CD82 (CD82 molecule)
- symbol:
- CD82
- locus group:
- protein-coding gene
- location:
- 11p11.2
- gene_family:
- CD molecules|Tetraspanins
- alias symbol:
- R2|IA4|TSPAN27
- alias name:
- suppression of tumorigenicity 6|R2…
- entrez id:
- 3732
- ensembl gene id:
- ENSG00000085117
- ucsc gene id:
- uc001myc.4
- refseq accession:
- NM_002231
- hgnc_id:
- HGNC:6210
- approved reserved:
- 1994-01-10
This metastasis suppressor gene product is a membrane glycoprotein that is a member of the transmembrane 4 superfamily. Expression of this gene has been shown to be downregulated in tumor progression of human cancers and can be activated by p53 through a consensus binding sequence in the promoter. Its expression and that of p53 are strongly correlated, and the loss of expression of these two proteins is associated with poor survival for prostate cancer patients. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
此转移抑制基因产物是一种膜糖蛋白，它是跨膜4超家族的成员。已经表明该基因的表达在人癌症的肿瘤进展被下调，并且可以通过p53基因通过在启动子的共有结合序列被激活。其表达与p53基因的强相关，而这两种蛋白质的表达的缺失与不良存活的前列腺癌患者。已经发现了这个基因编码两种不同亚型选择性剪接转录变异体。 [由RefSeq的，2008年7月提供]
基因本体信息
CD82基因（以及对应的蛋白质）的细胞分布位置：
- 质膜
- 细胞质
- 细胞外
- 高尔基体
- 囊泡
- 细胞骨架
- 内质网
- 细胞核
- 内体
- 溶酶体
- 线粒体
CD82基因的本体（GO）信息：
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Neoplasm Metastasis | 0.2481048 | 123 | 0 | BeFree_CTD_human_LHGDN_RGD |
| Prostatic Neoplasms | 0.131983168 | 8 | 0 | BeFree_CTD_human_LHGDN |
| Neoplasm Invasiveness | 0.12 | 1 | 0 | CTD_human |
| Spontaneous abortion | 0.12 | 1 | 0 | CTD_human |
| ovarian neoplasm | 0.080271442 | 2 | 0 | BeFree_RGD |
| Gliosis | 0.08 | 1 | 0 | RGD |
| Hypertensive disease | 0.08 | 1 | 0 | RGD |
| Mammary Neoplasms | 0.008715934 | 5 | 0 | BeFree_LHGDN |
| Malignant neoplasm of prostate | 0.008414698 | 31 | 0 | BeFree |
| Prostate carcinoma | 0.007328931 | 27 | 0 | BeFree |
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