CD3G (CD3 gamma subunit of T-cell receptor complex)

基因基本信息

基因基本信息

symbol:
CD3G
locus group:
protein-coding gene
location:
11q23.3
gene_family:
CD molecules
alias symbol:
CD3-GAMMA|CD3GAMMA
alias name:
T-cell surface glycoprotein CD3 ga…
entrez id:
917
ensembl gene id:
ENSG00000160654
ucsc gene id:
uc001psu.3
refseq accession:
NM_000073
hgnc_id:
HGNC:1675
approved reserved:
1988-05-11

基因染色体位置

基因染色体位置

11q23.3
基因染色体位置图

基因简述

基因简述

The protein encoded by this gene is the CD3-gamma polypeptide, which together with CD3-epsilon, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. Defects in this gene are associated with T cell immunodeficiency. [provided by RefSeq, Jul 2008]

由该基因编码的蛋白是CD3-γ多肽，它与CD3-ε，-delta和-zeta和T细胞受体α/β和γ/三角洲异在一起，形成T细胞受体CD3复合。这种复杂起着抗原识别耦合到几个细胞内信号转导途径中起重要作用。编码的ε，γ和δ的多肽的基因位于11号染色体的缺陷在该基因与T细胞免疫缺陷相关联的相同簇中。 [由RefSeq的，2008年7月提供]

OMIM数据库中对CCND1基因的介绍     Wikipedia数据库中对CCND1基因的介绍

基因序列

基因序列

CCND1基因的碱基序列：[NCBI]
Loading Gene Browser...

基因突变

基因突变

CD3G基因的碱基突变：           仅显示部分snp
rs2071381       rs2239695       rs3181259       rs7947185       rs12795615       rs36017260       rs45531936       rs45559236       rs45621535       rs60810919       rs68070310       rs73612298       rs76974878       rs79667493       rs111684880       rs114445484       rs138416327      

基因表达

基因表达

CD3G基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向Tm值
反向引物序列
反向Tm值
评分
TCTTCAAGGTACTTTGGCC
57
TTCCGTCAATATTCTGAGTCTG
58
CAGTCAATCAAAGGTGTATGAC
58
CTTCCCATCTTTAAACCATGTG
58
CCAGTCAATCAAAGGAAACCA
59
GGCTTCTGCATCACAAGTC
59
TTCTTCAAGGTACTTTGGCC
58
AAGTCAGAAGTACCGAACCA
59
CAATCAAAGGAGAAGCAGGA
58
CATACACCTTAACCAAGTGGT
58
TCTTCTTCAAGGTACTTTGGC
58
GGGTCACAGTTTGAGATGTG
59
CCAGTCAATCAAAGGAAACCA
59
GCTTCTGCATCACAAGTCAG
60
TCTTCTTCAAGGTACTTTGGC
58
GAGTATAGAAAGAAGCCATTTCTCC
60
TCTTCTTCAAGGTACTTTGGC
58
GCATCACAAGTCAGAAGTACC
59
CCCTCGAGGGATGTATCAG
59
TCTGCTTGTCTGAAGTTCTG
58

转录因子

转录因子

转录因子
影响基因
影响类型
参考文献链接（PubMed）
NFATC1
CD3G
Activation
15879122; 16219537
NFATC1
CD3G
Repression
15879122
NFATC2
CD3G
Repression
15879122; 16219537
NFKB1
CD3G
Activation
16219537

基因本体信息

CD3G基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 质膜
  • 细胞质
  • 细胞外
  • 高尔基体
  • 囊泡
  • 细胞骨架
  • 内质网
  • 细胞核
  • 内体
  • 溶酶体
  • 线粒体

CD3G基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0004888
A8MUH3 (UniProtKB)
IEA
GO:0007166
A8MUH3 (UniProtKB)
IEA
GO:0016020
A8MUH3 (UniProtKB)
IEA
GO:0004888
P09693 (UniProtKB)
IMP
GO:0005886
P09693 (UniProtKB)
TAS
GO:0005886
P09693 (UniProtKB)
TAS
GO:0005886
P09693 (UniProtKB)
TAS
GO:0005886
P09693 (UniProtKB)
TAS
GO:0005886
P09693 (UniProtKB)
TAS
GO:0005886
P09693 (UniProtKB)
TAS
GO:0005886
P09693 (UniProtKB)
TAS
GO:0005886
P09693 (UniProtKB)
TAS
GO:0005886
P09693 (UniProtKB)
TAS
GO:0005886
P09693 (UniProtKB)
TAS
GO:0005886
P09693 (UniProtKB)
TAS
GO:0005886
P09693 (UniProtKB)
TAS
GO:0005886
P09693 (UniProtKB)
TAS
GO:0005886
P09693 (UniProtKB)
TAS
GO:0005886
P09693 (UniProtKB)
TAS
GO:0005886
P09693 (UniProtKB)
TAS
GO:0005886
P09693 (UniProtKB)
TAS
GO:0005886
P09693 (UniProtKB)
TAS
GO:0005886
P09693 (UniProtKB)
TAS
GO:0005886
P09693 (UniProtKB)
TAS
GO:0005886
P09693 (UniProtKB)
TAS
GO:0005886
P09693 (UniProtKB)
TAS
GO:0005886
P09693 (UniProtKB)
TAS
GO:0005886
P09693 (UniProtKB)
TAS
GO:0005886
P09693 (UniProtKB)
TAS
GO:0005886
P09693 (UniProtKB)
TAS
GO:0005886
P09693 (UniProtKB)
TAS
GO:0005886
P09693 (UniProtKB)
TAS
GO:0005886
P09693 (UniProtKB)
TAS
GO:0005886
P09693 (UniProtKB)
TAS
GO:0005887
P09693 (UniProtKB)
NAS
GO:0006461
P09693 (UniProtKB)
NAS
GO:0007163
P09693 (UniProtKB)
IMP
GO:0007166
P09693 (UniProtKB)
IMP
GO:0015031
P09693 (UniProtKB)
IMP
GO:0030159
P09693 (UniProtKB)
NAS
GO:0031295
P09693 (UniProtKB)
TAS
GO:0038096
P09693 (UniProtKB)
TAS
GO:0042101
P09693 (UniProtKB)
NAS
GO:0042105
P09693 (UniProtKB)
IEA
GO:0042110
P09693 (UniProtKB)
NAS
GO:0042608
P09693 (UniProtKB)
NAS
GO:0046982
P09693 (UniProtKB)
IPI
GO:0050776
P09693 (UniProtKB)
TAS
GO:0050852
P09693 (UniProtKB)
TAS
GO:0070228
P09693 (UniProtKB)
IMP

基因相关microRNA

基因相关microRNA

可能调控 CD3G基因的相关microRNA：     

基因相互作用关系

基因相互作用关系

Reactome

BioGrid

mentha

String

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因通路

基因通路

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
IMMUNODEFICIENCY 17 0.24 0 3 CLINVAR_ORPHANET
IGA Glomerulonephritis 0.12 1 0 CTD_human
Celiac Disease 0.005091382 2 0 GAD_LHGDN
HTLV-I Infections 0.00272435 1 0 LHGDN
Rheumatoid Arthritis 0.002367032 1 0 GAD
leukemia 0.000542884 2 0 BeFree
Lymphopenia 0.000542884 2 0 BeFree
Severe Combined Immunodeficiency 0.000542884 2 0 BeFree
Lupus Erythematosus, Discoid 0.000271442 1 0 BeFree
Lymphoma 0.000271442 1 0 BeFree

基因相关服务

基因相关服务

联系方式

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