cdh1 by Cdh1:APC/C |
| Cdc20:Phospho-APC/C mediated degradation of Cyclin A |
| Cell Cycle |
| Cell Cycle Checkpoints |
| Cell Cycle, Mitotic |
| Cellular responses to stress |
| Cellular Senescence |
| Class I MHC mediated antigen processing & presentation |
| Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase |
| Immune System |
| Inactivation of APC/C via direct inhibition of the APC/C complex |
| Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components |
| M Phase |
| Mitotic Anaphase |
| Mitotic Metaphase and Anaphase |
| Mitotic Spindle Checkpoint |
| Phosphorylation of the APC/C |
| Regulation of APC/C activators between G1/S and early anaphase |
| Regulation of mitotic cell cycle |
| Senescence-Associated Secretory Phenotype (SASP) |
| Separation of Sister Chromatids |
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