CCND2 (cyclin D2)
- symbol:
- CCND2
- locus group:
- protein-coding gene
- location:
- 12p13.32
- gene_family:
- Cyclins
- alias symbol:
- None
- alias name:
- G1/S-specific cyclin D2
- entrez id:
- 894
- ensembl gene id:
- ENSG00000118971
- ucsc gene id:
- uc001qmo.4
- refseq accession:
- NM_001759
- hgnc_id:
- HGNC:1583
- approved reserved:
- 1991-12-10
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK4 or CDK6 and functions as a regulatory subunit of the complex, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. Knockout studies of the homologous gene in mouse suggest the essential roles of this gene in ovarian granulosa and germ cell proliferation. High level expression of this gene was observed in ovarian and testicular tumors. Mutations in this gene are associated with megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 3 (MPPH3). [provided by RefSeq, Sep 2014]
由该基因编码的蛋白质属于高度保守的细胞周期蛋白家族，其成员通过细胞周期的特征是急剧周期性的蛋白质丰度。细胞周期蛋白作为CDK激酶的监管。不同细胞周期蛋白表现出不同的表达和降解模式这有助于每个有丝分裂事件的时间协调。这个周期蛋白形成具有CDK4或CDK6和功能的复杂的复合物，其活性所需的细胞周期G1 / S期过渡的调节亚基。这种蛋白已经显示出交互和参与肿瘤抑制Rb蛋白的磷酸化。在小鼠的同源基因的敲除研究显示该基因在卵巢颗粒和生殖细胞增殖的重要作用。在卵巢和睾丸肿瘤中观察到这种基因的高水平表达。在这种基因突变与巨脑-多小脑-趾-积水综合征3（MPPH3）相关联。 [由RefSeq的，2014年9月提供]
基因本体信息
CCND2基因（以及对应的蛋白质）的细胞分布位置：
- 质膜
- 细胞质
- 细胞外
- 高尔基体
- 囊泡
- 细胞骨架
- 内质网
- 细胞核
- 内体
- 溶酶体
- 线粒体
CCND2基因的本体（GO）信息：
| 名称 |
|---|
| 4310 Wnt signaling pathway [PATH:hsa04310] |
| 4390 Hippo signaling pathway [PATH:hsa04390] |
| 4630 Jak-STAT signaling pathway [PATH:hsa04630] |
| 4068 FoxO signaling pathway [PATH:hsa04068] |
| 4151 PI3K-Akt signaling pathway [PATH:hsa04151] |
| 4110 Cell cycle [PATH:hsa04110] |
| 4115 p53 signaling pathway [PATH:hsa04115] |
| 4510 Focal adhesion [PATH:hsa04510] |
| 4917 Prolactin signaling pathway [PATH:hsa04917] |
| 5202 Transcriptional misregulation in cancers [PATH:hsa05202] |
| 5206 MicroRNAs in cancer [PATH:hsa05206] |
| 5203 Viral carcinogenesis [PATH:hsa05203] |
| 5166 HTLV-I infection [PATH:hsa05166] |
| 5162 Measles [PATH:hsa05162] |
| 名称 |
|---|
| Cell Cycle |
| Cell Cycle, Mitotic |
| Cyclin D associated events in G1 |
| G1 Phase |
| Mitotic G1-G1/S phases |
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Colonic Neoplasms | 0.2 | 1 | 0 | CTD_human_RGD |
| Prostatic Neoplasms | 0.122995792 | 2 | 0 | BeFree_CTD_human_LHGDN |
| Diabetes Mellitus, Non-Insulin-Dependent | 0.122909916 | 3 | 1 | BeFree_CTD_human_GAD |
| Colorectal Cancer | 0.120542884 | 2 | 4 | BeFree_GWASCAT |
| Megalanecephaly Polymicrogyria-Polydactyly Hydrocephalus Syndrome | 0.120271442 | 1 | 0 | BeFree_CTD_human |
| Cardiomegaly | 0.12 | 1 | 0 | CTD_human |
| MEGALENCEPHALY-POLYMICROGYRIA-POLYDACTYLY-HYDROCEPHALUS SYNDROME 3 | 0.12 | 1 | 0 | UNIPROT |
| Myocardial Ischemia | 0.12 | 1 | 0 | CTD_human |
| ovarian neoplasm | 0.12 | 1 | 0 | CTD_human |
| Fibrosis | 0.12 | 1 | 0 | CTD_human |
微信公众号
关注微信订阅号，实时查看信息，关注医学生物学动态。
版权所有 © 2025.Genelibs 济南弘晖生物技术有限公司 鲁ICP备13024435号-2
