CCR8 (C-C motif chemokine receptor 8)
- symbol:
- CCR8
- locus group:
- protein-coding gene
- location:
- 3p22.1
- gene_family:
- Chemokine receptors|CD molecules
- alias symbol:
- CY6|TER1|CKR-L1|GPR-CY6|CDw198
- alias name:
- None
- entrez id:
- 1237
- ensembl gene id:
- ENSG00000179934
- ucsc gene id:
- uc010hhr.3
- refseq accession:
- NM_005201
- hgnc_id:
- HGNC:1609
- approved reserved:
- 1997-04-21
This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are important for the migration of various cell types into the inflammatory sites. This receptor protein preferentially expresses in the thymus. I-309, thymus activation-regulated cytokine (TARC) and macrophage inflammatory protein-1 beta (MIP-1 beta) have been identified as ligands of this receptor. Studies of this receptor and its ligands suggested its role in regulation of monocyte chemotaxis and thymic cell apoptosis. More specifically, this receptor may contribute to the proper positioning of activated T cells within the antigenic challenge sites and specialized areas of lymphoid tissues. This gene is located at the chemokine receptor gene cluster region. [provided by RefSeq, Jul 2008]
该基因编码的测试趋化因子受体家族，其被预测为类似于G蛋白偶联受体具有七次跨膜蛋白的成员。趋化因子及其受体对各种细胞类型的迁移进入炎症部位重要。该受体蛋白优先地表达在胸腺。 Ⅰ-309，胸腺活化调节的细胞因子（TARC）和巨噬细胞炎性蛋白-1β（MIP-1β）已被确定为该受体的配体。这种受体的研究及其配体建议其在单核细胞趋和胸腺细胞凋亡调控作用。更具体地，该受体可能有助于活化的T细胞的抗原刺激部位和淋巴组织的专门领域内的正确定位。该基因位于趋化因子受体基因簇的区域。 [由RefSeq的，2008年7月提供]
基因本体信息
CCR8基因（以及对应的蛋白质）的细胞分布位置：
- 质膜
- 细胞质
- 细胞外
- 高尔基体
- 囊泡
- 细胞骨架
- 内质网
- 细胞核
- 内体
- 溶酶体
- 线粒体
CCR8基因的本体（GO）信息：
| 名称 |
|---|
| 4060 Cytokine-cytokine receptor interaction [PATH:hsa04060] |
| 4062 Chemokine signaling pathway [PATH:hsa04062] |
| 5203 Viral carcinogenesis [PATH:hsa05203] |
| 名称 |
|---|
| Chemokine receptors bind chemokines |
| Class A/1 (Rhodopsin-like receptors) |
| G alpha (i) signalling events |
| GPCR downstream signaling |
| GPCR ligand binding |
| Peptide ligand-binding receptors |
| Signal Transduction |
| Signaling by GPCR |
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Status Epilepticus | 0.12 | 1 | 0 | CTD_human |
| Asthma | 0.080542884 | 3 | 0 | BeFree_RGD |
| Pulmonary Fibrosis | 0.08 | 1 | 0 | RGD |
| Endometriosis | 0.002995792 | 1 | 0 | BeFree_LHGDN |
| Inflammation | 0.00272435 | 1 | 0 | LHGDN |
| Chronic Lymphocytic Leukemia | 0.002638474 | 2 | 0 | BeFree_GAD |
| HIV Infections | 0.001357209 | 5 | 0 | BeFree |
| Diffuse Large B-Cell Lymphoma | 0.000542884 | 2 | 0 | BeFree |
| Eczema | 0.000542884 | 2 | 0 | BeFree |
| Dermatitis, Atopic | 0.000542884 | 2 | 0 | BeFree |
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