CCL5 (C-C motif chemokine ligand 5)
- symbol:
- CCL5
- locus group:
- protein-coding gene
- location:
- 17q12
- gene_family:
- Chemokine ligands|Endogenous ligands
- alias symbol:
- RANTES|SISd|TCP228|MGC17164
- alias name:
- T-cell specific protein p288|T-cel…
- entrez id:
- 6352
- ensembl gene id:
- ENSG00000271503
- ucsc gene id:
- uc060eeh.1
- refseq accession:
- NM_002985
- hgnc_id:
- HGNC:10632
- approved reserved:
- 1990-07-05
CCL5（也称为RANTES，Regulated upon Activation, Normal T-cell Expressed and Secreted）是一种趋化因子（chemokine），属于CC趋化因子家族（CC chemokine family），该家族成员的特征是前两个半胱氨酸（cysteine）残基相邻（CC motif）。CCL5主要由T细胞、巨噬细胞、内皮细胞和血小板等分泌，其生物学功能主要是通过结合受体（如CCR1、CCR3、CCR5）招募免疫细胞（如T细胞、单核细胞、嗜酸性粒细胞等）到炎症或感染部位，参与免疫调节和炎症反应。CCL5在病毒感染（如HIV）、过敏性疾病、自身免疫病（如类风湿关节炎）和癌症中发挥重要作用。CCL5的突变或表达异常可能影响其与受体的结合能力，导致免疫细胞迁移障碍，从而影响机体的抗感染或炎症反应。例如，某些CCL5基因多态性（genetic polymorphisms）与HIV感染易感性或疾病进展相关。CCL5过表达可能加剧炎症性疾病（如哮喘）或促进肿瘤微环境中免疫抑制性细胞的聚集，而降低表达则可能削弱抗病毒免疫反应。CCL5还参与组织修复和血管生成，其异常表达可能与动脉粥样硬化或肿瘤血管生成有关。CC趋化因子家族的共性是通过CC motif结合G蛋白偶联受体（GPCRs），调控免疫细胞的迁移和活化。
This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, functions as a chemoattractant for blood monocytes, memory T helper cells and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor chemokine (C-C motif) receptor 5 (CCR5), and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Jul 2013]
该基因是聚集在17号染色??体的q臂上趋化因子构成涉及免疫调节和炎症过程的分泌蛋白的超家族几个趋化因子的基因之一。该超家族分为基于成熟的肽的N末端半胱氨酸残基的排列四个亚科。该趋化因子，所述CC亚家族的一个成员，用作用于血单核细胞，记忆性T辅助细胞和嗜酸性粒细胞趋化物。它会导致由嗜碱细胞的组胺释放并激活嗜酸性粒细胞。这种细胞因子是由CD8 +细胞产生的主要的HIV-抑制因素之一。它的功能作为天然配体的趋化因子受体趋化因子（C-C基序）受体5（CCR5）之一，它HIV-1的R5的菌株，它使用CCR5作为辅助受体的体外复制抑制。选择性剪接结果在多个抄本变形编码不同的亚型。 [由RefSeq的，2013年7月提供]
基因本体信息
CCL5基因（以及对应的蛋白质）的细胞分布位置：
- 质膜
- 细胞质
- 细胞外
- 高尔基体
- 囊泡
- 细胞骨架
- 内质网
- 细胞核
- 内体
- 溶酶体
- 线粒体
CCL5基因的本体（GO）信息：
| 名称 |
|---|
| 4668 TNF signaling pathway [PATH:hsa04668] |
| 4060 Cytokine-cytokine receptor interaction [PATH:hsa04060] |
| 4620 Toll-like receptor signaling pathway [PATH:hsa04620] |
| 4621 NOD-like receptor signaling pathway [PATH:hsa04621] |
| 4623 Cytosolic DNA-sensing pathway [PATH:hsa04623] |
| 4062 Chemokine signaling pathway [PATH:hsa04062] |
| 5323 Rheumatoid arthritis [PATH:hsa05323] |
| 5020 Prion diseases [PATH:hsa05020] |
| 5120 Epithelial cell signaling in Helicobacter pylori infection [PATH:hsa05120] |
| 5164 Influenza A [PATH:hsa05164] |
| 5168 Herpes simplex infection [PATH:hsa05168] |
| 5142 Chagas disease (American trypanosomiasis) [PATH:hsa05142] |
| 名称 |
|---|
| Chemokine receptors bind chemokines |
| Class A/1 (Rhodopsin-like receptors) |
| G alpha (i) signalling events |
| GPCR downstream signaling |
| GPCR ligand binding |
| Peptide ligand-binding receptors |
| Signal Transduction |
| Signaling by GPCR |
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Asthma | 0.258737317 | 38 | 1 | BeFree_CTD_human_GAD_LHGDN_RGD |
| Hyperoxaluria | 0.2 | 1 | 0 | CTD_human_RGD |
| Dermatitis, Atopic | 0.127534359 | 10 | 0 | BeFree_CTD_human_GAD_LHGDN |
| Pulmonary Fibrosis | 0.122995792 | 2 | 0 | BeFree_CTD_human_LHGDN |
| Glomerulonephritis | 0.120542884 | 3 | 0 | BeFree_CTD_human |
| Hepatitis, Alcoholic | 0.120271442 | 2 | 0 | BeFree_CTD_human |
| Hepatitis, Autoimmune | 0.12 | 1 | 0 | CTD_human |
| Peripheral Neuropathy | 0.12 | 1 | 0 | CTD_human |
| Biliary cirrhosis | 0.12 | 1 | 0 | CTD_human |
| Inflammation | 0.09728386 | 8 | 0 | GAD_LHGDN_RGD |
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