CDC23 (cell division cycle 23)
- symbol:
- CDC23
- locus group:
- protein-coding gene
- location:
- 5q31.2
- gene_family:
- Anaphase promoting complex subunits|Tetratricopeptide repeat domain containing
- alias symbol:
- APC8|ANAPC8|CUT23
- alias name:
- anaphase promoting complex subunit…
- entrez id:
- 8697
- ensembl gene id:
- ENSG00000094880
- ucsc gene id:
- uc003lcl.3
- refseq accession:
- NM_004661
- hgnc_id:
- HGNC:1724
- approved reserved:
- 1998-06-25
CDC23是细胞分裂周期蛋白23（Cell Division Cycle 23）的简称，属于后期促进复合物/环体（APC/C，Anaphase-Promoting Complex/Cyclosome）的核心亚基之一。APC/C是一个多亚基E3泛素连接酶，负责通过泛素-蛋白酶体系统调控细胞周期关键蛋白的降解，从而控制细胞周期的有序进行，尤其在姐妹染色单体分离和退出有丝分裂中起核心作用。CDC23作为APC/C的支架蛋白，帮助维持复合物的结构稳定性，并参与底物识别与泛素化过程。其表达产物主要定位于细胞核，在有丝分裂期富集于纺锤体和动粒（kinetochore）区域，确保染色体正确分离。若CDC23发生功能丧失性突变（如错义突变或缺失），可能导致APC/C组装或活性异常，引发染色体分离错误、非整倍体（染色体数目异常）和基因组不稳定性，进而促进癌症（如结直肠癌、乳腺癌）或发育缺陷。相反，CDC23过表达可能加速周期蛋白（如Cyclin B、Securin）的降解，导致细胞过早退出有丝分裂，同样破坏基因组完整性。CDC23属于APC/C基因家族，该家族成员（如CDC16、CDC27）均含TPR（Tetratricopeptide Repeat）蛋白互作结构域，通过形成复合物协同调控细胞周期。研究表明，CDC23在多种肿瘤中表达异常，其表达水平与化疗敏感性相关，可能成为癌症治疗的潜在靶点。专业术语解释：泛素-蛋白酶体系统（Ubiquitin-Proteasome System）是细胞内蛋白质选择性降解的主要途径；非整倍体（Aneuploidy）指细胞染色体数目偏离正常倍性；TPR结构域是一种介导蛋白质相互作用的重复序列模体。
The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae Cdc23, a protein essential for cell cycle progression through the G2/M transition. This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eukaryotic cells. APC catalyzes the formation of cyclin B-ubiquitin conjugate that is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. This protein and 3 other members of the APC complex contain the TPR (tetratricopeptide repeat), a protein domain important for protein-protein interaction. [provided by RefSeq, Jul 2008]
由该基因股酿酒酵母Cdc23，用于通过G2 / M过渡细胞周期进程必需的蛋白很强的相似性编码的蛋白质。这种蛋白质是后期促进复合物（APC），这是由八个蛋白质亚基，并在真核细胞中的高度保守的组分。 APC的催化细胞周期蛋白B-泛素缀合物的形成，它负责B型细胞周期蛋白的遍在蛋白介导的蛋白水解。这种蛋白质和APC复合物的3其他成员包含TPR（三十四肽重复），蛋白质结构域对于蛋白质 - 蛋白质相互作用重要。 [由RefSeq的，2008年7月提供]
基因本体信息
CDC23基因（以及对应的蛋白质）的细胞分布位置：
- 质膜
- 细胞质
- 细胞外
- 高尔基体
- 囊泡
- 细胞骨架
- 内质网
- 细胞核
- 内体
- 溶酶体
- 线粒体
CDC23基因的本体（GO）信息：
| 名称 |
|---|
| 4120 Ubiquitin mediated proteolysis [PATH:hsa04120] |
| 4110 Cell cycle [PATH:hsa04110] |
| 4114 Oocyte meiosis [PATH:hsa04114] |
| 4914 Progesterone-mediated oocyte maturation [PATH:hsa04914] |
| 5166 HTLV-I infection [PATH:hsa05166] |
| 名称 |
|---|
| Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins |
| Adaptive Immune System |
| Antigen processing: Ubiquitination & Proteasome degradation |
| APC-Cdc20 mediated degradation of Nek2A |
| APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint |
| APC/C-mediated degradation of cell cycle proteins |
| APC/C:Cdc20 mediated degradation of Cyclin B |
| APC/C:Cdc20 mediated degradation of mitotic proteins |
| APC/C:Cdc20 mediated degradation of Securin |
| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 |
| Autodegradation of Cdh1 by Cdh1:APC/C |
| Cdc20:Phospho-APC/C mediated degradation of Cyclin A |
| Cell Cycle |
| Cell Cycle Checkpoints |
| Cell Cycle, Mitotic |
| Cellular responses to stress |
| Cellular Senescence |
| Class I MHC mediated antigen processing & presentation |
| Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase |
| Immune System |
| Inactivation of APC/C via direct inhibition of the APC/C complex |
| Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components |
| M Phase |
| Mitotic Anaphase |
| Mitotic Metaphase and Anaphase |
| Mitotic Spindle Checkpoint |
| Phosphorylation of the APC/C |
| Regulation of APC/C activators between G1/S and early anaphase |
| Regulation of mitotic cell cycle |
| Senescence-Associated Secretory Phenotype (SASP) |
| Separation of Sister Chromatids |
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Colonic Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
| Thyroid carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Papillary thyroid carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Myeloid Leukemia | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of thyroid | 0.000271442 | 1 | 0 | BeFree |
| leukemia | 0.000271442 | 1 | 0 | BeFree |
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