The protein encoded by this gene is a type-1 membrane glycoprotein, which contains two immunoglobulin domains, and thus belongs to the immunoglobulin superfamily. Studies of the related genes in mouse and rat suggest that this gene may regulate myeloid cell activity and delivers an inhibitory signal for the macrophage lineage in diverse tissues. Multiple alternatively spliced transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
由该基因编码的蛋白质是一个1型膜糖蛋白,它包含两个免疫球蛋白结构域,并且因此属于免疫球蛋白超家族。在小鼠和大鼠的相关基因的研究表明,这种基因可调节骨髓细胞的活性,并提供了在不同的组织中的巨噬细胞谱系的抑制性信号。编码不同亚型多重选择性剪接转录变异体也发现了这种基因。 [由RefSeq的,2008年7月提供]
CD200基因(以及对应的蛋白质)的细胞分布位置:
CD200基因的本体(GO)信息:
名称 |
---|
Adaptive Immune System |
Immune System |
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Autoimmune Diseases | 0.08 | 0 | 0 | MGD |
melanoma | 0.002995792 | 2 | 0 | BeFree_LHGDN |
Colonic Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
Inflammation | 0.00272435 | 1 | 0 | LHGDN |
Parkinson Disease | 0.00272435 | 1 | 0 | LHGDN |
Atrial Fibrillation | 0.002367032 | 1 | 1 | GAD |
Tobacco Use Disorder | 0.002367032 | 1 | 0 | GAD |
Chronic Lymphocytic Leukemia | 0.001357209 | 5 | 0 | BeFree |
Multiple Myeloma | 0.001085767 | 4 | 0 | BeFree |
Malignant neoplasm of breast | 0.000542884 | 2 | 0 | BeFree |
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