CCND1 (cyclin D1)

基因基本信息

基因基本信息

symbol:
CCND1
locus group:
protein-coding gene
location:
11q13.3
gene_family:
Cyclins
alias symbol:
U21B31
alias name:
parathyroid adenomatosis 1|B-cell …
entrez id:
595
ensembl gene id:
ENSG00000110092
ucsc gene id:
uc001opa.4
refseq accession:
NM_053056
hgnc_id:
HGNC:1582
approved reserved:
1991-06-06

基因染色体位置

基因染色体位置

11q13.3
基因染色体位置图

基因简述

基因简述

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. [provided by RefSeq, Jul 2008]

由该基因编码的蛋白质属于高度保守的细胞周期蛋白家族，其成员的特征是不同的细胞周期蛋白丰度变化较大。细胞周期蛋白可以调控CDK激酶。不同细胞周期蛋白表现出不同的表达和降解模式这有助于每个有丝分裂事件的时间协调。这个周期蛋白形成具有复杂和功能与CDK4或CDK6的调节亚基，其活性所需的细胞周期G1 / S期转换。这种蛋白已经显示出与肿瘤抑制Rb蛋白相互作用和该基因的表达由铷正调控。突变，扩增和该基因，从而改变细胞周期进程的过度表达，在多种肿瘤中经常观察到，并可能有助于肿瘤的发生。 [由RefSeq的，2008年7月提供]

OMIM数据库中对CCND1基因的介绍     Wikipedia数据库中对CCND1基因的介绍

基因序列

基因序列

CCND1基因的碱基序列：[NCBI]
Loading Gene Browser...

基因突变

基因突变

CCND1基因的碱基突变：           仅显示部分snp
rs7177       rs7178       rs9344       rs586459       rs602652       rs616294       rs647451       rs649392       rs678653       rs954619       rs1050971       rs1051062       rs1051357       rs1131439       rs1352075       rs1944129       rs2220247      

基因表达

基因表达

CCND1基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向Tm值
反向引物序列
反向Tm值
评分
AGTGATCAAGTGTGACCCG
60
ATGAAGCTTTCCCTTCTGGT
59
CGGTGTCCTACTTCAAATGTG
59
TTCATCTTAGAGGCCACGA
58
TCATTGAACACTTCCTCTCCA
59
AACTTCACATCTGTGGCAC
58
TACACCGACAACTCCATCC
59
CTTGAGCTTGTTCACCAGG
59
CGGTGTCCTACTTCAAATGTG
59
ATGAACTTCACATCTCCAGCA
60
TCATTGAACACTTCCTCTCCA
59
AACTTCACATCTGTGGCAC
58
GAGTGATCAAGTGTGACCC
58
TGAAGCTTTCCCTTCTGGT
59
CGGTGTCCTACTTCAAATGTG
59
CGGTCCAGGTAGTTCATGG
60
TACACCGACAACTCCATCC
59
TTGAGCTTGTTCACCAGGA
59
CATTGAACACTTCCTCTCCA
58
GAACTTCACATCTGTGGCA
58

转录因子

转录因子

转录因子
影响基因
影响类型
参考文献链接（PubMed）
AHR
CCND1
Unknown
24380854
ATF2
CCND1
Activation
10464245; 10915780
BHLHE41
CCND1
Repression
18223678
BRCA1
CCND1
Unknown
12032322
BTG2
CCND1
Repression
15870875; 16849553
CTCF
CCND1
Unknown
18625744
CTNNB1
CCND1
Activation
17109766; 20300972
CTNNB1
CCND1
Repression
16628468
CTNNB1
CCND1
Unknown
18679417; 19662654; 19778454
E2F1
CCND1
Activation
20220142; 20655656; 8618861

基因本体信息

CCND1基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 质膜
  • 细胞质
  • 细胞外
  • 高尔基体
  • 囊泡
  • 细胞骨架
  • 内质网
  • 细胞核
  • 内体
  • 溶酶体
  • 线粒体

CCND1基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0007049
F5H437 (UniProtKB)
IEA
GO:0000082
P24385 (UniProtKB)
TAS
GO:0000082
P24385 (UniProtKB)
IDA
GO:0000122
P24385 (UniProtKB)
IDA
GO:0000122
P24385 (UniProtKB)
IDA
GO:0000307
P24385 (UniProtKB)
IDA
GO:0000307
P24385 (UniProtKB)
IDA
GO:0000320
P24385 (UniProtKB)
IEA
GO:0001934
P24385 (UniProtKB)
IDA
GO:0003714
P24385 (UniProtKB)
IDA
GO:0003714
P24385 (UniProtKB)
IDA
GO:0004672
P24385 (UniProtKB)
IEA
GO:0005515
P24385 (UniProtKB)
IPI
GO:0005515
P24385 (UniProtKB)
IPI
GO:0005515
P24385 (UniProtKB)
IPI
GO:0005515
P24385 (UniProtKB)
IPI
GO:0005515
P24385 (UniProtKB)
IPI
GO:0005515
P24385 (UniProtKB)
IPI
GO:0005515
P24385 (UniProtKB)
IPI
GO:0005515
P24385 (UniProtKB)
IPI
GO:0005515
P24385 (UniProtKB)
IPI
GO:0005515
P24385 (UniProtKB)
IPI
GO:0005515
P24385 (UniProtKB)
IPI
GO:0005515
P24385 (UniProtKB)
IPI
GO:0005515
P24385 (UniProtKB)
IPI
GO:0005515
P24385 (UniProtKB)
IPI
GO:0005515
P24385 (UniProtKB)
IPI
GO:0005515
P24385 (UniProtKB)
IPI
GO:0005515
P24385 (UniProtKB)
IPI
GO:0005515
P24385 (UniProtKB)
IPI
GO:0005515
P24385 (UniProtKB)
IPI
GO:0005515
P24385 (UniProtKB)
IPI
GO:0005515
P24385 (UniProtKB)
IPI
GO:0005515
P24385 (UniProtKB)
IPI
GO:0005515
P24385 (UniProtKB)
IPI
GO:0005515
P24385 (UniProtKB)
IPI
GO:0005515
P24385 (UniProtKB)
IPI
GO:0005515
P24385 (UniProtKB)
IPI
GO:0005515
P24385 (UniProtKB)
IPI
GO:0005515
P24385 (UniProtKB)
IPI
GO:0005515
P24385 (UniProtKB)
IPI
GO:0005515
P24385 (UniProtKB)
IPI
GO:0005515
P24385 (UniProtKB)
IPI
GO:0005622
P24385 (UniProtKB)
IDA
GO:0005634
P24385 (UniProtKB)
IDA
GO:0005654
P24385 (UniProtKB)
IDA
GO:0005654
P24385 (UniProtKB)
TAS
GO:0005654
P24385 (UniProtKB)
TAS
GO:0005654
P24385 (UniProtKB)
TAS
GO:0005654
P24385 (UniProtKB)
TAS
GO:0005654
P24385 (UniProtKB)
TAS
GO:0005654
P24385 (UniProtKB)
TAS
GO:0005654
P24385 (UniProtKB)
TAS
GO:0005654
P24385 (UniProtKB)
TAS
GO:0005654
P24385 (UniProtKB)
TAS
GO:0005654
P24385 (UniProtKB)
TAS
GO:0005654
P24385 (UniProtKB)
TAS
GO:0005654
P24385 (UniProtKB)
TAS
GO:0005654
P24385 (UniProtKB)
TAS
GO:0005829
P24385 (UniProtKB)
TAS
GO:0005829
P24385 (UniProtKB)
TAS
GO:0005829
P24385 (UniProtKB)
TAS
GO:0005829
P24385 (UniProtKB)
TAS
GO:0005829
P24385 (UniProtKB)
TAS
GO:0005829
P24385 (UniProtKB)
TAS
GO:0005829
P24385 (UniProtKB)
TAS
GO:0005829
P24385 (UniProtKB)
TAS
GO:0005923
P24385 (UniProtKB)
IEA
GO:0006351
P24385 (UniProtKB)
IEA
GO:0006468
P24385 (UniProtKB)
IEA
GO:0006974
P24385 (UniProtKB)
IDA
GO:0007595
P24385 (UniProtKB)
IEA
GO:0008134
P24385 (UniProtKB)
IPI
GO:0008134
P24385 (UniProtKB)
IPI
GO:0010039
P24385 (UniProtKB)
IEA
GO:0010165
P24385 (UniProtKB)
IEA
GO:0010243
P24385 (UniProtKB)
IEA
GO:0010971
P24385 (UniProtKB)
IDA
GO:0016020
P24385 (UniProtKB)
IEA
GO:0016538
P24385 (UniProtKB)
IEA
GO:0017053
P24385 (UniProtKB)
IDA
GO:0017053
P24385 (UniProtKB)
IDA
GO:0019899
P24385 (UniProtKB)
IPI
GO:0019901
P24385 (UniProtKB)
IPI
GO:0019901
P24385 (UniProtKB)
IPI
GO:0030178
P24385 (UniProtKB)
IEA
GO:0030857
P24385 (UniProtKB)
IEA
GO:0030968
P24385 (UniProtKB)
IEA
GO:0031571
P24385 (UniProtKB)
IDA
GO:0032026
P24385 (UniProtKB)
IEA
GO:0032355
P24385 (UniProtKB)
IEA
GO:0032403
P24385 (UniProtKB)
IEA
GO:0033197
P24385 (UniProtKB)
IEA
GO:0033327
P24385 (UniProtKB)
IEA
GO:0033598
P24385 (UniProtKB)
IEA
GO:0033601
P24385 (UniProtKB)
IEA
GO:0042493
P24385 (UniProtKB)
IEP
GO:0042826
P24385 (UniProtKB)
IPI
GO:0044321
P24385 (UniProtKB)
IDA
GO:0045444
P24385 (UniProtKB)
IEA
GO:0045471
P24385 (UniProtKB)
IEA
GO:0045737
P24385 (UniProtKB)
IDA
GO:0045787
P24385 (UniProtKB)
TAS
GO:0051301
P24385 (UniProtKB)
IEA
GO:0051412
P24385 (UniProtKB)
IEA
GO:0051592
P24385 (UniProtKB)
IEA
GO:0060070
P24385 (UniProtKB)
IEA
GO:0060749
P24385 (UniProtKB)
IEA
GO:0070064
P24385 (UniProtKB)
IDA
GO:0070141
P24385 (UniProtKB)
IDA
GO:0071157
P24385 (UniProtKB)
IDA
GO:0097421
P24385 (UniProtKB)
IEA

基因相关microRNA

基因相关microRNA

可能调控 CCND1基因的相关microRNA：     

基因相互作用关系

基因相互作用关系

Reactome

MINT

BioGrid

IntAct

mentha

String

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因通路

基因通路

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Multiple Myeloma 0.396704242 76 1 BeFree_CTD_human_GWASCAT_LHGDN_ORPHANET
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse 0.342985716 272 0 BeFree_CTD_human_LHGDN_ORPHANET
Chronic Lymphocytic Leukemia 0.256210567 52 0 BeFree_CTD_human_GAD_ORPHANET
Prostatic Neoplasms 0.216531667 9 0 BeFree_CTD_human_GAD_LHGDN_RGD
Carcinoma, Transitional Cell 0.20408156 7 0 BeFree_CTD_human_LHGDN_RGD
Mammary Neoplasms, Experimental 0.2 5 0 CTD_human_RGD
Mammary Neoplasms 0.193441786 59 0 BeFree_CTD_human_GAD_LHGDN
Colorectal Neoplasms 0.150067542 12 0 BeFree_CTD_human_GAD_LHGDN
Liver carcinoma 0.147012161 68 0 BeFree_CTD_human_GAD_LHGDN
Esophageal Neoplasms 0.145522924 24 3 BeFree_CTD_human_GAD_LHGDN

基因相关服务

基因相关服务

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