CD44 (CD44 molecule (Indian blood group))

基因基本信息

基因基本信息

symbol:
CD44
locus group:
protein-coding gene
location:
11p13
gene_family:
Blood group antigens|CD molecules|Proteoglycans - ungrouped
alias symbol:
IN|MC56|Pgp1|PGP-1|CD44R|HCELL|CSPG8|Hermes-1|CDw44|HUTCH-1|HUTCH-I|ECM-III|H-CAM
alias name:
hematopoietic cell E- and L-select…
entrez id:
960
ensembl gene id:
ENSG00000026508
ucsc gene id:
uc001mvu.4
refseq accession:
NM_000610
hgnc_id:
HGNC:1681
approved reserved:
1989-06-30

基因染色体位置

基因染色体位置

11p13
基因染色体位置图

基因简述

基因简述

The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis. [provided by RefSeq, Jul 2008]

由该基因编码的蛋白质是参与细胞 - 细胞相互作用，细胞粘附和迁移的细胞表面糖蛋白。它是透明质酸（HA）的受体，也可以与其它配位体，如骨桥蛋白，胶原，和基质金属蛋白酶（MMPs）相互作用。该蛋白参与了多种细胞功能，包括淋巴细胞的活化，再循环和归巢，造血和肿瘤转移。此基因的转录进行复杂的可变剪接，其导致许多功能不同的同种型，但是，其中的一些变体的全长性质尚未确定。选择性剪接是该蛋白质的结构和功能多样性的基础，并且可能与肿瘤转移。 [由RefSeq的，2008年7月提供]

OMIM数据库中对CCND1基因的介绍     Wikipedia数据库中对CCND1基因的介绍

基因序列

基因序列

CCND1基因的碱基序列：[NCBI]
Loading Gene Browser...

基因突变

基因突变

CD44基因的碱基突变：           仅显示部分snp
rs8193       rs13347       rs102518       rs112762       rs187115       rs187116       rs193276       rs241494       rs353558       rs353612       rs353613       rs353614       rs353615       rs353616       rs353617       rs353618       rs353619      

基因表达

基因表达

CD44基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向Tm值
反向引物序列
反向Tm值
评分
TGCTACCAGAGACCAAGAC
59
TTGACTCCCATGTGAGTGTC
60
AATCCCTGCTACCAAGCAG
60
GAGTAGAAGTTGTTGGATGGTC
59
TTCAGGAGATATGGACTCCAG
59
TCCAAATCTTCCACCAAACC
58
TGAAGGAAACTGGAACCCA
59
GTGACATCATTCCTATTTGTGC
58
CCACAAGGATGACTGTCCA
59
ATCTGTTGCCAAACCACTG
59
TTCAGGAGGAGACCAAGAC
58
CTTGACTCCCATGTGAGTG
58
TACATCACATGAAGGCTTGGA
60
AATGTGTCTTGGTCTCTGCT
59
CAGGGACAGCTGATATGGA
59
AATCTTCCACCAAACCTGTG
58
ATTTGAGACCTGCAGTTTGC
60
CCATTGCCACTGTTGATCAC
60
CAGCACTTCAGGAGATAGGA
59
TCCAGTAAAGTAGTTGAGCCT
59

转录因子

转录因子

转录因子
影响基因
影响类型
参考文献链接（PubMed）
CTNNB1
CD44
Unknown
17724465
HDAC1
CD44
Repression
18372343
HMGA1
CD44
Activation
15901130
IKBKB
CD44
Repression
18600306
MYCN
CD44
Activation
19885598
SMARCA1
CD44
Repression
14604992
SMARCA4
CD44
Repression
14604992
SMARCB1
CD44
Repression
14604992
SNAI2
CD44
Activation
20509143
SP1
CD44
Activation
12972613

基因本体信息

CD44基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 质膜
  • 细胞质
  • 细胞外
  • 高尔基体
  • 囊泡
  • 细胞骨架
  • 内质网
  • 细胞核
  • 内体
  • 溶酶体
  • 线粒体

CD44基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0005540
E9PKC6 (UniProtKB)
IEA
GO:0007155
E9PKC6 (UniProtKB)
IEA
GO:0016021
E9PKC6 (UniProtKB)
IEA
GO:0005540
H0Y2P0 (UniProtKB)
IEA
GO:0007155
H0Y2P0 (UniProtKB)
IEA
GO:0016021
H0Y2P0 (UniProtKB)
IEA
GO:0005540
H0Y5E4 (UniProtKB)
IEA
GO:0007155
H0Y5E4 (UniProtKB)
IEA
GO:0016021
H0Y5E4 (UniProtKB)
IEA
GO:0005540
H0YCV9 (UniProtKB)
IEA
GO:0007155
H0YCV9 (UniProtKB)
IEA
GO:0016021
H0YCV9 (UniProtKB)
IEA
GO:0005540
H0YD13 (UniProtKB)
IEA
GO:0007155
H0YD13 (UniProtKB)
IEA
GO:0016021
H0YD13 (UniProtKB)
IEA
GO:0005540
H0YD17 (UniProtKB)
IEA
GO:0007155
H0YD17 (UniProtKB)
IEA
GO:0016021
H0YD17 (UniProtKB)
IEA
GO:0005540
H0YD90 (UniProtKB)
IEA
GO:0007155
H0YD90 (UniProtKB)
IEA
GO:0016021
H0YD90 (UniProtKB)
IEA
GO:0033674
H0YD90 (UniProtKB)
IDA
GO:0005540
H0YDW7 (UniProtKB)
IEA
GO:0007155
H0YDW7 (UniProtKB)
IEA
GO:0016021
H0YDW7 (UniProtKB)
IEA
GO:0005540
H0YDX6 (UniProtKB)
IEA
GO:0007155
H0YDX6 (UniProtKB)
IEA
GO:0016021
H0YDX6 (UniProtKB)
IEA
GO:0007155
H0YE40 (UniProtKB)
IEA
GO:0016021
H0YE40 (UniProtKB)
IEA
GO:0007155
H0YEV3 (UniProtKB)
IEA
GO:0016021
H0YEV3 (UniProtKB)
IEA
GO:0007155
H0YF08 (UniProtKB)
IEA
GO:0016021
H0YF08 (UniProtKB)
IEA
GO:0007155
J3KN83 (UniProtKB)
IEA
GO:0016021
J3KN83 (UniProtKB)
IEA
GO:0004415
P16070 (UniProtKB)
IDA
GO:0005515
P16070 (UniProtKB)
IPI
GO:0005515
P16070 (UniProtKB)
IPI
GO:0005515
P16070 (UniProtKB)
IPI
GO:0005515
P16070 (UniProtKB)
IPI
GO:0005515
P16070 (UniProtKB)
IPI
GO:0005518
P16070 (UniProtKB)
NAS
GO:0005540
P16070 (UniProtKB)
IDA
GO:0005540
P16070 (UniProtKB)
IDA
GO:0005540
P16070 (UniProtKB)
NAS
GO:0005737
P16070 (UniProtKB)
IDA
GO:0005794
P16070 (UniProtKB)
IDA
GO:0005886
P16070 (UniProtKB)
IDA
GO:0005886
P16070 (UniProtKB)
TAS
GO:0005886
P16070 (UniProtKB)
TAS
GO:0005886
P16070 (UniProtKB)
TAS
GO:0005886
P16070 (UniProtKB)
TAS
GO:0005886
P16070 (UniProtKB)
TAS
GO:0005886
P16070 (UniProtKB)
TAS
GO:0005886
P16070 (UniProtKB)
TAS
GO:0005887
P16070 (UniProtKB)
NAS
GO:0005925
P16070 (UniProtKB)
IDA
GO:0007160
P16070 (UniProtKB)
NAS
GO:0009986
P16070 (UniProtKB)
IDA
GO:0009986
P16070 (UniProtKB)
IDA
GO:0016337
P16070 (UniProtKB)
NAS
GO:0022617
P16070 (UniProtKB)
TAS
GO:0030198
P16070 (UniProtKB)
TAS
GO:0030214
P16070 (UniProtKB)
IDA
GO:0030214
P16070 (UniProtKB)
TAS
GO:0033138
P16070 (UniProtKB)
IDA
GO:0034116
P16070 (UniProtKB)
IMP
GO:0035692
P16070 (UniProtKB)
IDA
GO:0043066
P16070 (UniProtKB)
IMP
GO:0043154
P16070 (UniProtKB)
IMP
GO:0043518
P16070 (UniProtKB)
IDA
GO:0044344
P16070 (UniProtKB)
IDA
GO:0050731
P16070 (UniProtKB)
IDA
GO:0050900
P16070 (UniProtKB)
TAS
GO:0051216
P16070 (UniProtKB)
IEP
GO:0060333
P16070 (UniProtKB)
TAS
GO:0070062
P16070 (UniProtKB)
IDA
GO:0070062
P16070 (UniProtKB)
IDA
GO:0070062
P16070 (UniProtKB)
IDA
GO:0070374
P16070 (UniProtKB)
IDA
GO:0070487
P16070 (UniProtKB)
IMP
GO:1900625
P16070 (UniProtKB)
IMP
GO:1902166
P16070 (UniProtKB)
IDA
GO:0004896
P16070 (UniProtKB)
IDA
GO:0005540
Q86UZ1 (UniProtKB)
IEA
GO:0007155
Q86UZ1 (UniProtKB)
IEA
GO:0016021
Q86UZ1 (UniProtKB)
IEA

基因相关microRNA

基因相关microRNA

可能调控 CD44基因的相关microRNA：     

基因相互作用关系

基因相互作用关系

Reactome

BioGrid

IntAct

mentha

String

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因通路

基因通路

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Neoplasm Metastasis 0.193600473 236 0 BeFree_CTD_human_LHGDN
Stomach Neoplasms 0.125991584 5 0 BeFree_CTD_human_LHGDN
Leukemia, Myelocytic, Acute 0.125981653 13 0 BeFree_CTD_human_LHGDN
Acute Promyelocytic Leukemia 0.12272435 3 0 CTD_human_LHGDN
Pancreatic Neoplasm 0.120814326 4 0 BeFree_CTD_human
Dermatologic disorders 0.120542884 3 0 BeFree_CTD_human
Contact Dermatitis 0.12 1 0 CTD_human
Peripheral Neuropathy 0.12 1 0 CTD_human
Nerve Degeneration 0.12 1 0 CTD_human
Vitiligo 0.12 1 0 CTD_human

基因相关服务

基因相关服务

联系方式

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