CD74 (CD74 molecule)

基因基本信息

基因基本信息

symbol:
CD74
locus group:
protein-coding gene
location:
5q33.1
gene_family:
CD molecules
alias symbol:
CLIP
alias name:
HLA-DR-gamma|Ia-associated invaria…
entrez id:
972
ensembl gene id:
ENSG00000019582
ucsc gene id:
uc003lse.4
refseq accession:
NM_004355
hgnc_id:
HGNC:1697
approved reserved:
1986-01-01

基因染色体位置

基因染色体位置

5q33.1
基因染色体位置图

基因简述

基因简述

CD74是一种重要的免疫相关基因，编码的蛋白质是主要组织相容性复合体II类分子（MHC-II）的恒定链（invariant chain，Ii）。它的主要功能是帮助MHC-II分子正确折叠并转运至内体（endosome），在那里与外来抗原肽结合，最终呈递给CD4+ T细胞以启动适应性免疫应答。CD74还在细胞信号传导中发挥作用，可作为巨噬细胞迁移抑制因子（MIF）的受体，参与炎症反应和细胞存活调控。CD74主要表达于抗原呈递细胞（如B细胞、树突状细胞和巨噬细胞），但在某些上皮细胞和肿瘤细胞中也有表达。CD74基因突变可能导致MHC-II分子组装或转运缺陷，引发免疫缺陷疾病如裸淋巴细胞综合征（bare lymphocyte syndrome）。CD74过表达常见于多种癌症（如淋巴瘤、乳腺癌和前列腺癌），与肿瘤进展、转移和不良预后相关，可能通过激活NF-κB等促生存信号通路。CD74表达降低则可能损害抗原呈递功能，导致免疫应答减弱。CD74属于MHC-II相关基因家族，该家族成员多参与抗原处理和呈递过程。CD74的剪切变体（如p41）还具有调节蛋白酶活性的功能，能影响内体中的抗原降解。在自身免疫疾病中，CD74-MIF相互作用可能促进炎症反应，成为治疗靶点。此外，CD74与病毒感染（如EB病毒）的免疫逃逸机制也有关联。

The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein, initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta). Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]

该基??因联营公司与Ⅱ类主要组织相容性复合体（MHC）编码的蛋白质，是一种调节抗原提呈的免疫反应的重要伴侣。它也可作为细胞因子巨噬细胞迁移抑制因子（MIF），当结合到编码蛋白质，启动存活途径和细胞增殖细胞表面受体。这种蛋白也与淀粉样前体蛋白（APP）相互作用，并抑制生产淀粉样蛋白β（Abeta的）的。编码不同亚型多重选择性剪接转录变异体已经确定。 [由RefSeq的，2011年8月提供]

OMIM数据库中对CD74基因的介绍     Wikipedia数据库中对CD74基因的介绍

基因序列

基因序列

CD74基因的碱基序列：[NCBI]
Loading Gene Browser...

基因突变

基因突变

CD74基因的碱基突变：           仅显示部分snp
rs1004978       rs1051661       rs1056400       rs1065086       rs1065303       rs1065357       rs1529696       rs1560661       rs2071368       rs2288817       rs2748247       rs2748248       rs2748249       rs3194843       rs3211023       rs3776828       rs3797618      

基因表达

基因表达

CD74基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向Tm值
反向引物序列
反向Tm值
评分
ATCTCCAACAATGAGCAACTG
59
GTACAGGAAGTAGGCGGTG
60
TAGACTGGAAGGTCTTTGAGAG
59
CCTGTACCTTTCGGTGGAG
60
ATCTCCAACAATGAGCAACTG
59
GTACAGGAAGTAGGCGGTG
60
AGAGGACCATGTGATGCAC
60
CAGCTCTCAAAGACCTTCCA
60
TCTCCAACAATGAGCAACTG
59
TACTTGGTGGCATTCTGCA
60
CTTACCCTCGTTCCTGTCC
60
ATACTTGGTGGCATTCTGC
58
TCTTTGAGAGCTGGATGCA
59
TCCAGTGACTCTTTCGGTG
59
CTTTGAGAGCTGGATGCAC
59
CTTGGTCAGTACTTTCGGTG
59
CTTTGAGAGCTGGATGCAC
59
CTTGGTCAGTACTTTCGGTG
59
AGAGGACCATGTGATGCAC
60
CAGCTCTCAAAGACCTTCCA
60

转录因子

转录因子

转录因子
影响基因
影响类型
参考文献链接（PubMed）
NFKB1
CD74
Unknown
8164652
RELA
CD74
Unknown
8164652

基因本体信息

CD74基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 质膜
  • 细胞质
  • 细胞外
  • 高尔基体
  • 囊泡
  • 细胞骨架
  • 内质网
  • 细胞核
  • 内体
  • 溶酶体
  • 线粒体

CD74基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0005622
E7EQJ3 (UniProtKB)
IEA
GO:0006886
E7EQJ3 (UniProtKB)
IEA
GO:0006955
E7EQJ3 (UniProtKB)
IEA
GO:0016021
E7EQJ3 (UniProtKB)
IEA
GO:0019882
E7EQJ3 (UniProtKB)
IEA
GO:0042289
E7EQJ3 (UniProtKB)
IEA
GO:0005622
E7ESL3 (UniProtKB)
IEA
GO:0006886
E7ESL3 (UniProtKB)
IEA
GO:0006955
E7ESL3 (UniProtKB)
IEA
GO:0016021
E7ESL3 (UniProtKB)
IEA
GO:0019882
E7ESL3 (UniProtKB)
IEA
GO:0042289
E7ESL3 (UniProtKB)
IEA
GO:0005622
H0YBZ2 (UniProtKB)
IEA
GO:0006886
H0YBZ2 (UniProtKB)
IEA
GO:0006955
H0YBZ2 (UniProtKB)
IEA
GO:0016021
H0YBZ2 (UniProtKB)
IEA
GO:0019882
H0YBZ2 (UniProtKB)
IEA
GO:0042289
H0YBZ2 (UniProtKB)
IEA
GO:0005622
H0YBZ8 (UniProtKB)
IEA
GO:0006886
H0YBZ8 (UniProtKB)
IEA
GO:0006955
H0YBZ8 (UniProtKB)
IEA
GO:0016021
H0YBZ8 (UniProtKB)
IEA
GO:0019882
H0YBZ8 (UniProtKB)
IEA
GO:0042289
H0YBZ8 (UniProtKB)
IEA
GO:0000139
P04233 (UniProtKB)
TAS
GO:0000139
P04233 (UniProtKB)
TAS
GO:0000187
P04233 (UniProtKB)
IEA
GO:0001516
P04233 (UniProtKB)
IDA
GO:0001540
P04233 (UniProtKB)
IPI
GO:0001961
P04233 (UniProtKB)
IMP
GO:0002606
P04233 (UniProtKB)
IEA
GO:0002792
P04233 (UniProtKB)
IDA
GO:0002830
P04233 (UniProtKB)
IEA
GO:0002906
P04233 (UniProtKB)
IEA
GO:0004896
P04233 (UniProtKB)
IDA
GO:0005515
P04233 (UniProtKB)
IPI
GO:0005622
P04233 (UniProtKB)
TAS
GO:0005765
P04233 (UniProtKB)
TAS
GO:0005765
P04233 (UniProtKB)
TAS
GO:0005765
P04233 (UniProtKB)
TAS
GO:0005765
P04233 (UniProtKB)
TAS
GO:0005765
P04233 (UniProtKB)
TAS
GO:0005765
P04233 (UniProtKB)
TAS
GO:0005771
P04233 (UniProtKB)
IEA
GO:0005773
P04233 (UniProtKB)
IDA
GO:0005886
P04233 (UniProtKB)
TAS
GO:0005886
P04233 (UniProtKB)
TAS
GO:0005886
P04233 (UniProtKB)
TAS
GO:0005886
P04233 (UniProtKB)
TAS
GO:0006461
P04233 (UniProtKB)
ISS
GO:0006886
P04233 (UniProtKB)
ISS
GO:0006952
P04233 (UniProtKB)
IEA
GO:0007165
P04233 (UniProtKB)
IDA
GO:0008283
P04233 (UniProtKB)
IDA
GO:0009897
P04233 (UniProtKB)
IEA
GO:0009986
P04233 (UniProtKB)
IDA
GO:0012507
P04233 (UniProtKB)
TAS
GO:0012507
P04233 (UniProtKB)
TAS
GO:0016020
P04233 (UniProtKB)
IDA
GO:0016021
P04233 (UniProtKB)
IDA
GO:0016064
P04233 (UniProtKB)
ISS
GO:0019883
P04233 (UniProtKB)
NAS
GO:0019886
P04233 (UniProtKB)
TAS
GO:0019955
P04233 (UniProtKB)
IPI
GO:0019955
P04233 (UniProtKB)
IPI
GO:0023026
P04233 (UniProtKB)
IDA
GO:0030658
P04233 (UniProtKB)
TAS
GO:0030658
P04233 (UniProtKB)
TAS
GO:0030666
P04233 (UniProtKB)
TAS
GO:0030666
P04233 (UniProtKB)
TAS
GO:0030669
P04233 (UniProtKB)
TAS
GO:0030669
P04233 (UniProtKB)
TAS
GO:0030890
P04233 (UniProtKB)
IMP
GO:0032588
P04233 (UniProtKB)
TAS
GO:0032588
P04233 (UniProtKB)
TAS
GO:0032588
P04233 (UniProtKB)
TAS
GO:0032588
P04233 (UniProtKB)
TAS
GO:0032588
P04233 (UniProtKB)
TAS
GO:0035691
P04233 (UniProtKB)
IEA
GO:0035692
P04233 (UniProtKB)
IDA
GO:0035693
P04233 (UniProtKB)
IEA
GO:0035718
P04233 (UniProtKB)
IPI
GO:0042289
P04233 (UniProtKB)
ISS
GO:0042289
P04233 (UniProtKB)
NAS
GO:0042658
P04233 (UniProtKB)
IDA
GO:0042802
P04233 (UniProtKB)
TAS
GO:0043030
P04233 (UniProtKB)
NAS
GO:0043066
P04233 (UniProtKB)
IDA
GO:0043202
P04233 (UniProtKB)
TAS
GO:0043518
P04233 (UniProtKB)
IDA
GO:0044183
P04233 (UniProtKB)
IDA
GO:0045058
P04233 (UniProtKB)
NAS
GO:0045059
P04233 (UniProtKB)
IEA
GO:0045060
P04233 (UniProtKB)
IEA
GO:0045581
P04233 (UniProtKB)
IEA
GO:0045582
P04233 (UniProtKB)
IEA
GO:0048146
P04233 (UniProtKB)
IMP
GO:0050731
P04233 (UniProtKB)
IDA
GO:0050900
P04233 (UniProtKB)
TAS
GO:0050998
P04233 (UniProtKB)
IEA
GO:0051085
P04233 (UniProtKB)
IEA
GO:0060907
P04233 (UniProtKB)
ISS
GO:0070062
P04233 (UniProtKB)
IDA
GO:0070062
P04233 (UniProtKB)
IDA
GO:0070374
P04233 (UniProtKB)
IMP
GO:0070374
P04233 (UniProtKB)
IDA
GO:0071556
P04233 (UniProtKB)
TAS
GO:0071556
P04233 (UniProtKB)
TAS
GO:0071556
P04233 (UniProtKB)
TAS
GO:0090023
P04233 (UniProtKB)
ISS
GO:1902166
P04233 (UniProtKB)
IMP
GO:2000343
P04233 (UniProtKB)
ISS
GO:0042613
P04233 (UniProtKB)
ISS

基因相关microRNA

基因相关microRNA

可能调控 CD74基因的相关microRNA：     

基因相互作用关系

基因相互作用关系

Reactome

MINT

BioGrid

IntAct

mentha

String

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因通路

基因通路

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Non-Small Cell Lung Carcinoma 0.121085767 5 0 BeFree_CTD_human
Mammary Neoplasms 0.120542884 3 0 BeFree_CTD_human
Liver Failure, Acute 0.12 1 0 CTD_human
Diabetic Nephropathy 0.003267234 3 0 BeFree_LHGDN
Lung Neoplasms 0.002995792 2 0 BeFree_LHGDN
Multiple Myeloma 0.002995792 1 0 BeFree_LHGDN
Liver carcinoma 0.00272435 1 0 LHGDN
Prostatic Neoplasms 0.00272435 1 0 LHGDN
Kidney Neoplasm 0.00272435 1 0 LHGDN
Celiac Disease 0.002367032 1 0 GAD

基因相关服务

基因相关服务

联系方式

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