CD86 (CD86 molecule)
- symbol:
- CD86
- locus group:
- protein-coding gene
- location:
- 3q13.33
- gene_family:
- CD molecules|V-set domain containing|Immunoglobulin-like domain containing
- alias symbol:
- B7.2|B7-2
- alias name:
- B-lymphocyte antigen B7-2
- entrez id:
- 942
- ensembl gene id:
- ENSG00000114013
- ucsc gene id:
- uc003eet.4
- refseq accession:
- NM_006889
- hgnc_id:
- HGNC:1705
- approved reserved:
- 1994-12-07
CD86（也称为B7-2）是一种重要的免疫共刺激分子，属于B7基因家族（B7 family），该家族成员（如CD80、CD86、PD-L1等）的共同特点是表达于抗原呈递细胞（APC，如树突细胞、巨噬细胞）表面，通过与T细胞表面的受体（如CD28或CTLA-4）结合，调控T细胞的活化或抑制。CD86的主要生物学功能是提供T细胞活化的第二信号（共刺激信号）。当抗原呈递细胞通过主要组织相容性复合体（MHC）向T细胞递呈抗原（第一信号）时，CD86与T细胞表面的CD28结合，促进T细胞增殖、细胞因子分泌（如IL-2）及免疫应答启动；若与CTLA-4结合则抑制T细胞过度活化，维持免疫平衡。CD86的作用位点集中在免疫突触（免疫细胞间接触的特定区域）。突变或异常表达可能导致免疫失调：例如CD86表达不足会削弱T细胞应答，引发免疫缺陷；而过表达可能驱动自身免疫疾病（如类风湿关节炎、多发性硬化）。研究发现，某些肿瘤细胞通过下调CD86逃避免疫监视。CD86过表达可能加剧炎症或自身免疫反应，而降低表达（如使用CTLA-4抑制剂阻断CD86/CD28通路）可增强抗肿瘤免疫，但可能引发免疫相关不良反应。在基因家族中，B7成员均含免疫球蛋白样结构域（IgV/IgC），通过受体互作调节免疫应答，但不同成员（如PD-L1）倾向于抑制信号。CD86的动态表达受炎症因子（如IFN-γ、LPS）调控，是免疫治疗（如检查点抑制剂）的潜在靶点之一。
This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in several transcript variants encoding different isoforms.[provided by RefSeq, May 2011]
本基因编码的I型膜蛋白，其是免疫球蛋白超家族中的一员。该蛋白质是由抗原呈递细胞表达，并且它是在T细胞，CD28抗原和细胞毒性T淋巴细胞相关蛋白4结合与CD28抗原的这种蛋白质的细胞表面的两种蛋白质的配位体为共刺激信号T细胞的活化。具有细胞毒性T淋巴细胞相关蛋白4的这种蛋白质结合负调节T细胞活化和降低免疫应答。在几个转录剪接变异体导致编码不同亚型。[由RefSeq的，2011年5月提供]
基因本体信息
CD86基因（以及对应的蛋白质）的细胞分布位置：
- 质膜
- 细胞质
- 细胞外
- 高尔基体
- 囊泡
- 细胞骨架
- 内质网
- 细胞核
- 内体
- 溶酶体
- 线粒体
CD86基因的本体（GO）信息：
| 名称 |
|---|
| 4514 Cell adhesion molecules (CAMs) [PATH:hsa04514] |
| 4620 Toll-like receptor signaling pathway [PATH:hsa04620] |
| 4672 Intestinal immune network for IgA production [PATH:hsa04672] |
| 5202 Transcriptional misregulation in cancers [PATH:hsa05202] |
| 5322 Systemic lupus erythematosus [PATH:hsa05322] |
| 5323 Rheumatoid arthritis [PATH:hsa05323] |
| 5320 Autoimmune thyroid disease [PATH:hsa05320] |
| 5330 Allograft rejection [PATH:hsa05330] |
| 5332 Graft-versus-host disease [PATH:hsa05332] |
| 5416 Viral myocarditis [PATH:hsa05416] |
| 4940 Type I diabetes mellitus [PATH:hsa04940] |
| 名称 |
|---|
| Adaptive Immune System |
| CD28 co-stimulation |
| CD28 dependent PI3K/Akt signaling |
| CD28 dependent Vav1 pathway |
| Constitutive Signaling by Aberrant PI3K in Cancer |
| Costimulation by the CD28 family |
| CTLA4 inhibitory signaling |
| DAP12 interactions |
| DAP12 signaling |
| Disease |
| Diseases of signal transduction |
| Downstream signal transduction |
| Downstream signaling events of B Cell Receptor (BCR) |
| Downstream signaling of activated FGFR1 |
| Downstream signaling of activated FGFR2 |
| Downstream signaling of activated FGFR3 |
| Downstream signaling of activated FGFR4 |
| Fc epsilon receptor (FCERI) signaling |
| GAB1 signalosome |
| Immune System |
| Innate Immune System |
| NGF signalling via TRKA from the plasma membrane |
| PI-3K cascade:FGFR1 |
| PI-3K cascade:FGFR2 |
| PI-3K cascade:FGFR3 |
| PI-3K cascade:FGFR4 |
| PI3K events in ERBB2 signaling |
| PI3K events in ERBB4 signaling |
| PI3K/AKT activation |
| PI3K/AKT Signaling in Cancer |
| PIP3 activates AKT signaling |
| Role of LAT2/NTAL/LAB on calcium mobilization |
| Signal Transduction |
| Signaling by EGFR |
| Signaling by ERBB2 |
| Signaling by ERBB4 |
| Signaling by FGFR |
| Signaling by FGFR1 |
| Signaling by FGFR2 |
| Signaling by FGFR3 |
| Signaling by FGFR4 |
| Signaling by PDGF |
| Signaling by SCF-KIT |
| Signaling by the B Cell Receptor (BCR) |
| Signalling by NGF |
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Multiple Sclerosis | 0.125005506 | 3 | 2 | BeFree_GAD_GWASCAT |
| Multiple Myeloma | 0.120814326 | 4 | 0 | BeFree_CTD_human |
| Diffuse Large B-Cell Lymphoma | 0.12 | 1 | 1 | GWASCAT |
| Contact Dermatitis | 0.12 | 1 | 0 | CTD_human |
| Lymphoma, Follicular | 0.12 | 1 | 1 | GWASCAT |
| Liver diseases | 0.12 | 1 | 0 | CTD_human |
| Asthma | 0.09099709 | 6 | 0 | BeFree_GAD_LHGDN_RGD |
| Adult T-Cell Lymphoma/Leukemia | 0.080271442 | 2 | 0 | BeFree_RGD |
| Experimental Autoimmune Encephalomyelitis | 0.080271442 | 2 | 0 | BeFree_RGD |
| Guillain-Barre Syndrome | 0.08 | 0 | 0 | MGD |
联系方式
山东省济南市章丘区文博路2号 齐鲁师范学院 genelibs生信实验室
山东省济南市高新区舜华路750号大学科技园北区F座4单元2楼
电话： 0531-88819269
E-mail: product@genelibs.com
微信公众号
关注微信订阅号，实时查看信息，关注医学生物学动态。
版权所有 © 2025.Genelibs 济南弘晖生物技术有限公司 鲁ICP备13024435号-2
